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1. 发明申请

US20090197331A1 Compositions for cryopreservation of cells 有权
标题翻译：冷冻保存细胞的组合物
公开(公告)号：US20090197331A1
公开(公告)日：2009-08-06
申请号：US11663539
申请日：2005-09-26
申请人： Yoichi Kato , Masahiro Sasaki , Hideyuki Yamada
发明人： Yoichi Kato , Masahiro Sasaki , Hideyuki Yamada
IPC分类号： C12N5/08
CPC分类号： A01N1/02 , A01N1/0221 , C07K14/43586 , C12N1/04
摘要： A composition for the cryopreservation of cells according to the present invention at least comprises sericin and one or more components selected from the group consisting of amino acids and saccharides. Further, a method for the cryopreservation of cells according to the present invention comprises the steps of placing target cells in the abovementioned composition for the cryopreservation of cells and cryopreserving them. According to the composition for the cryopreservation of cells of the present invention, cells can be cryopreserved over a long period of time without the use of serum and components derived from serum.
摘要翻译：根据本发明的用于细胞冷冻保存的组合物至少包含丝胶蛋白和选自氨基酸和糖的一种或多种组分。此外，根据本发明的用于细胞冷冻保存的方法包括以下步骤：将靶细胞置于上述组合物中用于细胞的冷冻保存并冷冻保存细胞。根据本发明细胞冷冻保存的组成，细胞可以在不使用血清和血清成分的情况下长时间冷冻保存。

2. 发明授权

US09055739B2 Compositions for cryopreservation of cells 有权
公开(公告)号：US09055739B2
公开(公告)日：2015-06-16
申请号：US11663539
申请日：2005-09-26
申请人： Yoichi Kato , Masahiro Sasaki , Hideyuki Yamada
发明人： Yoichi Kato , Masahiro Sasaki , Hideyuki Yamada
IPC分类号： C12N5/00 , A01N1/00 , A01N1/02 , C07K14/435 , C12N1/04
CPC分类号： A01N1/02 , A01N1/0221 , C07K14/43586 , C12N1/04
摘要： A composition for the cryopreservation of cells according to the present invention at least comprises sericin and one or more components selected from the group consisting of amino acids and saccharides. Further, a method for the cryopreservation of cells according to the present invention comprises the steps of placing target cells in the abovementioned composition for the cryopreservation of cells and cryopreserving them. According to the composition for the cryopreservation of cells of the present invention, cells can be cryopreserved over a long period of time without the use of serum and components derived from serum.

3. 发明申请

US20070275875A1 Method for preventing colon cancer 审中-公开
标题翻译：预防结肠癌的方法
公开(公告)号：US20070275875A1
公开(公告)日：2007-11-29
申请号：US11799578
申请日：2007-05-02
申请人： Masahiro Sasaki , Hideyuki Yamada , Masakazu Nomura
发明人： Masahiro Sasaki , Hideyuki Yamada , Masakazu Nomura
IPC分类号： A61K38/39
CPC分类号： A61K38/17 , A61K38/16
摘要： Provided are novel colon cancer preventives, and digestible food/drink additives and health supplements which not only are effective in body weight control and constipation prevention/treatment, but also have the action of accelerating the intestinal absorption of minerals. Sericin or it's hydrolyzed product is used as a colon cancer preventive, food/drink additive or health supplement.
摘要翻译：提供新型结肠癌预防药物，消化食品/饮料添加剂和保健品，不仅有效体重控制和便秘预防/治疗，而且还具有加速肠道吸收矿物质的作用。丝胶蛋白或其水解产物用作结肠癌预防，食物/饮料添加剂或健康补充剂。

4. 发明授权

US07157273B2 Medium additives and media for culturing animal cells 有权
标题翻译：用于培养动物细胞的培养基添加剂和培养基
公开(公告)号：US07157273B2
公开(公告)日：2007-01-02
申请号：US10311406
申请日：2002-04-17
申请人： Masahiro Sasaki , Hideyuki Yamada , Katsue Osada , Satoshi Terada
发明人： Masahiro Sasaki , Hideyuki Yamada , Katsue Osada , Satoshi Terada
IPC分类号： C12N5/00 , C12N5/06 , C07K14/00 , C12P21/04
CPC分类号： C12N5/0018 , C12N2500/82 , C12N2501/998
摘要： An object of the present invention is to provide a medium supplement for animal cell culture and an animal cell culture medium. The present invention relates to a medium supplement for animal cell culture comprising sericin or a sericin derivative and an animal cell culture medium comprising at least said medium supplement and a basal medium composition.
摘要翻译：本发明的目的是提供用于动物细胞培养的培养基和动物细胞培养基。本发明涉及包含丝胶蛋白或丝胶蛋白衍生物的动物细胞培养基培养基补充剂和至少包含所述培养基补充剂和基础培养基组合物的动物细胞培养基。

