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1. 发明授权

US08232052B2 Methods of selecting a dopaminergic neuron proliferative progenitor cells using Lrp4/Corin markers 有权
标题翻译：使用Lrp4 / Corin标记物选择多巴胺能神经元增殖祖细胞的方法
公开(公告)号：US08232052B2
公开(公告)日：2012-07-31
申请号：US12868598
申请日：2010-08-25
申请人： Yuichi Ono , Yasuko Nakagawa , Yoshimasa Sakamoto
发明人： Yuichi Ono , Yasuko Nakagawa , Yoshimasa Sakamoto
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： In neuron transplantation therapy, in terms of safety, it is preferable to use a cell population consisting only of a desired type of cells, and to use postmitotic neurons in consideration to avoid the risk of tumorigenesis. Moreover, greater therapeutic effects would be expected through the use of earlier progenitor cells in consideration of post-transplantation viability, proper network formation ability, and such.According to the present invention, Lrp4, a gene that is specifically expressed in dopaminergic neuron proliferative progenitor cells prior to cell cycle exit, was identified. The use of Lrp4 expression in cells as an index allows for the isolation. of cells suitable for transplantation therapy of neurodegenerative diseases such as Parkinson's disease in terms of safety, survival rate, and network formation ability.
摘要翻译：在神经元移植治疗中，在安全性方面，优选使用仅由期望类型的细胞组成的细胞群，并考虑使用神经元神经元以避免肿瘤发生的风险。此外，考虑到移植后的生存力，适当的网络形成能力等，通过使用较早的祖细胞可以预期更大的治疗效果。根据本发明，鉴定了在细胞周期退出之前在多巴胺能神经元增殖祖细胞中特异性表达的基因Lrp4。在细胞中使用Lrp4表达作为指标，可以进行分离。的细胞在安全性，存活率和网络形成能力方面适用于帕金森病等神经变性疾病的移植治疗。

2. 发明申请

US20110229889A1 DOPAMINERGIC NEURON PROLIFERATIVE PROGENITOR CELL MARKER Msx1/2 审中-公开
标题翻译：多巴胺神经元增殖性前体细胞标记Msx1 / 2
公开(公告)号：US20110229889A1
公开(公告)日：2011-09-22
申请号：US13071450
申请日：2011-03-24
申请人： Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani , Yoshimasa Sakamoto
发明人： Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani , Yoshimasa Sakamoto
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： G01N33/56966 , C07K16/18 , C12Q1/6881 , C12Q2600/158
摘要： The present invention is a probe, a primer, and an antibody, for detecting a dopaminergic neuron proliferative progenitor cell. According to the present invention, there is provided a polynucleotide probe and a polynucleotide primer for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell, which can hybridize with a polynucleotide consisting of a nucleotide sequence of an Msx1 gene or an Msx2 gene, or a complementary sequence thereto, and an antibody against an Msx1 protein or an Msx2 protein, or a part thereof for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell.
摘要翻译：本发明是用于检测多巴胺能神经元增殖祖细胞的探针，引物和抗体。根据本发明，提供了用于检测或选择多巴胺能神经元增殖祖细胞的多核苷酸探针和多核苷酸引物，其可以与由Msx1基因或Msx2基因的核苷酸序列组成的多核苷酸杂交，或其互补序列，以及针对用于检测或选择多巴胺能神经元增殖祖细胞的Msx1蛋白或Msx2蛋白或其一部分的抗体。

3. 发明授权

US08067161B2 Dopaminergic neuron proliferative progenitor cell marker Nato3 失效
标题翻译：多巴胺能神经元增殖祖细胞标记Nato3
公开(公告)号：US08067161B2
公开(公告)日：2011-11-29
申请号：US12064018
申请日：2006-08-18
申请人： Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani , Yoshimasa Sakamoto
发明人： Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani , Yoshimasa Sakamoto
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C07K16/18 , C07K14/47 , C12Q1/6881 , C12Q2600/158 , G01N33/5073
摘要： The present invention is a probe, a primer, and an antibody, for detecting a dopaminergic neuron proliferative progenitor cell. According to the present invention, there is provided a polynucleotide probe and a polynucleotide primer for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell, which can hybridize with a polynucleotide consisting of a nucleotide sequence of a Nato3 gene, or a complementary sequence thereto, and an antibody against a Nato3 protein, or a part thereof for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell.
摘要翻译：本发明是用于检测多巴胺能神经元增殖祖细胞的探针，引物和抗体。根据本发明，提供了用于检测或选择多巴胺能神经元增殖祖细胞的多核苷酸探针和多核苷酸引物，其可与由Nato3基因的核苷酸序列或互补的多核苷酸组成的多核苷酸杂交序列，以及针对Nato3蛋白或其部分的抗体用于检测或选择多巴胺能神经元增殖祖细胞。

