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1. 发明授权

US08916525B2 TNF-A and TWEAK dual antagonist for the prophylaxis and treatment of autoimmune diseases 有权
标题翻译： TNF-A和TWEAK双重拮抗剂用于预防和治疗自身免疫性疾病
公开(公告)号：US08916525B2
公开(公告)日：2014-12-23
申请号：US13635868
申请日：2011-03-18
申请人： Young Woo Park , Ki Won Jo , Srok Ho Yoo , Jung Yu , Dong Jin Kim , Sun-Ha Yoon , Eun Jung Song , Eun Kyung Lee , Jin Mi Oh , Kyu Won Cho , Mi La Cho , Ho Youn Kim , Mi Kyung Park , Hye Jwa Oh , Jin Sil Park , Yun Ju Woo , Jae Kyeong Byun , Jun Geol Ryu
发明人： Young Woo Park , Ki Won Jo , Srok Ho Yoo , Jung Yu , Dong Jin Kim , Sun-Ha Yoon , Eun Jung Song , Eun Kyung Lee , Jin Mi Oh , Kyu Won Cho , Mi La Cho , Ho Youn Kim , Mi Kyung Park , Hye Jwa Oh , Jin Sil Park , Yun Ju Woo , Jae Kyeong Byun , Jun Geol Ryu
IPC分类号： A61K38/17 , A61P17/00 , A61P19/02 , A61P19/04 , A61P21/00 , A61P25/00 , A61P3/10 , A61P7/06 , C07K14/525 , C07K14/705
CPC分类号： C07K14/525 , C07K14/70575 , C07K2319/32 , Y10S514/814 , Y10S514/885 , Y10S514/886 , Y10S514/903
摘要： The present invention relates to TNFR2-TWEAKR fusion protein, more precisely to TNFR2-TWEAKR fusion protein acting as a double-antagonist to TNF-α and TWEAK, known as major causes of autoimmune arthritis which is one of autoimmune diseases. When the composition comprising TNFR2-TWEAKR fusion protein was treated to Th17 cells, the secretion of the inflammatory cytokine IL-17 was reduced but the secretion of the anti-inflammatory cytokine IL-10 generated in Treg cells was increased. Such effect of TNFR2-TWEAKR fusion protein was far greater than that of a single protein such as TNFR2-Fc or TWEAK-Fc. The TNFR2-TWEAKR fusion protein of the present invention has not only excellent treatment effect on arthritis in CIA mouse model not also excellent treatment effect on autoimmune rheumatoid arthritis by increasing the expression of Treg, the immune suppressive cells. Therefore, the TNFR2-TWEAKR fusion protein of the present invention can be effectively used as an active ingredient for the composition for the prevention and treatment of autoimmune disease.
摘要翻译：本发明涉及TNFR2-TWEAKR融合蛋白，更确切地说，作为TNF-α和TWEAK的双拮抗剂的TNFR2-TWEAKR融合蛋白，被称为自身免疫性疾病之一的自身免疫性关节炎的主要原因。当将包含TNFR2-TWEAKR融合蛋白的组合物治疗至Th17细胞时，炎性细胞因子IL-17的分泌减少，但在Treg细胞中产生的抗炎细胞因子IL-10的分泌增加。 TNFR2-TWEAKR融合蛋白的这种作用远远大于单一蛋白如TNFR2-Fc或TWEAK-Fc的这种作用。本发明的TNFR2-TWEAKR融合蛋白不仅对CIA小鼠模型的关节炎具有优异的治疗作用，而且通过增加免疫抑制细胞Treg的表达，对自身免疫性类风湿性关节炎也不是很好的治疗效果。因此，本发明的TNFR2-TWEAKR融合蛋白可以有效地用作预防和治疗自身免疫性疾病的组合物的活性成分。

