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1. 发明专利

JP2011203739A Light intensity distribution correction optical system and optical microscope using the same 有权
标题翻译：光强度分布校正光学系统和使用该光学系统的光学显微镜
公开(公告)号：JP2011203739A
公开(公告)日：2011-10-13
申请号：JP2011098138
申请日：2011-04-26
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： TANAAMI TAKEO , SUGIYAMA YUMIKO
IPC分类号： G02B27/09 , G02B13/00 , G02B13/18 , G02B21/06
摘要： PROBLEM TO BE SOLVED: To provide a light intensity distribution correction optical system configured so that the intensity distribution of diverging light from a light source is made to be uniform, light utilization efficiency is improved, a difference in NA of the light source is easily absorbed, and cost reduction is achieved, and also to provide an optical microscope using the light intensity distribution correction optical system.SOLUTION: The light intensity distribution correction optical system corrects the intensity distribution of incident light having largely different divergent angles in XY planar directions to a flat intensity distribution. The light intensity distribution correction optical system includes: a first lens group 42 which is composed of at least one cylindrical lens having a positive refractive power in the large divergent angle direction of the incident light and not having a refractive power in a direction perpendicular to the direction; and a second lens group 43 which is composed of at least one cylindrical lens disposed behind the first lens group 42, and having a positive refractive power in the small divergent angle direction of the incident light and not having a refractive power in a direction perpendicular to the direction. The light intensity distribution correction optical system is configured to collimate the incident light emitted from a point light source 41 having the largely different divergent angles in the XY planar directions, and makes the intensity distribution of the incident light flat by the spherical aberrations of the respective lens groups 42 and 43 to emit the incident light.
摘要翻译：要解决的问题：为了提供一种光强度分布校正光学系统，其被配置为使来自光源的发散光的强度分布均匀，光利用效率提高，光源的NA差容易吸收，并且实现成本降低，并且还提供使用光强度分布校正光学系统的光学显微镜。解决方案：光强分布校正光学系统校正在XY平面方向上具有大致不同的发散角的入射光的强度分布，平坦的强度分布。光强分布校正光学系统包括：第一透镜组42，其由在入射光的大发散角方向上具有正折光力的至少一个柱面透镜构成，并且在垂直于该入射光的方向上不具有折射光焦度方向; 以及第二透镜组43，其由设置在第一透镜组42后面的至少一个柱面透镜构成，并且在入射光的小发散角方向上具有正折射光焦度，并且在垂直于方向。光强分布校正光学系统被配置为使从XY平面方向具有大致不同的发散角的点光源41发射的入射光准直，并使入射光的强度分布平坦化，透镜组42和43发射入射光。