4. 发明申请

US20100323366A1 Methods of Selecting a Dopaminergic Neuron Proliferative Progenitor Cells Using LRP4/CORIN Markers 有权
标题翻译：使用LRP4 / CORIN标记物选择多巴胺能神经元增殖祖细胞的方法
公开(公告)号：US20100323366A1
公开(公告)日：2010-12-23
申请号：US12868598
申请日：2010-08-25
申请人： Yuichi Ono , Yasuko Nakagawa , Yoshimasa Sakamoto
发明人： Yuichi Ono , Yasuko Nakagawa , Yoshimasa Sakamoto
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： In neuron transplantation therapy, in terms of safety, it is preferable to use a cell population consisting only of a desired type of cells, and to use postmitotic neurons in consideration to avoid the risk of tumorigenesis. Moreover, greater therapeutic effects would be expected through the use of earlier progenitor cells in consideration of post-transplantation viability, proper network formation ability, and such.According to the present invention, Lrp4, a gene that is specifically expressed in dopaminergic neuron proliferative progenitor cells prior to cell cycle exit, was identified. The use of Lrp4 expression in cells as an index allows for the isolation. of cells suitable for transplantation therapy of neurodegenerative diseases such as Parkinson's disease in terms of safety, survival rate, and network formation ability.
摘要翻译：在神经元移植治疗中，在安全性方面，优选使用仅由期望类型的细胞组成的细胞群，并考虑使用神经元神经元以避免肿瘤发生的风险。此外，考虑到移植后的生存力，适当的网络形成能力等，通过使用较早的祖细胞可以预期更大的治疗效果。根据本发明，鉴定了在细胞周期退出之前在多巴胺能神经元增殖祖细胞中特异性表达的基因Lrp4。在细胞中使用Lrp4表达作为指标，可以进行分离。的细胞在安全性，存活率和网络形成能力方面适用于帕金森病等神经变性疾病的移植治疗。

5. 发明申请

US20100203505A1 DOPAMINERGIC NEURON PROLIFERATIVE PROGENITOR CELL MARKER Msx1/2 审中-公开
标题翻译：多巴胺神经元增殖性前体细胞标记Msx1 / 2
公开(公告)号：US20100203505A1
公开(公告)日：2010-08-12
申请号：US12064019
申请日：2006-08-18
申请人： Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani , Yoshimasa Sakamoto
发明人： Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani , Yoshimasa Sakamoto
IPC分类号： C12Q1/68 , C07H21/04 , C07K16/00
CPC分类号： G01N33/56966 , C07K16/18 , C12Q1/6881 , C12Q2600/158
摘要： The present invention is a probe, a primer, and an antibody, for detecting a dopaminergic neuron proliferative progenitor cell. According to the present invention, there is provided a polynucleotide probe and a polynucleotide primer for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell, which can hybridize with a polynucleotide consisting of a nucleotide sequence of an Msx1 gene or an Msx2 gene, or a complementary sequence thereto, and an antibody against an Msx1 protein or an Msx2 protein, or a part thereof for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell.
摘要翻译：本发明是用于检测多巴胺能神经元增殖祖细胞的探针，引物和抗体。根据本发明，提供了用于检测或选择多巴胺能神经元增殖祖细胞的多核苷酸探针和多核苷酸引物，其可以与由Msx1基因或Msx2基因的核苷酸序列组成的多核苷酸杂交，或其互补序列，以及针对用于检测或选择多巴胺能神经元增殖祖细胞的Msx1蛋白或Msx2蛋白或其一部分的抗体。

