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1. 发明授权

US4579941A Thermally-denatured deoxyribonucleic acid MD-011 and antitumor agent 失效
标题翻译：热变性脱氧核糖核酸MD-011和抗肿瘤剂
公开(公告)号：US4579941A
公开(公告)日：1986-04-01
申请号：US407802
申请日：1982-08-13
申请人： Yoshio Furutani , Hiroshi Yamamoto , Tamotsu Fukuda , Shizuo Shimada , Osamu Yano
发明人： Yoshio Furutani , Hiroshi Yamamoto , Tamotsu Fukuda , Shizuo Shimada , Osamu Yano
IPC分类号： C07H21/00 , C07H15/12 , C07H17/00
CPC分类号： C07H21/00
摘要： Thermally-denatured DNA MD-011 having an antitumor activity was obtained by heating the substance separated from the disrupted cells of bacteria belonging to genus Mycobacterium.
摘要翻译：通过加热从分枝杆菌属细菌的破碎细胞分离的物质获得具有抗肿瘤活性的热变性DNA MD-011。

2. 发明授权

US4702910A Common antigen (PSC-A) to Pseudomonas aeruginosa which acts as an agent for pretecting Pseudomonas aeruginosa infection 失效
标题翻译：作为预防铜绿假单胞菌感染的药剂的普通抗原（PSC-A）与铜绿假单胞菌
公开(公告)号：US4702910A
公开(公告)日：1987-10-27
申请号：US797796
申请日：1985-11-14
申请人： Tamotsu Fukuda , Shiro Shigeta , Hiroaki Okuya , Yasuyuki Kuroiwa , Tadashi Sudo
发明人： Tamotsu Fukuda , Shiro Shigeta , Hiroaki Okuya , Yasuyuki Kuroiwa , Tadashi Sudo
IPC分类号： G01N33/569 , A61K38/00 , A61K39/00 , A61K39/104 , A61K39/395 , C07K14/005 , C07K14/195 , C07K14/21 , C07K14/41 , C07K16/00 , C07K16/12 , C07K19/00 , C12N15/00 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/385 , C12R1/91 , G01N33/577 , C07K15/04
CPC分类号： C07K16/1214 , C07K14/21 , A61K38/00 , A61K39/00 , Y10S530/825
摘要： PSC-A is a new serological common antigen to Pseudomonas aeruginosa having very low toxicity, and highly effective for protecting infection by any of the serotypes of Pseudomonas aeruginosa. PSC-A can be used as the active component in a pharmaceutical agent for protecting Pseudonomas aeruginosa infection.
摘要翻译： PSC-A是铜绿假单胞菌的新型血清学常见抗原，毒性非常低，对于保护铜绿假单胞菌血清型的感染非常有效。 PSC-A可用作用于保护铜绿假单胞菌感染的药剂中的活性成分。

3. 发明授权

US4164914A Air-fuel ratio controlling apparatus for an internal combustion engine 失效
标题翻译：用于内燃机的空燃比控制装置
公开(公告)号：US4164914A
公开(公告)日：1979-08-21
申请号：US783429
申请日：1977-03-31
申请人： Tadashi Hattori , Akira Takata , Tamotsu Fukuda , Takamichi Nakase
发明人： Tadashi Hattori , Akira Takata , Tamotsu Fukuda , Takamichi Nakase
IPC分类号： F02D35/00 , F02M23/04 , F02M7/00
CPC分类号： F02M23/04 , F02D35/003 , Y02T10/146
摘要： An apparatus for controlling the air-fuel ratio of an air-fuel mixture to be supplied into a combustion chamber of an internal combustion engine comprises a passage bypassing a carburetor and a throttle valve of the engine for supplying an additional air into the engine intake duct downstream of the throttle valve to dilute the air-fuel mixture to an air-fuel ratio most suited for the engine operation. An air valve is provided in the bypass passage to vary the air-flow cross-sectional area of the passage. The opening of the air valve is controlled mainly in accordance with the air-fuel ratio of the mixture as detected by an air-fuel ratio detector in the path of flow of engine exhaust gases. A variable orifice is provided in the bypass passage downstream of the air valve and defined by a valve seat and a needle valve operatively associated therewith to vary the opening area of the orifice. The needle valve is actuated by a pneumatic valve actuator which is responsive to variations in the engine manifold vacuum. The arrangement is such that the pressure difference across the air valve is kept substantially constant whereby the supply of the additional air is substantially in proportion to the engine intake air and free from influence by the engine manifold vacuum.
摘要翻译：用于控制供给到内燃机的燃烧室中的空气燃料混合物的空燃比的装置包括绕过化油器的通道和用于向发动机进气管道中供应附加空气的发动机的节气门在节流阀的下游，将空气 - 燃料混合物稀释到最适合发动机运转的空燃比。在旁通通道中设置有空气阀，以改变通道的气流横截面积。主要由发动机废气流动路径中的空燃比检测器检测出的混合气的空燃比主要控制空气阀的开度。在空气阀下游的旁通通道中设置可变孔口，并由阀座和与其可操作地相关联的针阀限定，以改变孔口的开口面积。针阀由气动阀致动器致动，该致动器响应发动机歧管真空度的变化。这种布置使得跨越空气阀的压力差保持基本恒定，由此附加空气的供应基本上与发动机进气成正比并且不受发动机歧管真空的影响。

