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1. 发明申请

US20070189970A1 Contrast medium for thrombus formation 审中-公开
标题翻译：血栓形成对比剂
公开(公告)号：US20070189970A1
公开(公告)日：2007-08-16
申请号：US10590295
申请日：2005-01-13
申请人： Yoshihiro Murakami , Toshiaki Aoki , Shintaro Nishimura , Kazuhiko Osoda
发明人： Yoshihiro Murakami , Toshiaki Aoki , Shintaro Nishimura , Kazuhiko Osoda
IPC分类号： A61K49/04 , C07D211/12 , C07D211/22 , C07D401/06
CPC分类号： C07D295/185 , A61K51/0406 , A61K51/0455 , C07C257/18 , C07C317/50 , C07D211/34 , C07D211/60 , Y02P20/55
摘要： It is intended to provide a contrast medium for thrombus capable of binding specifically to a thrombus, lowering background noise and thus improving the resolution in a contrast examination for thrombus formation; and a method of detecting a thrombus by using the same. A contrast medium for thrombus comprising, as the active substance, a substance obtained by labeling a compound capable of binding to GPIIb/IIIa which is selected from among compounds represented by the general formulae (I) to (IV) and physiologically acceptable salts thereof, and a method of detecting a thrombus by using the same.
摘要翻译：旨在提供能够特异性结合血栓的血栓造影剂，降低背景噪音，从而提高血栓形成对比检查中的分辨率; 以及使用该血栓检测血栓的方法。一种用于血栓的造影剂，其特征在于，作为活性物质，通过将通式（I）〜（IV）表示的化合物及其生理学上可接受的盐中选择的能够结合GPIIb / IIIa的化合物进行标记而得到的物质，以及使用该血栓检测血栓的方法。

2. 发明授权

US09242999B2 Cephem compound having pyridinium group 有权
标题翻译：具有吡啶鎓基的头孢烯化合物
公开(公告)号：US09242999B2
公开(公告)日：2016-01-26
申请号：US14129631
申请日：2012-06-26
申请人： Yasuhiro Nishitani , Toshiaki Aoki
发明人： Yasuhiro Nishitani , Toshiaki Aoki
IPC分类号： C07D501/36 , C07D501/60 , C07D505/00
CPC分类号： C07D501/60 , C07D501/36 , C07D505/00
摘要： The present invention provides a novel compound which has a broad antibacterial spectrum and particularly exhibits a high antibacterial activity on β-lactamase-producing gram-negative bacteria. Specifically provided are: a compound represented by formula (I) wherein the meaning of each symbol is as defined in the description, an amino-group-protected form of a type of the compound which has the amino group on a ring in a position-7 side chain, or a pharmaceutically acceptable salt of the compound or the amino-group-protected form; and a pharmaceutical composition containing the compound, the amino-group-protected form or the pharmaceutically acceptable salt.
摘要翻译：本发明提供了具有广谱抗菌谱的新型化合物，特别是对产生β-内酰胺酶的革兰氏阴性细菌表现出高抗菌活性。具体提供的是：式（I）表示的化合物，其中每个符号的含义如说明书中所定义，具有位置上具有环上的氨基的化合物的类型的氨基保护形式， 7侧链，或化合物的药学上可接受的盐或氨基保护形式; 和含有该化合物，氨基保护形式或药学上可接受的盐的药物组合物。

3. 发明授权

US09145425B2 Cephem compound having catechol group 有权
标题翻译：具有儿茶酚基的头孢烯化合物
公开(公告)号：US09145425B2
公开(公告)日：2015-09-29
申请号：US13639412
申请日：2011-04-04
申请人： Shinya Hisakawa , Yasushi Hasegawa , Toshiaki Aoki , Hiroki Kusano , Masayuki Sano , Jun Sato , Kenji Yamawaki
发明人： Shinya Hisakawa , Yasushi Hasegawa , Toshiaki Aoki , Hiroki Kusano , Masayuki Sano , Jun Sato , Kenji Yamawaki
IPC分类号： C07D471/08 , C07D501/56 , C07D505/24 , C07D501/46 , C07D519/06
CPC分类号： C07D505/24 , C07D471/08 , C07D501/46 , C07D501/56 , C07D519/06
摘要： This invention provides Cephem compounds having the formula: or an ester, a protected compound at the amino on the ring in the 7-side chain, a pharmaceutically acceptable salt, or a solvate thereof, a pharmaceutical composition thereof, and a method for treating a bacterial infectious disease with the compound, the ester, the protected compound, the salt, or the solvate thereof, wherein the symbols in the formula are defined in the specification. The compounds exhibit potent antimicrobial spectrum against a variety of bacteria including Gram negative bacteria and/or Gram positive bacteria, preferably beta-lactamase producing Gram negative bacteria, more preferably, multi-drug resistant microbials, in particular, Class B type metallo-beta-lactamase producing Gram negative bacteria, and still preferably extended-spectrum beta-lactamase (ESBL) producing bacteria. The compounds most preferably do not exhibit cross-resistance against known Cephem drugs or Carbapenem drugs.
摘要翻译：本发明提供具有下式的Cephem化合物：或酯，7-侧链上的环上的氨基上的被保护的化合物，其药学上可接受的盐或溶剂合物，其药物组合物和化合物，酯，受保护化合物，盐或其溶剂化物的细菌感染性疾病，其中式中的符号在说明书中定义。该化合物对各种细菌（包括革兰氏阴性细菌和/或革兰氏阳性细菌，优选β-内酰胺酶产生革兰氏阴性细菌，更优选多药耐药性微生物，特别是B类金属β- 产生革兰氏阴性细菌的内酰胺酶，更优选延长的β-内酰胺酶（ESBL）产生细菌。该化合物最优选不表现出对已知的Cephem药物或碳青霉烯类药物的抗药性。

