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1. 发明授权

US07309568B2 Method in inspecting DNA and apparatus therefor 有权
标题翻译：检查DNA及其仪器的方法
公开(公告)号：US07309568B2
公开(公告)日：2007-12-18
申请号：US10229204
申请日：2002-08-26
申请人： Yoshitada Oshida , Satoshi Takahashi , Kenji Yasuda , Taisaku Seino
发明人： Yoshitada Oshida , Satoshi Takahashi , Kenji Yasuda , Taisaku Seino
IPC分类号： C12Q1/68 , C12M1/00 , B32B5/02 , G01N21/00
CPC分类号： G01N21/6428 , G01J3/4406 , G01N21/6452
摘要： A method and apparatus of stably obtaining fluorescent images of two or more fluorescent samples includes disposing the samples onto compartments defined on a substrate. The compartments are sequentially irradiated with an exciting light where the intensity varies. A value of fluorescence as generated from each of the samples is determined, and a fluorescent image is obtained based on the value of fluorescence.
摘要翻译：稳定地获得两个或多个荧光样品的荧光图像的方法和装置包括将样品设置在限定在基底上的隔室上。这些隔室用强度变化的激发光依次照射。确定从每个样品产生的荧光值，并且基于荧光值获得荧光图像。

2. 发明授权

US07400753B2 Biological sample optical measuring method and biological sample optical measuring apparatus 有权
标题翻译：生物样品光学测量方法和生物样品光学测量仪器
公开(公告)号：US07400753B2
公开(公告)日：2008-07-15
申请号：US10482614
申请日：2001-07-03
申请人： Taisaku Seino , Satoshi Takahashi , Kenji Yasuda , Yoshitada Oshida
发明人： Taisaku Seino , Satoshi Takahashi , Kenji Yasuda , Yoshitada Oshida
IPC分类号： G06K9/00
CPC分类号： G01N21/6456 , G01N15/1475 , G01N21/6428 , G01N21/76 , G01N2021/1734 , G01N2021/6439 , G01N2021/6491
摘要： A fluorescent or luminescence image of at least part of a biological sample is imaged, then a transmission light image of at least part of the biological sample is imaged, and thereafter the fluorescent or luminescence image and the transmission light image are overlaid such that the identical area of the sample is coincided to display. The present invention allows detecting the accurate location of fluorescence or luminescence in a given part of the biological sample.
摘要翻译：将生物样品的至少一部分的荧光或发光图像成像，然后对生物样品的至少一部分的透射光图像进行成像，然后将荧光或发光图像和透射光图像重叠，使得相同样品的面积一致显示。本发明允许检测生物样品的给定部分中的荧光或发光的准确位置。

3. 发明授权

US06760105B2 Method and apparatus for inspecting DNA and method for detecting fluorescence 有权
标题翻译：检测DNA的方法和装置及荧光检测方法
公开(公告)号：US06760105B2
公开(公告)日：2004-07-06
申请号：US10053976
申请日：2002-01-18
申请人： Yoshitada Oshida , Satoshi Takahashi , Taisaku Seino , Kenji Yasuda
发明人： Yoshitada Oshida , Satoshi Takahashi , Taisaku Seino , Kenji Yasuda
IPC分类号： G01N2164
CPC分类号： G01N21/6452 , G01N21/6428 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441
摘要： A DNA sample added with a plurality of fluorescent marks is irradiated with excitation lights having a plurality of wavelengths and when fluorescence intensities are detected separately, the excitation light and a position on the sample are relatively changed over a desired area once to thereby detect the plurality of fluorescent marks at high speed.
摘要翻译：用多个荧光标记添加的DNA样品用具有多个波长的激发光照射，并且当单独检测荧光强度时，激发光和样品上的位置在期望的区域上相对地改变一次，从而检测多个的荧光标记。