4. 发明授权

US5908826A Freeze-dried preparation containing monoclonal antibody 失效
标题翻译：含有单克隆抗体的冻干制剂
公开(公告)号：US5908826A
公开(公告)日：1999-06-01
申请号：US340319
申请日：1994-11-14
申请人： Tamotsu Fukuda , Yukio Shimazaki , Yasuyuki Kuroiwa , Shiro Takagi
发明人： Tamotsu Fukuda , Yukio Shimazaki , Yasuyuki Kuroiwa , Shiro Takagi
IPC分类号： A61K9/14 , A61K38/00 , A61K39/00 , A61K39/395 , A61K47/12 , A61K47/42 , C07K16/00 , C07K16/12
CPC分类号： A61K39/39591 , C07K16/00 , C07K16/1214 , A61K38/00 , C07K2317/21
摘要： A freeze-dried monoclonal antibody preparation is prepared by adding to a solution of the monoclonal antibody gelatin or carboxylic acid or its salt, to prevent denaturation of the monoclonal antibodies during freeze-drying. Freeze-dried monoclonal antibody preparations having stablized antigen-binding activity result and may be used as an adminiculum for immunoauxotherapy for prophylaxis and treatment of bacterial infectious diseases and viral infectious diseases.
摘要翻译：通过加入单克隆抗体明胶或羧酸或其盐的溶液来制备冷冻干燥的单克隆抗体制剂，以防止在冷冻干燥期间单克隆抗体的变性。产生具有稳定的抗原结合活性的冻干单克隆抗体制剂，可用作免疫治疗用于预防和治疗细菌感染性疾病和病毒感染性疾病的用途。

5. 发明授权

US4192268A Air flow amount adjusting system for an internal combustion engine 失效
标题翻译：用于内燃机的空气流量调节系统
公开(公告)号：US4192268A
公开(公告)日：1980-03-11
申请号：US30953
申请日：1979-04-17
申请人： Tadashi Hattori , Akira Takata , Tamotsu Fukuda , Takamichi Nakase
发明人： Tadashi Hattori , Akira Takata , Tamotsu Fukuda , Takamichi Nakase
IPC分类号： F02B1/04 , F02D41/14 , F02M23/04 , F02D1/04
CPC分类号： F02D41/1481 , F02M23/04 , F02B1/04 , Y02T10/146
摘要： An air flow amount adjusting system produces an air-fuel mixture of a desirable air-fuel ratio by controlling the direction of movement of a bypass valve mounted in an additional air supply pipe adapted to supply additional air into either the intake system or exhaust system of an internal combustion engine in accordance with an output signal produced from a gas sensor mounted in the exhaust system of the engine and indicative of the air-fuel ratio of the mixture supplied to the engine. A two-level mode signal whose threshold corresponds to the desired air-fuel ratio is produced in accordance with the output signal of the gas detector. After the two-level mode signal has changed from one level to the other level, the movement of the bypass valve is stopped for a certain period of time. If desired, the stopping period of the bypass valve may be changed in accordance with the temperature of the engine.
摘要翻译：空气流量调节系统通过控制安装在附加空气供应管中的旁通阀的运动方向来产生期望空燃比的空气 - 燃料混合物，该附加空气供应管适于将额外空气供应到进气系统或排气系统根据从安装在发动机的排气系统中的气体传感器产生的输出信号的内燃机，其指示供应给发动机的混合物的空燃比。根据气体检测器的输出信号产生阈值对应于所需空燃比的两电平模式信号。在双电平模式信号从一个电平变化到另一个电平之后，旁路阀的运动停止一段时间。如果需要，可以根据发动机的温度来改变旁通阀的停止时段。

