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1. 发明申请

US20110189311A1 Highly Absorbable Drug Composition and Method of Producing the Same 审中-公开
标题翻译：高吸收性药物组合物及其制备方法
公开(公告)号：US20110189311A1
公开(公告)日：2011-08-04
申请号：US12870979
申请日：2010-08-30
申请人： Yuichi Tozuka , Hiromasa Uchiyama , Hirofumi Takeuchi , Yoshihisa Iida , Takashi Kometani
发明人： Yuichi Tozuka , Hiromasa Uchiyama , Hirofumi Takeuchi , Yoshihisa Iida , Takashi Kometani
IPC分类号： A61K36/00 , A61K31/70
CPC分类号： A61K31/10 , A61K9/0053 , A61K9/1623 , A61K31/192
摘要： Provided is a highly absorbable drug composition including one or more water-soluble compound (A) selected from an enzyme-treated hesperidin, a stevia extract, or an enzyme-treated stevia and a poorly water-soluble drug (B) selected from flurbiprofen or probucol.
摘要翻译：提供了一种高吸收性药物组合物，其包含一种或多种选自酶治疗的橙皮苷，甜叶菊提取物或经酶处理的甜菊中的水溶性化合物（A）和选自氟比洛芬或弱水溶性药物普罗布洛

2. 发明授权

US09090912B1 Nucleic acid complex and nucleic acid-delivering composition 有权
标题翻译：核酸复合物和核酸递送组合物
公开(公告)号：US09090912B1
公开(公告)日：2015-07-28
申请号：US13254770
申请日：2010-03-04
申请人： Hirofumi Takeuchi , Yuichi Tozuka , Mitsutaka Murata , Hidekazu Toyobuku
发明人： Hirofumi Takeuchi , Yuichi Tozuka , Mitsutaka Murata , Hidekazu Toyobuku
IPC分类号： C12N15/88 , C12N15/11
CPC分类号： C12N15/88 , A61K9/1271 , A61K9/1272 , A61K9/1278 , A61K31/7088 , A61K31/7105 , A61K47/36 , A61K47/40 , C12N15/111 , C12N2310/14 , C12N2310/3515 , C12N2320/32
摘要： This invention relates to a nucleic acid complex with low toxicity and high safety that can maintain a nucleic acid molecule capable of RNA interference or translation inhibition, such as siRNA or the like, in a cell; and a nucleic acid delivery composition that can efficiently deliver the nucleic acid complex into a cell. A nucleic acid complex with low toxicity and high safety that can maintain a nucleic acid in a cell can be obtained by forming a complex using a nucleic acid molecule capable of RNA interference or translation inhibition and a cycloamirose. Further, by using a carrier comprising (A) a diacylphosphatidylcholine, (B) cholesterol and/or a derivative thereof, and (C) an aliphatic primary amine as a nucleic acid delivery carrier to introduce the nucleic acid complex into a cell, the safety, efficiency of intracellular delivery, and persistence of the nucleic acid in the cell can be further improved.
摘要翻译：本发明涉及一种具有低毒性和高安全性的核酸复合物，其能够在细胞中维持能够进行RNA干扰或翻译抑制的核酸分子，例如siRNA等; 以及可以有效地将核酸复合物递送到细胞中的核酸递送组合物。可以通过使用能够进行RNA干扰或翻译抑制的核酸分子和循环波形来形成复合物来获得能够维持细胞中核酸的低毒性和高安全性的核酸复合物。此外，通过使用包含（A）二酰基磷脂酰胆碱，（B）胆固醇和/或其衍生物的载体，和（C）作为核酸递送载体的脂族伯胺将核酸复合物引入细胞，可以进一步提高细胞内递送的效率和核酸在细胞中的持续性。

