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    • 5. 发明授权
    • Method for determining analyte concentration in biological fluid using electrochemical sensor
    • 使用电化学传感器确定生物流体中分析物浓度的方法
    • US08383361B2
    • 2013-02-26
    • US13326071
    • 2011-12-14
    • Adam HellerBenjamin J. FeldmanNicolas ManoYueh-Lin Loo
    • Adam HellerBenjamin J. FeldmanNicolas ManoYueh-Lin Loo
    • C12Q1/54C12Q1/26C12Q1/32C12Q1/28C12N11/08C12N11/04C12M1/34
    • G01N27/3271C12Q1/001C12Q1/005C12Q1/006C12Q1/26G01N27/327
    • A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme. The polymer matrix may be hydrated, and the absorbed water may make it permeable to, for example, glucose. The polyaniline may be polyaniline itself or a substituted polyaniline; the water-soluble crosslinker may be poly(ethylene glycol)diglycidyl ether, and the redox enzyme may be glucose oxidase. The polymer matrix may be produced by co-crosslinking (1) an adduct of an electrically conductive polymer and a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme in a single step at an about neutral pH, curing by drying. After hydration, the crosslinked polymer matrix may form a 3-dimensional glucose-permeable bioelectrocatalyst, catalyzing the electrooxidation of glucose.
    • 可以通过共聚交联(1)通过模板化氧化聚合形成的聚苯胺在聚合物酸上的加合物来产生可涂覆在电极上的聚合物基质; (2)水溶性交联剂; 和(3)氧化还原酶。 聚合物基质可以是水合的,并且所吸收的水可以使其可以例如葡萄糖渗透。 聚苯胺可以是聚苯胺本身或取代的聚苯胺; 水溶性交联剂可以是聚(乙二醇)二缩水甘油醚,氧化还原酶可以是葡萄糖氧化酶。 聚合物基质可以通过共交联(1)导电聚合物的加合物和聚合物酸来制备; (2)水溶性交联剂; 和(3)在大约中性pH下在一个步骤中的氧化还原酶,通过干燥固化。 水合后,交联聚合物基质可形成3维葡萄糖可渗透的生物电催化剂,催化葡萄糖的电氧化。
    • 7. 发明授权
    • Crosslinked adduct of polyaniline and polymer acid containing redox enzyme for electrochemical sensor
    • 用于电化学传感器的聚苯胺和含有氧化还原酶的聚合酸的交联加合物
    • US08080385B2
    • 2011-12-20
    • US12114359
    • 2008-05-02
    • Adam HellerBenjamin J. FeldmanNicolas ManoYueh-Lin Loo
    • Adam HellerBenjamin J. FeldmanNicolas ManoYueh-Lin Loo
    • C12Q1/54C12Q1/26C12Q1/32C12Q1/28C12N11/08C12N11/04
    • G01N27/3271C12Q1/001C12Q1/005C12Q1/006C12Q1/26G01N27/327
    • A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme. The polymer matrix may be hydrated, and the absorbed water may make it permeable to, for example, glucose. The polyaniline may be polyaniline itself or a substituted polyaniline; the water-soluble crosslinker may be poly(ethylene glycol) diglycidyl ether, and the redox enzyme may be glucose oxidase. The polymer matrix may be produced by co-crosslinking (1) an adduct of an electrically conductive polymer and a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme in a single step at an about neutral pH, curing by drying. After hydration, the crosslinked polymer matrix may form a 3-dimensional glucose-permeable bioelectrocatalyst, catalyzing the electrooxidation of glucose.
    • 可以通过共聚交联(1)通过模板化氧化聚合形成的聚苯胺在聚合物酸上的加合物来产生可涂覆在电极上的聚合物基质; (2)水溶性交联剂; 和(3)氧化还原酶。 聚合物基质可以是水合的,并且所吸收的水可以使其可以例如葡萄糖渗透。 聚苯胺可以是聚苯胺本身或取代的聚苯胺; 水溶性交联剂可以是聚(乙二醇)二缩水甘油醚,氧化还原酶可以是葡萄糖氧化酶。 聚合物基质可以通过共交联(1)导电聚合物的加合物和聚合物酸来制备; (2)水溶性交联剂; 和(3)在大约中性pH下在一个步骤中的氧化还原酶,通过干燥固化。 水合后,交联聚合物基质可形成3维葡萄糖可渗透的生物电催化剂,催化葡萄糖的电氧化。
    • 10. 发明申请
    • ELECTRON-CONDUCTING CROSSLINKED POLYANILINE-BASED REDOX HYDROGEL, AND METHOD OF MAKING
    • 基于交联聚氨酯的REDOX HYDROGEL的电子导电及其制造方法
    • US20090321277A1
    • 2009-12-31
    • US12114359
    • 2008-05-02
    • Adam HellerBenjamin J. FeldmanNicolas ManoYueh-Lin Loo
    • Adam HellerBenjamin J. FeldmanNicolas ManoYueh-Lin Loo
    • C12Q1/54C12N9/96G01N27/30
    • G01N27/3271C12Q1/001C12Q1/005C12Q1/006C12Q1/26G01N27/327
    • A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme. The polymer matrix may be hydrated, and the absorbed water may make it permeable to, for example, glucose. The polyaniline may be polyaniline itself or a substituted polyaniline; the water-soluble crosslinker may be poly(ethylene glycol) diglycidyl ether, and the redox enzyme may be glucose oxidase. The polymer matrix may be produced by co-crosslinking (1) an adduct of an electrically conductive polymer and a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme in a single step at an about neutral pH, curing by drying. After hydration, the crosslinked polymer matrix may form a 3-dimensional glucose-permeable bioelectrocatalyst, catalyzing the electrooxidation of glucose.
    • 可以通过共聚交联(1)通过模板化氧化聚合形成的聚苯胺在聚合物酸上的加合物来产生可涂覆在电极上的聚合物基质; (2)水溶性交联剂; 和(3)氧化还原酶。 聚合物基质可以是水合的,并且所吸收的水可以使其可以例如葡萄糖渗透。 聚苯胺可以是聚苯胺本身或取代的聚苯胺; 水溶性交联剂可以是聚(乙二醇)二缩水甘油醚,氧化还原酶可以是葡萄糖氧化酶。 聚合物基质可以通过共交联(1)导电聚合物的加合物和聚合物酸来制备; (2)水溶性交联剂; 和(3)在大约中性pH下在一个步骤中的氧化还原酶,通过干燥固化。 水合后,交联聚合物基质可形成3维葡萄糖可渗透的生物电催化剂,催化葡萄糖的电氧化。