6. 发明授权

US4140093A Air-fuel ratio controlling system 失效
标题翻译：空燃比控制系统
公开(公告)号：US4140093A
公开(公告)日：1979-02-20
申请号：US792768
申请日：1977-05-02
申请人： Tadashi Hattori , Akira Takata , Tamotsu Fukuda , Takamichi Nakase , Toyota Jidosha Kogyo Kabushiki Kaisha
发明人： Tadashi Hattori , Akira Takata , Tamotsu Fukuda , Takamichi Nakase , Toyota Jidosha Kogyo Kabushiki Kaisha
IPC分类号： F02B1/04 , F02D41/14 , F02D1/04 , F02B15/00 , F02D33/00 , F02D35/00
CPC分类号： F02D41/1482 , F02B1/04
摘要： An air-fuel ratio controlling system for an internal combustion engine including a control circuit for controlling, in accordance with a detected air-fuel ratio, the operation of a drive motor of a control valve mounted in an additional air supply passage. The control circuit includes a timing pulse generator for generating timing pulses synchronized with a running speed of the engine and thus the control valve is intermittently rotated by a predetermined amount in response to the timing pulses. By increasing the frequency of the timing pulses during the periods of rapid acceleration and deceleration, a response to the change in the engine speed is further improved.
摘要翻译：一种用于内燃机的空燃比控制系统，包括控制电路，该控制电路根据检测到的空燃比控制安装在附加空气供应通道中的控制阀的驱动电动机的操作。控制电路包括定时脉冲发生器，用于产生与发动机的运行速度同步的定时脉冲，因此控制阀响应于定时脉冲间歇地旋转预定量。通过在快速加速和减速期间增加定时脉冲的频率，进一步提高对发动机转速变化的响应。

7. 发明授权

US4106451A Air-fuel ratio adjusting system for internal combustion engines 失效
标题翻译：内燃机空燃比调整系统
公开(公告)号：US4106451A
公开(公告)日：1978-08-15
申请号：US782748
申请日：1977-03-30
申请人： Tadashi Hattori , Akira Takata , Tamotsu Fukuda , Takamichi Nakase
发明人： Tadashi Hattori , Akira Takata , Tamotsu Fukuda , Takamichi Nakase
IPC分类号： F02D41/14 , F02B75/10 , F02B3/00 , F02M7/00
CPC分类号： F02D41/1482
摘要： An air-fuel ratio adjusting system controls the amount of additional air supply through the bypass passage of the carburetor to ensure optimum engine operation even in a warming up condition of the engine. The air-fuel ratio adjusting system includes an air-fuel ratio sensor disposed in the exhaust manifold, a warm-up sensor for detecting the temperature of engine cooling water or engine block, and a control unit for providing a control signal to a driving motor for the bypass valve. The bypass valve is controlled so that the air-fuel ratio of the mixture becomes the stoichiometric one and at the same time, during the warming up condition, the maximum opening of the bypass valve is limited to a predetermined degree depending on the temperature of the engine.
摘要翻译：空燃比调节系统控制通过化油器的旁通通道的附加空气供给量，以确保即使在发动机的预热状态下发动机的最佳运转。空燃比调节系统包括设置在排气歧管中的空燃比传感器，用于检测发动机冷却水或发动机缸体的温度的预热传感器，以及用于向驱动电动机提供控制信号的控制单元用于旁通阀。控制旁通阀使得混合物的空燃比变为化学计量比，同时在升温状态下，旁通阀的最大开度根据温度的不同而被限制在预定的程度发动机。

