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1. 发明专利

JP2014059189A Personal color diagnostic drapes and personal color diagnostic method including the personal color diagnostic drapes 有权
标题翻译：个人颜色诊断和个人颜色诊断方法，包括个人颜色诊断性皮肤
公开(公告)号：JP2014059189A
公开(公告)日：2014-04-03
申请号：JP2012203751
申请日：2012-09-17
申请人： Yasuko Nakagawa , 保子中川
发明人： NAKAGAWA YASUKO
IPC分类号： G01J3/52
摘要： PROBLEM TO BE SOLVED: To provide personal color diagnostic drapes and a personal color diagnostic method including the personal color diagnostic drapes that can determine a personal color for a person to be diagnosed more simply, more rapidly, and more accurately than a method including conventional drapes.SOLUTION: Personal color diagnostic drapes according to the present invention comprises: a plurality of kinds of hue drapes in gradation formed by one hue selected from 2:R (red), 8:Y (yellow), 12:G (green), 17:B (blue), 22:P (purple), and 24:RP (red purple) shown in a hue circle of the PCCS (Practical Color Co-ordinate System), and hues consecutively shown around the one hue in the hue circle; brightness drapes in which colors from white to black are combined to have gradation or stripes; and chromaticity drapes in which colors having arbitrary brightness and at least 3s-8s chromaticity in the PCCS are combined in the same way as the brightness drapes.
摘要翻译：要解决的问题：提供个人颜色诊断窗帘和个人颜色诊断方法，其包括个人颜色诊断窗帘，其可以比包括常规窗帘的方法更简单，更快速和更准确地确定要诊断的人的个人颜色解决方案：根据本发明的个人颜色诊断装置包括：通过从2：R（红色），8：Y（黄色），12：G（绿色）中选择的一种色调形成的灰度级的多种色调， 17：B（蓝色），22：P（紫色）和24：RP（红色紫色）在PCCS（实用色彩协调系统）的色相圆圈中显示，并且色调在色相中的一个色调周围连续显示圈; 其中从白色到黑色的颜色组合成具有渐变或条纹的亮度罩; 并且以与亮度显示相同的方式组合PCCS中具有任意亮度和至少3s-8s色度的颜色的色度罩。

2. 发明专利

JP2014059287A Personal color diagnostic drapes and personal color diagnostic method including the personal color diagnostic drapes 审中-公开
标题翻译：个人颜色诊断和个人颜色诊断方法，包括个人颜色诊断性皮肤
公开(公告)号：JP2014059287A
公开(公告)日：2014-04-03
申请号：JP2013046078
申请日：2013-03-08
申请人： Yasuko Nakagawa , 保子中川
发明人： NAKAGAWA YASUKO
IPC分类号： G01J3/52 , G01J3/46
摘要： PROBLEM TO BE SOLVED: To provide diagnostic drapes and a personal color diagnostic method that can simply, rapidly, and accurately determine a personal color for a person to be diagnosed.SOLUTION: Personal color diagnostic drapes comprises: drape groups including a plurality of kinds of hue drapes in which a reference hue selected from red, yellow, green, blue, purple, and red purple shown in a hue circle in the PCCS (Practical Color Co-ordinate System) and 1 to 12 grade hues shown consecutively in both clockwise and counterclockwise directions around the reference hue in the hue circle are combined so that boundaries between hues cannot be identified or combined in stripes; brightness drapes in which colors from white to black are combined so that boundaries between hues cannot be identified; and chromaticity drapes in which colors that are arbitrary colors having brightness whose value is constant in the PCCS and that have at least 3s-8s chromaticity in the PCCS are combined so that boundaries between hues cannot be identified or combined in stripes.
摘要翻译：要解决的问题：提供诊断窗帘和个人颜色诊断方法，其可以简单，快速和准确地确定待诊断的人的个人颜色。解决方案：个人颜色诊断窗帘包括：包括多种在PCCS（实用色彩协调系统）中的色相圆圈中显示的红色，黄色，绿色，蓝色，紫色和紫色紫色的参考色调和1至12色级色调的顺序显示顺时针和组合色调圈周围参考色调的逆时针方向，使得色相之间的边界不能被识别或组合成条纹; 将白色至黑色的颜色组合在一起，使得色调之间的边界无法识别; 以及其中在PCCS中具有恒定值并且在PCCS中具有至少3s-8s色度的具有亮度的任意颜色的颜色的色度组合，使得色相之间的边界不能被识别或组合成条纹。