6. 发明申请

US20060240432A1 Lrp4/corin dopamine-producing neuron proliferation precursor cell marker 审中-公开
标题翻译： Lrp4 / corin多巴胺产生神经元增殖前体细胞标记
公开(公告)号：US20060240432A1
公开(公告)日：2006-10-26
申请号：US10543003
申请日：2004-01-23
申请人： Yuichi Ono , Yasuko Nakagawa , Yoshimasa Sakamoto
发明人： Yuichi Ono , Yasuko Nakagawa , Yoshimasa Sakamoto
IPC分类号： C12Q1/68 , C12N5/08
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： In neuron transplantation therapy, in terms of safety, it is preferable to use a cell population consisting only of a desired type of cells, and to use postmitotic neurons in consideration to avoid the risk of tumorigenesis. Moreover, greater therapeutic effects would be expected through the use of earlier progenitor cells in consideration of post-transplantation viability, proper network formation ability, and such. According to the present invention, Lrp4, a gene that is specifically expressed in dopaminergic neuron proliferative progenitor cells prior to cell cycle exit, was identified. The use of Lrp4 expression in cells as an index allows for the isolation. of cells suitable for transplantation therapy of neurodegenerative diseases such as Parkinson's disease in terms of safety, survival rate, and network formation ability.
摘要翻译：在神经元移植治疗中，在安全性方面，优选使用仅由期望类型的细胞组成的细胞群，并考虑使用神经元神经元以避免肿瘤发生的风险。此外，考虑到移植后的生存力，适当的网络形成能力等，通过使用较早的祖细胞可以预期更大的治疗效果。根据本发明，鉴定了在细胞周期退出之前在多巴胺能神经元增殖祖细胞中特异性表达的基因Lrp4。在细胞中使用Lrp4表达作为指标，可以进行分离。的细胞在安全性，存活率和网络形成能力方面适用于帕金森病等神经变性疾病的移植治疗。

7. 发明申请

US20120252021A1 DOPAMINERGIC NEURON PROGENITOR CELL MARKER 187A5 有权
标题翻译：多巴胺神经元细胞标记187A5
公开(公告)号：US20120252021A1
公开(公告)日：2012-10-04
申请号：US13492733
申请日：2012-06-08
申请人： Yuichi Ono , Yoshimasa Sakamoto
发明人： Yuichi Ono , Yoshimasa Sakamoto
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C07K14/705 , A61K35/30 , A61K38/00 , C07K16/28 , C12Q1/6881 , C12Q2600/158 , G01N33/5058 , G01N33/5073 , G01N33/56966 , G01N2333/70571 , Y10S530/81
摘要： An object of the present invention is to provide a probe, a primer, a primer set and an antibody for use in the detection or selection of a dopaminergic neuron progenitor cell. The present invention provides a probe, a primer and a primer set for use in the detection or selection of a mesencephalon dopaminergic neuron progenitor cell, and preferably a dopaminergic neuron proliferative progenitor cell, which can hybridize with a nucleotide sequence of a 187A5 gene, or a complementary sequence thereto, and an antibody for use in the detection or selection of a mesencephalon dopaminergic neuron progenitor cell, and preferably a dopaminergic neuron progenitor cell, which is capable of binding to a 187A5 protein.
摘要翻译：本发明的目的是提供用于检测或选择多巴胺能神经元祖细胞的探针，引物，引物组和抗体。本发明提供了用于检测或选择中脑多巴胺能神经元祖细胞的探针，引物和引物组，优选多巴胺能神经元增殖祖细胞，其可以与187A5基因的核苷酸序列杂交，或其互补序列，以及用于检测或选择能够结合187A5蛋白的中脑多巴胺能神经元祖细胞，优选多巴胺能神经元祖细胞的抗体。

8. 发明申请

US20080280301A1 Lrp4/Corin DOPAMINERGIC NEURON PROLIFERATIVE PROGENITOR CELL MARKERS 有权
标题翻译： Lrp4 / Corin DOPAMINERGIC神经元增殖型细胞标志物
公开(公告)号：US20080280301A1
公开(公告)日：2008-11-13
申请号：US12110111
申请日：2008-04-25
申请人： Yuichi Ono , Yasuko Nakagawa , Yoshimasa Sakamoto
发明人： Yuichi Ono , Yasuko Nakagawa , Yoshimasa Sakamoto
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： In neuron transplantation therapy, in terms of safety, it is preferable to use a cell population consisting only of a desired type of cells, and to use postmitotic neurons in consideration to avoid the risk of tumorigenesis. Moreover, greater therapeutic effects would be expected through the use of earlier progenitor cells in consideration of post-transplantation viability, proper network formation ability, and such.According to the present invention, Lrp4, a gene that is specifically expressed in dopaminergic neuron proliferative progenitor cells prior to cell cycle exit, was identified. The use of Lrp4 expression in cells as an index allows for the isolation. of cells suitable for transplantation therapy of neurodegenerative diseases such as Parkinson's disease in terms of safety, survival rate, and network formation ability.
摘要翻译：在神经元移植治疗中，在安全性方面，优选使用仅由期望类型的细胞组成的细胞群，并考虑使用神经元神经元以避免肿瘤发生的风险。此外，考虑到移植后的生存力，适当的网络形成能力等，通过使用较早的祖细胞可以预期更大的治疗效果。根据本发明，鉴定了在细胞周期退出之前在多巴胺能神经元增殖祖细胞中特异性表达的基因Lrp4。在细胞中使用Lrp4表达作为指标，可以进行分离。的细胞在安全性，存活率和网络形成能力方面适用于帕金森病等神经变性疾病的移植治疗。