3. 发明授权

US08338584B2 Nucleic acid complex and nucleic acid delivery composition 有权
标题翻译：核酸复合物和核酸递送组合物
公开(公告)号：US08338584B2
公开(公告)日：2012-12-25
申请号：US12741457
申请日：2008-11-06
申请人： Hirofumi Takeuchi , Yuichi Tozuka , Yasuyuki Hira , Hidekazu Toyobuku
发明人： Hirofumi Takeuchi , Yuichi Tozuka , Yasuyuki Hira , Hidekazu Toyobuku
IPC分类号： C07H21/04 , C01H1/00 , A61K31/70
CPC分类号： A61K47/40 , A61K9/1272 , A61K47/543 , A61K47/6951 , A61K48/005 , B82Y5/00 , C12N15/88
摘要： The present invention provides a nucleic acid complex with low toxicity and high safety that can persistently maintain a nucleic acid, such as siRNA or the like, in a cell; and a nucleic acid delivery composition that can efficiently deliver the nucleic acid complex into a cell. A nucleic acid complex with low toxicity and high safety that can persistently maintain a nucleic acid in a cell can be obtained by forming a complex using a nucleic acid to be introduced into a cell, and a highly branched cyclic dextrin. Moreover, when a carrier comprising (A) a diacylphosphatidylcholine, (B) cholesterol and/or a derivative thereof, and (C) an aliphatic primary amine is used as a nucleic acid delivery carrier to introduce the nucleic acid complex into a cell, the safety, the efficiency of intracellular delivery, and the persistence of the nucleic acid in the cell can be further improved.
摘要翻译：本发明提供了一种具有低毒性和高安全性的核酸复合物，其可以在细胞中持续保持核酸如siRNA等; 以及可以有效地将核酸复合物递送到细胞中的核酸递送组合物。可以通过使用待引入细胞的核酸和高度支化的环糊精形成复合物来获得能够持续维持细胞中核酸的低毒性和高安全性的核酸复合物。此外，当使用包含（A）二酰基磷脂酰胆碱，（B）胆固醇和/或其衍生物和（C）脂肪族伯胺的载体作为核酸递送载体以将核酸复合物引入细胞时，可以进一步提高安全性，细胞内递送的效率和核酸在细胞中的持续性。

4. 发明申请

US20100305190A1 NUCLEIC ACID COMPLEX AND NUCLEIC ACID DELIVERY COMPOSITION 有权
标题翻译：核酸复合物和核酸递送组合物
公开(公告)号：US20100305190A1
公开(公告)日：2010-12-02
申请号：US12741457
申请日：2008-11-06
申请人： Hirofumi Takeuchi , Yuichi Tozuka , Yasuyuki Hira , Hidekazu Toyobuku
发明人： Hirofumi Takeuchi , Yuichi Tozuka , Yasuyuki Hira , Hidekazu Toyobuku
IPC分类号： C07H21/02 , C07H21/00 , A61K31/7105 , C12N5/00
CPC分类号： A61K47/40 , A61K9/1272 , A61K47/543 , A61K47/6951 , A61K48/005 , B82Y5/00 , C12N15/88
摘要： The present invention provides a nucleic acid complex with low toxicity and high safety that can persistently maintain a nucleic acid, such as siRNA or the like, in a cell; and a nucleic acid delivery composition that can efficiently deliver the nucleic acid complex into a cell. A nucleic acid complex with low toxicity and high safety that can persistently maintain a nucleic acid in a cell can be obtained by forming a complex using a nucleic acid to be introduced into a cell, and a highly branched cyclic dextrin. Moreover, when a carrier comprising (A) a diacylphosphatidylcholine, (B) cholesterol and/or a derivative thereof, and (C) an aliphatic primary amine is used as a nucleic acid delivery carrier to introduce the nucleic acid complex into a cell, the safety, the efficiency of intracellular delivery, and the persistence of the nucleic acid in the cell can be further improved.
摘要翻译：本发明提供了一种具有低毒性和高安全性的核酸复合物，其可以在细胞中持续保持核酸如siRNA等; 以及可以有效地将核酸复合物递送到细胞中的核酸递送组合物。可以通过使用待引入细胞的核酸和高度支化的环糊精形成复合物来获得能够持续维持细胞中核酸的低毒性和高安全性的核酸复合物。此外，当使用包含（A）二酰基磷脂酰胆碱，（B）胆固醇和/或其衍生物和（C）脂肪族伯胺的载体作为核酸递送载体以将核酸复合物引入细胞时，可以进一步提高安全性，细胞内递送的效率和核酸在细胞中的持续性。