4. 发明授权

US07064813B2 Apparatus and method for measuring micro area in specimen 失效
标题翻译：用于测量样品中微区的装置和方法
公开(公告)号：US07064813B2
公开(公告)日：2006-06-20
申请号：US10253479
申请日：2002-09-25
申请人： Satoshi Takahashi , Kenji Yasuda , Yoshitada Oshida , Taisaku Seino
发明人： Satoshi Takahashi , Kenji Yasuda , Yoshitada Oshida , Taisaku Seino
IPC分类号： G01N21/00
CPC分类号： G01N1/312
摘要： Disclosed is an apparatus for measuring a micro area in a specimen in which a reagent necessary for observation and examination of a cell smear specimen or a tissue specimen is dropped to cause a reaction for a measurement and an analysis by way of an image. The apparatus includes: a micro reaction unit that is able to select a specific micro area in the specimen and to subject the specific micro area to a reaction-operation; a unit that measures; records and displays an image of the micro area; and a control unit that controls the measuring, recording, and displaying unit. Reactions can be effected quickly on such specimens as smear cell specimens and tissue slice specimens. The application of the reagent solution can be saved. A comparison between local presence of a gene or anti-body and a cell image can be made quickly and easily.
摘要翻译：公开了一种用于测量样本中的微小区域的装置，其中用于观察和检查细胞涂片或组织样本的试剂下降以引起测量反应和通过图像进行分析。该装置包括：微反应单元，其能够选择样品中的特定微区域并使特定微区域进行反应操作; 衡量单位记录并显示微区图像; 以及控制单元，其控制测量，记录和显示单元。反应可以在诸如涂片细胞标本和组织切片标本的样品上快速实现。可以节省试剂溶液的应用。基因或抗体的局部存在与细胞图像的比较可以快速且容易地进行。

5. 发明授权

US07217573B1 Method of inspecting a DNA chip 有权
标题翻译：检查DNA芯片的方法
公开(公告)号：US07217573B1
公开(公告)日：2007-05-15
申请号：US09678652
申请日：2000-10-04
申请人： Yoshitada Oshida , Toshihiko Nakata , Tomoaki Sakata , Kenji Yasuda , Satoshi Takahashi
发明人： Yoshitada Oshida , Toshihiko Nakata , Tomoaki Sakata , Kenji Yasuda , Satoshi Takahashi
IPC分类号： G01N33/00 , G01N33/53 , C12Q1/68 , C12M3/00 , C07H21/04 , H01J3/14
CPC分类号： G01N21/6428 , G01N21/6452 , G01N21/6456 , Y10S436/80 , Y10T436/143333
摘要： A method of inspecting a DNA chip and an apparatus therefor that allow a picture to be reconstructed in the following steps: A plurality of irradiation spots are formed on a DNA probe array mounted on a stage. Then, the stage is displaced in X, Y directions so as to execute a scanning, thereby irradiating substantially all the entire surface of the DNA probe array. Next, a plurality of emitted fluorescent lights, which are generated from the plurality of irradiation spot portions on the DNA probe array, are converged and are then detected simultaneously by multi detectors. Finally, a data processing apparatus processes the detected signals, thereby reconstructing the picture.
摘要翻译：一种用于检查DNA芯片的方法及其装置，其允许以下列步骤重建图像：在安装在平台上的DNA探针阵列上形成多个照射点。然后，在X，Y方向上移位台，以进行扫描，从而基本上照射DNA探针阵列的整个表面。接下来，从DNA探针阵列上的多个照射点部分产生的多个发射荧光灯被会聚，然后由多个检测器同时检测。最后，数据处理装置处理检测到的信号，从而重建图像。

6. 发明授权

US08361784B2 Method of inspecting a DNA chip and apparatus thereof 有权
标题翻译：检查DNA芯片的方法及其装置
公开(公告)号：US08361784B2
公开(公告)日：2013-01-29
申请号：US11709120
申请日：2007-02-22
申请人： Yoshitada Oshida , Toshihiko Nakata , Tomoaki Sakata , Kenji Yasuda , Satoshi Takahashi
发明人： Yoshitada Oshida , Toshihiko Nakata , Tomoaki Sakata , Kenji Yasuda , Satoshi Takahashi
IPC分类号： C12M1/34 , G01N21/64
CPC分类号： G01N21/6428 , G01N21/6452 , G01N21/6456 , Y10S436/80 , Y10T436/143333
摘要： A DNA inspecting apparatus including driving means for relatively changing positions of the multi-spot lights and a position of the DNA chip so as to detect the fluorescent lights in such a manner that a desired area on the DNA chip is irradiated with the multi-spot lights, and a control system for determining and inspecting DNA information about the to-be-inspected DNA chip from fluorescent light intensities and fluorescent light positions of the desired area on the DNA chip, the fluorescent light intensities and the fluorescent light positions being detected by the driving means and the fluorescent light detecting means.
摘要翻译：一种DNA检查装置，包括用于相对改变多点灯位置的驱动装置和DNA芯片的位置，以便以这样的方式检测荧光，使得DNA芯片上的期望区域被多点照射灯和用于从DNA芯片上的期望区域的荧光强度和荧光灯位置确定和检查关于待检查DNA芯片的DNA信息的控制系统，荧光强度和荧光灯位置由驱动装置和荧光检测装置。

