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1. 发明授权

US09744031B2 Prosthetic heart valve and endoprosthesis comprising a prosthetic heart valve and a stent 有权
公开(公告)号：US09744031B2
公开(公告)日：2017-08-29
申请号：US13114582
申请日：2011-05-24
申请人： Michael J. Girard , Randy Lane , Arnulf Mayer
发明人： Michael J. Girard , Randy Lane , Arnulf Mayer
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2220/0025 , A61F2220/0075 , A61F2240/001
摘要： The invention relates to a prosthetic heart valve (100) for an endoprosthesis (1) used in the treatment of a stenotic cardiac valve and/or a cardiac valve insufficiency. The prosthetic heart valve (100) comprises of a plurality of leaflets (102), which consist of a natural and/or synthetic material and have a first opened position for opening the heart chamber and a second closed position for closing the heart chamber, the leaflets (102) being able to switch between their first and second position in response to the blood flow through the heart. In addition, the prosthetic heart valve (100) comprises a leaflet support portion (103), consisting of biological and/or synthetic material for mounting of the prosthetic heart valve (100) to a stent (10), and a bendable transition area (104) which forms a junction between the leaflets (102) and the leaflet support portion (103), the transition area (104) progressing essentially in a U-shaped manner similar to a cusp shape of a natural aortic or pulmonary heart valve for reducing tissue stresses during opening and closing motion of the leaflets (102). The invention further relates to an endoprosthesis (1) comprising a prosthetic heart valve (100) and a stent (10).

2. 发明授权

US08468667B2 Device for compressing a stent 失效
标题翻译：用于压缩支架的装置
公开(公告)号：US08468667B2
公开(公告)日：2013-06-25
申请号：US12778625
申请日：2010-05-12
申请人： Helmut Straubinger , Johannes Jung , Arnulf Mayer , Michael J. Girard , Randy Lane , Amir Miller
发明人： Helmut Straubinger , Johannes Jung , Arnulf Mayer , Michael J. Girard , Randy Lane , Amir Miller
IPC分类号： B21D39/04
CPC分类号： A61F2/2427 , A61F2/2412 , A61F2/95 , A61F2002/9522 , Y10T29/5367 , Y10T29/53878 , Y10T29/53952
摘要： The present disclosure relates to a device for compressing a stent or a stent with a prosthetic heart valve affixed thereto, as well as a method for loading a stent into a medical delivery system. The device may comprise a compressing mechanism designed so as to exert a compressive force in radial direction on at least parts of a stent accommodated within the compressing mechanism such that the cross-section of the stent is reduced to a predefinable value at least at certain areas. The device may further comprise a manipulating mechanism moveable relative to the compressing mechanism for moving at least one clamping means in the radial direction in order to adjust the internal cross-sectional diameter of the compressing mechanism.
摘要翻译：本公开涉及一种用于压缩固定在其上的假体心脏瓣膜的支架或支架的装置，以及用于将支架装载到医疗输送系统中的方法。该装置可以包括压缩机构，该压缩机构设计成在容纳在压缩机构内的支架的至少一部分上沿径向施加压缩力，使得至少在某些区域将支架的横截面减小到可预定值。该装置还可以包括可相对于压缩机构移动的操纵机构，用于沿径向方向移动至少一个夹紧装置，以调节压缩机构的内部横截面直径。