4. 发明申请

US20140114060A1 CEPHEM COMPOUND HAVING PYRIDINIUM GROUP 有权
标题翻译：具有吡咯烷基的化合物
公开(公告)号：US20140114060A1
公开(公告)日：2014-04-24
申请号：US14129631
申请日：2012-06-26
申请人： Yasuhiro Nishitani , Toshiaki Aoki
发明人： Yasuhiro Nishitani , Toshiaki Aoki
IPC分类号： C07D501/60
CPC分类号： C07D501/60 , C07D501/36 , C07D505/00
摘要： The present invention provides a novel compound which has a broad antibacterial spectrum and particularly exhibits a high antibacterial activity on β-lactamase-producing gram-negative bacteria. Specifically provided are: a compound represented by formula (I) wherein the meaning of each symbol is as defined in the description, an amino-group-protected form of a type of the compound which has the amino group on a ring in a position-7 side chain, or a pharmaceutically acceptable salt of the compound or the amino-group-protected form; and a pharmaceutical composition containing the compound, the amino-group-protected form or the pharmaceutically acceptable salt.
摘要翻译：本发明提供了具有广谱抗菌谱的新型化合物，特别是对产生β-内酰胺酶的革兰氏阴性细菌表现出高抗菌活性。具体提供的是：式（I）表示的化合物，其中每个符号的含义如说明书中所定义，具有位置上具有环上的氨基的化合物的类型的氨基保护形式， 7侧链，或化合物的药学上可接受的盐或氨基保护形式; 和含有该化合物，氨基保护形式或药学上可接受的盐的药物组合物。

5. 发明申请

US20110152268A1 NOVEL PHARMACEUTICAL COMPOSITION FOR TREATING NOCICEPTIVE PAIN 审中-公开
标题翻译：用于治疗疼痛的新型药物组合物
公开(公告)号：US20110152268A1
公开(公告)日：2011-06-23
申请号：US13061219
申请日：2009-09-10
申请人： Nobuaki Takeshita , Fusako Nishigaki , Toshiaki Aoki , Seiji Tamura , Kazumi Kikuchi , Akio Kuroda
发明人： Nobuaki Takeshita , Fusako Nishigaki , Toshiaki Aoki , Seiji Tamura , Kazumi Kikuchi , Akio Kuroda
IPC分类号： A61K31/5375 , C07D265/30 , A61P29/00
CPC分类号： C07D265/30 , A61K31/5375
摘要： The present invention relates to a pharmaceutical composition for treating nociceptive pain, containing a morpholine derivative or a pharmaceutically acceptable salt thereof, as an active ingredient. The present invention is useful in providing an excellent pharmaceutical composition for treating nociceptive pain. In addition, the present invention is particularly useful in providing a pharmaceutical composition for treating pain accompanying a disease selected from the group consisting of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, spondylosis deformans, gouty arthritis, juvenile arthritis, scapulohumeral periarthritis, and cervical syndrome, lumbago, lumbago accompanying spondylosis deformans, menalgia, pain and tumentia after inflammation, operation or injury, pain after odontectomy, and cancer pain. In addition, the present invention is particularly useful for alleviating pain in a damaged cartilage region, and is particularly useful for osteoarthritis in which NSAIDs are not effective.
摘要翻译：本发明涉及用于治疗伤害性疼痛的药物组合物，其含有吗啉衍生物或其药学上可接受的盐作为活性成分。本发明可用于提供用于治疗伤害性疼痛的优异药物组合物。此外，本发明特别可用于提供用于治疗伴随选自以下的疾病的药物组合物：选自类风湿性关节炎，类风湿性脊椎炎，骨关节炎，变形性椎关节强硬症，痛风性关节炎，幼年型关节炎，肩周炎性关节炎和子宫颈综合征，腰痛，腰痛伴椎关节僵硬，麻痹症，炎症，手术或损伤后疼痛，咽后切除术后的疼痛，以及癌症疼痛。此外，本发明特别可用于缓解软骨损伤区域的疼痛，特别适用于NSAIDs无效的骨关节炎。

