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1. 发明授权

US5491042A Method for manufacturing a resin-coated carrier for an electrophotographic developer 失效
标题翻译：电子照相显影剂用树脂涂布载体的制造方法
公开(公告)号：US5491042A
公开(公告)日：1996-02-13
申请号：US283249
申请日：1994-07-29
申请人： Yuji Sato , Toshiyuki Fukumoto , Yoshifumi Imamura , Toshio Honjo
发明人： Yuji Sato , Toshiyuki Fukumoto , Yoshifumi Imamura , Toshio Honjo
IPC分类号： G03G9/113
CPC分类号： G03G9/1131
摘要： This invention provides a method for manufacturing a resin-coated carrier for an electrophotographic developer comprising the steps of coating the surface of a carrier core which is a dielectric material, with a resin which is also a dielectric material and then baking the thus obtained resin coated carrier core by means of microwave heating under the conditions that a thickness of the resin-coated carrier layer to be baked is in the range of from 5 to 25 mm, the number of revolution of agitating blade for agitating the microwave is in the range of from 20 to 40 rpm and an irradiation time is in the range of from 30 seconds to 10 minutes, to obtain the resin-coated carrier. The resin-coated carriers are characterized by having an excellent durability, excellent resistance to the environment, as well as excellent producibility and economy.
摘要翻译：本发明提供了一种用于制造用于电子照相显影剂的树脂涂覆载体的方法，包括以下步骤：用作为介电材料的树脂涂覆作为介电材料的载体芯的表面，然后烘焙由此获得的树脂涂覆通过微波加热在被烘烤的树脂被覆载体层的厚度为5〜25mm的条件下，用于搅拌微波的搅拌叶片的转数为 20〜40rpm，照射时间为30秒〜10分钟，得到树脂被覆载体。树脂涂布载体的特征在于具有优异的耐久性，优异的耐环境性，以及优异的可生产性和经济性。

2. 发明授权

US6156762A Indolomorphinan derivative and agent for curing and preventing cerebral disorder 失效
标题翻译：吲哚并吗啡喃衍生物和治疗和预防脑病的药剂
公开(公告)号：US6156762A
公开(公告)日：2000-12-05
申请号：US142794
申请日：1998-09-24
申请人： Hiroshi Nagase , Yoshifumi Imamura , Junichi Hirokawa , Susumu Matsuda , Yasushi Miyauchi
发明人： Hiroshi Nagase , Yoshifumi Imamura , Junichi Hirokawa , Susumu Matsuda , Yasushi Miyauchi
IPC分类号： C07D489/00 , C07D491/18 , C07D491/20 , A61K31/485 , C07D489/10
CPC分类号： C07D489/00
摘要： The present invention provides an indolomorphinan derivative or a pharmacologically acceptable acid addition salt thereof, and an agent for curing and preventing cerebral disorders composed of the derivative and salt thereof, which is represented by the following formula (I): ##STR1## [wherein R.sup.1 represents cyclopropylmethyl or the like; R.sup.2 and R.sup.3 each represent hydroxy methoxy, or the like; R.sup.4 represents hydrogen, methyl, benzyl, 3-isothiocyanatopropyl, or the like; and (R.sup.5).sub.m represents hydrogen, substituted benzo, or the like]. The compounds of the present invention have the excellent effect of preventing damage of the cerebral nerve cells. Therefore, the compounds of the present invention are useful as medicines used for curing and preventing various cerebral diseases such as cerebral stroke, traumatic cerebral diseases, cerebral edema, and cerebral neurodegenerative diseases, ameliorating aftereffects thereof, and preventing the recurrence thereof by inhibiting various ischemic, hemorrhagic or traumatic cerebral disorders, and damages of the cerebral nerve cells caused by various nerve degenerations.
摘要翻译： PCT No.PCT / JP98 / 00092 Sec。 371日期：1998年9月24日 102（e）1998年9月24日PCT PCT 1998年1月13日PCT公布。公开号WO98 / 31684 日期：1998年7月23日本发明提供吲哚并吗啡衍生物或其药理学上可接受的酸加成盐，以及由下式（I）表示的由其衍生物和盐组成的脑病的治疗和预防剂：其中R1表示环丙基甲基等; R2和R3各自表示羟基甲氧基等; R4代表氢，甲基，苄基，3-异硫氰基丙基等; 和（R 5）m表示氢，取代的苯并或类似物]。本发明的化合物具有防止脑神经细胞损伤的优异效果。因此，本发明的化合物可用作治疗和预防各种脑疾病如脑中风，创伤性脑病，脑水肿和脑神经变性疾病的药物，改善其后遗症，并通过抑制各种缺血性疾病预防其复发，出血性或创伤性脑病，以及由各种神经变性引起的脑神经细胞损伤。

