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1. 发明申请

US20140072558A1 Activin Receptor Type II B Inhibitors Comprising DLK1 Extracellular Water-Soluble Domain 审中-公开
标题翻译：包含DLK1细胞外水溶性结构域的激活素受体II型B抑制剂
公开(公告)号：US20140072558A1
公开(公告)日：2014-03-13
申请号：US14009037
申请日：2012-04-03
申请人： Young Woo Park , Ki Won Jo , Donghee Lee , Eun Kyung Lee , Seil Jang , Chan Woong Park , Dong-Jin Kim , Hye Nan Kim , Yun Jung Park , Jae Eun Park , Ji Hyun Park , Seok Ho Yoo , Myeoung Hee Jang
发明人： Young Woo Park , Ki Won Jo , Donghee Lee , Eun Kyung Lee , Seil Jang , Chan Woong Park , Dong-Jin Kim , Hye Nan Kim , Yun Jung Park , Jae Eun Park , Ji Hyun Park , Seok Ho Yoo , Myeoung Hee Jang
IPC分类号： A61K39/395 , G01N33/68 , A61K38/17
CPC分类号： A61K39/3955 , A61K38/1709 , A61K38/177 , A61K39/39558 , C07K14/705 , C07K16/28 , C07K2317/21 , C07K2317/622 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/6893 , G01N33/74 , G01N2333/485 , A61K2300/00
摘要： The present invention relates to an activin receptor type II B (ACVR2B) inhibitor which comprises the delta-like 1 homolog (DLK1) extracellular water-soluble domain. More specifically, the present invention relates to an extracellular soluble domain of DLK1; fragments of the extracellular soluble domain of DLK1; mutants of the extracellular soluble domain of DLK1; a composition for suppressing ligand linkage with the ACVR2B receptor, which includes a fragment of the mutants as an active ingredient; and a pharmaceutical composition for prevention and treatment of diseases which comprises the same. The composition of the present invention competitively binds to the ACVR2B receptor and inhibits the binding of an ACVR2B ligand to the ACVR2B receptor, which inhibits protein signalling associated with such ligands, and will be useful for prevention and treatment of diseases associated therewith.
摘要翻译：本发明涉及包含δ-样1同系物（DLK1）细胞外水溶性结构域的激活素受体IIB型（ACVR2B）抑制剂。更具体地，本发明涉及DLK1的细胞外可溶性结构域; DLK1细胞外可溶性结构域的片段; DLK1细胞外可溶性结构域的突变体; 用于抑制与ACVR2B受体的配体键合的组合物，其包含突变体的片段作为活性成分; 以及用于预防和治疗包含该疾病的疾病的药物组合物。本发明的组合物竞争性地结合ACVR2B受体并且抑制ACVR2B配体与ACVR2B受体的结合，所述ACVR2B受体抑制与这种配体相关的蛋白质信号，并且将可用于预防和治疗与之相关的疾病。

