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1. 发明申请

US20100216778A1 PAIN REMEDY CONTAINING ROCK INHIBITOR 审中-公开
标题翻译：含缓蚀剂的缓蚀剂
公开(公告)号：US20100216778A1
公开(公告)日：2010-08-26
申请号：US12714608
申请日：2010-03-01
申请人： Nobuaki TAKESHITA
发明人： Nobuaki TAKESHITA
IPC分类号： A61K31/551 , A61K31/4409 , A61K31/415 , A61K31/165 , A61P29/00 , A61P19/02
CPC分类号： A61K31/166 , A61K31/4164 , A61K31/4409 , A61K31/551
摘要： Since a ROCK inhibitor exerts a potent analgesic effect by a single dose after the onset of a cartilage-related disease such as osteoarthritis, and can regenerate or suppress destruction of cartilage tissue and alleviate pain associated with cartilage diseases by multiple doses, administration of an therapeutically effective amount of the ROCK inhibitor to a patient with cartilage-related disease such as osteoarthritis or rheumatoid arthritis can treat the patient with cartilage-related disease and the ROCK inhibitor is thus useful.
摘要翻译：由于ROCK抑制剂在与软骨相关疾病如骨关节炎发生之后通过单次剂量发挥有效的镇痛作用，并且可以再生或抑制软骨组织的破坏并且通过多次剂量减轻与软骨疾病相关的疼痛，施用治疗对软骨相关疾病如骨关节炎或类风湿性关节炎的患者的有效量的ROCK抑制剂可以治疗患有软骨相关疾病的患者，因此ROCK抑制剂是有用的。

2. 发明申请

US20110152268A1 NOVEL PHARMACEUTICAL COMPOSITION FOR TREATING NOCICEPTIVE PAIN 审中-公开
标题翻译：用于治疗疼痛的新型药物组合物
公开(公告)号：US20110152268A1
公开(公告)日：2011-06-23
申请号：US13061219
申请日：2009-09-10
申请人： Nobuaki Takeshita , Fusako Nishigaki , Toshiaki Aoki , Seiji Tamura , Kazumi Kikuchi , Akio Kuroda
发明人： Nobuaki Takeshita , Fusako Nishigaki , Toshiaki Aoki , Seiji Tamura , Kazumi Kikuchi , Akio Kuroda
IPC分类号： A61K31/5375 , C07D265/30 , A61P29/00
CPC分类号： C07D265/30 , A61K31/5375
摘要： The present invention relates to a pharmaceutical composition for treating nociceptive pain, containing a morpholine derivative or a pharmaceutically acceptable salt thereof, as an active ingredient. The present invention is useful in providing an excellent pharmaceutical composition for treating nociceptive pain. In addition, the present invention is particularly useful in providing a pharmaceutical composition for treating pain accompanying a disease selected from the group consisting of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, spondylosis deformans, gouty arthritis, juvenile arthritis, scapulohumeral periarthritis, and cervical syndrome, lumbago, lumbago accompanying spondylosis deformans, menalgia, pain and tumentia after inflammation, operation or injury, pain after odontectomy, and cancer pain. In addition, the present invention is particularly useful for alleviating pain in a damaged cartilage region, and is particularly useful for osteoarthritis in which NSAIDs are not effective.
摘要翻译：本发明涉及用于治疗伤害性疼痛的药物组合物，其含有吗啉衍生物或其药学上可接受的盐作为活性成分。本发明可用于提供用于治疗伤害性疼痛的优异药物组合物。此外，本发明特别可用于提供用于治疗伴随选自以下的疾病的药物组合物：选自类风湿性关节炎，类风湿性脊椎炎，骨关节炎，变形性椎关节强硬症，痛风性关节炎，幼年型关节炎，肩周炎性关节炎和子宫颈综合征，腰痛，腰痛伴椎关节僵硬，麻痹症，炎症，手术或损伤后疼痛，咽后切除术后的疼痛，以及癌症疼痛。此外，本发明特别可用于缓解软骨损伤区域的疼痛，特别适用于NSAIDs无效的骨关节炎。