3. 发明授权

US08877449B2 Method for obtaining pancreatic progenitor cell using NEPH3 有权
标题翻译：使用NEPH3获得胰腺祖细胞的方法
公开(公告)号：US08877449B2
公开(公告)日：2014-11-04
申请号：US13141063
申请日：2009-12-18
申请人： Yuichi Ono , Tomoya Nakatani , Yasuko Nakagawa
发明人： Yuichi Ono , Tomoya Nakatani , Yasuko Nakagawa
IPC分类号： G01N33/53 , G01N33/68 , C07K14/47 , C12N5/071
CPC分类号： C12N5/0678
摘要： The present invention provides markers that can selectively distinguish pancreatic progenitor cells. The present invention also provides methods for distinguishing pancreatic progenitor cells by using the markers as an indicator, and reagents to be used in the methods.The present inventors successfully identified the surface marker Nephrin-like 3 (Neph3) which is specifically expressed in pancreatic progenitor cells, and isolated pancreatic progenitor cells using the marker as an indicator or such. Viable pancreatic progenitor cells can be selected by using Neph3 as an indicator without using translated products and transcripts of any foreign genes. The marker is useful in preparing and identifying pancreatic progenitor cells which are applied to regenerative medicine or such for treatment of pancreatic diseases.
摘要翻译：本发明提供了可以选择性区分胰腺祖细胞的标志物。本发明还提供了通过使用标记作为指标来区分胰腺祖细胞的方法，以及用于该方法的试剂。本发明人成功地鉴定了在胰腺祖细胞中特异性表达的表面标记物Nephrin样3（Neph3），以及使用该标记作为指示剂的分离的胰腺祖细胞。可以通过使用Neph3作为指标来选择可行的胰腺祖细胞，而不使用翻译的产物和任何外来基因的转录物。该标记物可用于制备和鉴定适用于再生医学或胰腺疾病治疗的胰腺祖细胞。

4. 发明授权

US08580523B2 Specific marker Lmx1a on dopaminergic neurons 有权
标题翻译：多巴胺能神经元上的特异性标记物Lmx1a
公开(公告)号：US08580523B2
公开(公告)日：2013-11-12
申请号：US13352241
申请日：2012-01-17
申请人： Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani
发明人： Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani
IPC分类号： C12N5/0793 , C12N5/071 , C12N5/00 , C12N5/07 , C12Q1/68 , G01N33/53 , G01N33/58
CPC分类号： C12Q1/6881 , C12Q1/6883 , C12Q2600/158 , G01N33/6896 , G01N33/9413 , G01N2800/2835
摘要： The present invention identified Lmx1a genes, which are expressed in dopaminergic neurons at all differentiation stages, from proliferating dopaminergic neuron progenitor cells before cell cycle exit to cells after cell cycle exit. Lmx1a expression in cells can be used as an indicator when selecting cells suitable for transplantation therapy for neurodegenerative diseases such as Parkinson's disease, and is useful as a marker for screening agents involved in the induction of dopaminergic neuron differentiation.
摘要翻译：本发明鉴定了在细胞周期退出至细胞周期后出现的细胞周期性增殖的多巴胺能神经元祖细胞中，在所有分化阶段的多巴胺能神经元中表达的Lmx1a基因。当选择适合于帕金森病等神经变性疾病的移植治疗的细胞时，细胞中的Lmx1a表达可用作指示剂，并且可用作参与多巴胺能神经元分化诱导的筛选剂的标记。

5. 发明授权

US08067161B2 Dopaminergic neuron proliferative progenitor cell marker Nato3 失效
标题翻译：多巴胺能神经元增殖祖细胞标记Nato3
公开(公告)号：US08067161B2
公开(公告)日：2011-11-29
申请号：US12064018
申请日：2006-08-18
申请人： Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani , Yoshimasa Sakamoto
发明人： Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani , Yoshimasa Sakamoto
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C07K16/18 , C07K14/47 , C12Q1/6881 , C12Q2600/158 , G01N33/5073
摘要： The present invention is a probe, a primer, and an antibody, for detecting a dopaminergic neuron proliferative progenitor cell. According to the present invention, there is provided a polynucleotide probe and a polynucleotide primer for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell, which can hybridize with a polynucleotide consisting of a nucleotide sequence of a Nato3 gene, or a complementary sequence thereto, and an antibody against a Nato3 protein, or a part thereof for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell.
摘要翻译：本发明是用于检测多巴胺能神经元增殖祖细胞的探针，引物和抗体。根据本发明，提供了用于检测或选择多巴胺能神经元增殖祖细胞的多核苷酸探针和多核苷酸引物，其可与由Nato3基因的核苷酸序列或互补的多核苷酸组成的多核苷酸杂交序列，以及针对Nato3蛋白或其部分的抗体用于检测或选择多巴胺能神经元增殖祖细胞。

