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1. 发明申请

US20120231055A1 Polymersomes And Production Method Thereof 有权
标题翻译：聚合物及其生产方法
公开(公告)号：US20120231055A1
公开(公告)日：2012-09-13
申请号：US13512375
申请日：2010-07-12
申请人： Yuki Sugiyama , Takashi Ohmori , Nobuyoshi Koga
发明人： Yuki Sugiyama , Takashi Ohmori , Nobuyoshi Koga
IPC分类号： C08L71/02 , A61Q19/00 , A61K8/84 , C08J9/00 , A61K8/11
CPC分类号： A61K8/14 , A61K8/11 , A61K8/86 , A61K9/1273 , A61K9/14 , A61K2800/75 , A61Q19/00 , B01J13/02 , C08G18/4833 , C08G18/4837 , C08G18/4854 , Y10S977/773
摘要： It is an object of the invention to provide a polymersome excellent in the safety and feeling in use; in particular, there is no sticky feeling but there is a good refreshing feeling; and with excellent base-agent stability. A polymersome of the present invention comprises a block-type alkylene oxide derivative represented by the following formula (I) as the membrane component: R1O-[(EO)I(AO)m(EO)n]-R2 (I) wherein AO is an oxyalkylene group having 3 to 4 carbon atoms, EO is an oxyethylene group, m and 1+n are the average addition mole numbers for the oxyalkylene group and the oxyethylene group, respectively, and 1≦m≦70, 1≦1+n≦70; the percentage of the oxyethylene groups with respect to the sum of the oxyalkylene groups having 3 to 4 carbon atoms and the oxyethylene groups is 20 to 80 mass %; the addition pattern of the oxyalkylene groups having 3 to 4 carbon atoms and the oxyethylene groups is block-type; and R1 and R2 are identical or different hydrocarbon groups having 1 to 4 carbon atoms.
摘要翻译：本发明的目的是提供一种在使用上的安全性和使用感好的聚合物组合物。特别是没有粘性的感觉，但有一个很好的清爽的感觉; 并具有优异的基质稳定性。本发明的聚合物组合物包含由下式（I）表示的嵌段型烯化氧衍生物作为膜组分：R 1 O - [（EO）I（AO）m（EO）n] -R 2（I）其中AO 是具有3〜4个碳原子的氧化烯基，EO是氧化乙烯基，m和1 + n分别是氧化烯基和氧化乙烯基的平均加成摩尔数，1和nlE; m＆nlE; 70,1＆ n＆nlE; 70; 氧化乙烯基相对于具有3〜4个碳原子的氧化烯基和氧化乙烯基的总和的比例为20〜80质量％。具有3〜4个碳原子的氧化烯基和氧化乙烯基的添加图案是嵌段型; 并且R 1和R 2是具有1至4个碳原子的相同或不同的烃基。

2. 发明授权

US08603533B2 Polymersomes and production method thereof 有权
标题翻译：聚合物及其制备方法
公开(公告)号：US08603533B2
公开(公告)日：2013-12-10
申请号：US13512375
申请日：2010-07-12
申请人： Yuki Sugiyama , Takashi Ohmori , Nobuyoshi Koga
发明人： Yuki Sugiyama , Takashi Ohmori , Nobuyoshi Koga
IPC分类号： A61K8/14 , A61K8/11 , A61K8/86 , A61K9/14 , A61Q19/00 , C08G18/48
CPC分类号： A61K8/14 , A61K8/11 , A61K8/86 , A61K9/1273 , A61K9/14 , A61K2800/75 , A61Q19/00 , B01J13/02 , C08G18/4833 , C08G18/4837 , C08G18/4854 , Y10S977/773
摘要： It is an object of the invention to provide a polymersome excellent in the safety and feeling in use; in particular, there is no sticky feeling but there is a good refreshing feeling; and with excellent base-agent stability. A polymersome of the present invention comprises a block-type alkylene oxide derivative represented by the following formula (I) as the membrane component: R1O-[(EO)l(AO)m(EO)n]—R2 (I) wherein AO is an oxyalkylene group having 3 to 4 carbon atoms, EO is an oxyethylene group, m and 1+n are the average addition mole numbers for the oxyalkylene group and the oxyethylene group, respectively, and 1≦m≦70, 1≦l+n≦70; the percentage of the oxyethylene groups with respect to the sum of the oxyalkylene groups having 3 to 4 carbon atoms and the oxyethylene groups is 20 to 80 mass %; the addition pattern of the oxyalkylene groups having 3 to 4 carbon atoms and the oxyethylene groups is block-type; and R1 and R2 are identical or different hydrocarbon groups having 1 to 4 carbon atoms.
摘要翻译：本发明的目的是提供一种在使用上的安全性和使用感好的聚合物组合物。特别是没有粘性的感觉，但有一个很好的清爽的感觉; 并具有优异的基质稳定性。本发明的聚合物组合物包括由下式（I）表示的嵌段型烯化氧衍生物作为膜组分：R 1 O - [（EO）1（AO）m（EO）n] -R 2（I）其中AO 是具有3〜4个碳原子的氧化烯基，EO是氧化乙烯基，m和1 + n分别是氧化烯基和氧化乙烯基的平均加成摩尔数，和1≤n≤70,1,1+ n @ 70; 氧化乙烯基相对于具有3〜4个碳原子的氧化烯基和氧化乙烯基的总和的比例为20〜80质量％。具有3〜4个碳原子的氧化烯基和氧化乙烯基的添加图案是嵌段型; 并且R 1和R 2是具有1至4个碳原子的相同或不同的烃基。

