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1. 发明授权

US08784481B2 Collapsible/expandable prosthetic heart valves with native calcified leaflet retention features 有权
标题翻译：具有天然钙化小叶保留特征的可折叠/可扩张的假体心脏瓣膜
公开(公告)号：US08784481B2
公开(公告)日：2014-07-22
申请号：US12733763
申请日：2008-09-26
申请人： Yousef F. Alkhatib , Michael J. Girard
发明人： Yousef F. Alkhatib , Michael J. Girard
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2230/0006 , A61F2230/0054 , A61F2230/0069 , A61F2230/0076
摘要： A prosthetic heart valve is circumferentially collapsible for less invasive delivery into a patient. The valve re-expands to operating size at the implant site in the patient. A frame structure of the valve includes restraining structure that can help to push one or more of the patient's native heart valve leaflets radially outwardly so that this native leaflet tissue does not interfere with the operation or service life of the prosthetic valve.
摘要翻译：假体心脏瓣膜是周向可折叠的，用于较少侵入性地输送到患者体内。瓣膜在病人的植入部位重新扩大到操作尺寸。阀的框架结构包括限制结构，其可以帮助推动病人的天然心脏瓣膜叶片中的一个或多个径向向外，使得该天然小叶组织不会干扰人工瓣膜的操作或使用寿命。

2. 发明申请

US20100249923A1 COLLAPSIBLE/EXPANDABLE PROSTHETIC HEART VALVES WITH NATIVE CALCIFIED LEAFLET RETENTION FEATURES 有权
标题翻译：具有先前计算的叶片保持特征的可拆卸/可扩展的前置心脏瓣膜
公开(公告)号：US20100249923A1
公开(公告)日：2010-09-30
申请号：US12733763
申请日：2008-09-26
申请人： Yousef F. Alkhatib , Michael J. Girard
发明人： Yousef F. Alkhatib , Michael J. Girard
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2230/0006 , A61F2230/0054 , A61F2230/0069 , A61F2230/0076
摘要： A prosthetic heart valve is circumferentially collapsible for less invasive delivery into a patient. The valve re-expands to operating size at the implant site in the patient. A frame structure of the valve includes restraining structure that can help to push one or more of the patient's native heart valve leaflets radially outwardly so that this native leaflet tissue does not interfere with the operation or service life of the prosthetic valve.
摘要翻译：假体心脏瓣膜是周向可折叠的，用于较少侵入性地输送到患者体内。瓣膜在病人的植入部位重新扩大到操作尺寸。阀的框架结构包括限制结构，其可以帮助推动病人的天然心脏瓣膜叶片中的一个或多个径向向外，使得该天然小叶组织不会干扰人工瓣膜的操作或使用寿命。

3. 发明授权

US09744031B2 Prosthetic heart valve and endoprosthesis comprising a prosthetic heart valve and a stent 有权
公开(公告)号：US09744031B2
公开(公告)日：2017-08-29
申请号：US13114582
申请日：2011-05-24
申请人： Michael J. Girard , Randy Lane , Arnulf Mayer
发明人： Michael J. Girard , Randy Lane , Arnulf Mayer
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2220/0025 , A61F2220/0075 , A61F2240/001
摘要： The invention relates to a prosthetic heart valve (100) for an endoprosthesis (1) used in the treatment of a stenotic cardiac valve and/or a cardiac valve insufficiency. The prosthetic heart valve (100) comprises of a plurality of leaflets (102), which consist of a natural and/or synthetic material and have a first opened position for opening the heart chamber and a second closed position for closing the heart chamber, the leaflets (102) being able to switch between their first and second position in response to the blood flow through the heart. In addition, the prosthetic heart valve (100) comprises a leaflet support portion (103), consisting of biological and/or synthetic material for mounting of the prosthetic heart valve (100) to a stent (10), and a bendable transition area (104) which forms a junction between the leaflets (102) and the leaflet support portion (103), the transition area (104) progressing essentially in a U-shaped manner similar to a cusp shape of a natural aortic or pulmonary heart valve for reducing tissue stresses during opening and closing motion of the leaflets (102). The invention further relates to an endoprosthesis (1) comprising a prosthetic heart valve (100) and a stent (10).