7. 发明申请

US20070154938A1 Method of inspecting a DNA chip and apparatus thereof 有权
标题翻译：检查DNA芯片的方法及其装置
公开(公告)号：US20070154938A1
公开(公告)日：2007-07-05
申请号：US11709120
申请日：2007-02-22
申请人： Yoshitada Oshida , Toshihiko Nakata , Tomoaki Sakata , Kenji Yasuda , Satoshi Takahashi
发明人： Yoshitada Oshida , Toshihiko Nakata , Tomoaki Sakata , Kenji Yasuda , Satoshi Takahashi
IPC分类号： C12Q1/68 , G01J3/42
CPC分类号： G01N21/6428 , G01N21/6452 , G01N21/6456 , Y10S436/80 , Y10T436/143333
摘要： A DNA inspecting apparatus including driving means for relatively changing positions of the multi-spot lights and a position of the DNA chip so as to detect the fluorescent lights in such a manner that a desired area on the DNA chip is irradiated with the multi-spot lights, and a control system for determining and inspecting DNA information about the to-be-inspected DNA chip from fluorescent light intensities and fluorescent light positions of the desired area on the DNA chip, the fluorescent light intensities and the fluorescent light positions being detected by the driving means and the fluorescent light detecting means.
摘要翻译：一种DNA检查装置，包括用于相对改变多点灯位置的驱动装置和DNA芯片的位置，以便以这样的方式检测荧光，使得DNA芯片上的期望区域被多点照射灯和用于从DNA芯片上的期望区域的荧光强度和荧光灯位置确定和检查关于待检查DNA芯片的DNA信息的控制系统，荧光强度和荧光灯位置由驱动装置和荧光检测装置。

8. 发明授权

US07678576B2 Chemical analysis apparatus and chemical analysis cartridge 有权
标题翻译：化学分析装置和化学分析盒
公开(公告)号：US07678576B2
公开(公告)日：2010-03-16
申请号：US11319680
申请日：2005-12-29
申请人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Noriyo Nishijima , Naruo Watanabe , Michihiro Saito , Taisaku Seino , Satoshi Takahashi
发明人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Noriyo Nishijima , Naruo Watanabe , Michihiro Saito , Taisaku Seino , Satoshi Takahashi
IPC分类号： G01N35/00 , B01F15/02
CPC分类号： B01F11/0071 , B01F13/0059 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/1816 , B01L2400/0409 , B01L2400/0442 , B01L2400/0475 , G01N21/0332 , G01N21/07 , G01N21/645 , G01N2021/0325 , G01N2035/00148 , G01N2035/00495 , G01N2035/00534 , Y10T436/111666
摘要： The invention provides a chemical analysis apparatus which easily agitates and warms up. A chemical analysis apparatus has a motor, a retaining disc which can be rotated by the motor, a plurality of inspection cartridges which are arranged on the retaining disc, a punching machine for punching the inspection cartridges, a warming apparatus and a detection apparatus. The inspection cartridge includes a container formed by a concave portion and a base plate having a flow path. A cover covering the container and the flow path is installed to the base plate. A liquid solution is moved to the container in an outer peripheral side with respect to a rotation axis from the container in an inner peripheral side with respect to the rotation axis via the flow path, by utilizing a centrifugal force generated on the basis of the rotation of the retaining disc. The inspection cartridge is provided with an agitating means for agitating the liquid solution within the container and a warming means for warming up the liquid solution within the container.
摘要翻译：本发明提供一种容易搅动和加热的化学分析装置。化学分析装置具有电动机，可由电动机旋转的保持盘，设置在保持盘上的多个检查筒，冲压检查筒的冲孔机，加温装置和检测装置。检查筒包括由凹部形成的容器和具有流路的基板。覆盖容器和流路的盖子安装在基板上。通过利用基于旋转产生的离心力，液体溶液在相对于旋转轴线的旋转轴线的相对于旋转轴线的内周侧的外周侧经由流路被移动到容器的保持盘。检查筒设置有用于搅拌容器内的液体溶液的搅拌装置和用于预热容器内的液体溶液的加温装置。

