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1. 发明申请

US20080090863A1 Pyridine Derivatives and Their Use as Medicaments for Treating Diseases Related to Mch Receptor 审中-公开
标题翻译：吡啶衍生物及其用作治疗与Mch受体相关疾病的药物
公开(公告)号：US20080090863A1
公开(公告)日：2008-04-17
申请号：US11664392
申请日：2005-09-27
申请人： Yoshinori Sekiguchi , Kosuke Kanuma , Katsunori Omodera , Kumi Sato , Masato Hayashi , Shuji Yamamoto
发明人： Yoshinori Sekiguchi , Kosuke Kanuma , Katsunori Omodera , Kumi Sato , Masato Hayashi , Shuji Yamamoto
IPC分类号： A61K31/44 , A61K31/4439 , A61K31/47 , A61P25/00 , A61P3/04 , A61P9/00 , C07D213/75 , C07D215/00 , C07D401/08 , C07D413/08
CPC分类号： C07D213/74 , C07D213/75 , C07D215/38 , C07D221/04 , C07D401/04
摘要： The present invention encompasses novel substituted pyridine compounds of Formula (I): which act as MCH receptor antagonists. These compositions and pharmaceutical compositions thereof are useful in the prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson's disease, epilepsy, and addiction.
摘要翻译：本发明包括式（I）的新型取代的吡啶化合物：其作为MCH受体拮抗剂。这些组合物及其药物组合物可用于预防或治疗改善记忆功能，睡眠和觉醒，焦虑，抑郁，情绪障碍，癫痫发作，肥胖，糖尿病，食欲和进食障碍，心血管疾病，高血压，血脂异常，心肌梗死，包括贪食症，厌食症，包括躁狂抑郁症，精神分裂症，del妄，痴呆，压力，认知障碍，注意力缺陷障碍，药物滥用障碍和包括帕金森氏病，癫痫和成瘾在内的运动障碍的暴饮暴食症。

2. 发明申请

US20100081825A1 1-NAPHTHYL ALKYLPIPERIDINE DERIVATIVE 审中-公开
公开(公告)号：US20100081825A1
公开(公告)日：2010-04-01
申请号：US12444275
申请日：2007-10-05
申请人： Yoshinori Sekiguchi , Kosuke Kanuma , Kazunari Sakagami , Masato Hayashi , Shuhei Kashiwa , Katsunori Omodera
发明人： Yoshinori Sekiguchi , Kosuke Kanuma , Kazunari Sakagami , Masato Hayashi , Shuhei Kashiwa , Katsunori Omodera
IPC分类号： C07D211/58 , C07D401/10
CPC分类号： C07D405/12 , C07D211/58 , C07D401/10 , C07D401/12 , C07D405/10 , C07D409/12
摘要： Disclosed is a pharmaceutical composition comprising a compound represented by the formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient, which has an antagonistic activity on a melanin-concentrating hormone receptor. The pharmaceutical composition is useful, due to its antagonistic activity on a MCH receptor, for the prevention or treatment of a disease such as depression, anxiety disorders (e.g., generalized anxiety disorder, post traumatic stress disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder), attention deficit disorder, mania, manic-depressive disorder, schizophrenia, mood disorders, stress, sleep disorder, attacks, memory impairment, cognitive impairment, dementia, amnesia, delirium, obesity, eating disorder, appetite disorder, hyperphagia, bulimia, cibophobia, diabetes, a cardiovascular diseases, hypertension, dyslipidemia, cardiac infarction, movement disorder (e.g., Parkinson's disease, epilepsy, convulsion, tremor), drug abuse and drug addiction.
摘要翻译：公开了一种药物组合物，其包含式（I）表示的化合物或其药学上可接受的盐作为活性成分，其对黑色素浓缩激素受体具有拮抗作用。由于其对MCH受体的拮抗活性，药物组合物可用于预防或治疗诸如抑郁症，焦虑症（例如广泛性焦虑症，创伤后应激障碍，恐慌症，强迫症，社会焦虑障碍），注意力缺陷障碍，躁狂症，躁狂抑郁障碍，精神分裂症，情绪障碍，压力，睡眠障碍，发作，记忆障碍，认知障碍，痴呆，遗忘症，del妄，肥胖，进食障碍，食欲障碍，糖尿病，心血管疾病，高血压，血脂异常，心肌梗死，运动障碍（如帕金森病，癫痫，惊厥，震颤），药物滥用和药物成瘾。

