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1. 发明授权

US07744854B2 Method for optimizing cancer therapy by monitoring maturation of tumor associated vasculature by selenium 失效
标题翻译：通过监测硒的肿瘤相关脉管系统成熟来优化癌症治疗的方法
公开(公告)号：US07744854B2
公开(公告)日：2010-06-29
申请号：US11728075
申请日：2007-03-23
申请人： Youcef M. Rustum , Arup Bhattacharya , Karoly Toth , Harry K. Slocum , Rami G. Azrak , Sreenivasulu Chintala , Mukund Seshadri , Richard Mazurchuk
发明人： Youcef M. Rustum , Arup Bhattacharya , Karoly Toth , Harry K. Slocum , Rami G. Azrak , Sreenivasulu Chintala , Mukund Seshadri , Richard Mazurchuk
IPC分类号： A61B5/055 , A61K31/44 , A61K31/28 , A61K31/095 , A61K31/505 , A61K33/24 , A61K49/00 , A01N37/12 , A01N43/02
CPC分类号： A61K49/06 , A61K31/282 , A61K31/4375 , A61K31/513 , A61K31/66 , A61K33/24 , A61K45/06 , B24B49/003 , A61K2300/00
摘要： This invention provides a method for a method for optimizing the regimen for the administration of chemotherapeutic agents. The method comprises administration of a selenium compound to an individual, monitoring the modulation of tumor vessel maturation (TVM) to identify an optimal time for administration of a chemotherapeutic agent. This invention also provides a method to determine whether or not a tumor is likely to be a responder to chemotherapy. The method comprises administration of a selenium compound to an individual and determining whether or not an increase in TVM is observed. An increased TVM following administration of selenium is an indication that the tumor will likely respond the chemotherapy.
摘要翻译：本发明提供了一种优化用于施用化学治疗剂的方案的方法。该方法包括向个体施用硒化合物，监测肿瘤血管成熟的调节（TVM）以鉴定给予化疗剂的最佳时间。本发明还提供了确定肿瘤是否可能是化学疗法的反应者的方法。该方法包括向个体施用硒化合物，并确定是否观察到TVM的增加。施用硒后增加的TVM表明肿瘤可能对化疗有反应。

2. 发明申请

US20080019919A1 Method for optimizing cancer therapy by monitoring maturation of tumor associated vasculature by selenium 失效
标题翻译：通过监测硒的肿瘤相关脉管系统成熟来优化癌症治疗的方法
公开(公告)号：US20080019919A1
公开(公告)日：2008-01-24
申请号：US11728075
申请日：2007-03-23
申请人： Youcef Rustum , Arup Bhattacharya , Karoly Toth , Harry Slocum , Rami Azrak , Sreenivasulu Chintala , Mukund Seshadri , Richard Mazurchuk
发明人： Youcef Rustum , Arup Bhattacharya , Karoly Toth , Harry Slocum , Rami Azrak , Sreenivasulu Chintala , Mukund Seshadri , Richard Mazurchuk
IPC分类号： A61K49/06 , A61K31/282 , A61K31/4375 , A61K31/513 , A61P35/00 , A61K31/66 , A61K33/24 , A61K49/00
CPC分类号： A61K49/06 , A61K31/282 , A61K31/4375 , A61K31/513 , A61K31/66 , A61K33/24 , A61K45/06 , B24B49/003 , A61K2300/00
摘要： This invention provides a method for a method for optimizing the regimen for the administration of chemotherapeutic agents. The method comprises administration of a selenium compound to an individual, monitoring the modulation of tumor vessel maturation (TVM) to identify an optimal time for administration of a chemotherapeutic agent. This invention also provides a method to determine whether or not a tumor is likely to be a responder to chemotherapy. The method comprises administration of a selenium compound to an individual and determining whether or not an increase in TVM is observed. An increased TVM following administration of selenium is an indication that the tumor will likely respond the chemotherapy.
摘要翻译：本发明提供了一种优化用于施用化学治疗剂的方案的方法。该方法包括向个体施用硒化合物，监测肿瘤血管成熟的调节（TVM）以鉴定给予化疗剂的最佳时间。本发明还提供了确定肿瘤是否可能是化学疗法的反应者的方法。该方法包括向个体施用硒化合物，并确定是否观察到TVM的增加。施用硒后增加的TVM表明肿瘤可能对化疗有反应。

3. 发明申请

US20060222587A1 Hybrid inorganic nanoparticles, methods of using and methods of making 审中-公开
标题翻译：混合无机纳米粒子，使用方法和制备方法
公开(公告)号：US20060222587A1
公开(公告)日：2006-10-05
申请号：US11392057
申请日：2006-03-29
申请人： Paras Prasad , Richard Mazurchuk , Dhruba Bharali , Dinesh Sukumaran , Earl Bergey , Joseph Spernyak , Mukund Seshadri
发明人： Paras Prasad , Richard Mazurchuk , Dhruba Bharali , Dinesh Sukumaran , Earl Bergey , Joseph Spernyak , Mukund Seshadri
IPC分类号： A61K51/00
CPC分类号： A61K49/1818 , A61K41/0071 , A61K49/0002 , A61K49/0036 , A61K49/0093 , A61K49/10 , A61K49/1881 , B82Y5/00
摘要： The invention provides hybrid inorganic nanoparticles, methods of making the hybrid inorganic nanoparticles and methods of using the hybrid inorganic nanoparticles.
摘要翻译：本发明提供了混合无机纳米粒子，制备杂化无机纳米颗粒的方法和使用杂化无机纳米粒子的方法。