2. 发明专利

JP2011152054A Concentration-measuring method, chip for measuring concentration and method for using the chip for the measurement 审中-公开
标题翻译：浓度测量方法，用于测量浓度的芯片和使用芯片测量的方法
公开(公告)号：JP2011152054A
公开(公告)日：2011-08-11
申请号：JP2010013840
申请日：2010-01-26
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： TANAAMI TAKEO , AOKI HIDETOSHI , SHIMODA SOICHIRO
IPC分类号： C12Q1/68 , C12M1/00 , C12N15/09 , G01N21/78 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide a concentration-measuring method, by which the concentration can quantitatively be measured with a chip, and the like.
SOLUTION: A reaction for binding specific probe molecules to target molecules is performed in a condition for binding the probe molecules to the target molecules with a calibration chip having the same performance as that of a measurement chip to determine the relation of the concentration of the target molecules in a calibration solution with a measurement quantity of light. The concentration of the target molecules in a measurement target solution is calculated on the basis of the measurement quantity of light determined at the step for determining the measurement quantity of light with the relation determined about the calibration chip.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种浓度测量方法，通过该浓度测量方法可以用芯片定量测量浓度等。解决方案：用特异性探针分子与靶分子结合的反应是在用具有与测量芯片相同性能的校准芯片将探针分子与靶分子结合的条件下进行的，以确定浓度的关系的目标分子在具有测量光量的校准溶液中。基于在确定了测量光量的步骤中确定的光的测量量与基于校准芯片确定的关系来计算目标分子在测量目标溶液中的浓度。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2011057813A Dendrimer coated magnetic fine particle, manufacturing method thereof, and application 有权
标题翻译： DENDRIMER涂层磁性微粒，其制造方法及应用
公开(公告)号：JP2011057813A
公开(公告)日：2011-03-24
申请号：JP2009207802
申请日：2009-09-09
申请人： Tokyo Univ Of Agriculture & Technology , Yokogawa Electric Corp , 国立大学法人東京農工大学 , 横河電機株式会社
发明人： MATSUNAGA TADASHI , TANAKA TAKESHI , HATAKEYAMA KEIICHI , TANAAMI TAKEO , WAKE HITOSHI , TAGUCHI TOMOYUKI , SHIGEKI GOSUKE
IPC分类号： C08G85/00 , C08G69/48 , C08G75/00 , C12N15/09
CPC分类号： B82Y25/00 , B22F2304/054 , B22F2998/00 , H01F1/0054 , B22F1/02 , B22F1/0018
摘要： PROBLEM TO BE SOLVED: To provide a magnetic fine particle coated with a dendrimer which is unlikely to cause aggregation after target substances, such as a nucleic acid, are adsorbed; and to provide its manufacturing method, and a method of recovery or purification of the nucleic acid using the same. SOLUTION: The dendrimer coated magnetic fine particle contains a magnetic fine particle, a lipid bilayer which covers the surface of this magnetic fine particle, and a dendrimer joined to the outer layer composing this lipid bilayer. The fine particle is a dendrimer coated magnetic fine particle, and the dendrimer is positively charged. A nucleic acid in the solution can be recovered by contacting the fine particle with a nucleic acid-containing solution, adsorbing the nucleic acid into the dendrimer, and collecting the dendrimer having the nucleic acid adsorbed thereto by means of magnetic force. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供涂覆有树枝状大分子的磁性微粒，其不吸收目标物质如核酸后不会引起聚集; 并提供其制造方法，以及使用该方法回收或纯化核酸的方法。解决方案：树枝状聚合物涂覆的磁性细颗粒含有磁性细颗粒，覆盖该磁性细颗粒表面的脂质双层和连接到构成该脂质双层的外层的树状聚合物。细颗粒是树枝状聚合物涂覆的磁性细颗粒，并且树枝状聚合物带正电荷。可以通过使细颗粒与含核酸的溶液接触，将核酸吸附到树枝状聚合物中并通过磁力收集具有吸附于其上的核酸的树状聚合物来回收溶液中的核酸。版权所有（C）2011，JPO＆INPIT

4. 发明专利

JP2010252962A Toxin removal amount measuring method and sampling device 有权
标题翻译：毒素去除量测量方法和采样装置
公开(公告)号：JP2010252962A
公开(公告)日：2010-11-11
申请号：JP2009105021
申请日：2009-04-23
申请人： Tohoku Univ , Yokogawa Electric Corp , 国立大学法人東北大学 , 横河電機株式会社
发明人： ICHIISHI EIICHIRO , YU ZHIQIAN , ISHIZAKI MAKOTO , SAWAI KOJI , TANAAMI TAKEO , FUKUSHIMA KAZUHISA
IPC分类号： A61M1/14
摘要： PROBLEM TO BE SOLVED: To provide a toxin removal amount measuring method or the like for easily and accurately recognizing a toxin removal amount in hemodialysis.
SOLUTION: A part of waste liquid of dialysate is sampled through a solenoid valve 21, and timing of sampling by the solenoid valve 21 is instructed by a timer 22. The timer 22 starts counting time at the start of dialysis on the basis of a signal from a dialysis controller 23 which executes control required for the dialysis by a dialyzer 1. The waste liquid of the dialysate sampled during the dialysis is preserved in a container 24. Also, by time-integrating a flow rate during the dialysis obtained by a flowmeter 26 in a control operation part 31, the total amount of the waste liquid of the dialysate is calculated.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供用于容易且准确地识别血液透析中的毒素去除量的毒素去除量测量方法等。解决方案：通过电磁阀21对透析液的一部分废液进行取样，由定时器22指示由电磁阀21取样的定时。定时器22在开始透析的基础上开始计数时间来自透析控制器23的信号，其执行由透析器1进行的透析所需的控制。在透析期间取样的透析液的废液被保存在容器24中。另外，通过对获得的透析期间的流量进行时间积分通过控制操作部31中的流量计26计算透析液的废液的总量。版权所有（C）2011，JPO＆INPIT

