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1. 发明专利

JP2010156629A Chemical treatment cartridge and method of using same 审中-公开
标题翻译：化学处理盒及其使用方法
公开(公告)号：JP2010156629A
公开(公告)日：2010-07-15
申请号：JP2008335708
申请日：2008-12-29
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： SHIGEKI GOSUKE , TANAAMI TAKEO , AOKI HIDETOSHI
IPC分类号： G01N35/08 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a chemical treatment cartridge and a method of using the same capable of measuring without lowering signal intensity after hybridization.
SOLUTION: This chemical treatment cartridge 1 for performing chemical treatment by sealing or moving a content by deformation caused by a force applied from the outside, includes a well 16 for storing a microarray; a well 14 connected to the well 16 through a channel, for storing a nucleic acid material; and wells 11-13 connected to the well 16 through a channel, for storing cleaning liquid for cleaning the nucleic acid material.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供化学处理盒和使用该化学处理盒的方法，其能够在不降低杂交后的信号强度的情况下进行测量。解决方案：用于通过由从外部施加的力引起的变形来密封或移动内容物进行化学处理的该化学处理盒1包括用于存储微阵列的阱16; 通过通道连接到井16的井14，用于储存核酸材料; 以及通过通道连接到井16的井11-13，用于存储用于清洁核酸材料的清洁液体。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2015042152A 複数遺伝子検出方法审中-公开
标题翻译：检测基因种类的方法
公开(公告)号：JP2015042152A
公开(公告)日：2015-03-05
申请号：JP2013174704
申请日：2013-08-26
申请人：横河電機株式会社 , Yokogawa Electric Corp
发明人： SHIGEKI GOSUKE , MITSUMORI YUJI , TAGUCHI TOMOYUKI , TANAAMI TAKEO , KIKUCHI NAGAYASU , AOKI HIDETOSHI
IPC分类号： C12Q1/68
摘要：【課題】DNAマイクロアレイを用いる核酸検出する場合に、検査コストと測定時間を抑制することができる複数遺伝子検出方法を提供する。【解決手段】第1の検出ステップにおける検出結果に基づいて、検出作業を続行するか否かを判断する判断ステップと、判断ステップによる判断が肯定された場合にのみ、第2の標識剤により標識化された標的遺伝子の有無を検出する第2の検出ステップと、を備える。第2の検出ステップでは、第1の標識化ステップ、第2の標識化ステップおよび第1の検出ステップを経由した遺伝子に対して標的遺伝子の有無を検出する。【選択図】図1
摘要翻译：要解决的问题：提供一种用于检测在使用DNA微阵列检测核酸时可以抑制检测成本和测量时间的多种基因的方法。解决方案：该方法包括判断步骤，判断检测是否为基于第一检测步骤中的检测结果继续或不继续，以及第二检测步骤，只有在通过判断步骤的判断被确认时才检测是否存在用第二标记物标记的靶基因。在第二检测步骤中，通过第一标记步骤，第二标记步骤和第一检测步骤检测基因的存在或不存在。

3. 发明专利

JP2013024818A Concentration measurement method and concentration measurement system 有权
标题翻译：浓度测量方法和浓度测量系统
公开(公告)号：JP2013024818A
公开(公告)日：2013-02-04
申请号：JP2011162518
申请日：2011-07-25
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： TANAAMI TAKEO , AOKI HIDETOSHI , SHIMODA SOICHIRO
IPC分类号： G01N33/53 , G01N21/64 , G01N33/543
CPC分类号： C12Q1/6837 , C12Q2545/113
摘要： PROBLEM TO BE SOLVED: To provide a concentration measurement method and the like capable of performing quantitative measurement using a chip.SOLUTION: A relation between concentration of a target molecule of calibration liquid and a quantity of measurement light is obtained with respect to a calibration chip by the binding reaction of a probe molecule and the target molecule on the condition that a specific probe molecule and the target molecule perform the binding reaction by using a calibration chip of the same performance as a measurement chip. The relation obtained with respect to the calibration chip is used to calculate concentration of the target molecule in solution to be measured on the basis of the quantity of measurement light obtained in the step for obtaining the quantity of measurement light.
摘要翻译：要解决的问题：提供能够使用芯片进行定量测量的浓度测量方法等。解决方案：通过探针分子和靶分子的结合反应，在特定的探针分子的条件下，通过校准芯片获得校准液的目标分子的浓度与测量光的量之间的关系并且目标分子通过使用与测量芯片具有相同性能的校准芯片来执行结合反应。根据在获得测量光量的步骤中获得的测量光量，使用相对于校准芯片获得的关系来计算待测溶液中的目标分子的浓度。版权所有（C）2013，JPO＆INPIT