2. 发明申请

US20130017226A1 TNF-A and TWEAK Dual Antagonist for the Prophylaxis and Treatment of Autoimmune Diseases 有权
标题翻译： TNF-A和TWEAK双重拮抗剂预防和治疗自身免疫性疾病
公开(公告)号：US20130017226A1
公开(公告)日：2013-01-17
申请号：US13635868
申请日：2011-03-18
申请人： Young Woo Park , Ki Won Jo , Srok Ho Yoo , Jung Yu , Dong Ji Kim , Sun-Ha Yoon , Eun Jung Song , Eun Kyung Lee , Jin Mi Oh , Kyu Won Cho , Mi La Cho , Ho Youn Kim , Mi Kyung Park , Hye Jwa Oh , Jin Sil Park , Yun Ju Woo , Jae Kyeong Byun , Jun Geol Ryu
发明人： Young Woo Park , Ki Won Jo , Srok Ho Yoo , Jung Yu , Dong Ji Kim , Sun-Ha Yoon , Eun Jung Song , Eun Kyung Lee , Jin Mi Oh , Kyu Won Cho , Mi La Cho , Ho Youn Kim , Mi Kyung Park , Hye Jwa Oh , Jin Sil Park , Yun Ju Woo , Jae Kyeong Byun , Jun Geol Ryu
IPC分类号： C07K19/00 , C12N15/63 , C12N1/21 , C12N5/10 , A61K38/17 , A61P19/04 , A61P7/06 , A61P3/10 , A61P19/02 , A61P25/00 , A61P17/00 , A61P21/00 , C12N15/62 , A61P37/06
CPC分类号： C07K14/525 , C07K14/70575 , C07K2319/32 , Y10S514/814 , Y10S514/885 , Y10S514/886 , Y10S514/903
摘要： The present invention relates to TNFR2-TWEAKR fusion protein, more precisely to TNFR2-TWEAKR fusion protein acting as a double-antagonist to TNF-α and TWEAK, known as major causes of autoimmune arthritis which is one of autoimmune diseases. When the composition comprising TNFR2-TWEAKR fusion protein was treated to Th17 cells, the secretion of the inflammatory cytokine IL-17 was reduced but the secretion of the anti-inflammatory cytokine IL-10 generated in Treg cells was increased. Such effect of TNFR2-TWEAKR fusion protein was far greater than that of a single protein such as TNFR2-Fc or TWEAK-Fc. The TNFR2-TWEAKR fusion protein of the present invention has not only excellent treatment effect on arthritis in CIA mouse model not also excellent treatment effect on autoimmune rheumatoid arthritis by increasing the expression of Treg, the immune suppressive cells. Therefore, the TNFR2-TWEAKR fusion protein of the present invention can be effectively used as an active ingredient for the composition for the prevention and treatment of autoimmune disease.
摘要翻译：本发明涉及TNFR2-TWEAKR融合蛋白，更确切地说，作为TNF-α和TWEAK的双拮抗剂的TNFR2-TWEAKR融合蛋白，被称为自身免疫性疾病之一的自身免疫性关节炎的主要原因。当将包含TNFR2-TWEAKR融合蛋白的组合物治疗至Th17细胞时，炎性细胞因子IL-17的分泌减少，但在Treg细胞中产生的抗炎细胞因子IL-10的分泌增加。 TNFR2-TWEAKR融合蛋白的这种作用远远大于单一蛋白如TNFR2-Fc或TWEAK-Fc的这种作用。本发明的TNFR2-TWEAKR融合蛋白不仅对CIA小鼠模型的关节炎具有优异的治疗作用，而且通过增加免疫抑制细胞Treg的表达，对自身免疫性类风湿性关节炎也不是很好的治疗效果。因此，本发明的TNFR2-TWEAKR融合蛋白可以有效地用作预防和治疗自身免疫性疾病的组合物的活性成分。

