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1. 发明申请

US20100034776A1 REPLICATION-COMPETENT ANTI-CANCER VECTORS 失效
标题翻译：复制抗体抗体向量
公开(公告)号：US20100034776A1
公开(公告)日：2010-02-11
申请号：US12561016
申请日：2009-09-16
申请人： William S.M. Wold , Karoly Toth , Konstantin Doronin , Ann E. Tollefson
发明人： William S.M. Wold , Karoly Toth , Konstantin Doronin , Ann E. Tollefson
IPC分类号： A61K35/76 , C12N15/00 , C12N5/07
CPC分类号： C12N7/00 , A61K35/761 , A61K48/00 , C07K14/005 , C12N15/86 , C12N2710/10322 , C12N2710/10332 , C12N2710/10343 , C12N2830/001 , C12N2830/008
摘要： Novel vectors which are replication competent in neoplastic cells and which overexpress an adenovirus death protein are disclosed. Some of the disclosed vectors are replication-restricted to neoplastic cells or to neoplastic alveolar type II cells. Compositions and methods for promoting the death of neoplastic cells using these replication-competent vectors are also disclosed.
摘要翻译：公开了在肿瘤细胞中具有复制能力并且过表达腺病毒死亡蛋白的新型载体。一些所公开的载体是复制限于肿瘤细胞或肿瘤性肺泡II型细胞。还公开了使用这些具有复制能力的载体促进肿瘤细胞死亡的组合物和方法。

2. 发明授权

US08658610B2 Replication-competent anti-cancer vectors 失效
标题翻译：具有复制能力的抗癌载体
公开(公告)号：US08658610B2
公开(公告)日：2014-02-25
申请号：US12561016
申请日：2009-09-16
申请人： William S. M. Wold , Karoly Toth , Konstantin Doronin , Ann E. Tollefson
发明人： William S. M. Wold , Karoly Toth , Konstantin Doronin , Ann E. Tollefson
IPC分类号： A61K48/00 , A61K39/235
CPC分类号： C12N7/00 , A61K35/761 , A61K48/00 , C07K14/005 , C12N15/86 , C12N2710/10322 , C12N2710/10332 , C12N2710/10343 , C12N2830/001 , C12N2830/008
摘要： Novel vectors which are replication competent in neoplastic cells and which overexpress an adenovirus death protein are disclosed. Some of the disclosed vectors are replication-restricted to neoplastic cells or to neoplastic alveolar type II cells. Compositions and methods for promoting the death of neoplastic cells using these replication-competent vectors are also disclosed.
摘要翻译：公开了在肿瘤细胞中具有复制能力并且过表达腺病毒死亡蛋白的新型载体。一些所公开的载体是复制限于肿瘤细胞或肿瘤性肺泡II型细胞。还公开了使用这些具有复制能力的载体促进肿瘤细胞死亡的组合物和方法。

3. 发明申请

US20090017448A1 SCREENING TOOL FOR ANTIVIRAL AGENTS 有权
标题翻译：防毒剂的筛选工具
公开(公告)号：US20090017448A1
公开(公告)日：2009-01-15
申请号：US12124807
申请日：2008-05-21
申请人： Karoly Toth , William S. M. Wold
发明人： Karoly Toth , William S. M. Wold
IPC分类号： C12Q1/70
CPC分类号： G01N33/5088 , C12N7/00 , C12N15/86 , C12N2710/10343 , G01N2333/075
摘要： A method is provided for screening anti-adenovirus agents. The method includes reducing the activation of the immune system of a small mammal, administering a human adenovirus vector to the small mammal, monitoring the tumor cells in the mammal, and analyzing infectious virus units within the tumor cells and the organs of the small mammal. Specifically, the immune system of the small mammal is suppressed using cyclophosphamide. The small mammal may be, but is not limited to, one of the following: mice, rabbits, cotton rats, hamsters, rats, and other small rodents.
摘要翻译：提供了用于筛选抗腺病毒剂的方法。该方法包括减少小哺乳动物的免疫系统的活化，向小哺乳动物施用人腺病毒载体，监测哺乳动物中的肿瘤细胞，以及分析肿瘤细胞和小哺乳动物的器官内的感染病毒单位。具体来说，使用环磷酰胺抑制小哺乳动物的免疫系统。小哺乳动物可以是但不限于以下之一：小鼠，兔，棉鼠，仓鼠，大鼠和其他小啮齿动物。

4. 发明申请

US20060029596A1 Replication-competent anti-cancer vectors 有权
公开(公告)号：US20060029596A1
公开(公告)日：2006-02-09
申请号：US11249873
申请日：2005-10-13
申请人： William Wold , Karoly Toth , Konstantin Doronin , Ann Tollefson
发明人： William Wold , Karoly Toth , Konstantin Doronin , Ann Tollefson
IPC分类号： A61K39/395 , A61K48/00
CPC分类号： C12N7/00 , A61K35/761 , A61K48/00 , C07K14/005 , C12N15/86 , C12N2710/10322 , C12N2710/10332 , C12N2710/10343 , C12N2830/001 , C12N2830/008
摘要： Novel vectors which are replication competent in neoplastic cells and which overexpress an adenovirus death protein are disclosed. Some of the disclosed vectors are replication-restricted to neoplastic cells or to neoplastic alveolar type II cells. Compositions and methods for promoting the death of neoplastic cells using these replication-competent vectors are also disclosed.