3. 发明授权

US5776945A 4A-aryldecahydroisoquinoline compound and medicinal use of the same 失效
标题翻译： 4A-芳基十氢异喹啉化合物及其药用
公开(公告)号：US5776945A
公开(公告)日：1998-07-07
申请号：US809226
申请日：1997-05-08
申请人： Hiroshi Nagase , Yoshifumi Imamura , Hiroshi Ohno , Takashi Endo
发明人： Hiroshi Nagase , Yoshifumi Imamura , Hiroshi Ohno , Takashi Endo
IPC分类号： C07D217/16 , C07D405/12 , C07D217/04 , A61K31/46
CPC分类号： C07D405/12 , C07D217/16
摘要： The present invention relates to a 4a-aryldecahydroisoquinoline compound, which is represented by a compound 1, or a pharmacologically acceptable salt thereof. ##STR1## As the results of in vitro and in vivo pharmacological evaluations, it was found that the compounds of the present invention had excellent preventive effects on ischemic death of cerebral neurocytes, suppressive effects on development of cerebral infarction, and strong analgesic and antitussive effects; therefore the compounds of the present invention can be utilized in the medicinal field as a useful cerebral cytoprotective agent, which is aimed at preventing and treating cerebrovascular disorder, ischemic cerebral disorder, cerebral neurocyte disorder, and dementia, an analgesic, and an antitussive.
摘要翻译： PCT No.PCT / JP96 / 02030 Sec。 371日期：1997年5月8日 102（e）日期1997年5月8日PCT PCT 1996年7月19日PCT公布。公开号WO97 / 03968 日期：1997年2月6日本发明涉及由化合物1表示的4a-芳基十氢异喹啉化合物或其药理学上可接受的盐。作为体外和体内药理学评价的结果，发现本发明的化合物对脑神经细胞的缺血性死亡具有优异的预防作用，对脑梗死发展的抑制作用以及强镇痛和镇咳药效果; 因此，本发明的化合物可用作药用领域，作为有用的脑细胞保护剂，其旨在预防和治疗脑血管障碍，缺血性脑病，脑神经细胞病和痴呆，镇痛药和镇咳药。