3. 发明申请

US20090029970A1 PAIN REMEDY CONTAINING ROCK INHIBITOR 审中-公开
标题翻译：含缓蚀剂的缓蚀剂
公开(公告)号：US20090029970A1
公开(公告)日：2009-01-29
申请号：US11816425
申请日：2006-02-16
申请人： Nobuaki Takeshita
发明人： Nobuaki Takeshita
IPC分类号： A61K31/551 , A61K31/44 , A61K31/165 , A61P29/00 , A61K31/404
CPC分类号： A61K31/166 , A61K31/4164 , A61K31/4409 , A61K31/551
摘要： Since a ROCK inhibitor exerts a potent analgesic effect by a single dose after the onset of a cartilage-related disease such as osteoarthritis, and can regenerate or suppress destruction of cartilage tissue and alleviate pain associated with cartilage diseases by multiple doses, administration of an therapeutically effective amount of the ROCK inhibitor to a patient with cartilage-related disease such as osteoarthritis or rheumatoid arthritis can treat the patient with cartilage-related disease and the ROCK inhibitor is thus useful.
摘要翻译：由于ROCK抑制剂在与软骨相关疾病如骨关节炎发生之后通过单次剂量发挥有效的镇痛作用，并且可以再生或抑制软骨组织的破坏并且通过多次剂量减轻与软骨疾病相关的疼痛，施用治疗对软骨相关疾病如骨关节炎或类风湿性关节炎的患者的有效量的ROCK抑制剂可以治疗患有软骨相关疾病的患者，因此ROCK抑制剂是有用的。

4. 发明授权

US08098288B2 Imaging apparatus and method of controlling imaging 有权
标题翻译：成像设备及成像控制方法
公开(公告)号：US08098288B2
公开(公告)日：2012-01-17
申请号：US12347665
申请日：2008-12-31
申请人： Nobuaki Takeshita
发明人： Nobuaki Takeshita
IPC分类号： H04N5/228
CPC分类号： H04N5/235 , H04N5/145 , H04N5/2258 , H04N19/105 , H04N19/132 , H04N19/172 , H04N19/577 , H04N19/587
摘要： In an imaging apparatus according to an aspect of the present invention, three images are picked up by a CCD having a color filter, and thirteen images are picked up by a CMOS having no color filter. Three of thirteen images are picked up at the same timing as by the CCD. A motion vector data between the images is calculated from the thirteen image data of the CCD. Further, the motion vector data is integrated to calculate motion vector data between a previous pickup image and a present pickup image, and motion vector data between the present pickup image and a following pickup image. A predicted image of the present pickup image is generated from the motion vector data, the previous pickup image, and the following pickup image. A weighted average is calculated between the predicted image and the present pickup image, which are synthesized into an image having decreased hand jiggling.
摘要翻译：在根据本发明的一个方面的成像装置中，由具有滤色器的CCD拾取三个图像，并且由不具有滤色器的CMOS拾取13个图像。在与CCD相同的时间拍摄十三个图像中的三个。根据CCD的十三个图像数据计算图像之间的运动矢量数据。此外，运动矢量数据被积分以计算先前拍摄图像和当前拍摄图像之间的运动矢量数据，以及当前拍摄图像和跟随拍摄图像之间的运动矢量数据。从运动矢量数据，先前拍摄图像和随后的拍摄图像生成当前拍摄图像的预测图像。在预测图像和当前拾取图像之间计算加权平均值，其被合成为具有减少的手抖动的图像。

5. 发明申请

US20090174789A1 IMAGING APPARATUS AND METHOD OF CONTROLLING IMAGING 有权
标题翻译：成像装置和控制成像的方法
公开(公告)号：US20090174789A1
公开(公告)日：2009-07-09
申请号：US12347665
申请日：2008-12-31
申请人： Nobuaki TAKESHITA
发明人： Nobuaki TAKESHITA
IPC分类号： H04N5/228
CPC分类号： H04N5/235 , H04N5/145 , H04N5/2258 , H04N19/105 , H04N19/132 , H04N19/172 , H04N19/577 , H04N19/587
摘要： In an imaging apparatus according to an aspect of the present invention, three images are picked up by a CCD having a color filter, and thirteen images are picked up by a CMOS having no color filter. Three of thirteen images are picked up at the same timing as by the CCD. A motion vector data between the images is calculated from the thirteen image data of the CCD. Further, the motion vector data is integrated to calculate motion vector data between a previous pickup image and a present pickup image, and motion vector data between the present pickup image and a following pickup image. A predicted image of the present pickup image is generated from the motion vector data, the previous pickup image, and the following pickup image. A weighted average is calculated between the predicted image and the present pickup image, which are synthesized into an image having decreased hand jiggling.
摘要翻译：在根据本发明的一个方面的成像装置中，由具有滤色器的CCD拾取三个图像，并且由不具有滤色器的CMOS拾取13个图像。在与CCD相同的时间拍摄十三个图像中的三个。根据CCD的十三个图像数据计算图像之间的运动矢量数据。此外，运动矢量数据被积分以计算先前拍摄图像和当前拍摄图像之间的运动矢量数据，以及当前拍摄图像和跟随拍摄图像之间的运动矢量数据。从运动矢量数据，先前拍摄图像和随后的拍摄图像生成当前拍摄图像的预测图像。在预测图像和当前拾取图像之间计算加权平均值，其被合成为具有减少的手抖动的图像。