5. 发明授权

US06555331B1 Bacteriophage assay 失效
标题翻译：噬菌体测定
公开(公告)号：US06555331B1
公开(公告)日：2003-04-29
申请号：US09674537
申请日：2001-01-12
申请人： Lizbeth Jane Hyman , Ian Karoly Toth
发明人： Lizbeth Jane Hyman , Ian Karoly Toth
IPC分类号： C12Q100
CPC分类号： C12Q1/04
摘要： There is provided an assay suitable for the typing of bacterial strains. In the assay a predetermined amount of phage is combined with a bacterial isolate of unknown strain, the mixture being located in a suitable container. The mixture of phage and bacteria is conveniently held in a liquid or semi-liquid medium facilitating interaction of the two species. The extent of bacterial growth in the presence of the phage is measured by conventional means, preferably by means of an OD reading. Desirably the phage is retained in the selected container, which is conveniently a micro-titer plate, through use of a fixant such as 5% gelatin.
摘要翻译：提供了适用于细菌菌株分型的测定法。在测定中，将预定量的噬菌体与未知菌株的细菌分离物组合，混合物位于合适的容器中。噬菌体和细菌的混合物方便地保持在液体或半液体介质中，促进两种物质的相互作用。在噬菌体存在下细菌生长的程度通过常规方法测量，优选通过OD读数测量。通过使用诸如5％明胶的固定剂，期望将噬菌体保留在选定的容器中，其通常是微滴定板。

6. 发明授权

US09011820B2 Screening tool for antiviral agents 有权
标题翻译：抗病毒药物筛选工具
公开(公告)号：US09011820B2
公开(公告)日：2015-04-21
申请号：US12124807
申请日：2008-05-21
申请人： Karoly Toth , William S. M. Wold
发明人： Karoly Toth , William S. M. Wold
IPC分类号： A61K49/00 , A61K39/235 , C12Q1/70 , C12N15/00 , G01N33/50 , C12N7/00 , C12N15/86
CPC分类号： G01N33/5088 , C12N7/00 , C12N15/86 , C12N2710/10343 , G01N2333/075
摘要： A method is provided for screening anti-adenovirus agents. The method includes reducing the activation of the immune system of a small mammal, administering a human adenovirus vector to the small mammal, monitoring the tumor cells in the mammal, and analyzing infectious virus units within the tumor cells and the organs of the small mammal. Specifically, the immune system of the small mammal is suppressed using cyclophosphamide. The small mammal may be, but is not limited to, one of the following: mice, rabbits, cotton rats, hamsters, rats, and other small rodents.
摘要翻译：提供了用于筛选抗腺病毒剂的方法。该方法包括减少小哺乳动物的免疫系统的活化，向小哺乳动物施用人腺病毒载体，监测哺乳动物中的肿瘤细胞，以及分析肿瘤细胞和小哺乳动物的器官内的感染病毒单位。具体来说，使用环磷酰胺抑制小哺乳动物的免疫系统。小哺乳动物可以是但不限于以下之一：小鼠，兔，棉鼠，仓鼠，大鼠和其他小啮齿动物。

7. 发明授权

US07589069B1 Replication-competent anti-cancer vectors 有权
公开(公告)号：US07589069B1
公开(公告)日：2009-09-15
申请号：US09351778
申请日：1999-07-12
申请人： William S. M. Wold , Karoly Toth , Konstantin Doronin , Ann E. Tollefson
发明人： William S. M. Wold , Karoly Toth , Konstantin Doronin , Ann E. Tollefson
IPC分类号： A61K48/00 , A61K39/235
CPC分类号： C12N7/00 , A61K35/761 , A61K48/00 , C07K14/005 , C12N15/86 , C12N2710/10322 , C12N2710/10332 , C12N2710/10343 , C12N2830/001 , C12N2830/008
摘要： Novel vectors which are replication competent in neoplastic cells and which overexpress an adenovirus death protein are disclosed. Some of the disclosed vectors are replication-restricted to neoplastic cells or to neoplastic alveolar type II cells. Compositions and methods for promoting the death of neoplastic cells using these replication-competent vectors are also disclosed.