5. 发明专利

JP2010032400A Biochip reader 审中-公开
标题翻译：生物阅读器
公开(公告)号：JP2010032400A
公开(公告)日：2010-02-12
申请号：JP2008195585
申请日：2008-07-30
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： TANAAMI TAKEO , SUGIYAMA YUMIKO , NAITO YOSHINAO
IPC分类号： G01N21/64
摘要： PROBLEM TO BE SOLVED: To provide a biochip reader capable of suppressing the change in the quantity of exciting light based on the positional shift in the optical axis direction of the biochip to suppress the lowering of reading precision.
SOLUTION: An illumination optical system 20 is constituted so that an exciting light beam vertically illuminates the whole surface 11 of the biochip 1. Accordingly, the intensity of the exciting light beam is not changed even if the position of the surface 11 of the biochip 1 is shifted from a regular position in the P-direction (optical axis direction) shown by Fig.1. As a result, a change in the intensity of the exciting light or the lowering of detection precision caused by intensity irregularity can be prevented.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够基于生物芯片的光轴方向的位置偏移来抑制激发光量的变化的生物芯片读取器，以抑制读取精度的降低。解决方案：照明光学系统20被构造成使得激发光束垂直照射生物芯片1的整个表面11.因此，即使激光束的表面11的位置生物芯片1从图1所示的P方向（光轴方向）的规则位置移位。结果，可以防止由强度不均匀引起的激发光强度的变化或检测精度的降低。版权所有（C）2010，JPO＆INPIT

6. 发明专利

JP2009058523A Biochip reading device 审中-公开
标题翻译：生物阅读器
公开(公告)号：JP2009058523A
公开(公告)日：2009-03-19
申请号：JP2008287667
申请日：2008-11-10
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： TANAAMI TAKEO , SUGIYAMA YUMIKO
IPC分类号： G01N21/64
摘要： PROBLEM TO BE SOLVED: To provide a biochip reading device capable of fully attenuating the reflected excitation light which serves as the background light.
SOLUTION: This biochip reading device for transmission type is constituted to apply exciting light to a sample and form an image by the fluorescence generated from a fluorescent substance, in the sample via an image-forming optical system to read the image by a light-receiving device. In this biochip reading device, a barrier filter, having the action and effects of allowing the fluorescence generated from the fluorescent substance to pass through it, but attenuating the exciting light that passes through the sample is arranged between the sample in the image forming optical system and an objective lens or directly in front of the light receiver, or at both the positions to let the exciting light, passing through the sample to be incident on the barrier filter at an angle of incidence within ±5 degrees.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供能够完全衰减用作背景光的反射激发光的生物芯片读取装置。解决方案：用于透射型的生物芯片读取装置被构造成通过图像形成光学系统在样品中由荧光物质产生的荧光向样品施加激发光并形成图像，以通过图像形成光学系统读取图像光接收装置。在该生物芯片读取装置中，具有使荧光物质产生的荧光通过的荧光屏障的作用和效果，但通过样品的激发光衰减地配置在图像形成光学系统的样品之间或物镜，或者直接位于光接收器的前面，或者在使激发光的两个位置处以±5度的入射角通过样品入射到阻挡滤光器上。版权所有（C）2009，JPO＆INPIT