9. 发明申请

US20060159586A1 Chemical analysis apparatus and chemical analysis cartridge 有权
标题翻译：化学分析仪和化学分析盒
公开(公告)号：US20060159586A1
公开(公告)日：2006-07-20
申请号：US11319680
申请日：2005-12-29
申请人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Noriyo Nishijima , Naruo Watanabe , Michihiro Saito , Taisaku Seino , Satoshi Takahashi
发明人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Noriyo Nishijima , Naruo Watanabe , Michihiro Saito , Taisaku Seino , Satoshi Takahashi
IPC分类号： G01N31/22
CPC分类号： B01F11/0071 , B01F13/0059 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/1816 , B01L2400/0409 , B01L2400/0442 , B01L2400/0475 , G01N21/0332 , G01N21/07 , G01N21/645 , G01N2021/0325 , G01N2035/00148 , G01N2035/00495 , G01N2035/00534 , Y10T436/111666
摘要： The invention provides a chemical analysis apparatus which easily agitates and warms up. A chemical analysis apparatus has a motor, a retaining disc which can be rotated by the motor, a plurality of inspection cartridges which are arranged on the retaining disc, a punching machine for punching the inspection cartridges, a warming apparatus and a detection apparatus. The inspection cartridge includes a container formed by a concave portion and a base plate having a flow path. A cover covering the container and the flow path is installed to the base plate. A liquid solution is moved to the container in an outer peripheral side with respect to a rotation axis from the container in an inner peripheral side with respect to the rotation axis via the flow path, by utilizing a centrifugal force generated on the basis of the rotation of the retaining disc. The inspection cartridge is provided with an agitating means for agitating the liquid solution within the container and a warming means for warming up the liquid solution within the container.
摘要翻译：本发明提供一种容易搅动和加热的化学分析装置。化学分析装置具有电动机，可由电动机旋转的保持盘，设置在保持盘上的多个检查筒，冲压检查筒的冲孔机，加温装置和检测装置。检查筒包括由凹部形成的容器和具有流路的基板。覆盖容器和流路的盖子安装在基板上。通过利用基于旋转产生的离心力，液体溶液在相对于旋转轴线的旋转轴线的相对于旋转轴线的内周侧的外周侧经由流路被移动到容器的保持盘。检查筒设置有用于搅拌容器内的液体溶液的搅拌装置和用于预热容器内的液体溶液的加温装置。

10. 发明授权

US5057438A Electrophoretic antigen-antibody determination with laminate of multiple membranes 失效
标题翻译：电泳抗原 - 抗体用多层膜叠层测定
公开(公告)号：US5057438A
公开(公告)日：1991-10-15
申请号：US31665
申请日：1987-03-30
申请人： Kazumichi Imai , Daizo Tokinaga , Teruaki Kobayashi , Kenji Yasuda , Keiichi Nagai , Satoshi Takahashi
发明人： Kazumichi Imai , Daizo Tokinaga , Teruaki Kobayashi , Kenji Yasuda , Keiichi Nagai , Satoshi Takahashi
IPC分类号： G01N33/561
CPC分类号： G01N33/561 , Y10S436/809 , Y10S436/824
摘要： Determination of a plurality of species of antibodies or antigens is attained by a method which comprises forming a plurality of different kinds of reaction membranes each having a different species of antibody or antigen on an electrophoretic carrier, superposing these reaction membranes, optionally superposing a filter on the laminate of reaction membranes, inserting the laminate in an electrolyte, adding a plurality of different species of antigens or antibodies corresponding to the plurality of species of antibodies or antigens supported in the aforementioned reaction membranes, electrophoretically moving the added antigens or antibodies through the electrolyte and enabling them to react with the antibodies or antigens supported on the reaction membranes, and measuring the concentrations of either the antigens or antibodies resulting from the reaction or the antibodies or antigens supported in an unreacted form on the reaction membranes.
摘要翻译：通过包括在电泳载体上形成多个不同种类的抗体或抗原的不同种类的反应膜，叠加这些反应膜，任选地将过滤器叠加在一起的方法来实现多种抗体或抗原的测定反应膜的层压体，将层压体插入电解质中，加入与上述反应膜中支持的多种抗体或抗原相对应的多种不同种类的抗原或抗体，通过电解质电泳移动加入的抗原或抗体并使其能够与支持在反应膜上的抗体或抗原反应，并测量由反应产生的抗原或抗体的浓度，或反应膜上以未反应形式负载的抗体或抗原的浓度。

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