4. 发明授权

US08468667B2 Device for compressing a stent 失效
标题翻译：用于压缩支架的装置
公开(公告)号：US08468667B2
公开(公告)日：2013-06-25
申请号：US12778625
申请日：2010-05-12
申请人： Helmut Straubinger , Johannes Jung , Arnulf Mayer , Michael J. Girard , Randy Lane , Amir Miller
发明人： Helmut Straubinger , Johannes Jung , Arnulf Mayer , Michael J. Girard , Randy Lane , Amir Miller
IPC分类号： B21D39/04
CPC分类号： A61F2/2427 , A61F2/2412 , A61F2/95 , A61F2002/9522 , Y10T29/5367 , Y10T29/53878 , Y10T29/53952
摘要： The present disclosure relates to a device for compressing a stent or a stent with a prosthetic heart valve affixed thereto, as well as a method for loading a stent into a medical delivery system. The device may comprise a compressing mechanism designed so as to exert a compressive force in radial direction on at least parts of a stent accommodated within the compressing mechanism such that the cross-section of the stent is reduced to a predefinable value at least at certain areas. The device may further comprise a manipulating mechanism moveable relative to the compressing mechanism for moving at least one clamping means in the radial direction in order to adjust the internal cross-sectional diameter of the compressing mechanism.
摘要翻译：本公开涉及一种用于压缩固定在其上的假体心脏瓣膜的支架或支架的装置，以及用于将支架装载到医疗输送系统中的方法。该装置可以包括压缩机构，该压缩机构设计成在容纳在压缩机构内的支架的至少一部分上沿径向施加压缩力，使得至少在某些区域将支架的横截面减小到可预定值。该装置还可以包括可相对于压缩机构移动的操纵机构，用于沿径向方向移动至少一个夹紧装置，以调节压缩机构的内部横截面直径。

5. 发明授权

US07326174B2 Cardiac disease treatment and device 失效
标题翻译：心脏病治疗及器械
公开(公告)号：US07326174B2
公开(公告)日：2008-02-05
申请号：US10839724
申请日：2004-05-04
申请人： James Cox , Michael J. Girard , Donald F. Palme, II , Donald G. Rohrbaugh , Hani N. Sabbah , J. Edward Shapland, II , Robert G. Walsh
发明人： James Cox , Michael J. Girard , Donald F. Palme, II , Donald G. Rohrbaugh , Hani N. Sabbah , J. Edward Shapland, II , Robert G. Walsh
IPC分类号： A61F13/00 , A61F2/00
CPC分类号： A61F2/2481 , D04B21/12 , D10B2509/08 , Y10S977/907
摘要： A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device including a jacket adapted to be secured to the heart, and a non-adherent material in association with the jacket. The jacket is fabricated from a flexible material defining a volume between an upper and a lower end, the jacket being adapted to be adjusted on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain expansion of the heart beyond the maximum adjusted volume during diastole and permit substantially unimpeded contraction of the heart during systole. As a result of the flexible material, the jacket allows unimpeded diastolic filling of the heart. Also described is a method for treating cardiac disease including surgically accessing the heart, applying the treatment device of the invention, securing the treatment device to the heart, and surgically closing access to the heart while leaving the treatment device on the heart.
摘要翻译：一种用于治疗心脏的心脏疾病的装置，其具有由A-V凹槽分隔的上部和下部，所述装置包括适于固定到心脏的护套以及与护套相关联的非粘附材料。护套由限定上下端之间的体积的柔性材料制成，护套适于在心脏上调节以紧密地符合心脏的外部几何形状，并假设用于护套约束的最大调节体积舒张期心脏扩张超出最大调节体积，并允许心脏在收缩期间基本无阻碍地收缩心脏。作为柔性材料的结果，护套可以无阻碍地舒张心脏填充心脏。还描述了一种治疗心脏疾病的方法，包括手术进入心脏，施用本发明的治疗装置，将治疗装置固定到心脏，以及在将治疗装置留在心脏上时手术闭合进入心脏。