7. 发明专利

JP2008272645A Contents transfer device and chemical treatment system 审中-公开
标题翻译：目录转移装置和化学处理系统
公开(公告)号：JP2008272645A
公开(公告)日：2008-11-13
申请号：JP2007117984
申请日：2007-04-27
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： TANAAMI TAKEO , UCHIDA ISAO
IPC分类号： B01J4/00 , B01L99/00 , G01N35/10
CPC分类号： F04B43/082 , B01L3/50273 , B01L2300/0816 , B01L2300/1805 , B01L2400/0439 , B01L2400/0481 , B01L2400/0655
摘要： PROBLEM TO BE SOLVED: To provide a contents transfer device which is universally applicable for various chemical treatment cartridges and to provide a chemical treatment system. SOLUTION: The contents transfer device is provided with a plurality of members 1, 1, ... and a driving means 2 to independently drive the members 1, 1, ... with each other to the up and down direction. The contents can be transferred by a smoother pulsating action besides the similar action to the case using a roller because a plurality of members 1 are independently driven. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供普遍适用于各种化学处理药筒的内容物转移装置，并提供化学处理系统。内容传送装置设置有多个构件1,1和驱动装置2，以独立地驱动构件1,1，...彼此上下方向。除了独立地驱动多个构件1之外，除了与使用辊的情况相似的动作之外，还可以通过更平滑的脉动动作传递内容物。版权所有（C）2009，JPO＆INPIT

8. 发明专利

JP2008175608A Cartridge for chemical reaction and its use 审中-公开
标题翻译：化学反应及其使用用途
公开(公告)号：JP2008175608A
公开(公告)日：2008-07-31
申请号：JP2007007807
申请日：2007-01-17
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： TANAAMI TAKEO , ITO ATSUSHI , AOKI HIDETOSHI
IPC分类号： G01N1/00
CPC分类号： G01N33/521 , A61B5/150022 , A61B5/15003
摘要： PROBLEM TO BE SOLVED: To safely introduce a specimen into a cartridge for chemical reaction. SOLUTION: A needle 5 with its inner end connected to a sampling chamber 8, a needle 6 with its inner end connected to a chamber 7, and a protective member 4 for the needles comprise an end part of this cartridge 1. By using this cartridge 1, the needles 5 and 6 are stuck into a rubber plug 14 while inserting a blood collecting tube 13 into a hole part 4a in the protective member 4. By putting air or the like in the blood collecting tube 13 through the chamber 7, blood 2 is pressed out and input into the sampling chamber 8. Inspection is performed with the blood collecting tube 13 connected to the cartridge 1, and the blood collecting tube 13 and the cartridge 1 are to be discarded as they are. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：将样品安全地引入化学反应的药筒中。解决方案：针5，其内端连接到采样室8，其内端连接到室7的针6，针的保护构件4包括该盒1的端部。通过使用该药筒1，将针5,6插入橡胶塞14，同时将血液收集管13插入保护部件4的孔部4a。通过室内将空气等放入集血管13中如图7所示，血液2被压出并输入到取样室8.检查是与采血管13连接到药筒1进行的，采集管13和药筒1原样放弃。版权所有（C）2008，JPO＆INPIT

