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1. 发明授权

US09315828B2 Prompt nucleic acid delivery carrier composition 有权
标题翻译：提示核酸递送载体组成
公开(公告)号：US09315828B2
公开(公告)日：2016-04-19
申请号：US12532949
申请日：2008-03-26
申请人： Hirofumi Takeuchi , Yasuyuki Hira , Koji Nakano , Hidekazu Toyobuku
发明人： Hirofumi Takeuchi , Yasuyuki Hira , Koji Nakano , Hidekazu Toyobuku
IPC分类号： A61K48/00 , C07H21/02 , C12N15/88 , C12N15/87 , A61K9/127 , A61K31/7088 , A61K31/713 , C12N15/11
CPC分类号： C12N15/87 , A61K9/127 , A61K31/7088 , A61K31/713 , A61K48/00 , C12N15/111 , C12N2310/14 , C12N2320/32
摘要： An object of the present invention is to provide a carrier composition for nucleic acid delivery, which can efficiently deliver a nucleic acid into cells when a nucleic acid such as siRNA is administered to animal-derived cells or animals, and also has low toxicity and high safety, and a composition for nucleic acid delivery containing the carrier composition and nucleic acid.A carrier for nucleic acid delivery is prepared by using (A) a diacylphosphatidylcholine, (B) at least one member selected from the group consisting of cholesterol and derivatives thereof, and (C) an aliphatic primary amine. Also, a composition for nucleic acid delivery is prepared by mixing the carrier for nucleic acid delivery with a nucleic acid.
摘要翻译：本发明的目的是提供一种用于核酸递送的载体组合物，当向动物来源的细胞或动物施用siRNA等核酸时，可以将核酸有效地递送到细胞中，并且还具有低毒性和高安全性和用于含有载体组合物和核酸的核酸递送的组合物。通过使用（A）二酰基磷脂酰胆碱，（B）至少一种选自胆固醇及其衍生物的组分和（C）脂族伯胺制备核酸递送载体。而且，通过将用于核酸递送的载体与核酸混合来制备用于核酸递送的组合物。

2. 发明授权

US08338584B2 Nucleic acid complex and nucleic acid delivery composition 有权
标题翻译：核酸复合物和核酸递送组合物
公开(公告)号：US08338584B2
公开(公告)日：2012-12-25
申请号：US12741457
申请日：2008-11-06
申请人： Hirofumi Takeuchi , Yuichi Tozuka , Yasuyuki Hira , Hidekazu Toyobuku
发明人： Hirofumi Takeuchi , Yuichi Tozuka , Yasuyuki Hira , Hidekazu Toyobuku
IPC分类号： C07H21/04 , C01H1/00 , A61K31/70
CPC分类号： A61K47/40 , A61K9/1272 , A61K47/543 , A61K47/6951 , A61K48/005 , B82Y5/00 , C12N15/88
摘要： The present invention provides a nucleic acid complex with low toxicity and high safety that can persistently maintain a nucleic acid, such as siRNA or the like, in a cell; and a nucleic acid delivery composition that can efficiently deliver the nucleic acid complex into a cell. A nucleic acid complex with low toxicity and high safety that can persistently maintain a nucleic acid in a cell can be obtained by forming a complex using a nucleic acid to be introduced into a cell, and a highly branched cyclic dextrin. Moreover, when a carrier comprising (A) a diacylphosphatidylcholine, (B) cholesterol and/or a derivative thereof, and (C) an aliphatic primary amine is used as a nucleic acid delivery carrier to introduce the nucleic acid complex into a cell, the safety, the efficiency of intracellular delivery, and the persistence of the nucleic acid in the cell can be further improved.
摘要翻译：本发明提供了一种具有低毒性和高安全性的核酸复合物，其可以在细胞中持续保持核酸如siRNA等; 以及可以有效地将核酸复合物递送到细胞中的核酸递送组合物。可以通过使用待引入细胞的核酸和高度支化的环糊精形成复合物来获得能够持续维持细胞中核酸的低毒性和高安全性的核酸复合物。此外，当使用包含（A）二酰基磷脂酰胆碱，（B）胆固醇和/或其衍生物和（C）脂肪族伯胺的载体作为核酸递送载体以将核酸复合物引入细胞时，可以进一步提高安全性，细胞内递送的效率和核酸在细胞中的持续性。