3. 发明授权

US08302215B2 Glove and manufacturing method thereof 有权
标题翻译：手套及其制造方法
公开(公告)号：US08302215B2
公开(公告)日：2012-11-06
申请号：US12866176
申请日：2009-02-10
申请人： Kazutaka Matsunobu , Nobuyoshi Koga , Yukiko Tsuchimochi
发明人： Kazutaka Matsunobu , Nobuyoshi Koga , Yukiko Tsuchimochi
IPC分类号： A41D19/00
CPC分类号： A41D19/0065 , B29C41/14 , B29C41/22 , B29L2031/4864
摘要： A glove which can ensure flexibility thereof and can prevent peeling-off of a resin film formed on a surface of a glove base body is provided. Also provided is a manufacturing method of the glove. The glove (G) includes a glove base body (1) constituted of a knitted glove, a first resin film layer (2) formed on a surface of the glove base body (1), and a second resin film layer (3) formed on the first resin film layer (2). The first resin film layer (2) and the second resin film layer (3) cover a palm portion and side portions of the glove base body (1), a palm side and side parts of respective fingers, and areas ranging from fingertip portions to a back portion of the glove base body (1) including the fingertip portions. An uncovered back portion (4) where a resin film layer is not present is formed on a remaining portion of the back portion. The second resin film layer (3) is formed on the first resin film layer (2) in an overlapping manner. A peripheral portion (31) of the second resin film layer (3) extends beyond a peripheral portion (21) of the first resin film layer (2) and is brought into direct contact with the glove base body (1), and the resin liquid in contact with the glove base body (1) permeates into the inside of the glove base body (1) and forms a peeling-off preventing portion.
摘要翻译：提供了能够确保柔软性且能够防止在手套基体的表面形成的树脂膜的剥离的手套。还提供了手套的制造方法。手套（G）包括由手套基体（1）的表面上形成的编织手套，第一树脂膜层（2）和形成于第二树脂膜层（3）的手套基体（1）在第一树脂膜层（2）上。第一树脂膜层（2）和第二树脂膜层（3）覆盖手套基部主体（1）的手掌部分和手指侧部以及各个手指的侧部，以及指尖部分包括指尖部分的手套基体（1）的后部。在背部的剩余部分上形成有不存在树脂膜层的未覆盖的背部（4）。第二树脂膜层（3）以重叠的方式形成在第一树脂膜层（2）上。第二树脂膜层（3）的周边部分（31）延伸超过第一树脂膜层（2）的周边部分（21）并与手套基体（1）直接接触，树脂与手套基体（1）接触的液体渗透到手套基体（1）的内部，形成防剥离部。