3. 发明授权

US09200058B2 Dual antagonist for TNF-α and IL-21 for preventing and treating autoimmune diseases 有权
标题翻译：用于预防和治疗自身免疫性疾病的TNF-α和IL-21的双重拮抗剂
公开(公告)号：US09200058B2
公开(公告)日：2015-12-01
申请号：US13635874
申请日：2011-03-18
申请人： Young Woo Park , Ki Won Jo , Srok Ho Yoo , Jung Yu , Sun-Ha Yoon , Ji Hyun Park , Eun Jung Song , Jong-Ho Lee , Min Ji Seo , Sun Jung Cho , Mi La Cho , Ho Youn Kim , Mi Kyung Park , Hye Jwa Oh , Jin Sil Park , Yun Ju Woo , Jae Kyeong Byun , Jun Geol Ryu
发明人： Young Woo Park , Ki Won Jo , Srok Ho Yoo , Jung Yu , Sun-Ha Yoon , Ji Hyun Park , Eun Jung Song , Jong-Ho Lee , Min Ji Seo , Sun Jung Cho , Mi La Cho , Ho Youn Kim , Mi Kyung Park , Hye Jwa Oh , Jin Sil Park , Yun Ju Woo , Jae Kyeong Byun , Jun Geol Ryu
IPC分类号： C07K14/715
CPC分类号： C07K14/7151 , C07K14/7155 , C07K2319/00
摘要： The present invention relates to TNFR2-IL21R fusion protein acting as a double-antagonist to TNF-alpha (α) and IL-21. The composition containing the double antagonist to TNF-α and Il-21 (TNFR2-IL21R fusion protein), known as major causes of autoimmune rheumatoid arthritis, one of autoimmune diseases, can reduce the secretion of inflammatory cytokine, increase the secretion of anti-inflammatory cytokine, and suppress the differentiation of osteoclasts better than single proteins such as TNFR2-Fc and IL21R-Fc. The TNFR2-IL21R fusion protein of the present invention has not only excellent treatment effect on arthritis in CIA mouse model not also excellent treatment effect on autoimmune rheumatoid arthritis by increasing the expression of Treg, the immune suppressive cells. Therefore, the TNFR2-IL21R fusion protein of the present invention can be effectively used as an active ingredient for the composition for the prevention and treatment of autoimmune disease.
摘要翻译：本发明涉及作为TNF-α（α）和IL-21的双重拮抗剂的TNFR2-IL21R融合蛋白。含有TNF-α和II-21（TNFR2-IL21R融合蛋白）的双重拮抗剂的组合物，被称为自身免疫性类风湿性关节炎的主要原因（自身免疫性疾病之一）可以减少炎性细胞因子的分泌，炎性细胞因子，并且比单一蛋白如TNFR2-Fc和IL21R-Fc更好地抑制破骨细胞的分化。本发明的TNFR2-IL21R融合蛋白不仅对CIA小鼠模型的关节炎具有优异的治疗作用，而且通过增加免疫抑制细胞Treg的表达，对自身免疫性类风湿性关节炎也不是很好的治疗效果。因此，本发明的TNFR2-IL21R融合蛋白可以有效地用作预防和治疗自身免疫性疾病的组合物的活性成分。