8. 发明授权

US5521085A Transformed cell lines producing human monoclonal antibodies specific for Pseudomonas aeruginosa serotypes 失效
标题翻译：产生对铜绿假单胞菌血清型特异性的人单克隆抗体的转化细胞系
公开(公告)号：US5521085A
公开(公告)日：1996-05-28
申请号：US41244
申请日：1993-04-01
申请人： Tamotsu Fukuda , Yasushi Ono , Shiro Shigeta , Yasuyuki Kuriowa , Hisayoshi Ooka
发明人： Tamotsu Fukuda , Yasushi Ono , Shiro Shigeta , Yasuyuki Kuriowa , Hisayoshi Ooka
IPC分类号： A61K38/00 , C07K16/12 , C12N5/16 , C12N5/10 , C07K16/18
CPC分类号： C07K16/1214 , C12N5/163 , A61K38/00
摘要： The present invention relates to human monoclonal antibodies capable of plurally binding with O-antigens of Pseudomonas aeruginosa, relates to novel parent cell lines for producing human hybridomas derived from human immunoglobulin synthesizing cells, which cell lines themselves incapable of producing human immunoglobulin and capable of fusing with human antibody-producing cells, relates to human-human hybridomas which can secrete monoclonal antibodies capable of binding with at least one of serotypes of Pseudomonas aeruginosa, relates to pharmaceutical compositions for prophylaxis or therapy of Pseudomonas aeruginosa infectious diseases, and relates to prophylactic or therapeutic methods for Pseudomonas aeruginosa infectious diseases.
摘要翻译：本发明涉及能够多次与铜绿假单胞菌的O-抗原结合的人单克隆抗体，涉及用于产生源自人免疫球蛋白合成细胞的人杂交瘤的新型亲本细胞系，该细胞系本身不能产生人免疫球蛋白并能够融合涉及可以分泌能够与铜绿假单胞菌的至少一种血清型结合的单克隆抗体的人 - 人杂交瘤，涉及用于预防或治疗铜绿假单胞菌感染性疾病的药物组合物，涉及预防或铜绿假单胞菌感染性疾病的治疗方法。

9. 发明授权

US4608827A Cooling system of an internal combustion engine having a turbo-charger 失效
标题翻译：具有涡轮增压器的内燃机的冷却系统
公开(公告)号：US4608827A
公开(公告)日：1986-09-02
申请号：US719552
申请日：1985-04-03
申请人： Mitsuru Hasegawa , Tamotsu Fukuda
发明人： Mitsuru Hasegawa , Tamotsu Fukuda
IPC分类号： F01P3/12 , F01P3/20 , F01P11/02 , F02B39/00 , F02C6/12 , F02B33/44
CPC分类号： F02C6/12 , F01P11/02 , F01P3/12 , F01P3/20 , F02B39/005 , F01P11/029 , F01P2060/12
摘要： A water jacket in the turbo-charger is positioned at the same level or higher than a water jacket in an engine cylinder head. The turbo-charger cooling water circulation passageway includes a water volume or tank positioned at a level higher than the turbo-charger cooling portion, and the volume or tank is connected to a cooling water reservoir tank via a pressure relief valve which is opened when pressure in the volume or tank exceeds a predetermined value to supply cooling water to the volume or tank.
摘要翻译：涡轮增压器中的水套位于与发动机气缸盖中的水套相同的高度或更高的位置。涡轮增压器冷却水循环通道包括位于高于涡轮增压器冷却部分的水位的水量或罐，并且容积或罐通过压力安全阀连接到冷却水储存罐，压力释放阀在压力在容积或容器中超过预定值以将冷却水供应到容积或罐中。

10. 发明授权

US4327685A Air-fuel intake system for internal combustion engines 失效
标题翻译：内燃机空燃系统
公开(公告)号：US4327685A
公开(公告)日：1982-05-04
申请号：US102899
申请日：1979-12-12
申请人： Kenichi Akutagawa , Hitoshi Yoshida , Tadashi Hattori , Akira Takata , Tamotsu Fukuda
发明人： Kenichi Akutagawa , Hitoshi Yoshida , Tadashi Hattori , Akira Takata , Tamotsu Fukuda
IPC分类号： C22F1/043 , C22C21/00 , C22F1/00 , F02M9/127 , F02M69/04 , F02M69/46 , F02D9/12
CPC分类号： F02M69/46 , F02M69/043 , F02M9/127
摘要： An intake system for internal combustion engines comprises a throttling system mounted in an intake pipe between a fuel injection valve and an intake manifold, the throttling system including a stationary valve body fixed in the intake pipe in opposed relation with the injection valve and a hollow valve body mounted in the intake pipe for movement in the axial direction of the intake pipe. The hollow valve body has a downwardly converged inner wall surface surrounding the stationary valve body to define therebetween valve opening of variable opening area. The stationary valve body includes a frusto-conical portion and a cylindrical portion, of which lower edge is in the form of sinusoidal wave to cooperate with the hollow valve body in producing the valve opening of gradually increasing opening area.
摘要翻译：用于内燃机的进气系统包括安装在燃料喷射阀和进气歧管之间的进气管中的节流系统，所述节流系统包括固定在进气管中的与喷射阀相对的静止阀体和中空阀主体安装在进气管中，用于沿进气管的轴向移动。中空阀体具有围绕固定阀体的向下收敛的内壁表面，以在其间限定可变开口面积的阀开口。固定阀体包括截头圆锥形部分和圆柱形部分，其下边缘为正弦波形状，以与中空阀体协作以产生逐渐增加的开口面积的阀门开口。

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