5. 发明申请

US20100112043A1 TRANSPULMONARY LIPOSOME FOR CONTROLLING DRUG ARRIVAL 有权
标题翻译：用于控制药物到达的透析液
公开(公告)号：US20100112043A1
公开(公告)日：2010-05-06
申请号：US12593827
申请日：2008-03-28
申请人： Hirofumi Takeuchi , Koji Nakano , Hidekazu Toyobuku
发明人： Hirofumi Takeuchi , Koji Nakano , Hidekazu Toyobuku
IPC分类号： A61K9/127 , A61K47/32 , A61K48/00
CPC分类号： A61K9/1277 , A61K9/007 , A61K9/0078 , A61K9/1271 , A61K45/06 , A61K47/32 , A61K47/36 , A61K48/00 , A61K48/0075 , C12N15/88 , C12N2810/10
摘要： An object of the present invention is to provide a liposome which is excellent in intrapulmonary delivery controllability of drugs or genes and is suited for pulmonary administration.By modifying the surface of a liposome using a terminal hydrophobized polyvinyl alcohol and/or chitosan, retention of drugs or genes encapsulated in the liposome on the surface of lung tissue and transfer of drugs or genes into lung tissue can be properly modulated, and thus in vivo behavior can be controlled.
摘要翻译：本发明的目的是提供一种在药物或基因的肺内递送可控性优异且适于肺部给药的脂质体。通过使用末端疏水化聚乙烯醇和/或壳聚糖改性脂质体的表面，可以适当地调节将包封在脂质体中的药物或基因保留在肺组织表面上并将药物或基因转移到肺组织中，可以控制体内行为。

6. 发明授权

US5204999A Flush water supply system for toilet stool 失效
标题翻译：厕所水冲洗供水系统
公开(公告)号：US5204999A
公开(公告)日：1993-04-27
申请号：US713437
申请日：1991-06-10
申请人： Atsuo Makita , Hirofumi Takeuchi , Shinji Shibata , Noboru Shimbara
发明人： Atsuo Makita , Hirofumi Takeuchi , Shinji Shibata , Noboru Shimbara
IPC分类号： E03D5/00 , E03D5/10 , E03D9/16
CPC分类号： E03D5/10 , E03D5/00 , E03D9/16 , E03D2201/30 , E03D2201/40 , Y10S4/03
摘要： A flush water supply system comprising a passageway valve mounted in a pipeline for supplying flush water to a toilet stool, and a control circuit for controlling the closing and opening of the passageway valve. A constant flow valve is mounted in the pipeline for keeping a predetermined amount of discharge flow, irrespective of water supply pressure.
摘要翻译：一种冲洗水供应系统，包括安装在用于向马桶便器提供冲洗水的管道中的通道阀，以及用于控制通道阀的关闭和打开的控制电路。不管供水压力如何，恒流阀安装在管道中以保持预定量的排放流量。

7. 发明授权

US5133089A Water closet flushing apparatus 失效
公开(公告)号：US5133089A
公开(公告)日：1992-07-28
申请号：US385072
申请日：1989-07-24
申请人： Osamu Tsutsui , Atsuo Makita , Hirofumi Takeuchi , Shinji Shibata , Noboru Shinbara
发明人： Osamu Tsutsui , Atsuo Makita , Hirofumi Takeuchi , Shinji Shibata , Noboru Shinbara
IPC分类号： E03D5/00 , E03D5/10
CPC分类号： E03D5/00 , E03D5/10 , E03D2201/30
摘要： In a water closet flushing apparatus of the type in which the flushing water from a flushing water supply source is fed through different flushing water feed lines to a bowl portion and a trap discharge passage defined adjacent to the bottom portion of the bowl portion, a water jet injector is provided so as to inject the flushing water jet toward the trap discharge passage, an opening-closing valve is disposed in each of different feed lines, and the operation of the opening-closing valve is controlled by a control unit. The flushing water is flushed into the bowl portion so as to clean the same while the jet of flushing water is injected into the trap discharge passage to cause the same to act as a siphon, whereby waste matter is discharged.