3. 发明申请

US20110295363A1 Prosthetic Heart Valve And Transcatheter Delivered Endoprosthesis Comprising A Prosthetic Heart Valve And A Stent 有权
标题翻译：假性心脏瓣膜和经导管交付假体心脏瓣膜和支架的内置假体
公开(公告)号：US20110295363A1
公开(公告)日：2011-12-01
申请号：US13114582
申请日：2011-05-24
申请人： Michael J. Girard , Randy Lane , Arnulf Mayer
发明人： Michael J. Girard , Randy Lane , Arnulf Mayer
IPC分类号： A61F2/82 , A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2220/0025 , A61F2220/0075 , A61F2240/001
摘要： The invention relates to a prosthetic heart valve (100) for an endoprosthesis (1) used in the treatment of a stenotic cardiac valve and/or a cardiac valve insufficiency. The prosthetic heart valve (100) comprises of a plurality of leaflets (102), which consist of a natural and/or synthetic material and have a first opened position for opening the heart chamber and a second closed position for closing the heart chamber, the leaflets (102) being able to switch between their first and second position in response to the blood flow through the heart. In addition, the prosthetic heart valve (100) comprises a leaflet support portion (103), consisting of biological and/or synthetic material for mounting of the prosthetic heart valve (100) to a stent (10), and a bendable transition area (104) which forms a junction between the leaflets (102) and the leaflet support portion (103), the transition area (104) progressing essentially in a U-shaped manner similar to a cusp shape of a natural aortic or pulmonary heart valve for reducing tissue stresses during opening and closing motion of the leaflets (102). The invention further relates to an endoprosthesis (1) comprising a prosthetic heart valve (100) and a stent (10)
摘要翻译：本发明涉及用于治疗狭窄心脏瓣膜和/或心脏瓣膜功能不全的内用假体（1）的假体心脏瓣膜（100）。所述假体心脏瓣膜（100）包括由天然和/或合成材料组成并且具有用于打开心室的第一打开位置和用于闭合心室的第二闭合位置的多个小叶（102），小叶（102）能够响应于通过心脏的血流而在它们的第一和第二位置之间切换。此外，假体心脏瓣膜（100）包括由用于将假体心脏瓣膜（100）安装到支架（10）的生物和/或合成材料组成的小叶支撑部分（103）和可弯曲的过渡区域 104），其形成在小叶（102）和小叶支撑部分（103）之间的连接处，过渡区域（104）基本上以类似于天然主动脉或肺心脏瓣膜的尖端形状的U形方式前进，用于还原在小叶（102）的打开和关闭运动期间的组织应力。本发明还涉及一种包括假体心脏瓣膜（100）和支架（10）的内用假体（1）

4. 发明申请

US20100292780A1 DEVICE FOR COMPRESSING A STENT AS WELL AS SYSTEM AND METHOD FOR LOADING A STENT INTO A MEDICAL DELIVERY SYSTEM 失效
标题翻译：用于压缩作为系统的步骤的装置和用于将固定装入医疗交付系统的方法
公开(公告)号：US20100292780A1
公开(公告)日：2010-11-18
申请号：US12778625
申请日：2010-05-12
申请人： Helmut Straubinger , Johannes Jung , Arnulf Mayer , Michael J. Girard , Randy Lane , Amir Miller
发明人： Helmut Straubinger , Johannes Jung , Arnulf Mayer , Michael J. Girard , Randy Lane , Amir Miller
IPC分类号： A61F2/84
CPC分类号： A61F2/2427 , A61F2/2412 , A61F2/95 , A61F2002/9522 , Y10T29/5367 , Y10T29/53878 , Y10T29/53952
摘要： The invention relates to a device (1a-1d) for compressing a stent (100) or a stent (100) with a prosthetic heart valve affixed thereto. The invention further relates to a system as well as a method for loading a stent (100) into a medical delivery system. The device (1a-1d) according to the invention comprises a compressing mechanism (10a-10d), within which a stent (100) to be compressed can be at least partly accommodated, wherein the compressing mechanism (10a-10d) comprises externally-manipulatable clamping means (50; 70.1-70.n; 90.1-90.n; 110.1-110.n) and is designed so as to exert a compressive force in radial direction on at least parts of a stent (100) accommodated within the compressing mechanism (10a-10d) such that the cross-section of the stent (100) is reduced to a predefinable value at least at certain areas. The inventive device (1a-1d) further comprises a manipulating mechanism (40a-40d) for manipulating the at least one clamping means (50; 70.1-70.n; 90.1-90.n; 110.1-110.n), said manipulating mechanism (40a-40d) being moveable relative to the compressing mechanism (10a-10d) for moving the at least one clamping means (50; 70.1-70.n; 90.1-90.n; 110.1-110.n) in the radial direction in order to adjust the internal cross-sectional diameter of the compressing mechanism (10a-10d).
摘要翻译：本发明涉及一种用于用固定在其上的假体心脏瓣膜来压缩支架（100）或支架（100）的装置（1a-1d）。本发明还涉及一种系统以及将支架（100）装载到医疗输送系统中的方法。根据本发明的装置（1a-1d）包括压缩机构（10a-10d），其中可以至少部分地容纳待压缩的支架（100），其中压缩机构（10a-10d）可操纵的夹紧装置（50; 70.1-70.n; 90.1-90.n; 110.1-1.10.n）并且被设计成在径向方向上施加压缩力至少在容纳在压缩机构（10a-10d），使得至少在某些区域将支架（100）的横截面减小到预定值。本发明的装置（1a-1d）还包括用于操纵至少一个夹持装置（50; 70.1-70.n; 90.1-90.n; 110.1-1.10.n）的操纵机构（40a-40d），所述操纵机构（40a-40d）可相对于所述压缩机构（10a-10d）移动，用于将所述至少一个夹紧装置（50; 70.1-70.n; 90.1-90.n; 110.1-1.10.n）移动到所述径向方向，以调节压缩机构（10a-10d）的内部横截面直径。