9. 发明申请

US20070122882A1 GENE SPECIFICALLY EXPRESSED IN POSTMITOTIC DOPAMINERGIC NEURON PRECURSOR CELLS 审中-公开
标题翻译：基因在POSTMITOTIC DOPAMINERGIC神经元前体细胞中明确表达
公开(公告)号：US20070122882A1
公开(公告)日：2007-05-31
申请号：US11622312
申请日：2007-01-11
申请人： Yasuko Nakagawa , Yuichi Ono , Yoshimasa Sakamoto , Eri Mizuhara , Tomoya Nakatani , Yoshimi Takai
发明人： Yasuko Nakagawa , Yuichi Ono , Yoshimasa Sakamoto , Eri Mizuhara , Tomoya Nakatani , Yoshimi Takai
IPC分类号： C07K14/705 , C07K16/28 , C07H21/04 , C12P21/06
CPC分类号： G01N33/6896 , C07K14/47
摘要： A novel gene 65B13 expressed specifically and transiently in dopaminergic neuron precursor cells immediately after cell cycle exit was obtained by the present invention. The cellular expression of 65B13 can be used as an index to select cells that are suitable in terms of their safety, survival rate, and network formation ability, for transplant therapy of neurodegenerative diseases such as Parkinson's disease.
摘要翻译：通过本发明获得在细胞周期出口后立即在多巴胺能神经元前体细胞中特异性和瞬时表达的新基因65B13。 65B13的细胞表达可用作选择适合于其安全性，存活率和网络形成能力的细胞的指标，用于神经变性疾病如帕金森病的移植治疗。

10. 发明授权

US07807371B2 Methods of selecting dopaminergic neuron proliferative progenitor cells using Lrp4/Corin markers 有权
标题翻译：使用Lrp4 / Corin标记物选择多巴胺能神经元增殖祖细胞的方法
公开(公告)号：US07807371B2
公开(公告)日：2010-10-05
申请号：US12110111
申请日：2008-04-25
申请人： Yuichi Ono , Yasuko Nakagawa , Yoshimasa Sakamoto
发明人： Yuichi Ono , Yasuko Nakagawa , Yoshimasa Sakamoto
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： In neuron transplantation therapy, in terms of safety, it is preferable to use a cell population consisting only of a desired type of cells, and to use postmitotic neurons in consideration to avoid the risk of tumorigenesis. Moreover, greater therapeutic effects would be expected through the use of earlier progenitor cells in consideration of post-transplantation viability, proper network formation ability, and such.According to the present invention, Lrp4, a gene that is specifically expressed in dopaminergic neuron proliferative progenitor cells prior to cell cycle exit, was identified. The use of Lrp4 expression in cells as an index allows for the isolation. of cells suitable for transplantation therapy of neurodegenerative diseases such as Parkinson's disease in terms of safety, survival rate, and network formation ability.
摘要翻译：在神经元移植治疗中，在安全性方面，优选使用仅由期望类型的细胞组成的细胞群，并考虑使用神经元神经元以避免肿瘤发生的风险。此外，考虑到移植后的生存力，适当的网络形成能力等，通过使用较早的祖细胞可以预期更大的治疗效果。根据本发明，鉴定了在细胞周期退出之前在多巴胺能神经元增殖祖细胞中特异性表达的基因Lrp4。在细胞中使用Lrp4表达作为指标，可以进行分离。的细胞在安全性，存活率和网络形成能力方面适用于帕金森病等神经变性疾病的移植治疗。

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