4. 发明申请

US20130022642A1 Dual Antagonist for TNF-A and IL-21 for Preventing and Treating Autoimmune Diseases 有权
标题翻译：用于预防和治疗自身免疫性疾病的TNF-A和IL-21的双重拮抗剂
公开(公告)号：US20130022642A1
公开(公告)日：2013-01-24
申请号：US13635874
申请日：2011-03-18
申请人： Young Woo Park , Ki Won Jo , Srok Ho Yoo , Jung Yu , Sun-Ha Yoon , Ji Hyun Park , Eun Jung Song , Jong-Ho Lee , Min Ji Seo , Sun Jung Cho , Mi La Cho , Ho Youn Kim , Mi Kyung Park , Hye Jwa Oh , Jin Sil Park , Yun Ju Woo , Jae Kyeong Byun , Jun Geol Ryu
发明人： Young Woo Park , Ki Won Jo , Srok Ho Yoo , Jung Yu , Sun-Ha Yoon , Ji Hyun Park , Eun Jung Song , Jong-Ho Lee , Min Ji Seo , Sun Jung Cho , Mi La Cho , Ho Youn Kim , Mi Kyung Park , Hye Jwa Oh , Jin Sil Park , Yun Ju Woo , Jae Kyeong Byun , Jun Geol Ryu
IPC分类号： C07K19/00 , C12N15/63 , C12N1/21 , C12N5/10 , A61K38/17 , A61P21/00 , A61P3/10 , A61P19/02 , A61P37/06 , A61P25/00 , A61P17/00 , C12N15/62 , A61P7/06
CPC分类号： C07K14/7151 , C07K14/7155 , C07K2319/00
摘要： The present invention relates to TNFR2-IL21R fusion protein acting as a double-antagonist to TNF-alpha (α) and IL-21. The composition containing the double antagonist to TNF-α and Il-21 (TNFR2-IL21R fusion protein), known as major causes of autoimmune rheumatoid arthritis, one of autoimmune diseases, can reduce the secretion of inflammatory cytokine, increase the secretion of anti-inflammatory cytokine, and suppress the differentiation of osteoclasts better than single proteins such as TNFR2-Fc and IL21R-Fc. The TNFR2-IL21R fusion protein of the present invention has not only excellent treatment effect on arthritis in CIA mouse model not also excellent treatment effect on autoimmune rheumatoid arthritis by increasing the expression of Treg, the immune suppressive cells. Therefore, the TNFR2-IL21R fusion protein of the present invention can be effectively used as an active ingredient for the composition for the prevention and treatment of autoimmune disease.
摘要翻译：本发明涉及作为TNF-α（α）和IL-21的双重拮抗剂的TNFR2-IL21R融合蛋白。含有TNF-α和II-21（TNFR2-IL21R融合蛋白）的双重拮抗剂的组合物，被称为自身免疫性类风湿性关节炎的主要原因（自身免疫性疾病之一）可以减少炎性细胞因子的分泌，炎性细胞因子，并且比单一蛋白如TNFR2-Fc和IL21R-Fc更好地抑制破骨细胞的分化。本发明的TNFR2-IL21R融合蛋白不仅对CIA小鼠模型的关节炎具有优异的治疗作用，而且通过增加免疫抑制细胞Treg的表达，对自身免疫性类风湿性关节炎也不是很好的治疗效果。因此，本发明的TNFR2-IL21R融合蛋白可以有效地用作预防和治疗自身免疫性疾病的组合物的活性成分。

5. 发明授权

US07387971B2 Fabricating method for flat panel display device 有权
标题翻译：平板显示装置的制造方法
公开(公告)号：US07387971B2
公开(公告)日：2008-06-17
申请号：US11260393
申请日：2005-10-28
申请人： Gee Sung Chae , Mi Kyung Park
发明人： Gee Sung Chae , Mi Kyung Park
IPC分类号： H01L21/31 , H01L21/469
CPC分类号： H01L27/124 , H01L27/1292
摘要： A fabricating method for a flat panel display device having a thin film pattern over a substrate is disclosed. The fabricating method includes depositing a hydrophilic resin over a substrate and patterning the hydrophilic resin to form hydrophilic resin patterns over areas outside where thin film patterns are to be formed over the substrate. The fabricating method also includes depositing a hydrophobic nano powder thin film material over the substrate and between the hydrophilic resin patterns and removing the hydrophilic resin patterns to form hydrophobic nano powder thin film patterns over the substrate. Moreover, the fabricating method includes treating the hydrophobic nano powder thin film patterns to form the thin film pattern.
摘要翻译：公开了一种在衬底上具有薄膜图形的平板显示装置的制造方法。该制造方法包括在衬底上沉积亲水性树脂并且图案化亲水树脂以在要在衬底上形成薄膜图案的区域外的区域上形成亲水性树脂图案。该制造方法还包括在衬底上和亲水性树脂图案之间沉积疏水性纳米粉末薄膜材料并除去亲水性树脂图案以在衬底上形成疏水性纳米粉末薄膜图案。此外，制造方法包括处理疏水性纳米粉末薄膜图案以形成薄膜图案。