5. 发明授权

US08790395B2 Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient 有权
标题翻译：用于在患者心脏中的植入部位中定位和锚定瓣膜假体的支架
公开(公告)号：US08790395B2
公开(公告)日：2014-07-29
申请号：US13896905
申请日：2013-05-17
申请人： Helmut Straubinger , Johannes Jung , Michael J. Girard , Arnulf Mayer
发明人： Helmut Straubinger , Johannes Jung , Michael J. Girard , Arnulf Mayer
IPC分类号： A61F2/82 , A61F2/24
CPC分类号： A61F2/2418 , A61F2/07 , A61F2/2412 , A61F2220/0058 , A61F2220/0075 , A61F2230/0023 , A61F2230/0054
摘要： The present invention relates to a stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient. Specifically, the present invention relates to an expandable stent for an endoprosthesis used in the treatment of a narrowing of a cardiac valve and/or a cardiac valve insufficiency. So as to ensure that no longitudinal displacement of a valvular prosthesis fastened to a stent will occur relative the stent in the implanted state of the stent, even given the peristaltic motion of the heart, the stent according to the invention comprises at least one fastening portion via which the valvular prosthesis is connectable to the stent. The stent further comprises positioning arches and retaining arches, whereby at least one positioning arch is connected to at least one retaining arch.
摘要翻译：本发明涉及一种用于在患者心脏中的植入部位定位和锚定瓣膜假体的支架。具体地，本发明涉及用于治疗心脏瓣膜变窄和/或心脏瓣膜功能不全的内用假体的可扩张支架。为了确保即使给予心脏的蠕动运动，固定在支架上的瓣膜假体也不会相对于支架的植入状态发生纵向位移，所以根据本发明的支架包括至少一个紧固部分瓣膜假体可以通过其连接到支架上。支架还包括定位拱门和保持拱门，由此至少一个定位弓连接到至少一个保持拱。

6. 发明授权

US08465540B2 Stent for the positioning and anchoring of a valvular prosthesis 有权
标题翻译：支架用于定位和锚定瓣膜假体
公开(公告)号：US08465540B2
公开(公告)日：2013-06-18
申请号：US13033023
申请日：2011-02-23
申请人： Helmut Straubinger , Johannes Jung , Michael J. Girard , Arnulf Mayer
发明人： Helmut Straubinger , Johannes Jung , Michael J. Girard , Arnulf Mayer
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/07 , A61F2/2412 , A61F2220/0058 , A61F2220/0075 , A61F2230/0023 , A61F2230/0054
摘要： The present invention relates to a stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient. Specifically, the present invention relates to an expandable stent for an endoprosthesis used in the treatment of a narrowing of a cardiac valve and/or a cardiac valve insufficiency. So as to ensure that no longitudinal displacement of a valvular prosthesis fastened to a stent will occur relative the stent in the implanted state of the stent, even given the peristaltic motion of the heart, the stent according to the invention comprises at least one fastening portion via which the valvular prosthesis is connectable to the stent. The stent further comprises positioning arches and retaining arches, whereby at least one positioning arch is connected to at least one retaining arch.
摘要翻译：本发明涉及一种用于在患者心脏中的植入部位定位和锚定瓣膜假体的支架。具体地，本发明涉及用于治疗心脏瓣膜变窄和/或心脏瓣膜功能不全的内用假体的可扩张支架。为了确保即使给予心脏的蠕动运动，固定在支架上的瓣膜假体也不会相对于支架的植入状态发生纵向位移，所以根据本发明的支架包括至少一个紧固部分瓣膜假体可以通过其连接到支架上。支架还包括定位拱门和保持拱门，由此至少一个定位弓连接到至少一个保持拱。