2. 发明授权

US08916525B2 TNF-A and TWEAK dual antagonist for the prophylaxis and treatment of autoimmune diseases 有权
标题翻译： TNF-A和TWEAK双重拮抗剂用于预防和治疗自身免疫性疾病
公开(公告)号：US08916525B2
公开(公告)日：2014-12-23
申请号：US13635868
申请日：2011-03-18
申请人： Young Woo Park , Ki Won Jo , Srok Ho Yoo , Jung Yu , Dong Jin Kim , Sun-Ha Yoon , Eun Jung Song , Eun Kyung Lee , Jin Mi Oh , Kyu Won Cho , Mi La Cho , Ho Youn Kim , Mi Kyung Park , Hye Jwa Oh , Jin Sil Park , Yun Ju Woo , Jae Kyeong Byun , Jun Geol Ryu
发明人： Young Woo Park , Ki Won Jo , Srok Ho Yoo , Jung Yu , Dong Jin Kim , Sun-Ha Yoon , Eun Jung Song , Eun Kyung Lee , Jin Mi Oh , Kyu Won Cho , Mi La Cho , Ho Youn Kim , Mi Kyung Park , Hye Jwa Oh , Jin Sil Park , Yun Ju Woo , Jae Kyeong Byun , Jun Geol Ryu
IPC分类号： A61K38/17 , A61P17/00 , A61P19/02 , A61P19/04 , A61P21/00 , A61P25/00 , A61P3/10 , A61P7/06 , C07K14/525 , C07K14/705
CPC分类号： C07K14/525 , C07K14/70575 , C07K2319/32 , Y10S514/814 , Y10S514/885 , Y10S514/886 , Y10S514/903
摘要： The present invention relates to TNFR2-TWEAKR fusion protein, more precisely to TNFR2-TWEAKR fusion protein acting as a double-antagonist to TNF-α and TWEAK, known as major causes of autoimmune arthritis which is one of autoimmune diseases. When the composition comprising TNFR2-TWEAKR fusion protein was treated to Th17 cells, the secretion of the inflammatory cytokine IL-17 was reduced but the secretion of the anti-inflammatory cytokine IL-10 generated in Treg cells was increased. Such effect of TNFR2-TWEAKR fusion protein was far greater than that of a single protein such as TNFR2-Fc or TWEAK-Fc. The TNFR2-TWEAKR fusion protein of the present invention has not only excellent treatment effect on arthritis in CIA mouse model not also excellent treatment effect on autoimmune rheumatoid arthritis by increasing the expression of Treg, the immune suppressive cells. Therefore, the TNFR2-TWEAKR fusion protein of the present invention can be effectively used as an active ingredient for the composition for the prevention and treatment of autoimmune disease.
摘要翻译：本发明涉及TNFR2-TWEAKR融合蛋白，更确切地说，作为TNF-α和TWEAK的双拮抗剂的TNFR2-TWEAKR融合蛋白，被称为自身免疫性疾病之一的自身免疫性关节炎的主要原因。当将包含TNFR2-TWEAKR融合蛋白的组合物治疗至Th17细胞时，炎性细胞因子IL-17的分泌减少，但在Treg细胞中产生的抗炎细胞因子IL-10的分泌增加。 TNFR2-TWEAKR融合蛋白的这种作用远远大于单一蛋白如TNFR2-Fc或TWEAK-Fc的这种作用。本发明的TNFR2-TWEAKR融合蛋白不仅对CIA小鼠模型的关节炎具有优异的治疗作用，而且通过增加免疫抑制细胞Treg的表达，对自身免疫性类风湿性关节炎也不是很好的治疗效果。因此，本发明的TNFR2-TWEAKR融合蛋白可以有效地用作预防和治疗自身免疫性疾病的组合物的活性成分。

3. 发明申请

US20130017226A1 TNF-A and TWEAK Dual Antagonist for the Prophylaxis and Treatment of Autoimmune Diseases 有权
标题翻译： TNF-A和TWEAK双重拮抗剂预防和治疗自身免疫性疾病
公开(公告)号：US20130017226A1
公开(公告)日：2013-01-17
申请号：US13635868
申请日：2011-03-18
申请人： Young Woo Park , Ki Won Jo , Srok Ho Yoo , Jung Yu , Dong Ji Kim , Sun-Ha Yoon , Eun Jung Song , Eun Kyung Lee , Jin Mi Oh , Kyu Won Cho , Mi La Cho , Ho Youn Kim , Mi Kyung Park , Hye Jwa Oh , Jin Sil Park , Yun Ju Woo , Jae Kyeong Byun , Jun Geol Ryu
发明人： Young Woo Park , Ki Won Jo , Srok Ho Yoo , Jung Yu , Dong Ji Kim , Sun-Ha Yoon , Eun Jung Song , Eun Kyung Lee , Jin Mi Oh , Kyu Won Cho , Mi La Cho , Ho Youn Kim , Mi Kyung Park , Hye Jwa Oh , Jin Sil Park , Yun Ju Woo , Jae Kyeong Byun , Jun Geol Ryu
IPC分类号： C07K19/00 , C12N15/63 , C12N1/21 , C12N5/10 , A61K38/17 , A61P19/04 , A61P7/06 , A61P3/10 , A61P19/02 , A61P25/00 , A61P17/00 , A61P21/00 , C12N15/62 , A61P37/06
CPC分类号： C07K14/525 , C07K14/70575 , C07K2319/32 , Y10S514/814 , Y10S514/885 , Y10S514/886 , Y10S514/903
摘要： The present invention relates to TNFR2-TWEAKR fusion protein, more precisely to TNFR2-TWEAKR fusion protein acting as a double-antagonist to TNF-α and TWEAK, known as major causes of autoimmune arthritis which is one of autoimmune diseases. When the composition comprising TNFR2-TWEAKR fusion protein was treated to Th17 cells, the secretion of the inflammatory cytokine IL-17 was reduced but the secretion of the anti-inflammatory cytokine IL-10 generated in Treg cells was increased. Such effect of TNFR2-TWEAKR fusion protein was far greater than that of a single protein such as TNFR2-Fc or TWEAK-Fc. The TNFR2-TWEAKR fusion protein of the present invention has not only excellent treatment effect on arthritis in CIA mouse model not also excellent treatment effect on autoimmune rheumatoid arthritis by increasing the expression of Treg, the immune suppressive cells. Therefore, the TNFR2-TWEAKR fusion protein of the present invention can be effectively used as an active ingredient for the composition for the prevention and treatment of autoimmune disease.
摘要翻译：本发明涉及TNFR2-TWEAKR融合蛋白，更确切地说，作为TNF-α和TWEAK的双拮抗剂的TNFR2-TWEAKR融合蛋白，被称为自身免疫性疾病之一的自身免疫性关节炎的主要原因。当将包含TNFR2-TWEAKR融合蛋白的组合物治疗至Th17细胞时，炎性细胞因子IL-17的分泌减少，但在Treg细胞中产生的抗炎细胞因子IL-10的分泌增加。 TNFR2-TWEAKR融合蛋白的这种作用远远大于单一蛋白如TNFR2-Fc或TWEAK-Fc的这种作用。本发明的TNFR2-TWEAKR融合蛋白不仅对CIA小鼠模型的关节炎具有优异的治疗作用，而且通过增加免疫抑制细胞Treg的表达，对自身免疫性类风湿性关节炎也不是很好的治疗效果。因此，本发明的TNFR2-TWEAKR融合蛋白可以有效地用作预防和治疗自身免疫性疾病的组合物的活性成分。