3. 发明申请

US20080318923A1 1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle 有权
标题翻译： 1,3-二氢-2H-吲哚-2-酮化合物和吡咯烷-2-酮化合物与芳香族杂环
公开(公告)号：US20080318923A1
公开(公告)日：2008-12-25
申请号：US11883236
申请日：2006-01-30
申请人： Yoshinori Sekiguchi , Takeshi Kuwada , Masato Hayashi , Dai Nozawa , Yuri Amada , Tsuyoshi Shibata , Shuji Yamamoto , Hiroshi Ohta , Taketoshi Okubo , Takeshi Koami
发明人： Yoshinori Sekiguchi , Takeshi Kuwada , Masato Hayashi , Dai Nozawa , Yuri Amada , Tsuyoshi Shibata , Shuji Yamamoto , Hiroshi Ohta , Taketoshi Okubo , Takeshi Koami
IPC分类号： A61K31/397 , C07D209/04 , C07D401/02 , C07D213/02 , C07D217/00 , C07D413/02 , C07D403/14 , C07D241/02 , C07D471/02 , A61P25/00 , C07C317/14 , A61K31/437 , A61K31/501 , A61K31/496 , A61K31/5377 , A61K31/4725 , A61K31/4545 , A61K31/454 , A61K31/404
CPC分类号： C07D401/12 , C07C309/87 , C07D209/38 , C07D209/40 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/04 , C07D417/12
摘要： It is intended to provide a drug which is efficacious against pathological conditions relating to arginine-vasopressin V1b receptor. More particularly speaking, it is intended to provide a drug which has a therapeutic or preventive effect on depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorders, hypertension, digestive diseases, drug addiction, epilepsy, brain infarction, brain ischemia, brain edema, head injury, inflammation, immune diseases, alopecia and so on. As the results of intensive studies, a novel 1,3-dihydro-2H-indol-2-one compound and a pyrrolidin-2-one compound fused with a heteroaromatic ring, which are highly selective antagonists of arginine-vasopressin V1b receptor, have high metabolic stabilities and show favorable brain penetration and high plasma concentrations, are found, thereby achieving the above objective.
摘要翻译：旨在提供对精氨酸 - 加压素V1b受体有关的病理状况有效的药物。更具体地说，它旨在提供一种对抑郁，焦虑，阿尔茨海默病，帕金森病，亨廷顿氏舞蹈病，进食障碍，高血压，消化系统疾病，药物成瘾，癫痫，脑梗死，脑缺血具有治疗或预防作用的药物，脑水肿，头部损伤，炎症，免疫疾病，脱发等。作为深入研究的结果，作为精氨酸 - 加压素V1b受体的高度选择性拮抗剂的与杂芳环稠合的新的1,3-二氢-2H-吲哚-2-酮化合物和吡咯烷-2-酮化合物具有发现高代谢稳定性并显示有利的脑渗透和高血浆浓度，从而达到上述目的。

4. 发明授权

US08030499B2 1,3-dihydro-2H-indole-2-one compound and pyrrolidine-2-one compound fused with aromatic heterocycle 有权
标题翻译： 1,3-二氢-2H-吲哚-2-酮化合物和与芳族杂环稠合的吡咯烷-2-酮化合物
公开(公告)号：US08030499B2
公开(公告)日：2011-10-04
申请号：US11883236
申请日：2006-01-30
申请人： Yoshinori Sekiguchi , Takeshi Kuwada , Masato Hayashi , Dai Nozawa , Yuri Amada , Tsuyoshi Shibata , Shuji Yamamoto , Hiroshi Ohta , Taketoshi Okubo , Takeshi Koami
发明人： Yoshinori Sekiguchi , Takeshi Kuwada , Masato Hayashi , Dai Nozawa , Yuri Amada , Tsuyoshi Shibata , Shuji Yamamoto , Hiroshi Ohta , Taketoshi Okubo , Takeshi Koami
IPC分类号： C07D209/04 , A61K31/404
CPC分类号： C07D401/12 , C07C309/87 , C07D209/38 , C07D209/40 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/04 , C07D417/12
摘要： It is intended to provide a drug which is efficacious against pathological conditions relating to arginine-vasopressin V1b receptor. More particularly speaking, it is intended to provide a drug which has a therapeutic or preventive effect on depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorders, hypertension, digestive diseases, drug addiction, epilepsy, brain infarction, brain ischemia, brain edema, head injury, inflammation, immune diseases, alopecia and so on. As the results of intensive studies, a novel 1,3-dihydro-2H-indol-2-one compound and a pyrrolidin-2-one compound fused with a heteroaromatic ring, which are highly selective antagonists of arginine-vasopressin V1b receptor, have high metabolic stabilities and show favorable brain penetration and high plasma concentrations, are found, thereby achieving the above objective.
摘要翻译：旨在提供对精氨酸 - 加压素V1b受体有关的病理状况有效的药物。更具体地说，它旨在提供一种对抑郁，焦虑，阿尔茨海默病，帕金森病，亨廷顿氏舞蹈病，进食障碍，高血压，消化系统疾病，药物成瘾，癫痫，脑梗死，脑缺血具有治疗或预防作用的药物，脑水肿，头部损伤，炎症，免疫疾病，脱发等。作为深入研究的结果，作为精氨酸 - 加压素V1b受体的高度选择性拮抗剂的与杂芳环稠合的新的1,3-二氢-2H-吲哚-2-酮化合物和吡咯烷-2-酮化合物具有发现高代谢稳定性并显示有利的脑渗透和高血浆浓度，从而实现上述目的。