4. 发明专利

JP2009210571A Apparatus and method for measuring number of molecule 有权
标题翻译：用于测量分子数的装置和方法
公开(公告)号：JP2009210571A
公开(公告)日：2009-09-17
申请号：JP2009026584
申请日：2009-02-06
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： TANAAMI TAKEO , AOKI HIDETOSHI , SATO SAAYA , SUGIYAMA YUMIKO
IPC分类号： G01N21/64
CPC分类号： G01N21/6458
摘要： PROBLEM TO BE SOLVED: To provide an apparatus and method for measuring the number of molecule, for calculating the number of molecule in a sample by comparing a measured value of a light quantity with a theoretical light quantity per single molecule. SOLUTION: The number of molecule of the sample is quantitatively measured based on a light quantity correlated with the number of molecule. The method for measuring the number of molecule includes the step of calculating the theoretical light quantity per single molecule, the step of measuring a light quantity of the sample by use of an imaging system, and the step of calculating the number of molecule of the sample based on a ratio of the measured light quantity of the sample to the calculated theoretical light quantity. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种测量分子数的装置和方法，用于通过将光量的测量值与每个分子的理论光量进行比较来计算样品中的分子数。解决方案：根据与分子数相关的光量定量测定样品的分子数。测定分子数的方法包括计算每个分子的理论光量的步骤，使用成像系统测量样品的光量的步骤，以及计算样品分子数的步骤基于所测量的样品的光量与计算的理论光量的比率。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2009103552A Microarray 审中-公开
标题翻译： MICROARRAY
公开(公告)号：JP2009103552A
公开(公告)日：2009-05-14
申请号：JP2007274822
申请日：2007-10-23
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： TANAAMI TAKEO , AOKI HIDETOSHI
IPC分类号： G01N33/53 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a microarray capable of detecting a target polymer with high sensitivity.
SOLUTION: Each probe chain corresponding to each target DNA which is different relative to each detection portion is immobilized. A probe chain 2 corresponding to a target DNA 1 having a sequence 'A' is shown as a representative. The probe chain 2 which is a DNA chain having a sequence 'XX...X' repeating a sequence 'X' which is complimentary to the sequence 'A' is immobilized on a substrate 3. When performing hybridization by adding a fluorescent marker 11 to the target DNA 1, the target DNA 1 is bonded to each portion of the sequence 'A' in the probe chain 2.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供能够以高灵敏度检测目标聚合物的微阵列。解决方案：固定了与每个检测部分不同的每个靶DNA相应的每个探针链。示出了与具有序列'A'的靶DNA 1相对应的探针链2作为代表。作为与序列“A”互补的序列“X”的序列“XX ... X”的DNA链的探针链2被固定在基板3上。当通过添加荧光标记物11进行杂交时对靶DNA 1，靶DNA 1与探针链2中的序列“A”的各部分结合。版权所有（C）2009，JPO＆INPIT