6. 发明授权

US08303829B2 Method of fabricating an apparatus of fabricating an flat panel display device and method for fabricating flat panel display device 有权
标题翻译：制造平板显示装置的方法和制造平板显示装置的方法
公开(公告)号：US08303829B2
公开(公告)日：2012-11-06
申请号：US11950215
申请日：2007-12-04
申请人： Jin Wuk Kim , Mi Kyung Park
发明人： Jin Wuk Kim , Mi Kyung Park
IPC分类号： B29D11/00 , C03C15/00 , C03C25/68
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00 , G02F1/1362 , H01L27/1288 , H01L27/1292
摘要： A method of fabricating an apparatus of fabricating a flat panel display device and method of fabricating flat panel display device is disclosed, which enables simplification of process by performing a patterning process without a photo process, the method for fabricating an apparatus of fabricating flat panel display device comprising, preparing a master mold including a thin film pattern, coating a liquid-type molding material including oligomer on the master mold, forming a soft mold including a groove provided with a pattern in a shape corresponding to the thin film pattern of the master mold and adhering the soft mold to a mold support plate, wherein the soft mold is adhered to the mold support plate by a covalent bonding in the interface between the oligomer and the mold support plate.
摘要翻译：公开了一种制造平板显示装置的制造方法以及制造平板显示装置的方法，其通过在不进行光刻处理的情况下执行图案化处理来简化工艺，制造平板显示装置的方法装置，包括：制备包括薄膜图案的母模，在所述母模上涂覆包含低聚物的液态成型材料，形成软模，所述软模包括设置有与所述母模的薄膜图案相对应的图案的凹槽模具并将软模粘合到模具支撑板上，其中软模具通过在低聚物和模具支撑板之间的界面中的共价键合而附着到模具支撑板上。

7. 发明授权

US07465612B2 Fabricating method for thin film transistor substrate and thin film transistor substrate using the same 有权
标题翻译：薄膜晶体管基板和使用其的薄膜晶体管基板的制造方法
公开(公告)号：US07465612B2
公开(公告)日：2008-12-16
申请号：US11312605
申请日：2005-12-21
申请人： Gee Sung Chae , Mi Kyung Park
发明人： Gee Sung Chae , Mi Kyung Park
IPC分类号： H01L21/00 , H01L21/84 , H01L21/20
CPC分类号： H01L29/4908 , H01L27/1292 , H01L29/0673 , H01L29/7869 , H01L29/78696 , Y10S977/938
摘要： A thin film transistor substrate and its fabrication method are discussed. According to an embodiment, the fabricating method of a thin film transistor substrate includes forming a gate electrode on a substrate; forming a gate insulating film on the gate electrode, the gate insulating film having a groove in an area corresponding to an area where an active layer of a thin film transistor is to be formed; forming the active layer of the thin film transistor by use of a nanowire in the groove of the gate insulating film; and forming a source electrode and a drain electrode on the active layer.
摘要翻译：讨论了薄膜晶体管基板及其制造方法。根据实施例，薄膜晶体管基板的制造方法包括在基板上形成栅电极; 在所述栅电极上形成栅极绝缘膜，所述栅极绝缘膜在与要形成薄膜晶体管的有源层的区域对应的区域中具有沟槽; 通过在栅极绝缘膜的沟槽中使用纳米线来形成薄膜晶体管的有源层; 并在有源层上形成源电极和漏电极。