4. 发明授权

US08962137B2 Branched nanowire and method for fabrication of the same 有权
标题翻译：分支纳米线及其制造方法
公开(公告)号：US08962137B2
公开(公告)日：2015-02-24
申请号：US12401891
申请日：2009-03-11
申请人： Eun Kyung Lee , Byoung Ryong Choi , Sang Jin Lee
发明人： Eun Kyung Lee , Byoung Ryong Choi , Sang Jin Lee
IPC分类号： H01L29/06 , H01L21/02 , C30B11/12 , C30B25/00 , C30B25/20 , C30B29/06 , C30B29/60
CPC分类号： H01L21/02521 , C30B11/12 , C30B25/005 , C30B25/20 , C30B29/06 , C30B29/605 , H01L21/02381 , H01L21/02488 , H01L21/02532 , H01L21/02565 , H01L21/02573 , H01L21/02603 , H01L21/02639 , H01L21/02645 , H01L21/02653 , Y10S977/762 , Y10S977/773 , Y10T428/2913 , Y10T428/2922 , Y10T428/2927
摘要： Disclosed herein are a branched nanowire having parasitic nanowires grown at a surface of the branched nanowire, and a method for fabricating the same. The branched nanowire may be fabricated in a fractal form and seeds of the parasitic nanowires may be formed by thermal energy irradiation and/or a wet-etching process. The branched nanowire may effectively be used in a wide variety of applications such as, for example, sensors, photodetectors, light emitting elements, light receiving elements, and the like.
摘要翻译：本文公开了具有在分支纳米线表面生长的寄生纳米线的支链纳米线及其制造方法。分支纳米线可以以分形形式制造，并且寄生纳米线的种子可以通过热能照射和/或湿法蚀刻工艺形成。分支纳米线可以有效地用于各种应用中，例如传感器，光电检测器，发光元件，光接收元件等。

5. 发明授权

US08575089B2 Composition for preventing or treating inflammation 有权
标题翻译：用于预防或治疗炎症的组合物
公开(公告)号：US08575089B2
公开(公告)日：2013-11-05
申请号：US13390888
申请日：2010-08-17
申请人： Young Sook Son , Hyun Sook Hong , Do Yeon Kim , Eun Kyung Lee
发明人： Young Sook Son , Hyun Sook Hong , Do Yeon Kim , Eun Kyung Lee
IPC分类号： A61K38/00 , A61P5/00
CPC分类号： A61K38/08
摘要： The present invention relates to a composition containing Substance P for preventing or treating an inflammation. The composition containing Substance P according to the present invention exhibits the effect of decreasing leukocytes, neutrophils and hematopoietic stem cells in a blood, which are associated with the inflammation, and of increasing anti-inflammatory cytokines, regulatory T-lymphocytes, anti-inflammatory macrophages and the like, thereby terminating inflammatory response at an early stage, and is thus highly effective in preventing and treating the inflammation caused by a non-traumatic, traumatic, infectious or ischemic retinal injury.
摘要翻译：本发明涉及含有用于预防或治疗炎症的物质P的组合物。含有根据本发明的物质P的组合物具有降低血液中与炎症相关的白细胞，嗜中性粒细胞和造血干细胞以及增加抗炎细胞因子，调节性T淋巴细胞，抗炎巨噬细胞的作用从而在早期终止炎症反应，因此在预防和治疗由非创伤性，创伤性，感染性或缺血性视网膜损伤引起的炎症方面非常有效。