9. 发明专利

JP2008051544A Chemical reaction device 审中-公开
标题翻译：化学反应装置
公开(公告)号：JP2008051544A
公开(公告)日：2008-03-06
申请号：JP2006225502
申请日：2006-08-22
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： RAN MUNEKI , TANAAMI TAKEO , KAKURYU NOBUYUKI , NOGUCHI MASAKATSU
IPC分类号： G01N35/08 , B01J19/00 , G01N1/00 , G01N21/49 , G01N21/59 , G01N21/64 , G01N29/02 , G01N37/00
CPC分类号： B01L3/50273 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0481 , B01L2400/0655
摘要： PROBLEM TO BE SOLVED: To provide a chemical reaction device capable of certainly preventing a liquid sending error or the empty feed of a liquid and capable of realizing the sending of the liquid and the automation of the sending of the liquid of high reliability.
SOLUTION: The chemical reaction device 100 for sending solutions X and Y to chemically react them includes a substrate 1, a cartridge 3 having a plurality of chambers 21-25 in which the solutions X and Y are housed and the flow channels 26a, 26b, 27a and 27b for connecting a plurality of the chambers 21-25 between the substrate 1 and the elastomer 2 provided so as to be superposed on the substrate 1, a plurality of squeegees 41-43 freely movable in a mutually independent state with respect to the cartridge 3 and moved in contact with the surface of the elastomer 2 to apply external force to the elastomer 2 to seal or move the solutions X and Y in the flow channels 26a, 26b, 27a and 27b or the chambers 21-25 and detection sensors 71 and 72 for detecting the state of the solution pool in the flow channels 26a, 26b, 27a and 27b or the chambers 21-25.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够肯定地防止液体发生错误或液体空进而能够实现液体的发送和自动化发送高可靠性的液体的化学反应装置。解决方案：用于发送溶液X和Y以使其化学反应的化学反应装置100包括基底1，具有容纳溶液X和Y的多个腔室21-25的药筒3和流路26a ，26b，27a和27b，用于将基板1和弹性体2之间的多个室21-25连接以设置成叠置在基板1上，多个可相互独立状态地自由移动的刮墨辊41-43，相对于盒3并且与弹性体2的表面接触移动以向弹性体2施加外力，以密封或移动流动通道26a，26b，27a和27b或室21-25中的溶液X和Y 以及检测传感器71和72，用于检测流道26a，26b，27a和27b或室21-25中的溶液池的状态。版权所有（C）2008，JPO＆INPIT

10. 发明专利

JP2008039511A Biochemical reaction apparatus and method 有权
标题翻译：生化反应装置及方法
公开(公告)号：JP2008039511A
公开(公告)日：2008-02-21
申请号：JP2006212202
申请日：2006-08-03
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： SATO SAAYA , TANAAMI TAKEO
IPC分类号： G01N35/08 , B01J19/00 , C12M1/00 , C12M1/34 , G01N37/00
CPC分类号： B01L3/502 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2400/0481 , B01L2400/0605 , Y10T137/0391
摘要： PROBLEM TO BE SOLVED: To provide a biochemical reaction apparatus and a biochemical reaction method, capable of surely perform liquid transport by solving liquid remaining or liquid back flow. SOLUTION: The biochemical reaction apparatus 100 includes a cartridge 3 having a plurality of chambers 21-24 storing solutions X and Y and a flow passage 25 connecting the plurality of chambers 21-24, which are disposed between a substrate 1 and an elastic body 2 placed over the substrate 1; and a roller 4 which applies external force to the elastic body 2 to partially deform the passage 25 or the chambers 21-24 or the both to thereby move the solutions X and Y located in the passage 2 or the chambers 21-24. The sectional shape orthogonal to a roller shaft 41 of the roller 4 has at least three or more angle parts 431-434, the length n of each side of each angle part 431-434 being equal. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种生物化学反应装置和生物化学反应方法，其能够通过解决液体残留或液体回流确保进行液体输送。生物化学反应装置100包括：具有存储溶液X和Y的多个室21-24和连接多个室21-24的流路25的盒3，其设置在基板1和放置在基板1上的弹性体2; 以及向弹性体2施加外力以使通道25或室21-24或两者部分变形从而移动位于通道2或室21-24中的溶液X和Y的辊4。与辊4的辊轴41正交的截面形状具有至少三个以上的角部431-434，每个角部431-434的每一侧的长度n相等。版权所有（C）2008，JPO＆INPIT

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