8. 发明授权

US5057323A Hollow granular medicine and its preparation 失效
标题翻译：中空粒状药物及其制备
公开(公告)号：US5057323A
公开(公告)日：1991-10-15
申请号：US367948
申请日：1989-06-19
申请人： Toshiyuki Niwa , Yoshiaki Kawashima , Hirofumi Takeuchi , Yoji Ito
发明人： Toshiyuki Niwa , Yoshiaki Kawashima , Hirofumi Takeuchi , Yoji Ito
IPC分类号： A61K9/00 , A61K9/16
CPC分类号： A61K9/0065 , A61K9/1676
摘要： A granular medicine with slow drug-release characteristics that is sufficiently absorbed in the intestines, in which the granular medicine has a hollow spherical structure, a drug is dispersed in the shell, which mainly consists of an enteron-soluble polymer. The method for preparing the medicine includes the steps of: (a) mixing a hydrophilic or hydrophobic drug with an enteron-soluble polymer in a mixture of an aliphatic alcohol and a chlorohydrocarbon; and (b) pouring this mixture into water or an aqueous medium, and stirring the solution to precipitate the medicine.
摘要翻译：具有缓慢的药物释放特性的颗粒药物在肠中充分吸收，其中颗粒药物具有中空球形结构，药物分散在壳中，其主要由肠溶性聚合物组成。制备药物的方法包括以下步骤：（a）将亲水或疏水性药物与肠溶性聚合物混合在脂族醇和氯代烃的混合物中; 和（b）将该混合物倒入水或水性介质中，并搅拌该溶液以沉淀药物。

9. 发明授权

US4955535A Automatically operating valve for regulating water flow and faucet provided with said valve 失效
公开(公告)号：US4955535A
公开(公告)日：1990-09-11
申请号：US409918
申请日：1989-09-20
申请人： Osamu Tsutsui , Hisato Haraga , Kinya Arita , Atsuo Makita , Hirofumi Takeuchi , Ryoichi Tsukada
发明人： Osamu Tsutsui , Hisato Haraga , Kinya Arita , Atsuo Makita , Hirofumi Takeuchi , Ryoichi Tsukada
IPC分类号： G05D11/16 , G05D23/13 , H01L41/09
CPC分类号： H02N2/023 , G05D23/1393 , Y10T137/87249 , Y10T137/87684 , Y10T137/87877
摘要： An automatically operating valve for regulating water flow, especially a mixing valve for automatically mixing hot water and cold water to obtain a mixed water of a desired temperature is characterized by employing piezoelectric actuators for operating valve bodies thereof. Due to such a construction, the valve can not only fully close or open but also carries out the fine flow amount control by regulating the opening rate or angle of the valve body. Especially in case the automatically operating valve is a mixing valve, the mixing ratio of hot water and cold water can be accurately regulated so that the mixed water of a desired temperature can be always automatically obtained.

10. 发明授权

US4768705A Cold/hot water discharging apparatus 失效
标题翻译：冷/热水排放装置
公开(公告)号：US4768705A
公开(公告)日：1988-09-06
申请号：US136908
申请日：1987-12-22
申请人： Osamu Tsutsui , Yukihiro Muroya , Hirofumi Takeuchi , Keiji Hayashi , Shingo Tanaka
发明人： Osamu Tsutsui , Yukihiro Muroya , Hirofumi Takeuchi , Keiji Hayashi , Shingo Tanaka
IPC分类号： A61H33/00 , G05D23/13
CPC分类号： G05D23/1393 , A61H33/0095 , Y10T137/86421
摘要： This invention relates to a cold/hot water discharging apparatus which is used for cold/hot water massage shower, and the like. In order to alternately switch and supply hot water of a predetermined temperature supplied from a hot water source to a discharge portion, a valve of a cold/hot water mixing tap is driven by a motor and is reciprocated in a pre-set period between a position where high temperature hot water is discharged and low temperature hot water is discharged. In each of the periods for discharging low/high temperature hot water, an optimum gain of this period is determined from the previous period and previous gain so as to shorten the discharge period of cold/hot water and to obtain a stable curve of the discharge hot water.

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