4. 发明授权

US08265992B1 Churn prediction using relationship strength quantification 失效
标题翻译：使用关系强度量化进行流失预测
公开(公告)号：US08265992B1
公开(公告)日：2012-09-11
申请号：US12409853
申请日：2009-03-24
申请人： Mukund Seshadri , Sridhar Machiraju , Jean Bolot
发明人： Mukund Seshadri , Sridhar Machiraju , Jean Bolot
IPC分类号： G06Q10/00 , G06Q50/00 , G06N5/02
CPC分类号： G06Q10/10
摘要： An embodiment of the current invention is directed to determining that a wireless-service subscriber using a given mobile computing device is likely to transition to another provider (“to churn”). A list of mobile computing devices that have communicated with the given mobile computing device is determined. A relationship-strength value for each mobile computing device in the list is determined. A risk value of the given mobile computing device is determined based on the relationship-strength values of each of the mobile computing devices in the list that have churned. If the risk value is not greater than a risk value threshold, the given mobile computing device is not likely to churn. If the risk value is greater than the risk value threshold, the given mobile computing device is likely to churn.
摘要翻译：本发明的一个实施例涉及确定使用给定移动计算设备的无线服务订户很可能转换到另一供应商（“转播”）。确定与给定移动计算设备通信的移动计算设备的列表。确定列表中每个移动计算设备的关系强度值。基于已经搅动的列表中的每个移动计算设备的关系强度值来确定给定移动计算设备的风险值。如果风险值不大于风险值阈值，则给定的移动计算设备不太可能流失。如果风险值大于风险值阈值，给定的移动计算设备很可能会流失。

5. 发明授权

US09491055B1 Determining user communities in communication networks 有权
标题翻译：确定通信网络中的用户社区
公开(公告)号：US09491055B1
公开(公告)日：2016-11-08
申请号：US12764730
申请日：2010-04-21
申请人： Ashwin Sridharan , Mukund Seshadri , James Christopher Schneider , Bodicherla Aditya Prakash , Christos Faloutsos , Sridhar Machiraju
发明人： Ashwin Sridharan , Mukund Seshadri , James Christopher Schneider , Bodicherla Aditya Prakash , Christos Faloutsos , Sridhar Machiraju
IPC分类号： H04L12/24 , G06K9/62
CPC分类号： H04L41/12 , G06K9/6224 , G06Q50/01
摘要： What is disclosed is a method of operating a communication network, where the communication network comprises a set of users. The method includes obtaining usage activity for each of the users of the set and processing the usage activity to determine connectivity information between individual ones of the users of the set. The method also includes processing the connectivity information to determine users of the set with similar connectivity, and processing the users of the set with similar connectivity to identify a community of users within the users of the set with similar connectivity. The method also includes monitoring at least one of the users in the community to determine if action is needed for at least another one of the users in the community.
摘要翻译：公开的是一种操作通信网络的方法，其中通信网络包括一组用户。所述方法包括获得所述集合的每个用户的使用活动并处理所述使用活动以确定所述集合的个体用户之间的连接性信息。该方法还包括处理连通性信息以确定具有相似连接性的集合的用户，以及处理具有相似连接性的集合的用户以识别具有相似连接性的集合的用户群体。该方法还包括监视社区中的至少一个用户以确定社区中至少另一个用户是否需要采取行动。

6. 发明授权

US08352299B1 Assessment of item listing quality by impact prediction 有权
标题翻译：通过影响预测评估项目列表质量
公开(公告)号：US08352299B1
公开(公告)日：2013-01-08
申请号：US13114840
申请日：2011-05-24
申请人： Mukund Seshadri , Deepak Jain , Tevye Rachelson Krynski
发明人： Mukund Seshadri , Deepak Jain , Tevye Rachelson Krynski
IPC分类号： G06Q40/00
CPC分类号： G06Q30/0601
摘要： Systems and methods use behavioral data to assess listings for items. The behavior data may relate to information regarding user actions in connection with listings for the items. The listings may be collections of information about the items. Behavioral data in connection with a collection of listings is used to assess how changing listings affects one or more performance measures and/or to score listing quality. The assessment may be used for various purposes, such as identifying listings that may be changed to achieve one or more improved performance measures for corresponding items and for other applications.
摘要翻译：系统和方法使用行为数据来评估项目的列表。行为数据可以涉及关于与物品的列表有关的用户动作的信息。列表可以是关于项目的信息的集合。与列表集合相关的行为数据用于评估变更的列表如何影响一个或多个绩效评估和/或评分列表质量。评估可以用于各种目的，例如识别可能被改变以实现相应项目和其他应用的一个或多个改进的性能测量的列表。

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