6. 发明授权

US08513641B2 Core-shell nanowire comprising silicon rich oxide core and silica shell 有权
标题翻译：核壳纳米线包括富硅氧化物核和二氧化硅壳
公开(公告)号：US08513641B2
公开(公告)日：2013-08-20
申请号：US12350709
申请日：2009-01-08
申请人： Eun Kyung Lee , Byoung Lyong Choi , Gyeong Su Park , Jai Yong Han
发明人： Eun Kyung Lee , Byoung Lyong Choi , Gyeong Su Park , Jai Yong Han
IPC分类号： H01L29/06
CPC分类号： B82Y20/00 , B82Y40/00 , C01B33/113 , H01L29/0669 , H01L29/068 , H01L29/66 , H01L33/18
摘要： Disclosed herein is a nanowire including silicon rich oxide and a method for producing the same. The nanowire exhibits excellent electrically conducting properties and optical characteristics, and therefore is effectively used in a variety of applications including, for example, solar cells, sensors, photodetectors, light emitting diodes, laser diodes, EL devices, PL devices, CL devices, FETs, CTFs, surface plasmon waveguides, MOS capacitors and the like.
摘要翻译：本文公开了包含富硅氧化物的纳米线及其制造方法。纳米线表现出优异的导电性能和光学特性，因此有效地用于各种应用中，包括例如太阳能电池，传感器，光电探测器，发光二极管，激光二极管，EL器件，PL器件，CL器件，FET ，CTF，表面等离子体波导，MOS电容器等。

7. 发明授权

US08354666B2 Organic polymer semiconductor, method of preparing the same, and ambipolar organic thin film transistor using the same 有权
标题翻译：有机聚合物半导体，其制备方法和使用其的双极性有机薄膜晶体管
公开(公告)号：US08354666B2
公开(公告)日：2013-01-15
申请号：US11790755
申请日：2007-04-27
申请人： Bang Lin Lee , Eun Kyung Lee , Kook Min Han
发明人： Bang Lin Lee , Eun Kyung Lee , Kook Min Han
IPC分类号： H01L51/00
CPC分类号： H01L51/0036 , C08G61/122 , C08G61/124 , C08G61/125 , C08G61/126 , C09K11/06 , C09K2211/1458 , C09K2211/1466 , H01L51/0545 , H05B33/14
摘要： Disclosed are an organic polymer semiconductor, an ambipolar organic thin film transistor using the same, an electronic device comprising the ambipolar organic thin film transistor and methods of fabricating the same. Example embodiments relate to an organic polymer semiconductor, which may include an aromatic ring derivative having p-type semiconductor properties and a heteroaromatic ring having n-type semiconductor properties in the main chain thereof, and which thus may exhibit both p-type transistor properties and n-type transistor properties when used in the organic active layer of an electronic device, e.g., an organic thin film transistor, an ambipolar organic thin film transistor using such an organic polymer semiconductor, an electronic device comprising the ambipolar organic thin film transistor and methods of fabricating the same.
摘要翻译：公开了有机聚合物半导体，使用该有机聚合物半导体的双极性有机薄膜晶体管，包含双极性有机薄膜晶体管的电子器件及其制造方法。示例性实施方案涉及有机聚合物半导体，其可以包括具有p型半导体性质的芳族环衍生物和在其主链中具有n型半导体性质的杂芳族环，因此可以表现出p型晶体管性质和当用于电子器件的有机活性层（例如有机薄膜晶体管，使用这种有机聚合物半导体的双极性有机薄膜晶体管），包括双极性有机薄膜晶体管的电子器件和方法的制造。