4. 发明授权

US06172078B2 Quinolinomorphinane derivatives and medicinal use thereof 失效
标题翻译：喹啉吗啡烷衍生物及其医药用途
公开(公告)号：US06172078B2
公开(公告)日：2001-01-09
申请号：US09194538
申请日：1999-01-13
申请人： Hiroshi Nagase , Yoshifumi Imamura , Hiroshi Ohno , Masanobu Kaneeda , Susumu Matsuda , Yasushi Miyauchi
发明人： Hiroshi Nagase , Yoshifumi Imamura , Hiroshi Ohno , Masanobu Kaneeda , Susumu Matsuda , Yasushi Miyauchi
IPC分类号： C07D51500
CPC分类号： C07D489/00
摘要： The present invention provides a quinolinomorphinan derivative or a pharmacologically acceptable acid addition salt thereof, and an agent for curing or preventing cerebral disorders composed of the derivative and salt thereof, which is represented by the following formula (I): (wherein R1 represents cyclopropylmethyl or the like; R2 and R3 independently represent hydroxy, methoxy, or the like; R4 represents hydrogen, methyl, amino or the like; and (R5)m represents hydrogen, substituted benzo, or the like. The compounds of the present invention prevent damages of the cerebral nerve cells and are useful as medicine for curing or preventing various cerebral diseases such as cerebral stroke, traumatic cerebral diseases, cerebral edema, and cerebral neurodegenerative diseases. The compounds of the present invention also ameliorate the after-effects of these diseases and prevent the recurrence of these diseases by inhibiting various ischemic, hemorrhagic or traumatic cerebral disorders, and damages of the cerebral nerve cells caused by various nerve degenerations.
摘要翻译：本发明提供喹啉吗啡喃衍生物或其药理学上可接受的酸加成盐，以及由下式（I）表示的用于治疗或预防由其衍生物和盐组成的脑病的药剂:(其中R1表示环丙基甲基或 R 2和R 3独立地表示羟基，甲氧基等; R 4表示氢，甲基，氨基等;（R 5）m表示氢，取代的苯并或类似物，本发明化合物可以防止损害的脑神经细胞，可用作治疗或预防各种脑疾病如脑中风，创伤性脑疾病，脑水肿和脑神经变性疾病的药物，本发明的化合物还可以改善这些疾病的后遗症和通过抑制各种缺血性，出血性或创伤性脑病，预防这些疾病的复发，以及d 大脑神经细胞由各种神经变性引起的药物。

5. 发明授权

US6147084A Brain cell protective agent 失效
标题翻译：脑细胞保护剂
公开(公告)号：US6147084A
公开(公告)日：2000-11-14
申请号：US262791
申请日：1999-03-04
申请人： Hiroshi Nagase , Yoshifumi Imamura , Takashi Endo , Susumu Matsuda , Yasushi Miyauchi
发明人： Hiroshi Nagase , Yoshifumi Imamura , Takashi Endo , Susumu Matsuda , Yasushi Miyauchi
IPC分类号： A61K31/485 , C07D489/00 , C07D491/08
CPC分类号： A61K31/485 , C07D489/00
摘要： The present invention relates to a novel brain cell protective agent having for its active ingredient a morphinan derivative represented with Compound 1 ##STR1## or pharmacologically acceptable acid addition salt thereof. The compounds used in the present invention were found to have excellent defensive effects against brain nerve cell necrosis in both in vitro and in vivo pharmacological evaluations, and can be used as useful preventive and therapeutic agents of ischemic brain disorders, brain nerve cell disorders and dementia.
摘要翻译：本发明涉及一种新颖的脑细胞保护剂，其具有由化合物1表示的吗啡喃衍生物或其药理学上可接受的酸加成盐。发现本发明中使用的化合物在体外和体内药理学评价中对脑神经细胞坏死具有优异的防御作用，并且可以用作缺血性脑病，脑神经细胞病症和痴呆的有用的预防和治疗剂。

6. 发明授权

US5972953A Brain cell protective agent 失效
公开(公告)号：US5972953A
公开(公告)日：1999-10-26
申请号：US745041
申请日：1996-11-07
申请人： Hiroshi Nagase , Yoshifumi Imamura , Takashi Endo , Susumu Matsuda , Yasushi Miyauchi
发明人： Hiroshi Nagase , Yoshifumi Imamura , Takashi Endo , Susumu Matsuda , Yasushi Miyauchi
IPC分类号： A61K31/485 , C07D489/00
CPC分类号： A61K31/485 , C07D489/00
摘要： The present invention relates to a novel brain cell protective agent having for its active ingredient a morphinan derivative represented with Compound 1 ##STR1## or pharmacologically acceptable acid addition salt thereof. The compounds used in the present invention were found to have excellent defensive effects against brain nerve cell necrosis in both in vitro and in vivo pharmacological evaluations, and can be used as useful preventive and therapeutic agents of ischemic brain disorders, brain nerve cell disorders and dementia.

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