4. 发明申请

US20100107304A1 METHOD FOR FORMING RESIN SURFACE, METHOD FOR MANUFACTURING ARTICLE WHICH FORMS RECESSED PORTIONS DIFFERENT IN SIZE RANDOMLY ON SURFACE THEREOF AND ARTICLE MANUFACTURED BY THE METHOD, AND METHOD FOR MANUFACTURING GLOVES AND GLOVES MANUFACTURED BY THE METHOD 有权
标题翻译：形成树脂表面的方法，用于制造不同尺寸的不同尺寸的物品的方法以及通过该方法制造的制品的方法，以及通过该方法制造的手套和手套的方法
公开(公告)号：US20100107304A1
公开(公告)日：2010-05-06
申请号：US12532920
申请日：2008-03-27
申请人： Kazutaka Matsunobu , Nobuyoshi Koga , Yukiko Tsuchimochi
发明人： Kazutaka Matsunobu , Nobuyoshi Koga , Yukiko Tsuchimochi
IPC分类号： A41D19/00 , B05D3/12 , B32B3/26
CPC分类号： B29C59/022 , A41D19/0055 , A41D19/01547 , A41D2400/80 , B05D5/02 , B29C41/14 , B29C59/02 , B29C59/026 , B29C67/202 , B29C2059/023 , B29C2059/028 , B29K2021/00 , B29K2105/0064 , B29K2105/04 , B29K2105/24 , B29K2105/246 , B29K2105/251 , B29K2995/0072 , B29L2009/00 , B29L2031/4864 , Y10T428/249953
摘要： A method for forming a resin surface on which recessed portions different in size are formed randomly includes: forming first recessed portions by allowing all or some granular and/or powdery adhering material to adhere to a surface of an unset resin composition containing air bubbles so that at least a portion of the granular and/or powdery adhering material bites into the surface and by removing the adhering material after the resin composition is set; and forming second recessed portions smaller than the first recessed portions in size by allowing some of the air bubbles contained in the unset or set resin composition to open on the aforementioned surface of the resin composition.
摘要翻译：一种用于形成树脂表面的方法，其中形成尺寸不同的凹入部分的方法包括：通过使所有或一些颗粒状和/或粉末粘附材料粘附到含有气泡的未固化树脂组合物的表面上来形成第一凹部，使得颗粒状和/或粉状粘附材料的至少一部分咬入表面，并且在树脂组合物被固化之后除去粘附材料; 并且通过使所述未固化树脂组合物中包含的一些气泡在所述树脂组合物的上述表面上开口而形成比所述第一凹部小的第二凹部。

5. 发明申请

US20110165323A1 Production method of dry water 审中-公开
标题翻译：干水生产方法
公开(公告)号：US20110165323A1
公开(公告)日：2011-07-07
申请号：US12926497
申请日：2010-11-22
申请人： Takashi Oka , Nobuyoshi Koga , Emiko Takasu , Toshio Yanaki
发明人： Takashi Oka , Nobuyoshi Koga , Emiko Takasu , Toshio Yanaki
IPC分类号： B05D5/00 , B05D7/00 , B82Y99/00
CPC分类号： A61K8/11 , A61K2800/412 , A61Q1/12 , B01F3/1214 , B01F3/1221
摘要： A production method of dry water containing an aqueous ingredient coated with a hydrophobic powder to form a powder state capable of liquefying upon embrocation at the time of use, wherein the dry water is produced by charging a hydrophobic powder and an aqueous ingredient into a hollow container forming a hydrophobic enclosed space in the inside thereof, followed by agitating at a high speed in the enclosed hydrophobic hollow container to form the aqueous ingredient to fine aqueous droplets, and then allowing the surfaces of the fine aqueous droplets to be uniformly adsorbed with the hydrophobic powder, whereby the dry water in the form of a powder state, but is capable of being liquefied upon embrocation at the time of use to be simply produced in a large scale.
摘要翻译：一种干燥水的制造方法，其含有涂覆有疏水性粉末的水性成分，以形成在使用时能够在通气时液化的粉末状态，其中所述干燥水是通过将疏水性粉末和水性成分装入中空容器在其内部形成疏水封闭空间，随后在封闭的疏水性中空容器中高速搅拌，以形成水性成分以精细的水滴，然后使细小水滴的表面均匀地被疏水性吸附粉末，由此形成粉末形式的干燥水，但是在使用时能够在刺穿时液化，以便大量简单地生产。