6. 发明申请

US20110144947A1 Online Diagnostic Method and Online Diagnostic System for Geothermal Generation Facility 有权
标题翻译：地热发电设备在线诊断方法及在线诊断系统
公开(公告)号：US20110144947A1
公开(公告)日：2011-06-16
申请号：US13054972
申请日：2009-10-19
申请人： Ichiro Myougan , Toshikazu Kato , Isamu Osawa , Yasuyuki Hishi , Daisuke Fukuda , Yasuto Futagoishi , Toshiaki Aoki
发明人： Ichiro Myougan , Toshikazu Kato , Isamu Osawa , Yasuyuki Hishi , Daisuke Fukuda , Yasuto Futagoishi , Toshiaki Aoki
IPC分类号： G06F15/00
CPC分类号： F03G7/04 , Y02E10/10
摘要： An online diagnostic system for a geothermal generation facility is discloses that includes: an automatic steam measurement device for measuring a characteristic of steam to be supplied to a steam turbine from a steam-water separator at the geothermal generation facility that outputs analysis data. A monitor•control device controls an operation of the geothermal generation facility while monitoring the geothermal generation facility. A diagnostic device performs at least one of an evaluation of a steam characteristic at the geothermal generation facility, an evaluation of the steam-water separator, and an evaluation of pulsation and confluence of a production well based on the analysis data from the automatic steam measurement device and performance data of the geothermal generation facility from the monitor•control device. An operating status of the geothermal generation facility is diagnosed.
摘要翻译：公开了一种用于地热发电设备的在线诊断系统，其包括：自动蒸汽测量装置，用于从输出分析数据的地热发生设备处的蒸汽水分离器测量要供应给蒸汽轮机的蒸汽的特性。监测•控制装置控制地热发电设施的运行，同时监测地热发电设施。诊断装置基于来自自动蒸汽测量的分析数据执行对地热发电设备的蒸汽特性的评价，蒸汽水分离器的评价以及生产井的脉动和汇合的评价中的至少一个控制装置的地热发电设备的设备和性能数据。诊断地热发电设施的运行状况。

7. 发明申请

US20100113451A1 NOVEL PREVENTIVE AND/OR THERAPEUTIC AGENT FOR DIABETIC NEUROPATHY 审中-公开
标题翻译：新型预防和/或治疗糖尿病神经病变药物
公开(公告)号：US20100113451A1
公开(公告)日：2010-05-06
申请号：US12530745
申请日：2008-03-14
申请人： Toshiaki Aoki , Nobuhito Murai , Seiji Tamura , Hiroko Yamamoto , Nozomu Hamakawa
发明人： Toshiaki Aoki , Nobuhito Murai , Seiji Tamura , Hiroko Yamamoto , Nozomu Hamakawa
IPC分类号： A61K31/5375 , A61P25/00
CPC分类号： C07D265/30 , A61K31/5375
摘要： The present invention relates to an agent for preventing and/or treating diabetic neuropathy comprising a 2-[(substituted-inden-7-yloxy)methyl]morpholine of the formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient. The invention is useful for providing an excellent agent for preventing and/or treating diabetic neuropathy, and particularly useful for providing an agent for preventing and/or treating diabetic motor neuropathy (such as muscle weakness disorder (such as muscle weakness disorder with inability to walk independently)), diabetic sensory neuropathy (such as paresthesia (such as vibration perception abnormality), allodynia, hypoesthesia (such as numbness of extremities or cold sensation), or pain), or diabetic autonomic neuropathy (such as stool abnormality (such as constipation or diarrhea), urination disorder, impotence, orthostatic hypotension, sudomotor dysfunction, abnormal heart rate variability, or delayed gastric emptying). Further, the invention is particularly useful for providing an agent for improving pathophysiology of diabetic neuropathy.
摘要翻译：本发明涉及用于预防和/或治疗糖尿病性神经病变的药剂，其包含式（I）的2 - [（取代 - 茚-7-基氧基）甲基]吗啉或其药学上可接受的盐作为活性成分。本发明可用于提供用于预防和/或治疗糖尿病性神经病变的优异剂，特别可用于提供用于预防和/或治疗糖尿病运动神经病变（如肌肉无力障碍（例如无力行走的肌肉无力障碍）独立）），糖尿病感觉神经病变（如感觉异常（如振动感知异常），异常性疼痛，麻醉（如四肢麻木或感冒）或疼痛）或糖尿病性自主神经病变（如便秘便秘）或腹泻），排尿障碍，阳ence，直立性低血压，苏体功能障碍，异常心率变异性或延迟胃排空）。此外，本发明特别可用于提供改善糖尿病性神经病变病理生理学的药剂。