8. 发明授权

US08158803B2 Heterocyclic antiviral compounds 失效
标题翻译：杂环抗病毒化合物
公开(公告)号：US08158803B2
公开(公告)日：2012-04-17
申请号：US12766064
申请日：2010-04-23
申请人： Eun Kyung Lee , Ryan Craig Schoenfeld , Francisco Xavier Talamas
发明人： Eun Kyung Lee , Ryan Craig Schoenfeld , Francisco Xavier Talamas
IPC分类号： C07D211/72 , A61K31/44
CPC分类号： C07D405/04 , C07D213/64 , C07D213/76 , C07D237/14 , C07D239/54 , C07D241/18
摘要： Compounds having the formula I wherein R1, R2, R3, R4, R5a, R5b, R5c and R6 are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.
摘要翻译：具有式I的化合物，其中R1，R2，R3，R4，R5a，R5b，R5c和R6如本文所定义，是丙型肝炎病毒NS5b聚合酶抑制剂。还公开了用于治疗HCV感染和抑制HCV复制的组合物和方法。

9. 发明授权

US08120010B2 Quantum dot electroluminescent device and method for fabricating the same 有权
标题翻译：量子点电致发光器件及其制造方法
公开(公告)号：US08120010B2
公开(公告)日：2012-02-21
申请号：US12534226
申请日：2009-08-03
申请人： Kyung Sang Cho , Byoung Lyong Choi , Eun Kyung Lee
发明人： Kyung Sang Cho , Byoung Lyong Choi , Eun Kyung Lee
IPC分类号： H01L29/06 , H01L31/00
CPC分类号： H05B33/14 , C09K11/025 , C09K11/565 , C09K11/883 , H01L51/0037 , H01L51/0039 , H01L51/502 , H01L51/5048
摘要： A quantum dot electroluminescent device that includes a substrate, a quantum dot light-emitting layer disposed on the substrate, a first electrode which injects charge carriers into the quantum dot light-emitting layer, a second electrode which injects charge carriers, which have an opposite charge than the charge carriers injected by the first electrode, into the quantum dot light-emitting layer, a hole transport layer disposed between the first electrode and the quantum dot light-emitting layer, and an electron transport layer disposed between the second electrode and the quantum dot light-emitting layer, wherein the quantum dot light-emitting layer has a first surface in contact with the hole transport layer and a second surface in contact with an electron transport layer, and wherein the first surface has an organic ligand distribution that is different from an organic ligand distribution of the second surface.
摘要翻译：一种量子点电致发光器件，包括衬底，设置在衬底上的量子点发光层，将电荷载流子注入量子点发光层的第一电极，注入电荷载流子的第二电极，其具有相反的电荷比由第一电极注入的电荷载流子进入量子点发光层，设置在第一电极和量子点发光层之间的空穴传输层和设置在第二电极和量子点发光层之间的电子传输层量子点发光层，其中量子点发光层具有与空穴传输层接触的第一表面和与电子传输层接触的第二表面，并且其中第一表面具有有机配体分布不同于第二表面的有机配体分布。

10. 发明授权

US07863628B2 Light-emitting device and light-receiving device using transistor structure 有权
标题翻译：使用晶体管结构的发光器件和光接收器件
公开(公告)号：US07863628B2
公开(公告)日：2011-01-04
申请号：US12031287
申请日：2008-02-14
申请人： Byoung Lyong Choi , Kyung Sang Cho , Eun Kyung Lee , O Gweon Seo
发明人： Byoung Lyong Choi , Kyung Sang Cho , Eun Kyung Lee , O Gweon Seo
IPC分类号： H01L27/15
CPC分类号： H01L51/5296 , B82Y20/00 , H01L51/0545 , H01L51/5012 , H01L51/5203
摘要： Disclosed is a light-emitting device using a transistor structure, including a substrate, a first gate electrode, a first insulating layer, a source electrode, a drain electrode, and a light-emitting layer formed between the source electrode and the drain electrode in a direction parallel to these electrodes. In the light-emitting device using the transistor structure, it is possible to adjust the mobility of electrons or holes and to selectively set a light-emitting region through the control of the magnitude of voltage applied to the gate electrode, thus increasing the lifespan of the light-emitting device, facilitating the manufacturing process thereof, and realizing light-emitting or light-receiving properties having high efficiency and high purity.
摘要翻译：公开了一种使用晶体管结构的发光装置，其包括基板，第一栅电极，第一绝缘层，源电极，漏电极和形成在源电极和漏电极之间的发光层，与这些电极平行的方向。在使用晶体管结构的发光装置中，可以通过控制施加到栅电极的电压的大小来调节电子或空穴的迁移率并选择性地设置发光区域，从而增加寿命发光装置，便于其制造工艺，并实现高效率和高纯度的发光或光接收性能。

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