6. 发明授权

US08211919B2 Amide derivatives as rock inhibitors 失效
标题翻译：酰胺衍生物作为岩石抑制剂
公开(公告)号：US08211919B2
公开(公告)日：2012-07-03
申请号：US12065043
申请日：2006-08-29
申请人： Kouzo Sawada , Tatsuya Zenkoh , Takeshi Terasawa , Yoshimasa Imamura , Hiroki Fukudome , Satoru Kuroda , Jun Maeda , Junko Watanabe , Hiroshi Inami , Nobuaki Takeshita
发明人： Kouzo Sawada , Tatsuya Zenkoh , Takeshi Terasawa , Yoshimasa Imamura , Hiroki Fukudome , Satoru Kuroda , Jun Maeda , Junko Watanabe , Hiroshi Inami , Nobuaki Takeshita
IPC分类号： A61K31/44 , A61K31/47 , A61K31/505 , A61K31/54 , C07D239/02 , C07D413/00 , C07D499/48
CPC分类号： C07D213/40 , C07D213/61 , C07D213/75 , C07D239/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D417/12
摘要： This invention relates to novel amide derivatives and salts thereof. More particularly, it relates to novel amide derivatives and salts thereof which act as a ROCK inhibitor, to a pharmaceutical composition comprising the same and to a method of using the same therapeutically in the treatment and/or prevention of ROCK-related disease.
摘要翻译：本发明涉及新颖的酰胺衍生物及其盐。更具体地说，本发明涉及作为ROCK抑制剂的新型酰胺衍生物及其盐，涉及包含该酰胺衍生物及其盐的治疗和/或预防ROCK相关疾病的方法。

7. 发明申请

US20090105231A1 AMIDE DERIVATIVES AS ROCK INHIBITORS 失效
标题翻译：酰胺衍生物作为岩石抑制剂
公开(公告)号：US20090105231A1
公开(公告)日：2009-04-23
申请号：US12065043
申请日：2006-08-29
申请人： Kouzo Sawada , Tatsuya Zenkoh , Takeshi Terasawa , Yoshimasa Imamura , Hiroki Fukudome , Satoru Kuroda , Jun Maeda , Junko Watanabe , Hiroshi Inami , Nobuaki Takeshita
发明人： Kouzo Sawada , Tatsuya Zenkoh , Takeshi Terasawa , Yoshimasa Imamura , Hiroki Fukudome , Satoru Kuroda , Jun Maeda , Junko Watanabe , Hiroshi Inami , Nobuaki Takeshita
IPC分类号： A61K31/541 , C07D213/56 , A61K31/4409 , A61K31/4725 , C07D409/12 , A61P25/28 , A61K31/506 , C07D401/12 , C07D417/12
CPC分类号： C07D213/40 , C07D213/61 , C07D213/75 , C07D239/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D417/12
摘要： This invention relates to novel amide derivatives and salts thereof. More particularly, it relates to novel amide derivatives and salts thereof which act as a ROCK inhibitor, to a pharmaceutical composition comprising the same and to a method of using the same therapeutically in the treatment and/or prevention of ROCK-related disease.
摘要翻译：本发明涉及新颖的酰胺衍生物及其盐。更具体地说，本发明涉及作为ROCK抑制剂的新型酰胺衍生物及其盐，涉及包含该酰胺衍生物及其盐的治疗和/或预防ROCK相关疾病的方法。

8. 发明申请

US20050245540A1 New methods 审中-公开
标题翻译：新方法
公开(公告)号：US20050245540A1
公开(公告)日：2005-11-03
申请号：US10996589
申请日：2004-11-26
申请人： Nobuaki Takeshita , Takayuki Inoue
发明人： Nobuaki Takeshita , Takayuki Inoue
IPC分类号： A61K31/454 , A61K31/496
CPC分类号： A61K31/454 , A61K31/496
摘要： This invention relates to a method for preventing and/or treating bone diseases which comprises administering a potentiator of TGF-beta activity such as the compound of the formula [I] or pharmaceutically acceptable salts thereof to human being or animals. wherein R1 is hydrogen, etc., R2 is optionally substituted ar(lower)alkyl or optionally substituted heterocyclic(lower)alkyl, etc., R3 is hydrogen, optionally substituted hydroxy, etc., R4 is hydrogen or lower alkyl, and X is CH or N.
摘要翻译：本发明涉及一种预防和/或治疗骨疾病的方法，其包括向人或动物施用TGF-β活化增强剂，例如式[I]化合物或其药学上可接受的盐。其中R 1是氢等，R 2是任选取代的芳（低级）烷基或任选取代的杂环（低级）烷基等，R 3 H 2是氢，任选取代的羟基等，R 4是氢或低级烷基，X是CH或N.

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