8. 发明授权

US06168076A Electronic cash register and price calculation method 失效
标题翻译：电子收款机和价格计算方法
公开(公告)号：US06168076A
公开(公告)日：2001-01-02
申请号：US09149176
申请日：1998-09-08
申请人： Mayumi Yamamoto , Toshiaki Aoki
发明人： Mayumi Yamamoto , Toshiaki Aoki
IPC分类号： G07G100
CPC分类号： G06Q20/387 , G06Q20/20 , G07G1/0036 , G07G1/12
摘要： Unit items ordered by a customer are accepted. An automatic selection is given of unit items, from among the accepted unit items, which compose at least one of predetermined set-menu item combinations having respective predetermined discount prices. A price corresponding to a customer's order is calculated in response to the predetermined discount price of the previously-mentioned one of the predetermined set-menu item combinations.
摘要翻译：接受客户订购的单位物品。从所接受的单位项目中给出单元项目的自动选择，其组成具有各自的预定折扣价格的预定设置菜单项目组合中的至少一个。响应于先前提到的预定设置菜单项组合的预定折扣价格计算与客户订单相对应的价格。

9. 发明授权

US09795184B2 Shoe positioning plate for bicycle shoes 有权
公开(公告)号：US09795184B2
公开(公告)日：2017-10-24
申请号：US12636943
申请日：2009-12-14
申请人： Yutaka Ueda , Junichi Kikuta , Toshiaki Aoki
发明人： Yutaka Ueda , Junichi Kikuta , Toshiaki Aoki
IPC分类号： A43B5/00 , B62M3/08 , A43B5/14 , A43B13/14
CPC分类号： A43B5/14 , A43B13/14 , Y10T74/217
摘要： A shoe positioning plate has a shoe facing side surface, a sole surface and a shoe positioning member. The sole surface is configured to be a part of a shoe sole when the shoe facing side surface is attached the shoe sole. The shoe positioning member includes at least one abutment disposed on an opposite side of the shoe positioning plate from the shoe facing side surface and extending in an elongated direction of a shoe when the shoe positioning plate is attached the shoe sole.

10. 发明授权

US09236334B2 Wiring substrate and method for manufacturing wiring substrates 有权
标题翻译：布线基板和制造布线基板的方法
公开(公告)号：US09236334B2
公开(公告)日：2016-01-12
申请号：US13410031
申请日：2012-03-01
申请人： Kentaro Kaneko , Toshiaki Aoki , Hiromi Denda
发明人： Kentaro Kaneko , Toshiaki Aoki , Hiromi Denda
IPC分类号： H05K1/09 , H01L23/498 , H05K3/24 , H05K1/11 , H05K3/46
CPC分类号： H01L23/49811 , H01L23/49816 , H01L23/49822 , H01L23/49866 , H01L2224/16225 , H01L2224/32225 , H01L2224/48227 , H01L2224/48228 , H01L2224/73204 , H01L2224/73265 , H01L2924/01322 , H05K1/112 , H05K3/244 , H05K3/4661 , H05K2203/0307 , H01L2924/00
摘要： A wiring substrate includes a wiring layer, an outermost insulating layer laminated to the wiring layer, and a pad electrically connected to the wiring layer and exposed from a surface of the outermost insulating layer. The pad consists essentially of a first metal layer and a second metal layer. The first metal layer includes a first surface, which is exposed from the surface of the outermost insulating layer, and a second surface, which is located opposite to the first surface. The second metal layer includes is formed between the second surface of the first metal layer and the wiring layer. The first metal layer is formed from a metal selected from gold or silver or from an alloy including at least one of gold and silver. The second metal layer is formed from palladium or a palladium alloy.
摘要翻译：布线基板包括布线层，层叠到布线层的最外层绝缘层，以及与布线层电连接并从最外层绝缘层的表面露出的焊盘。垫基本上由第一金属层和第二金属层组成。第一金属层包括从最外绝缘层的表面露出的第一表面和与第一表面相对的第二表面。第二金属层包括形成在第一金属层的第二表面和布线层之间。第一金属层由选自金或银的金属或由包含金和银中的至少一种的合金形成。第二金属层由钯或钯合金形成。

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