6. 发明申请

US20100323366A1 Methods of Selecting a Dopaminergic Neuron Proliferative Progenitor Cells Using LRP4/CORIN Markers 有权
标题翻译：使用LRP4 / CORIN标记物选择多巴胺能神经元增殖祖细胞的方法
公开(公告)号：US20100323366A1
公开(公告)日：2010-12-23
申请号：US12868598
申请日：2010-08-25
申请人： Yuichi Ono , Yasuko Nakagawa , Yoshimasa Sakamoto
发明人： Yuichi Ono , Yasuko Nakagawa , Yoshimasa Sakamoto
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： In neuron transplantation therapy, in terms of safety, it is preferable to use a cell population consisting only of a desired type of cells, and to use postmitotic neurons in consideration to avoid the risk of tumorigenesis. Moreover, greater therapeutic effects would be expected through the use of earlier progenitor cells in consideration of post-transplantation viability, proper network formation ability, and such.According to the present invention, Lrp4, a gene that is specifically expressed in dopaminergic neuron proliferative progenitor cells prior to cell cycle exit, was identified. The use of Lrp4 expression in cells as an index allows for the isolation. of cells suitable for transplantation therapy of neurodegenerative diseases such as Parkinson's disease in terms of safety, survival rate, and network formation ability.
摘要翻译：在神经元移植治疗中，在安全性方面，优选使用仅由期望类型的细胞组成的细胞群，并考虑使用神经元神经元以避免肿瘤发生的风险。此外，考虑到移植后的生存力，适当的网络形成能力等，通过使用较早的祖细胞可以预期更大的治疗效果。根据本发明，鉴定了在细胞周期退出之前在多巴胺能神经元增殖祖细胞中特异性表达的基因Lrp4。在细胞中使用Lrp4表达作为指标，可以进行分离。的细胞在安全性，存活率和网络形成能力方面适用于帕金森病等神经变性疾病的移植治疗。

7. 发明申请

US20100203505A1 DOPAMINERGIC NEURON PROLIFERATIVE PROGENITOR CELL MARKER Msx1/2 审中-公开
标题翻译：多巴胺神经元增殖性前体细胞标记Msx1 / 2
公开(公告)号：US20100203505A1
公开(公告)日：2010-08-12
申请号：US12064019
申请日：2006-08-18
申请人： Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani , Yoshimasa Sakamoto
发明人： Yuichi Ono , Yasuko Nakagawa , Tomoya Nakatani , Yoshimasa Sakamoto
IPC分类号： C12Q1/68 , C07H21/04 , C07K16/00
CPC分类号： G01N33/56966 , C07K16/18 , C12Q1/6881 , C12Q2600/158
摘要： The present invention is a probe, a primer, and an antibody, for detecting a dopaminergic neuron proliferative progenitor cell. According to the present invention, there is provided a polynucleotide probe and a polynucleotide primer for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell, which can hybridize with a polynucleotide consisting of a nucleotide sequence of an Msx1 gene or an Msx2 gene, or a complementary sequence thereto, and an antibody against an Msx1 protein or an Msx2 protein, or a part thereof for use in the detection or selection of a dopaminergic neuron proliferative progenitor cell.
摘要翻译：本发明是用于检测多巴胺能神经元增殖祖细胞的探针，引物和抗体。根据本发明，提供了用于检测或选择多巴胺能神经元增殖祖细胞的多核苷酸探针和多核苷酸引物，其可以与由Msx1基因或Msx2基因的核苷酸序列组成的多核苷酸杂交，或其互补序列，以及针对用于检测或选择多巴胺能神经元增殖祖细胞的Msx1蛋白或Msx2蛋白或其一部分的抗体。