6. 发明授权

US06730016B1 Cardiac disease treatment and device 有权
标题翻译：心脏病治疗及器械
公开(公告)号：US06730016B1
公开(公告)日：2004-05-04
申请号：US09591875
申请日：2000-06-12
申请人： James Cox , Michael J. Girard , Donald F. Palme, II , Donald G. Rohrbaugh , Hani N. Sabbah , J. Edward Shapland, II , Robert G. Walsh
发明人： James Cox , Michael J. Girard , Donald F. Palme, II , Donald G. Rohrbaugh , Hani N. Sabbah , J. Edward Shapland, II , Robert G. Walsh
IPC分类号： A61F200
CPC分类号： A61F2/2481 , D04B21/12 , D10B2509/08 , Y10S977/907
摘要： A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device including a jacket adapted to be secured to the heart, and a non-adherent material in association with the jacket. The jacket is fabricated from a flexible material defining a volume between an upper and a lower end, the jacket being adapted to be adjusted on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain expansion of the heart beyond the maximum adjusted volume during diastole and permit substantially unimpeded contraction of the heart during systole. As a result of the flexible material, the jacket allows unimpeded diastolic filling of the heart. Also described is a method for treating cardiac disease including surgically accessing the heart, applying the treatment device of the invention, securing the treatment device to the heart, and surgically closing access to the heart while leaving the treatment device on the heart.
摘要翻译：一种用于治疗心脏的心脏疾病的装置，其具有由A-V凹槽分隔的上部和下部，所述装置包括适于固定到心脏的护套以及与护套相关联的非粘附材料。护套由限定上下端之间的体积的柔性材料制成，护套适于在心脏上调节以紧密地符合心脏的外部几何形状，并且假设用于护套约束的最大调节体积舒张期心脏扩张超出最大调节体积，并允许心脏在收缩期间基本无阻碍地收缩心脏。作为柔性材料的结果，护套可以无阻碍地舒张心脏填充心脏。还描述了一种治疗心脏疾病的方法，包括手术进入心脏，施用本发明的治疗装置，将治疗装置固定到心脏，以及在将治疗装置留在心脏上时手术闭合进入心脏。

7. 发明授权

US06682476B2 Cardiac disease treatment and device 失效
公开(公告)号：US06682476B2
公开(公告)日：2004-01-27
申请号：US10279176
申请日：2002-10-23
申请人： Clifton A. Alferness , Donald G. Rohrbaugh , J. Edward Shapland , Michael J. Girard , Donald F. Palme, II , James E. Cox
发明人： Clifton A. Alferness , Donald G. Rohrbaugh , J. Edward Shapland , Michael J. Girard , Donald F. Palme, II , James E. Cox
IPC分类号： A61F200
CPC分类号： A61F2/2481 , Y10S623/904
摘要： A jacket of biological compatible material has an internal volume dimensioned for an apex of the heart to be inserted into the volume and for the jacket to be slipped over the heart. The jacket has a longitudinal dimension between upper and lower ends sufficient for the jacket to surround a lower portion of the heart with the jacket surrounding a valvular annulus of the heart and further surrounding the lower portion to cover at least the ventricular lower extremities of the heart. The jacket is adapted to be secured to the heart with the jacket surrounding at least the valvular annulus and the ventricular lower extremities. The jacket is adjustable on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole.

8. 发明授权

US06176876B1 Leaflet positioning for a mechanical heart valve 有权
标题翻译：机械心脏瓣膜的小叶定位
公开(公告)号：US06176876B1
公开(公告)日：2001-01-23
申请号：US09205673
申请日：1998-12-04
申请人： Tanya Shipkowitz , Paul J. Fordenbacher , Yi-Ren Woo , Michael J. Girard , Stephen A. Petersen
发明人： Tanya Shipkowitz , Paul J. Fordenbacher , Yi-Ren Woo , Michael J. Girard , Stephen A. Petersen
IPC分类号： A61F224
CPC分类号： A61F2/2403 , A61F2/2472
摘要： A bi-leaflet prosthetic heart valve, comprising an annular body having an upstream edge, a downstream edge and a passageway therebetween includes first and second leaflets pivotally mounted in the annular body. Each leaflet has an upstream edge, a downstream edge and a leaflet length therebetween. First and second pivot axes associated respectively with the first and second leaflets are provided and each leaflet rotates about its respective pivot axes between an open position allowing blood flow through the passageway of the annular body and a closed position blocking blood flow. The valve is configured such that the leaflets have an angle in the naturally open position of more than about 85°.
摘要翻译：一种双瓣假体心脏瓣膜，包括具有上游边缘，下游边缘和其间的通道的环形体，包括枢转地安装在环形体中的第一和第二小叶。每个小叶具有上游边缘，下游边缘和它们之间的小叶长度。提供分别与第一和第二小叶相关联的第一和第二枢转轴线，并且每个小叶围绕其相应的枢转轴线在允许血液流过环形体的通道的打开位置和阻塞血液流动的关闭位置之间旋转。阀构造成使得小叶在自然打开位置具有大于约85°的角度。