7. 发明授权

US08398704B2 Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient 有权
标题翻译：用于在患者心脏中的植入部位中定位和锚定瓣膜假体的支架
公开(公告)号：US08398704B2
公开(公告)日：2013-03-19
申请号：US12713058
申请日：2010-02-25
申请人： Helmut Straubinger , Johannes Jung , Michael J. Girard , Arnulf Mayer
发明人： Helmut Straubinger , Johannes Jung , Michael J. Girard , Arnulf Mayer
IPC分类号： A61F2/82 , A61F2/24
CPC分类号： A61F2/2418 , A61F2220/0016 , A61F2220/0058 , A61F2220/0075 , A61F2230/0023 , A61F2230/0054
摘要： The present invention relates to a stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient. Specifically, the present invention relates to an expandable stent for an endoprosthesis used in the treatment of a narrowing of a cardiac valve and/or a cardiac valve insufficiency. So as to ensure that no longitudinal displacement of a valvular prosthesis fastened to a stent will occur relative the stent in the implanted state of the stent, even given the peristaltic motion of the heart, the stent according to the invention comprises at least one fastening portion via which the valvular prosthesis is connectable to the stent. The stent further comprises positioning arches and retaining arches, whereby at least one positioning arch is connected to at least one retaining arch.
摘要翻译：本发明涉及一种用于在患者心脏中的植入部位定位和锚定瓣膜假体的支架。具体地，本发明涉及用于治疗心脏瓣膜变窄和/或心脏瓣膜功能不全的内用假体的可扩张支架。为了确保即使给予心脏的蠕动运动，固定在支架上的瓣膜假体也不会相对于支架的植入状态发生纵向位移，所以根据本发明的支架包括至少一个紧固部分瓣膜假体可以通过其连接到支架上。支架还包括定位拱门和保持拱门，由此至少一个定位弓连接到至少一个保持拱。

8. 发明申请

US20110208290A1 STENT FOR THE POSITIONING AND ANCHORING OF A VALVULAR PROSTHESIS IN AN IMPLANTATION SITE IN THE HEART OF A PATIENT 有权
标题翻译：在患者心脏中的植入位置的定位和锚定的固定
公开(公告)号：US20110208290A1
公开(公告)日：2011-08-25
申请号：US13033023
申请日：2011-02-23
申请人： Helmut Straubinger , Johannes Jung , Michael J. Girard , Arnulf Mayer
发明人： Helmut Straubinger , Johannes Jung , Michael J. Girard , Arnulf Mayer
IPC分类号： A61F2/82
CPC分类号： A61F2/2418 , A61F2/07 , A61F2/2412 , A61F2220/0058 , A61F2220/0075 , A61F2230/0023 , A61F2230/0054
摘要： The present invention relates to a stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient. Specifically, the present invention relates to an expandable stent for an endoprosthesis used in the treatment of a narrowing of a cardiac valve and/or a cardiac valve insufficiency. So as to ensure that no longitudinal displacement of a valvular prosthesis fastened to a stent will occur relative the stent in the implanted state of the stent, even given the peristaltic motion of the heart, the stent according to the invention comprises at least one fastening portion via which the valvular prosthesis is connectable to the stent. The stent further comprises positioning arches and retaining arches, whereby at least one positioning arch is connected to at least one retaining arch.
摘要翻译：本发明涉及一种用于在患者心脏中的植入部位定位和锚定瓣膜假体的支架。具体地，本发明涉及用于治疗心脏瓣膜变窄和/或心脏瓣膜功能不全的内用假体的可扩张支架。为了确保即使给予心脏的蠕动运动，固定在支架上的瓣膜假体也不会相对于支架的植入状态发生纵向位移，所以根据本发明的支架包括至少一个紧固部分瓣膜假体可以通过其连接到支架上。支架还包括定位拱门和保持拱门，由此至少一个定位弓连接到至少一个保持拱。