8. 发明申请

US20050201936A1 Models for viral-based cancer therapy 审中-公开
标题翻译：基于病毒的癌症治疗模型
公开(公告)号：US20050201936A1
公开(公告)日：2005-09-15
申请号：US11057710
申请日：2005-02-14
申请人： William Wold , Karoly Toth , Maria Thomas
发明人： William Wold , Karoly Toth , Maria Thomas
IPC分类号： A61K49/00 , C12N15/861 , C12Q1/70
CPC分类号： A61K49/0008 , A01K67/0273 , A01K2207/05 , A01K2207/12 , A01K2227/10 , A01K2227/105 , A01K2267/0337
摘要： The present invention relates to the use of cotton rats and Syrian hamsters as models for adenoviral gene therapy. In particular, the models are directed to the examination of the ability of various replicative, non-replicative and conditionally-replicative adenovirus vectors to treat cancer.
摘要翻译：本发明涉及棉花大鼠和叙利亚仓鼠作为腺病毒基因治疗的模型的用途。特别地，这些模型旨在检查各种复制，非复制和有条件复制的腺病毒载体治疗癌症的能力。

9. 发明授权

US07744854B2 Method for optimizing cancer therapy by monitoring maturation of tumor associated vasculature by selenium 失效
标题翻译：通过监测硒的肿瘤相关脉管系统成熟来优化癌症治疗的方法
公开(公告)号：US07744854B2
公开(公告)日：2010-06-29
申请号：US11728075
申请日：2007-03-23
申请人： Youcef M. Rustum , Arup Bhattacharya , Karoly Toth , Harry K. Slocum , Rami G. Azrak , Sreenivasulu Chintala , Mukund Seshadri , Richard Mazurchuk
发明人： Youcef M. Rustum , Arup Bhattacharya , Karoly Toth , Harry K. Slocum , Rami G. Azrak , Sreenivasulu Chintala , Mukund Seshadri , Richard Mazurchuk
IPC分类号： A61B5/055 , A61K31/44 , A61K31/28 , A61K31/095 , A61K31/505 , A61K33/24 , A61K49/00 , A01N37/12 , A01N43/02
CPC分类号： A61K49/06 , A61K31/282 , A61K31/4375 , A61K31/513 , A61K31/66 , A61K33/24 , A61K45/06 , B24B49/003 , A61K2300/00
摘要： This invention provides a method for a method for optimizing the regimen for the administration of chemotherapeutic agents. The method comprises administration of a selenium compound to an individual, monitoring the modulation of tumor vessel maturation (TVM) to identify an optimal time for administration of a chemotherapeutic agent. This invention also provides a method to determine whether or not a tumor is likely to be a responder to chemotherapy. The method comprises administration of a selenium compound to an individual and determining whether or not an increase in TVM is observed. An increased TVM following administration of selenium is an indication that the tumor will likely respond the chemotherapy.
摘要翻译：本发明提供了一种优化用于施用化学治疗剂的方案的方法。该方法包括向个体施用硒化合物，监测肿瘤血管成熟的调节（TVM）以鉴定给予化疗剂的最佳时间。本发明还提供了确定肿瘤是否可能是化学疗法的反应者的方法。该方法包括向个体施用硒化合物，并确定是否观察到TVM的增加。施用硒后增加的TVM表明肿瘤可能对化疗有反应。

10. 发明授权

US07608255B2 Replication-competent anti-cancer vectors 有权
标题翻译：具有复制能力的抗癌载体
公开(公告)号：US07608255B2
公开(公告)日：2009-10-27
申请号：US11249873
申请日：2005-10-13
申请人： William S. M. Wold , Karoly Toth , Konstantin Doronin , Ann E. Tollefson
发明人： William S. M. Wold , Karoly Toth , Konstantin Doronin , Ann E. Tollefson
IPC分类号： A61K48/00 , C12N15/63 , C12N15/86 , C12Q1/70
CPC分类号： C12N7/00 , A61K35/761 , A61K48/00 , C07K14/005 , C12N15/86 , C12N2710/10322 , C12N2710/10332 , C12N2710/10343 , C12N2830/001 , C12N2830/008
摘要： Novel vectors which are replication competent in neoplastic cells and which overexpress an adenovirus death protein are disclosed. Some of the disclosed vectors are replication-restricted to neoplastic cells or to neoplastic alveolar type II cells. Compositions and methods for promoting the death of neoplastic cells using these replication-competent vectors are also disclosed.
摘要翻译：公开了在肿瘤细胞中具有复制能力并且过表达腺病毒死亡蛋白的新型载体。一些所公开的载体是复制限于肿瘤细胞或肿瘤性肺泡II型细胞。还公开了使用这些具有复制能力的载体促进肿瘤细胞死亡的组合物和方法。

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