6. 发明专利

JP2007090138A Cartridge for chemical treatments, and its using method 审中-公开
标题翻译：化学处理剂及其使用方法
公开(公告)号：JP2007090138A
公开(公告)日：2007-04-12
申请号：JP2005279505
申请日：2005-09-27
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： TANAAMI TAKEO , AOKI HIDETOSHI , SATO SAAYA , SHIGEKI GOSUKE
IPC分类号： B01J19/00 , B01F5/00 , B01F15/02 , B67D7/70 , B67D7/78 , C12M1/34 , C12M3/00 , G01N37/00
CPC分类号： B01L3/502707 , B01F5/0641 , B01F5/0645 , B01F5/0693 , B01F5/0696 , B01F13/0059 , B01F15/0201 , B01F15/025 , B01J19/0093 , B01J2219/00783 , B01J2219/00833 , B01J2219/00835 , B01J2219/0086 , B01J2219/00889 , B01J2219/00891 , B01L3/5027 , B01L2300/0816 , B01L2300/0867 , B01L2400/0481
摘要： PROBLEM TO BE SOLVED: To provide a cartridge for chemical treatments which is capable of stably and safely conducting the chemical treatment, and to provide its using method. SOLUTION: The cartridge for chemical treatment is provided with a substrate 1 and an elastic member 2 which is superposed on the substrate. A recessed part with a predetermined profile which is recessed at the surface side is formed in the back face of the elastic member. The recessed part, with a created space between the cartridge substrate and the elastic member, constitutes a well 21 to store a main agent of an epoxy adhesive, a passage 22 communicating with the well 21, a well 23 to store a curing agent of the epoxy adhesive, a passage 24 communicating with the well 23, a mixing part 25 to mix the main agent and the curing agent and a discharge path 26 to discharge the mixture. The passage 22, passage 24 and the discharge pass 26 are closed when the cartridge for chemical treatment is not used, and the well 21 and the well 23 are substantially under gas-tight conditions. The mixing part 25 consists of a plurality of passages 25 which are crossed mutually. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够稳定且安全地进行化学处理的化学处理用盒，并提供其使用方法。
解决方案：用于化学处理的盒设置有基板1和叠置在基板上的弹性部件2。在弹性构件的背面形成有在表面侧凹陷的具有预定轮廓的凹部。在盒基板和弹性构件之间形成空间的凹部构成了用于存储环氧树脂粘合剂的主剂，与井21连通的通道22的井21，以及井23的固化剂环氧树脂粘合剂，与井23连通的通道24，用于混合主剂和固化剂的混合部分25和用于排出混合物的排出路径26。当不使用用于化学处理的盒，并且井21和井23基本上处于气密条件下时，通道22，通道24和排放通道26关闭。混合部分25由相互交叉的多个通道25组成。版权所有（C）2007，JPO＆INPIT

7. 发明专利

JP2011038772A Method and device for measuring quantity of fluorescence or quantity of extinction 有权
标题翻译：用于测量荧光量或超量量的方法和装置
公开(公告)号：JP2011038772A
公开(公告)日：2011-02-24
申请号：JP2009183317
申请日：2009-08-06
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： TANAAMI TAKEO , AOKI HIDETOSHI , SUGIYAMA YUMIKO , SHIMODA SOICHIRO , RAN MUNEKI
IPC分类号： G01N21/64 , G01N21/27
CPC分类号： G01N21/6452 , G01N21/6428
摘要： PROBLEM TO BE SOLVED: To quantitatively measure a quantity of the fluorescence emitted from a sample as "quantity of light per a unit area traceable to the National Standard" different from a ratio (ratio value) used heretofore.
SOLUTION: A method for measuring the quantity of fluorescence is constituted so as to measure the fluorescence emitted from the sample irradiated with exciting light by a light detection element through a light receiving optical system and includes the step of irradiating the sample with the exciting light having the quantity value of light per a unit area traceable to the National Standard and preliminarily indicated on the surface of the sample, the step of measuring the fluorescence emitted from the sample by the light detection element through the light receiving optical system and the step of operating the quantity of the fluorescence measured by the light receiving element on the basis of the indicated quantity of exciting light per a unit area, the optical coefficient of the light detection element and the light receiving coefficient of the light detection optical system to calculate the same as the quantity value of light per a unit area traceable to the National Standard.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：定量测量从样品发出的荧光的量，与以前使用的比率（比值）不同，“可追溯到国家标准的单位面积的光量”不同。解决方案：用于测量荧光量的方法被构成为通过光接收光学系统测量由光检测元件照射激光的样品发出的荧光，并且包括以下步骤：具有可追溯到国家标准并在样品表面上预先指示的单位面积的光量的激发光，通过光接收光学系统测量由光检测元件从样品发出的荧光的步骤，以及基于每单位面积的指示的激发光量，光检测元件的光学系数和光检测光学系统的光接收系数来操作由光接收元件测量的荧光量的步骤，以计算与可追溯到国家标准的单位面积的光量相同。版权所有（C）2011，JPO＆INPIT