5. 发明授权

US07528124B2 1,3-dihydro-2H-indol-2-one derivative 失效
标题翻译： 1,3-二氢-2H-吲哚-2-酮衍生物
公开(公告)号：US07528124B2
公开(公告)日：2009-05-05
申请号：US10569833
申请日：2004-08-27
申请人： Toshihito Kumagai , Takeshi Kuwada , Tsuyoshi Shibata , Masato Hayashi , Yuri Fujisawa , Yoshinori Sekiguchi
发明人： Toshihito Kumagai , Takeshi Kuwada , Tsuyoshi Shibata , Masato Hayashi , Yuri Fujisawa , Yoshinori Sekiguchi
IPC分类号： A61K31/404 , C07D209/04 , C07D403/04
CPC分类号： C07D403/04
摘要： A 1,3-dihydro-2H-indol-2-one derivative expressed by Formula 1 (wherein R1 is a halogen atom, a C1 to C4 alkyl group, etc., and R2 is a hydrogen atom, a halogen atom, etc., or R2 is in the 6-position of the indol-2-one and R1 and R2 join together to form a C3 to C6 alkylene group, R3 is a halogen atom, a hydroxyl group, etc., and R4 is a hydrogen atom, a halogen atom, a C1 to C4 alkyl group, etc., or R4 is in the 3-position of the phenyl and R3 and R4 join together to form a methylenedioxy group, R5 is a hydrogen atom or a fluorine atom, R6 is an ethylamino group, a dimethylamino group, etc., R7 is a C1 to C4 alkoxy group, and R8 is a C1 to C4 alkoxy group), or a pharmaceutically acceptable salt of this derivative. This is a novel compound that has antagonistic activity against an aruginine-vasopressin V1b receptor.
摘要翻译：由式1表示的1,3-二氢-2H-吲哚-2-酮衍生物（其中，R 1为卤素原子，C 1〜C 4烷基等，R 2为氢原子，卤素原子等），或R2为吲哚-2-酮的6-位，R 1和R 2连接在一起形成C 3〜C 6亚烷基，R 3为卤素原子，羟基等，R 4为氢原子卤素原子，C 1〜C 4烷基等，或者R 4在苯基的3-位，R3和R4连接在一起形成亚甲二氧基，R5是氢原子或氟原子，R6是乙基氨基，二甲基氨基等，R7为C1〜C4烷氧基，R8为C1〜C4烷氧基）或该衍生物的药学上可接受的盐。这是一种新的化合物，具有对抗葡萄糖酸加压素V1b受体的拮抗作用。

