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    • 5. 发明授权
    • Producing Z-isomer of hydrogen bromide salt of 2-aminothiazole derivative
    • 生产2-氨基噻唑衍生物溴化氢盐的Z-异构体
    • US06403572B1
    • 2002-06-11
    • US09991728
    • 2001-11-26
    • Isao KurimotoNorihiko HirataAkihiko NakamuraYuichiro Aratake
    • Isao KurimotoNorihiko HirataAkihiko NakamuraYuichiro Aratake
    • C07D27740
    • C07D277/20
    • There is disclosed a process for producing an acid salt of a (Z)-2-aminothiazole compound of the formula (I): wherein R1 and R2 independently represent an alkyl group having 1 to 5 carbon atoms, Y represents a halogen atom, —OSO3H or —OPO(OH)2, m indicates the valence number of an inorganic acid of the formula: HY wherein Y represents the same as defined above, and n indicates an integer of 1 or 2, which process is characterized by: reacting an acid salt of a 2-aminothiazole compound of the formula (II): wherein R1 and R2 independently represent an alkyl group having 1 to 5 carbon atoms, X represents a bromine atom or an iodine atom, and the wavy line means that this compound is a mixture of the E- and Z-isomers, with the inorganic acid of the formula HY.
    • 公开了式(I)的(Z)-2-氨基噻唑化合物的酸式盐的制造方法:其中,R 1和R 2分别表示碳原子数1〜5的烷基,Y表示卤原子,-OSO 3 H 或-OPO(OH)2,m表示下式的无机酸的价数:HY,其中Y表示与上述相同的含义,n表示1或2的整数,该方法的特征在于:使酸盐 的式(II)的2-氨基噻唑化合物:其中R 1和R 2独立地表示具有1至5个碳原子的烷基,X表示溴原子或碘原子,并且波浪线表示该化合物是混合物 的E-和Z-异构体与式HY的无机酸反应。