9. 发明申请

US20100191320A1 STENT FOR THE POSITIONING AND ANCHORING OF A VALVULAR PROSTHESIS IN AN IMPLANTATION SITE IN THE HEART OF A PATIENT 有权
标题翻译：在患者心脏中的植入位置的定位和锚定的固定
公开(公告)号：US20100191320A1
公开(公告)日：2010-07-29
申请号：US12713058
申请日：2010-02-25
申请人： Helmut Straubinger , Johannes Jung , Michael Girad , Arnulf Mayer
发明人： Helmut Straubinger , Johannes Jung , Michael Girad , Arnulf Mayer
IPC分类号： A61F2/82
CPC分类号： A61F2/2418 , A61F2220/0016 , A61F2220/0058 , A61F2220/0075 , A61F2230/0023 , A61F2230/0054
摘要： The present invention relates to a stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient. Specifically, the present invention relates to an expandable stent for an endoprosthesis used in the treatment of a narrowing of a cardiac valve and/or a cardiac valve insufficiency. So as to ensure that no longitudinal displacement of a valvular prosthesis fastened to a stent will occur relative the stent in the implanted state of the stent, even given the peristaltic motion of the heart, the stent according to the invention comprises at least one fastening portion via which the valvular prosthesis is connectable to the stent. The stent further comprises positioning arches and retaining arches, whereby at least one positioning arch is connected to at least one retaining arch.
摘要翻译：本发明涉及一种用于在患者心脏中的植入部位定位和锚定瓣膜假体的支架。具体地，本发明涉及用于治疗心脏瓣膜变窄和/或心脏瓣膜功能不全的内用假体的可扩张支架。为了确保即使给予心脏的蠕动运动，固定在支架上的瓣膜假体也不会相对支架的植入状态发生纵向位移，所以根据本发明的支架包括至少一个紧固部分瓣膜假体可以通过其连接到支架上。支架还包括定位拱门和保持拱门，由此至少一个定位弓连接到至少一个保持拱。

10. 发明授权

US10856978B2 Catheter system 有权
公开(公告)号：US10856978B2
公开(公告)日：2020-12-08
申请号：US12801090
申请日：2010-05-20
申请人： Helmut Straubinger , Arnulf Mayer , Johannes Jung
发明人： Helmut Straubinger , Arnulf Mayer , Johannes Jung
IPC分类号： A61F2/24 , A61F2/966 , A61F2/95 , A61M25/09
摘要： The invention relates to catheter system for introducing an expandable heart valve stent (150) into the body of a patient, the catheter system comprising: a catheter tip (10) having a seat portion for accommodating the stent (150) in its collapsed state and a stent holder (15) for releasably fixing the stent (150), wherein the seat portion is constituted by a first sleeve-shaped member (11) and a second sleeve-shaped member (21), said sleeve-shaped members (11, 21) being moveable relative to each other and relative to the stent holder (15), and a catheter shaft (30) for connecting the catheter tip (10) to a handle (70). The catheter shaft (30) comprising: first force transmitting means (31) connected to the first sleeve-shaped member (11), second force transmitting means (41) connected to the second sleeve-shaped member (21) and a distal end section connectable to second operating means (81) of the handle (70), and guiding means (51) having a passageway extending there between, wherein the first and second force transmitting means (31, 41) are at least partly received within the passageway such as to be moveable relative to the guiding means (51), and wherein the proximal end of the guiding means (51) terminates distal to the catheter tip (10).

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