6. 发明申请

US20120164357A1 External Preparation 审中-公开
标题翻译：外部准备
公开(公告)号：US20120164357A1
公开(公告)日：2012-06-28
申请号：US13393702
申请日：2010-07-23
申请人： Daisuke Suzuki , Junko Tamada , Nobuyoshi Koga
发明人： Daisuke Suzuki , Junko Tamada , Nobuyoshi Koga
IPC分类号： B32B1/08 , A61Q19/00 , A61K8/92
CPC分类号： A61Q19/02 , A61K8/342 , A61K8/44 , A61K8/466 , A61K8/8147 , Y10T428/13
摘要： The present invention is an external preparation that comprises (A) a higher alcohol, (B) 0.01-5 wt % of a long chain acyl sulfonate anionic surfactant represented by the following general formula (1), such as stearoyl methyltaurate, and (C) 0.1-5 wt % of tranexamic acid, and has a pH of 3.0-6.0. R1CO-a-(CH2)nSO3M1 (1) [R′CO— denotes a saturated or unsaturated fatty acid residue (acyl group) having 10-22 carbon atoms on average; a denotes —O— or —NR2— (R2 denotes a hydrogen atom or an alkyl group having 1-3 carbon atoms); M1 denotes a hydrogen atom, alkali metal, alkali earth metal, ammonium, or organic amine; n denotes an integer 1-3.]The object of the present invention is to provide an external preparation containing tranexamic acid that does not cause precipitation of tranexamic acid crystals.
摘要翻译：本发明是一种外用制剂，其包含（A）高级醇，（B）0.01-5重量％的由以下通式（1）表示的长链酰基磺酸盐阴离子表面活性剂，例如硬脂酰甲基牛磺酸酯和（C ）0.1-5重量％的氨甲环酸，并且具有3.0-6.0的pH。 R1CO-a-（CH2）nSO3M1（1）[R'CO-表示平均具有10-22个碳原子的饱和或不饱和脂肪酸残基（酰基） a表示-O-或-NR2-（R2表示氢原子或具有1-3个碳原子的烷基）; M1表示氢原子，碱金属，碱土金属，铵或有机胺; n表示整数1-3。]本发明的目的是提供一种不引起凝血酸结晶沉淀的凝血酸的外用制剂。

7. 外观设计

USD704381S1 Working glove 有权
标题翻译：工作手套
公开(公告)号：USD704381S1
公开(公告)日：2014-05-06
申请号：US29430936
申请日：2012-08-31
申请人： Nobuyoshi Koga , Tsuneo Tanaka
设计人： Nobuyoshi Koga , Tsuneo Tanaka

8. 发明申请

US20100325779A1 GLOVE AND MANUFACTURING METHOD THEREOF 有权
标题翻译：手套及其制造方法
公开(公告)号：US20100325779A1
公开(公告)日：2010-12-30
申请号：US12866176
申请日：2009-02-10
申请人： Kazutaka Matsunobu , Nobuyoshi Koga , Yukiko Tsuchimochi
发明人： Kazutaka Matsunobu , Nobuyoshi Koga , Yukiko Tsuchimochi
IPC分类号： A41D19/00 , A41D19/02
CPC分类号： A41D19/0065 , B29C41/14 , B29C41/22 , B29L2031/4864
摘要： A glove which can ensure flexibility thereof and can prevent peeling-off of a resin film formed on a surface of a glove base body is provided. Also provided is a manufacturing method of the glove. The glove (G) includes a glove base body (1) constituted of a knitted glove, a first resin film layer (2) formed on a surface of the glove base body (1), and a second resin film layer (3) formed on the first resin film layer (2). The first resin film layer (2) and the second resin film layer (3) cover a palm portion and side portions of the glove base body (1), a palm side and side parts of respective fingers, and areas ranging from finger tip portions to a back portion of the glove base body (1) including the finger tip portions. An uncovered back portion (4) where a resin film layer is not present is formed on a remaining portion of the back portion. At the portion of the glove (G) where the first resin film layer (2) covers the glove base body (1), a resin liquid does not permeate until the resin liquid reaches a rear surface of the glove base body (1). The second resin film layer (3) is formed on the first resin film layer (2) in an overlapping manner. A peripheral portion (31) of the second resin film layer (3) extends beyond a peripheral portion (21) of the first resin film layer (2) and is brought into direct contact with the glove base body (1), and the resin liquid in contact with the glove base body (1) permeates into the inside of the glove base body (1) and forms a peeling-off preventing portion.
摘要翻译：提供了能够确保柔软性且能够防止在手套基体的表面形成的树脂膜的剥离的手套。还提供了手套的制造方法。手套（G）包括由手套基体（1）的表面上形成的编织手套，第一树脂膜层（2）和形成于第二树脂膜层（3）的手套基体（1）在第一树脂膜层（2）上。第一树脂膜层（2）和第二树脂膜层（3）覆盖手套基部主体（1）的手掌部分和手指侧部以及各个手指的侧部的手指部分和指尖部分涉及包括指尖部分的手套基体（1）的后部。在背部的剩余部分上形成有不存在树脂膜层的未覆盖的背部（4）。在第一树脂膜层（2）覆盖手套基体（1）的手套（G）的部分，树脂液体在树脂液到达手套基体（1）的后表面之前不渗透。第二树脂膜层（3）以重叠的方式形成在第一树脂膜层（2）上。第二树脂膜层（3）的周边部分（31）延伸超过第一树脂膜层（2）的周边部分（21）并与手套基体（1）直接接触，树脂与手套基体（1）接触的液体渗透到手套基体（1）的内部，形成防剥离部。