6. 发明申请

US20060276449A1 1,3-Dihydro-2h-indol-2-one derivative 失效
标题翻译： 1,3-二氢-2H-吲哚-2-酮衍生物
公开(公告)号：US20060276449A1
公开(公告)日：2006-12-07
申请号：US10569833
申请日：2004-08-27
申请人： Toshihito Kumagai , Takeshi Kuwada , Tsuyoshi Shibata , Masato Hayashi , Yuri Fujisawa , Yoshinori Sekiguchi
发明人： Toshihito Kumagai , Takeshi Kuwada , Tsuyoshi Shibata , Masato Hayashi , Yuri Fujisawa , Yoshinori Sekiguchi
IPC分类号： A61K31/404 , C07D403/14 , C07D403/04
CPC分类号： C07D403/04
摘要： A 1,3-dihydro-2H-indol-2-one derivative expressed by Formula 1 (wherein R1 is a halogen atom, a C1 to C4 alkyl group, etc., and R2 is a hydrogen atom, a halogen atom, etc., or R2 is in the 6-position of the indol-2-one and R1 and R2 join together to form a C3 to C6 alkylene group, R3 is a halogen atom, a hydroxyl group, etc., and R4 is a hydrogen atom, a halogen atom, a C1 to C4 alkyl group, etc., or R4 is in the 3-position of the phenyl and R3 and R4 join together to form a methylenedioxy group, R5 is a hydrogen atom or a fluorine atom, R6 is an ethylamino group, a dimethylamino group, etc., R7 is a C1 to C4 alkoxy group, and R8 is a C1 to C4 alkoxy group), or a pharmaceutically acceptable salt of this derivative. This is a novel compound that has antagonistic activity against an aruginine-vasopressin V1b receptor.
摘要翻译：由式1表示的1,3-二氢-2H-吲哚-2-酮衍生物（其中R 1是卤素原子，C 1至C 1烷基， 4个烷基等，R 2是氢原子，卤原子等，或R 2 2位在6位的吲哚-2-酮和R 1和R 2连接在一起以形成C 6 -C 6亚烷基，亚烷基，R 3是卤素原子，羟基等，R 4是氢原子，卤原子，C 1， / SUB→C 4烷基等，或R 4在苯基的3位和R 3和R 3 连接在一起形成亚甲二氧基，R 5是氢原子或氟原子，R 6是乙氨基，二甲基氨基基团等，R 7是C 1-4烷氧基的C 1至C 8，并且R 8是 C 1至C 4烷氧基），或该衍生物的药学上可接受的盐。这是一种新的化合物，具有对抗葡萄糖酸加压素V1b受体的拮抗作用。

7. 发明申请

US20120010414A1 GLYCINE TRANSPORTER INHIBITING SUBSTANCES 失效
标题翻译：糖果运输保护物质
公开(公告)号：US20120010414A1
公开(公告)日：2012-01-12
申请号：US13257258
申请日：2010-03-19
申请人： Akito Yasuhara , Shuji Yamamoto , Hiroshi Ohta , Yoshihisa Shirasaki , Kazunari Sakagami , Masato Hayashi , Tsuyoshi Shibata , Youichi Shimazaki , Yuko Araki , Kumi Abe , Xiang-Min Sun
发明人： Akito Yasuhara , Shuji Yamamoto , Hiroshi Ohta , Yoshihisa Shirasaki , Kazunari Sakagami , Masato Hayashi , Tsuyoshi Shibata , Youichi Shimazaki , Yuko Araki , Kumi Abe , Xiang-Min Sun
IPC分类号： C07D471/04 , C07D405/12 , C07D409/12 , C07D405/14
CPC分类号： C07D471/04 , C07D405/12 , C07D405/14 , C07D409/12
摘要： The present invention aims to provide novel compounds of formula [I] or pharmaceutically acceptable salts thereof that are based on a glycine uptake inhibiting action and which are useful in the prevention or treatment of such diseases as schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsory disorder, social anxiety disorder, posttraumatic stress disorder, specific phobia, acute stress disorder, etc.), depression, drug addiction, spasm, tremor, and sleep disorder:
摘要翻译：本发明旨在提供基于甘氨酸摄取抑制作用的新颖的式[I]化合物或其药学上可接受的盐，其可用于预防或治疗精神分裂症，阿尔茨海默病，认知功能障碍，痴呆，焦虑症（广泛性焦虑障碍，恐慌症，强迫症，社会焦虑症，创伤后应激障碍，特定恐惧症，急性应激障碍等），抑郁症，药物成瘾，痉挛，震颤和睡眠障碍：

8. 发明授权

US08623898B2 Glycine transporter inhibiting substances 失效
标题翻译：甘氨酸转运蛋白抑制物质
公开(公告)号：US08623898B2
公开(公告)日：2014-01-07
申请号：US13257258
申请日：2010-03-19
申请人： Akito Yasuhara , Shuji Yamamoto , Hiroshi Ohta , Yoshihisa Shirasaki , Kazunari Sakagami , Masato Hayashi , Tsuyoshi Shibata , Youichi Shimazaki , Yuko Araki , Kumi Abe , Xiang-Min Sun
发明人： Akito Yasuhara , Shuji Yamamoto , Hiroshi Ohta , Yoshihisa Shirasaki , Kazunari Sakagami , Masato Hayashi , Tsuyoshi Shibata , Youichi Shimazaki , Yuko Araki , Kumi Abe , Xiang-Min Sun
IPC分类号： C07D471/04 , C07D405/12 , C07D409/12 , C07D405/14 , A01N43/64 , A01N43/50 , A61K31/41
CPC分类号： C07D471/04 , C07D405/12 , C07D405/14 , C07D409/12
摘要： The present invention aims to provide novel compounds of formula [I] or pharmaceutically acceptable salts thereof that are based on a glycine uptake inhibiting action and which are useful in the prevention or treatment of such diseases as schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsory disorder, social anxiety disorder, posttraumatic stress disorder, specific phobia, acute stress disorder, etc.), depression, drug addiction, spasm, tremor, and sleep disorder:
摘要翻译：本发明旨在提供基于甘氨酸摄取抑制作用的新颖的式[I]化合物或其药学上可接受的盐，其可用于预防或治疗精神分裂症，阿尔茨海默病，认知功能障碍，痴呆，焦虑症（广泛性焦虑障碍，恐慌症，强迫症，社会焦虑症，创伤后应激障碍，特定恐惧症，急性应激障碍等），抑郁症，药物成瘾，痉挛，震颤和睡眠障碍：

