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1. 发明申请

US20060242716A1 Disease model animal carrying foreign ppar alpha gene transferred thereinto and use thereof 审中-公开
标题翻译：携带携带外来pparα基因的疾病模型动物及其使用
公开(公告)号：US20060242716A1
公开(公告)日：2006-10-26
申请号：US10521174
申请日：2003-07-14
申请人： Yuichiro Amano , Yasuo Sugiyama , Mayumi Nishida , Shigehisa Taketomi
发明人： Yuichiro Amano , Yasuo Sugiyama , Mayumi Nishida , Shigehisa Taketomi
IPC分类号： A01K67/027
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C07K14/705 , C07K14/70567 , G01N33/5088
摘要： The present invention provides a non-human mammal, or a part of its living body, which stably retains a DNA encoding a heterologous PPARα in an expressible state, and has one or more different genetic modifications resulting in a pathological condition identical or similar to a disease associated with the regulation of PPARα activity or a foreign DNA under the control of a promoter having PPRE, as well as a method of screening for agonists/antagonists for the heterologous PPARα using the animal.
摘要翻译：本发明提供了一种非人哺乳动物或其一部分活体，其可稳定地保留编码可表达状态的异源PPARα的DNA，并具有一种或多种不同的遗传修饰，导致病理状况与与PPARα活性调节相关的疾病或在具有PPRE的启动子控制下的外源DNA，以及使用该动物筛选异源PPARα的激动剂/拮抗剂的方法。

2. 发明申请

US20090186946A1 Genetically Modified Animal and Use Thereof 审中-公开
标题翻译：转基因动物及其使用
公开(公告)号：US20090186946A1
公开(公告)日：2009-07-23
申请号：US12306480
申请日：2007-06-26
申请人： Shigehisa Taketomi , Mayumi Nishida
发明人： Shigehisa Taketomi , Mayumi Nishida
IPC分类号： A61K31/137 , A01K67/00
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2267/03
摘要： The present invention provides a non-human mammal deficient in the expression of the SLC-1 gene, having the characteristics of (1) a lower blood insulin level in glucose tolerance test, (2) increased insulin sensitivity, (3) higher resistance to obesity even on high fat diet, (4) a smaller white fat cell size, and (5) accentuated lipolysis, compared with the corresponding wild-type animal, or a portion of the body thereof. Also provided is an obesity and/or type II diabetes model non-human mammal that is deficient in the expression of the SLC-1 gene, having the characteristics of (1) elevated expression of adiponectin, (2) delayed onset of hyperglycemia, (3) a lower blood glycohemoglobin level, and (4) accentuated energy consumption, compared with the corresponding obesity and/or type II diabetes model non-human mammal wherein the expression of the gene is normal, or a portion of the body thereof.
摘要翻译：本发明提供了缺乏SLC-1基因表达的非人类哺乳动物，具有以下特征：（1）葡萄糖耐量试验中血糖水平越低，（2）胰岛素敏感性越高，（3）抗性越高肥胖甚至高脂肪饮食，（4）较小的白色脂肪细胞大小，和（5）与相应的野生动物相比，或其一部分体重增加的脂肪分解。还提供了缺乏SLC-1基因表达的肥胖和/或II型糖尿病模型，具有以下特征：（1）脂联素的表达升高，（2）高血糖迟发性发作（ 3）较低血糖血红蛋白水平，和（4）加强能量消耗，与基因表达正常或身体的一部分相应的肥胖和/或II型糖尿病模型非人哺乳动物相比较。

3. 发明授权

US07053079B2 Dihydroxy (3-pyridyl) borane compounds 有权
标题翻译：二羟基（3-吡啶基）硼烷化合物
公开(公告)号：US07053079B2
公开(公告)日：2006-05-30
申请号：US10493847
申请日：2002-11-27
申请人： Mayumi Nishida , Tsuyoshi Tagata , Masaki Shimada
发明人： Mayumi Nishida , Tsuyoshi Tagata , Masaki Shimada
IPC分类号： C07F5/02 , A61K31/44
CPC分类号： C07F5/025
摘要： A dihydroxy(3-pyridyl)borane compound of the formula (1): wherein R1 represents a hydrogen atom, halogen atom or alkoxycarbonylamino group; R2 represents a hydrogen atom, halogen atom, alkyl group or fluoroalkyl group; with the proviso that the case wherein both R1 and R2 are hydrogen atoms is excepted.
摘要翻译：式（1）的二羟基（3-吡啶基）硼烷化合物：其中R 1表示氢原子，卤素原子或烷氧基羰基氨基; R 2表示氢原子，卤素原子，烷基或氟代烷基; 条件是其中R 1和R 2均为氢原子的情况除外。

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