9. 发明申请

US20080241101A1 Skin vitalizing composition for external use anti-aging preparation 审中-公开
标题翻译：皮肤活性成分外用抗衰老制剂
公开(公告)号：US20080241101A1
公开(公告)日：2008-10-02
申请号：US12155285
申请日：2008-06-02
申请人： Satoshi Amano , Yuki Ogura , Yukiko Matsunaga , Takanari Tsuda , Yukari Aoyama , Nobuyoshi Koga
发明人： Satoshi Amano , Yuki Ogura , Yukiko Matsunaga , Takanari Tsuda , Yukari Aoyama , Nobuyoshi Koga
IPC分类号： A61K38/20 , A61K38/18 , C12N5/02
CPC分类号： A61K8/64 , A61K8/553 , A61K8/97 , A61K8/985 , A61K2800/782 , A61Q1/02 , A61Q19/00 , A61Q19/08
摘要： The invention provides an epidermal basement membrane structure formation accelerating preparation and a skin external preparation comprising a serine protease inhibitor, and optionally an accelerator of production of extracellular matrix protein components of the epidermal basement membrane. It also provides, as a means for producing artificial skin having an adequately formed basement membrane, an artificial skin-forming medium which comprises a serine protease inhibitor, and optionally an accelerator of production of extracellular matrix protein components of the epidermal basement membrane and a matrix metalloprotease inhibitor, as well as a method for producing the same.
摘要翻译：本发明提供了一种表皮基底膜结构形成促进制剂和皮肤外用制剂，其包含丝氨酸蛋白酶抑制剂和任选的表皮基底膜细胞外基质蛋白组分产生促进剂。它还提供了用于生产具有充分形成的基底膜的人造皮肤的手段，人造皮肤形成培养基包括丝氨酸蛋白酶抑制剂和任选的表皮基底膜的细胞外基质蛋白组分的产生促进剂和基质金属蛋白酶抑制剂，以及其制备方法。

10. 发明授权

US08387167B2 Method for forming resin surface, method for manufacturing article which forms recessed portions different in size randomly on surface thereof and article manufactured by the method, and method for manufacturing gloves and gloves manufactured by the method 有权
标题翻译：树脂表面形成方法，其表面上随机地形成尺寸不同的凹部的制品的制造方法和通过该方法制造的手套和手套的制造方法
公开(公告)号：US08387167B2
公开(公告)日：2013-03-05
申请号：US12532920
申请日：2008-03-27
申请人： Kazutaka Matsunobu , Nobuyoshi Koga , Yukiko Tsuchimochi
发明人： Kazutaka Matsunobu , Nobuyoshi Koga , Yukiko Tsuchimochi
IPC分类号： A41D19/00
CPC分类号： B29C59/022 , A41D19/0055 , A41D19/01547 , A41D2400/80 , B05D5/02 , B29C41/14 , B29C59/02 , B29C59/026 , B29C67/202 , B29C2059/023 , B29C2059/028 , B29K2021/00 , B29K2105/0064 , B29K2105/04 , B29K2105/24 , B29K2105/246 , B29K2105/251 , B29K2995/0072 , B29L2009/00 , B29L2031/4864 , Y10T428/249953
摘要： A method for forming a resin surface on which recessed portions different in size are formed randomly includes: forming first recessed portions by allowing all or some granular and/or powdery adhering material to adhere to a surface of an unset resin composition containing air bubbles so that at least a portion of the granular and/or powdery adhering material bites into the surface and by removing the adhering material after the resin composition is set; and forming second recessed portions smaller than the first recessed portions in size by allowing some of the air bubbles contained in the unset or set resin composition to open on the aforementioned surface of the resin composition.
摘要翻译：一种用于形成树脂表面的方法，其中形成尺寸不同的凹入部分的方法包括：通过使所有或一些颗粒状和/或粉末粘附材料粘附到含有气泡的未固化树脂组合物的表面上来形成第一凹部，使得颗粒状和/或粉状粘附材料的至少一部分咬入表面，并且在树脂组合物被固化之后除去粘附材料; 并且通过使所述未固化树脂组合物中包含的一些气泡在所述树脂组合物的上述表面上开口而形成比所述第一凹部小的第二凹部。

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