9. 发明申请

US20120136201A1 CARDIAC SUPPORT DEVICE 有权
标题翻译： CARDIAC支持设备
公开(公告)号：US20120136201A1
公开(公告)日：2012-05-31
申请号：US13367255
申请日：2012-02-06
申请人： Michael J. Girard , J. Edward Shapland , Donald F. Palme, II
发明人： Michael J. Girard , J. Edward Shapland , Donald F. Palme, II
IPC分类号： A61F2/00
CPC分类号： A61F2/2481
摘要： A highly compliant and elastic cardiac support device is provided. The device is constructed from a biocompatible material is applied to an external surface of a heart. The device can be used to resist dilatation of the heart, to provide acute wall support, or to enhance reduction in the size of the heart using stored potential energy, without interfering with systolic contraction.
摘要翻译：提供高度兼容和弹性的心脏支持装置。该装置由生物相容性材料构成，被施加到心脏的外表面。该装置可以用于抵抗心脏的扩张，提供急性壁支持，或者使用储存的势能增强心脏尺寸的减小，而不会干扰收缩期的收缩。

10. 发明申请

US20100292780A1 DEVICE FOR COMPRESSING A STENT AS WELL AS SYSTEM AND METHOD FOR LOADING A STENT INTO A MEDICAL DELIVERY SYSTEM 失效
标题翻译：用于压缩作为系统的步骤的装置和用于将固定装入医疗交付系统的方法
公开(公告)号：US20100292780A1
公开(公告)日：2010-11-18
申请号：US12778625
申请日：2010-05-12
申请人： Helmut Straubinger , Johannes Jung , Arnulf Mayer , Michael J. Girard , Randy Lane , Amir Miller
发明人： Helmut Straubinger , Johannes Jung , Arnulf Mayer , Michael J. Girard , Randy Lane , Amir Miller
IPC分类号： A61F2/84
CPC分类号： A61F2/2427 , A61F2/2412 , A61F2/95 , A61F2002/9522 , Y10T29/5367 , Y10T29/53878 , Y10T29/53952
摘要： The invention relates to a device (1a-1d) for compressing a stent (100) or a stent (100) with a prosthetic heart valve affixed thereto. The invention further relates to a system as well as a method for loading a stent (100) into a medical delivery system. The device (1a-1d) according to the invention comprises a compressing mechanism (10a-10d), within which a stent (100) to be compressed can be at least partly accommodated, wherein the compressing mechanism (10a-10d) comprises externally-manipulatable clamping means (50; 70.1-70.n; 90.1-90.n; 110.1-110.n) and is designed so as to exert a compressive force in radial direction on at least parts of a stent (100) accommodated within the compressing mechanism (10a-10d) such that the cross-section of the stent (100) is reduced to a predefinable value at least at certain areas. The inventive device (1a-1d) further comprises a manipulating mechanism (40a-40d) for manipulating the at least one clamping means (50; 70.1-70.n; 90.1-90.n; 110.1-110.n), said manipulating mechanism (40a-40d) being moveable relative to the compressing mechanism (10a-10d) for moving the at least one clamping means (50; 70.1-70.n; 90.1-90.n; 110.1-110.n) in the radial direction in order to adjust the internal cross-sectional diameter of the compressing mechanism (10a-10d).
摘要翻译：本发明涉及一种用于用固定在其上的假体心脏瓣膜来压缩支架（100）或支架（100）的装置（1a-1d）。本发明还涉及一种系统以及将支架（100）装载到医疗输送系统中的方法。根据本发明的装置（1a-1d）包括压缩机构（10a-10d），其中可以至少部分地容纳待压缩的支架（100），其中压缩机构（10a-10d）可操纵的夹紧装置（50; 70.1-70.n; 90.1-90.n; 110.1-1.10.n）并且被设计成在径向方向上施加压缩力至少在容纳在压缩机构（10a-10d），使得至少在某些区域将支架（100）的横截面减小到预定值。本发明的装置（1a-1d）还包括用于操纵至少一个夹持装置（50; 70.1-70.n; 90.1-90.n; 110.1-1.10.n）的操纵机构（40a-40d），所述操纵机构（40a-40d）可相对于所述压缩机构（10a-10d）移动，用于将所述至少一个夹紧装置（50; 70.1-70.n; 90.1-90.n; 110.1-1.10.n）移动到所述径向方向，以调节压缩机构（10a-10d）的内部横截面直径。

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