8. 发明专利

JP2011152054A Concentration-measuring method, chip for measuring concentration and method for using the chip for the measurement 审中-公开
标题翻译：浓度测量方法，用于测量浓度的芯片和使用芯片测量的方法
公开(公告)号：JP2011152054A
公开(公告)日：2011-08-11
申请号：JP2010013840
申请日：2010-01-26
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： TANAAMI TAKEO , AOKI HIDETOSHI , SHIMODA SOICHIRO
IPC分类号： C12Q1/68 , C12M1/00 , C12N15/09 , G01N21/78 , G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide a concentration-measuring method, by which the concentration can quantitatively be measured with a chip, and the like.
SOLUTION: A reaction for binding specific probe molecules to target molecules is performed in a condition for binding the probe molecules to the target molecules with a calibration chip having the same performance as that of a measurement chip to determine the relation of the concentration of the target molecules in a calibration solution with a measurement quantity of light. The concentration of the target molecules in a measurement target solution is calculated on the basis of the measurement quantity of light determined at the step for determining the measurement quantity of light with the relation determined about the calibration chip.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种浓度测量方法，通过该浓度测量方法可以用芯片定量测量浓度等。解决方案：用特异性探针分子与靶分子结合的反应是在用具有与测量芯片相同性能的校准芯片将探针分子与靶分子结合的条件下进行的，以确定浓度的关系的目标分子在具有测量光量的校准溶液中。基于在确定了测量光量的步骤中确定的光的测量量与基于校准芯片确定的关系来计算目标分子在测量目标溶液中的浓度。版权所有（C）2011，JPO＆INPIT

9. 发明专利

JP2008175608A Cartridge for chemical reaction and its use 审中-公开
标题翻译：化学反应及其使用用途
公开(公告)号：JP2008175608A
公开(公告)日：2008-07-31
申请号：JP2007007807
申请日：2007-01-17
申请人： Yokogawa Electric Corp , 横河電機株式会社
发明人： TANAAMI TAKEO , ITO ATSUSHI , AOKI HIDETOSHI
IPC分类号： G01N1/00
CPC分类号： G01N33/521 , A61B5/150022 , A61B5/15003
摘要： PROBLEM TO BE SOLVED: To safely introduce a specimen into a cartridge for chemical reaction. SOLUTION: A needle 5 with its inner end connected to a sampling chamber 8, a needle 6 with its inner end connected to a chamber 7, and a protective member 4 for the needles comprise an end part of this cartridge 1. By using this cartridge 1, the needles 5 and 6 are stuck into a rubber plug 14 while inserting a blood collecting tube 13 into a hole part 4a in the protective member 4. By putting air or the like in the blood collecting tube 13 through the chamber 7, blood 2 is pressed out and input into the sampling chamber 8. Inspection is performed with the blood collecting tube 13 connected to the cartridge 1, and the blood collecting tube 13 and the cartridge 1 are to be discarded as they are. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：将样品安全地引入化学反应的药筒中。解决方案：针5，其内端连接到采样室8，其内端连接到室7的针6，针的保护构件4包括该盒1的端部。通过使用该药筒1，将针5,6插入橡胶塞14，同时将血液收集管13插入保护部件4的孔部4a。通过室内将空气等放入集血管13中如图7所示，血液2被压出并输入到取样室8.检查是与采血管13连接到药筒1进行的，采集管13和药筒1原样放弃。版权所有（C）2008，JPO＆INPIT

10. 发明专利

JP2008032395A Blood diagnosing method of artificial dialysis patient, and dialyzer 审中-公开
标题翻译：人工脱水患者和DIALYZER血液检测方法
公开(公告)号：JP2008032395A
公开(公告)日：2008-02-14
申请号：JP2006202680
申请日：2006-07-26
申请人： Tohoku Univ , Yokogawa Electric Corp , 国立大学法人東北大学 , 横河電機株式会社
发明人： ICHIISHI EIICHIRO , ISHIZAKI MAKOTO , FUKUSHIMA KAZUHISA , SAWAI KOJI , AOKI HIDETOSHI , ITO ATSUSHI
IPC分类号： G01N33/53 , A61M1/14 , C12Q1/68 , G01N37/00
CPC分类号： G01N33/491
摘要： PROBLEM TO BE SOLVED: To provide a blood diagnosing method having general-purpose properties and capable of applying a diagnostic marker contributing to the evaluation of a dialytic prescription and a clinical effect.
SOLUTION: The blood diagnosing method has a step of sampling blood samples before and after the dialysis of an artificial dialysis patient and a step of performing the genetic diagnosis based on an mRNA marker with respect to the collected blood samples. The mRNA marker is preliminarily identified on the basis of the correlation between clinical data and an mRNA profile.
COPYRIGHT: (C)2008,JPO&INPIT

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