8. 发明申请

US20060240432A1 Lrp4/corin dopamine-producing neuron proliferation precursor cell marker 审中-公开
标题翻译： Lrp4 / corin多巴胺产生神经元增殖前体细胞标记
公开(公告)号：US20060240432A1
公开(公告)日：2006-10-26
申请号：US10543003
申请日：2004-01-23
申请人： Yuichi Ono , Yasuko Nakagawa , Yoshimasa Sakamoto
发明人： Yuichi Ono , Yasuko Nakagawa , Yoshimasa Sakamoto
IPC分类号： C12Q1/68 , C12N5/08
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： In neuron transplantation therapy, in terms of safety, it is preferable to use a cell population consisting only of a desired type of cells, and to use postmitotic neurons in consideration to avoid the risk of tumorigenesis. Moreover, greater therapeutic effects would be expected through the use of earlier progenitor cells in consideration of post-transplantation viability, proper network formation ability, and such. According to the present invention, Lrp4, a gene that is specifically expressed in dopaminergic neuron proliferative progenitor cells prior to cell cycle exit, was identified. The use of Lrp4 expression in cells as an index allows for the isolation. of cells suitable for transplantation therapy of neurodegenerative diseases such as Parkinson's disease in terms of safety, survival rate, and network formation ability.
摘要翻译：在神经元移植治疗中，在安全性方面，优选使用仅由期望类型的细胞组成的细胞群，并考虑使用神经元神经元以避免肿瘤发生的风险。此外，考虑到移植后的生存力，适当的网络形成能力等，通过使用较早的祖细胞可以预期更大的治疗效果。根据本发明，鉴定了在细胞周期退出之前在多巴胺能神经元增殖祖细胞中特异性表达的基因Lrp4。在细胞中使用Lrp4表达作为指标，可以进行分离。的细胞在安全性，存活率和网络形成能力方面适用于帕金森病等神经变性疾病的移植治疗。

9. 发明授权

US08609405B2 GABA neuron progenitor cell marker 65B13 有权
标题翻译： GABA神经元祖细胞标记65B13
公开(公告)号：US08609405B2
公开(公告)日：2013-12-17
申请号：US12524153
申请日：2008-02-07
申请人： Yuichi Ono , Yasuko Nakagawa , Eri Mizuhara
发明人： Yuichi Ono , Yasuko Nakagawa , Eri Mizuhara
IPC分类号： C07K16/18 , C12N15/09 , C12Q1/08 , C12Q1/68 , G01N33/53
CPC分类号： C07K16/40 , C07K14/47 , C07K16/18 , G01N33/5023 , G01N33/5058 , G01N33/5073 , G01N33/56966 , G01N33/9426
摘要： The present inventors identified a selective marker 65B13 for GABA neuron progenitor cells of the spinal dorsal horn and cerebellum, and successfully isolated GABA neuron progenitor cells using antibodies that bind to a protein encoded by the gene. 65B13 was demonstrated to be useful as a marker to isolate GABA-producing neuron progenitor cells in the spinal dorsal horn and cerebellum. GABA neuron progenitor cells can be efficiently identified or isolated by using the identified marker as an indicator.
摘要翻译：本发明人鉴定了用于脊髓背角和小脑的GABA神经元祖细胞的选择性标记65B13，并且使用结合由该基因编码的蛋白质的抗体成功分离GABA神经元祖细胞。 65B13被证明可用作分离脊髓背角和小脑中产生GABA的神经元祖细胞的标志物。通过使用鉴定的标记作为指标，可以有效地鉴定或分离GABA神经元祖细胞。

10. 发明授权

US08232052B2 Methods of selecting a dopaminergic neuron proliferative progenitor cells using Lrp4/Corin markers 有权
标题翻译：使用Lrp4 / Corin标记物选择多巴胺能神经元增殖祖细胞的方法
公开(公告)号：US08232052B2
公开(公告)日：2012-07-31
申请号：US12868598
申请日：2010-08-25
申请人： Yuichi Ono , Yasuko Nakagawa , Yoshimasa Sakamoto
发明人： Yuichi Ono , Yasuko Nakagawa , Yoshimasa Sakamoto
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： In neuron transplantation therapy, in terms of safety, it is preferable to use a cell population consisting only of a desired type of cells, and to use postmitotic neurons in consideration to avoid the risk of tumorigenesis. Moreover, greater therapeutic effects would be expected through the use of earlier progenitor cells in consideration of post-transplantation viability, proper network formation ability, and such.According to the present invention, Lrp4, a gene that is specifically expressed in dopaminergic neuron proliferative progenitor cells prior to cell cycle exit, was identified. The use of Lrp4 expression in cells as an index allows for the isolation. of cells suitable for transplantation therapy of neurodegenerative diseases such as Parkinson's disease in terms of safety, survival rate, and network formation ability.
摘要翻译：在神经元移植治疗中，在安全性方面，优选使用仅由期望类型的细胞组成的细胞群，并考虑使用神经元神经元以避免肿瘤发生的风险。此外，考虑到移植后的生存力，适当的网络形成能力等，通过使用较早的祖细胞可以预期更大的治疗效果。根据本发明，鉴定了在细胞周期退出之前在多巴胺能神经元增殖祖细胞中特异性表达的基因Lrp4。在细胞中使用Lrp4表达作为指标，可以进行分离。的细胞在安全性，存活率和网络形成能力方面适用于帕金森病等神经变性疾病的移植治疗。

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