8. 发明授权

US07491560B2 Fabricating method of flat panel display device 有权
标题翻译：平板显示装置的制造方法
公开(公告)号：US07491560B2
公开(公告)日：2009-02-17
申请号：US11474361
申请日：2006-06-26
申请人： Jin Wuk Kim , Mi Kyung Park
发明人： Jin Wuk Kim , Mi Kyung Park
IPC分类号： H01L21/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00 , G02F1/134363 , G02F1/13439
摘要： A fabricating method of a flat panel display device according to the present invention includes providing a thin film on a substrate; providing a soft mold having a groove and a projection on the thin film; contacting the projection of the soft mold and the thin film; and spreading a hydrophilic polymer resin on the thin film to pattern the thin film.
摘要翻译：根据本发明的平板显示装置的制造方法包括在基板上设置薄膜; 提供在薄膜上具有凹槽和突起的软模具; 接触软模和薄膜的突起; 并将亲水性聚合物树脂铺展在薄膜上以对薄膜进行图案化。

9. 发明申请

US20110201575A1 STABILIZED SOLID DISPERSION OF ADEFOVIR DIPIVOXIL AND PREPARATION METHOD THEREOF 审中-公开
标题翻译： ADEPOVIR DIPIVOXIL的稳定化固体分散体及其制备方法
公开(公告)号：US20110201575A1
公开(公告)日：2011-08-18
申请号：US13119154
申请日：2009-09-16
申请人： Yong Tack Lee , Myeong Sik Yoon , Hye Suk Hong , Il Hwan Cho , Tae Kun An , Si Beum Lee , Hae Jong Jang , Mi Kyung Park
发明人： Yong Tack Lee , Myeong Sik Yoon , Hye Suk Hong , Il Hwan Cho , Tae Kun An , Si Beum Lee , Hae Jong Jang , Mi Kyung Park
IPC分类号： A61K31/675 , A61P31/18
CPC分类号： C07D473/32 , A61K9/146
摘要： The present invention relates to an amorphous solid dispersion with improved stability comprising 9-[2-[[bis[(pivaloyloxy)methyl]phosphono]methoxy]ethyl]adenine as a nucleotide analogue, a pharmaceutical composition comprising the same, and a method for preparing the same.
摘要翻译：本发明涉及具有改进的稳定性的无定形固体分散体，其包含9- [2 - [[双[（新戊酰氧基）甲基]膦酰基]甲氧基]乙基]腺嘌呤作为核苷酸类似物，包含其的药物组合物和准备一样

10. 发明授权

US07732318B2 Fabricating method for flat display device 有权
标题翻译：平面显示装置的制造方法
公开(公告)号：US07732318B2
公开(公告)日：2010-06-08
申请号：US11315153
申请日：2005-12-23
申请人： Gee Sung Chae , Mi Kyung Park
发明人： Gee Sung Chae , Mi Kyung Park
IPC分类号： H01L21/00
CPC分类号： H05K3/101 , H01L21/288 , H01L21/76838 , H01L27/1292 , H05K3/04 , H05K3/102 , H05K2201/0257 , H05K2201/0272 , H05K2203/0108 , Y10S977/777
摘要： A fabricating method of a flat panel display device can reduce manufacturing costs of the flat panel display device. A fabricating method of a flat panel display device includes providing a conductive nanopowder thin film material having a first conductive nanopowder and a second conductive nanopowder, spreading the conductive nanopowder thin film material over a substrate, forming a conductive thin film pattern by patterning the conductive nanopowder thin film material, and forming a conductive thin film by baking the conductive thin film pattern, wherein the first conductive nanopowder is located in a middle of the conductive thin film and the second conductive nanopowder is located in an outer part of the conductive thin film.
摘要翻译：平板显示装置的制造方法可以降低平板显示装置的制造成本。平板显示装置的制造方法包括提供具有第一导电纳米粉末和第二导电纳米粉末的导电纳米粉末薄膜材料，将导电纳米粉末薄膜材料铺展在基板上，通过图案化导电纳米粉末形成导电薄膜图案薄膜材料，并通过烘烤导电薄膜图案形成导电薄膜，其中第一导电纳米粉末位于导电薄膜的中间，第二导电纳米粉末位于导电薄膜的外部。

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