3. 发明申请

US20100305190A1 NUCLEIC ACID COMPLEX AND NUCLEIC ACID DELIVERY COMPOSITION 有权
标题翻译：核酸复合物和核酸递送组合物
公开(公告)号：US20100305190A1
公开(公告)日：2010-12-02
申请号：US12741457
申请日：2008-11-06
申请人： Hirofumi Takeuchi , Yuichi Tozuka , Yasuyuki Hira , Hidekazu Toyobuku
发明人： Hirofumi Takeuchi , Yuichi Tozuka , Yasuyuki Hira , Hidekazu Toyobuku
IPC分类号： C07H21/02 , C07H21/00 , A61K31/7105 , C12N5/00
CPC分类号： A61K47/40 , A61K9/1272 , A61K47/543 , A61K47/6951 , A61K48/005 , B82Y5/00 , C12N15/88
摘要： The present invention provides a nucleic acid complex with low toxicity and high safety that can persistently maintain a nucleic acid, such as siRNA or the like, in a cell; and a nucleic acid delivery composition that can efficiently deliver the nucleic acid complex into a cell. A nucleic acid complex with low toxicity and high safety that can persistently maintain a nucleic acid in a cell can be obtained by forming a complex using a nucleic acid to be introduced into a cell, and a highly branched cyclic dextrin. Moreover, when a carrier comprising (A) a diacylphosphatidylcholine, (B) cholesterol and/or a derivative thereof, and (C) an aliphatic primary amine is used as a nucleic acid delivery carrier to introduce the nucleic acid complex into a cell, the safety, the efficiency of intracellular delivery, and the persistence of the nucleic acid in the cell can be further improved.
摘要翻译：本发明提供了一种具有低毒性和高安全性的核酸复合物，其可以在细胞中持续保持核酸如siRNA等; 以及可以有效地将核酸复合物递送到细胞中的核酸递送组合物。可以通过使用待引入细胞的核酸和高度支化的环糊精形成复合物来获得能够持续维持细胞中核酸的低毒性和高安全性的核酸复合物。此外，当使用包含（A）二酰基磷脂酰胆碱，（B）胆固醇和/或其衍生物和（C）脂肪族伯胺的载体作为核酸递送载体以将核酸复合物引入细胞时，可以进一步提高安全性，细胞内递送的效率和核酸在细胞中的持续性。

4. 发明申请

US20100063131A1 PROMPT NUCLEIC ACID DELIVERY CARRIER COMPOSITION 有权
标题翻译：提示核酸递送载体组成
公开(公告)号：US20100063131A1
公开(公告)日：2010-03-11
申请号：US12532949
申请日：2008-03-26
申请人： Hirofumi Takeuchi , Yasuyuki Hira , Koji Nakano , Hidekazu Toyobuku
发明人： Hirofumi Takeuchi , Yasuyuki Hira , Koji Nakano , Hidekazu Toyobuku
IPC分类号： A61K31/7105 , A61K31/7088 , C12N5/07 , A61P35/00
CPC分类号： C12N15/87 , A61K9/127 , A61K31/7088 , A61K31/713 , A61K48/00 , C12N15/111 , C12N2310/14 , C12N2320/32
摘要： An object of the present invention is to provide a carrier composition for nucleic acid delivery, which can efficiently deliver a nucleic acid into cells when a nucleic acid such as siRNA is administered to animal-derived cells or animals, and also has low toxicity and high safety, and a composition for nucleic acid delivery containing the carrier composition and nucleic acid.A carrier for nucleic acid delivery is prepared by using (A) a diacylphosphatidylcholine, (B) at least one member selected from the group consisting of cholesterol and derivatives thereof, and (C) an aliphatic primary amine. Also, a composition for nucleic acid delivery is prepared by mixing the carrier for nucleic acid delivery with a nucleic acid.
摘要翻译：本发明的目的是提供一种用于核酸递送的载体组合物，当向动物来源的细胞或动物施用siRNA等核酸时，可以将核酸有效地递送到细胞中，并且还具有低毒性和高安全性和用于含有载体组合物和核酸的核酸递送的组合物。通过使用（A）二酰基磷脂酰胆碱，（B）至少一种选自胆固醇及其衍生物的组分和（C）脂族伯胺制备核酸递送载体。而且，通过将用于核酸递送的载体与核酸混合来制备用于核酸递送的组合物。

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