9. 发明申请

US20120116095A1 GLYCINE TRANSPORTER INHIBITORS 审中-公开
标题翻译：甘油运输车辆抑制剂
公开(公告)号：US20120116095A1
公开(公告)日：2012-05-10
申请号：US13383513
申请日：2010-07-15
申请人： Akito Yasuhara , Kazunari Sakagami , Hiroshi Ohta , Masato Hayashi , Yoshihisa Shirasaki , Shuji Yamamoto , Youichi Shimazaki , Yuko Araki , Kumi Abe , Xiang-Min Sun
发明人： Akito Yasuhara , Kazunari Sakagami , Hiroshi Ohta , Masato Hayashi , Yoshihisa Shirasaki , Shuji Yamamoto , Youichi Shimazaki , Yuko Araki , Kumi Abe , Xiang-Min Sun
IPC分类号： C07D249/12 , C07D233/14
CPC分类号： C07D249/10
摘要： The present invention aims to provide novel compounds represented by formula [I] or pharmaceutically acceptable salts thereof: which are useful for prevention or treatment of diseases such as schizophrenia, Alzheimer's disease, cognitive impairment, dementia, anxiety disorders (e.g., generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, post-traumatic stress disorder, specific phobias, acute stress disorder), depression, drug dependence, convulsion, tremor, pain, or sleep disorders, based on their inhibitory effect against glycine uptake.
摘要翻译：本发明旨在提供由式[I]表示的新化合物或其药学上可接受的盐：其可用于预防或治疗诸如精神分裂症，阿尔茨海默病，认知障碍，痴呆，焦虑症（例如广泛性焦虑症，基于它们对甘氨酸摄取的抑制效果，恐慌症，强迫症，社交焦虑症，创伤后应激障碍，特异性恐惧症，急性应激障碍），抑郁症，药物依赖性，惊厥，震颤，疼痛或睡眠障碍。

10. 发明授权

US08608378B2 Temperature measuring apparatus 有权
标题翻译：温度测量仪
公开(公告)号：US08608378B2
公开(公告)日：2013-12-17
申请号：US13516916
申请日：2010-12-06
申请人： Hisaki Ishida , Masato Hayashi , Koudai Higashi
发明人： Hisaki Ishida , Masato Hayashi , Koudai Higashi
IPC分类号： G01K7/00
CPC分类号： G01K1/18 , H01L21/67248 , H01L2224/48091 , H01L2224/8592 , H01L2924/00014
摘要： Disclosed is a temperature measuring apparatus which is provided with: a substrate (2); a temperature sensor (3) disposed on one surface of the substrate (2); and a wire (8) disposed to electrically connect together a circuit, which detects a temperature using the temperature sensor (3), and the temperature sensor (3). In said surface of the substrate (2), a recessed section (7) having a heat capacity smaller than that of the material of the substrate (2) is formed on the periphery of the temperature sensor (3). The recessed section (7) is formed at a predetermined interval from the temperature sensor (3) such that the recessed section surrounds the temperature sensor (3) and has predetermined width and depth. Preferably, the low heat capacity zone is the recessed section (7), i.e., the groove having a recessed cross-section.
摘要翻译：公开了一种温度测量装置，其设置有：基板（2）; 设置在所述基板（2）的一个表面上的温度传感器（3）; 以及布置成将使用温度传感器（3）检测温度的电路和温度传感器（3）电连接在一起的线（8）。在基板（2）的所述表面中，在温度传感器（3）的周围形成有具有小于基板（2）的材料的热容的凹部（7）。凹部（7）从温度传感器（3）以预定的间隔形成，使得凹部包围温度传感器（3）并且具有预定的宽度和深度。优选地，低热容区是凹部（7），即凹槽具有凹入的横截面。

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