5. 发明授权

US07803616B2 Medium supplement and animal cell culture medium 有权
标题翻译：培养基和动物细胞培养基
公开(公告)号：US07803616B2
公开(公告)日：2010-09-28
申请号：US11523343
申请日：2006-09-19
申请人： Masahiro Sasaki , Hideyuki Yamada , Katsue Osada , Satoshi Terada
发明人： Masahiro Sasaki , Hideyuki Yamada , Katsue Osada , Satoshi Terada
IPC分类号： C12N5/02 , C12P21/04
CPC分类号： C12N5/0018 , C12N2500/82 , C12N2501/998
摘要： An object of the present invention is to provide a medium supplement for animal cell culture and an animal cell culture medium. The present invention relates to a medium supplement for animal cell culture comprising sericin or a sericin derivative and an animal cell culture medium comprising at least said medium supplement and a basal medium composition.
摘要翻译：本发明的目的是提供用于动物细胞培养的培养基和动物细胞培养基。本发明涉及包含丝胶蛋白或丝胶蛋白衍生物的动物细胞培养基培养基补充剂和至少包含所述培养基补充剂和基础培养基组合物的动物细胞培养基。

6. 发明申请

US20090269825A1 METHOD FOR STABILIZATION OF BIOLOGICAL MOLECULE AND COMPOSITION 审中-公开
标题翻译：生物分子和组合物稳定化方法
公开(公告)号：US20090269825A1
公开(公告)日：2009-10-29
申请号：US12093267
申请日：2006-11-09
申请人： Takahide Kishimoto , Kayoko Kajitani , Kazuo Kajitani , Hideyuki Yamada , Masahiro Sasaki
发明人： Takahide Kishimoto , Kayoko Kajitani , Kazuo Kajitani , Hideyuki Yamada , Masahiro Sasaki
IPC分类号： C12N9/96 , C07K1/02
CPC分类号： C07K16/00 , C12N9/96 , G01N33/531
摘要： The object is to provide a method for stabilization of a biological molecule and a composition, specifically a method for stabilization of an enzyme or a labeled antibody for use in a clinical diagnosis and a composition. Thus, disclosed is a method for stabilization of a biological molecule which is characterized by allowing (a) the biological molecule and (b) sericin and/or a hydrolysate or equivalence thereof to coexist with each other. Also disclosed is a composition having a biological molecule stabilized therein, which is characterized in that the components (a) and (b) coexist with each other in the composition. Further disclosed is a composition for stabilizing a biological molecule, which comprises sericin and/or a hydrolysate or equivalence thereof.
摘要翻译：本发明的目的是提供一种用于稳定生物分子和组合物的方法，特别是用于稳定临床诊断和组合物中的酶或标记抗体的方法。因此，公开了一种稳定生物分子的方法，其特征在于允许（a）生物分子和（b）丝胶蛋白和/或其水解产物或其等同物彼此共存。还公开了其中稳定化学生物分子的组合物，其特征在于组分（a）和（b）在组合物中彼此共存。还公开了用于稳定生物分子的组合物，其包含丝胶蛋白和/或其水解物或其等同物。

7. 发明申请

US20070020760A1 Medium supplement and animal cell culture medium 有权
标题翻译：培养基和动物细胞培养基
公开(公告)号：US20070020760A1
公开(公告)日：2007-01-25
申请号：US11523343
申请日：2006-09-19
申请人： Masahiro Sasaki , Hideyuki Yamada , Katsue Osada , Satoshi Terada
发明人： Masahiro Sasaki , Hideyuki Yamada , Katsue Osada , Satoshi Terada
IPC分类号： C12N15/86 , C12N5/00 , C12N7/00
CPC分类号： C12N5/0018 , C12N2500/82 , C12N2501/998
摘要： An object of the present invention is to provide a medium supplement for animal cell culture and an animal cell culture medium. The present invention relates to a medium supplement for animal cell culture comprising sericin or a sericin derivative and an animal cell culture medium comprising at least said medium supplement and a basal medium composition.
摘要翻译：本发明的目的是提供用于动物细胞培养的培养基和动物细胞培养基。本发明涉及包含丝胶蛋白或丝胶蛋白衍生物的动物细胞培养基培养基补充剂和至少包含所述培养基补充剂和基础培养基组合物的动物细胞培养基。

8. 发明授权

US08558527B2 Switching power supply system provided with under voltage lock out circuit 有权
标题翻译：开关电源系统配有欠压锁定电路
公开(公告)号：US08558527B2
公开(公告)日：2013-10-15
申请号：US13109331
申请日：2011-05-17
申请人： Masahiro Sasaki , Tetsuya Kawashima
发明人： Masahiro Sasaki , Tetsuya Kawashima
IPC分类号： G05F1/00
CPC分类号： H02M1/32 , H02M1/36 , H02M3/1588 , H02M2001/0012 , Y02B70/1466
摘要： A switching power supply system controlling switching operations of switching devices by a control circuit to convert an input voltage into a desired output voltage, the system being provided with a under voltage lock out circuit including: an input voltage detection unit detecting an input voltage and producing an input voltage digital signal corresponding to the input voltage Vin; and a voltage level comparison unit carrying out digital comparison of the input voltage digital signal with each of two voltage detection level data and outputting the results of the comparisons as an output signal, in which by changing voltage detection level data stored in two registers, desired voltage detection levels and hysteresis characteristic are easily actualized.
摘要翻译：一种开关电源系统，其通过控制电路来控制开关器件的开关动作，将输入电压转换成期望的输出电压，所述系统配备有欠压锁定电路，包括：输入电压检测单元，检测输入电压并产生对应于输入电压Vin的输入电压数字信号; 以及电压电平比较单元，对输入电压数字信号与两个电压检测电平数据中的每一个进行数字比较，并输出比较结果作为输出信号，其中通过改变存储在两个寄存器中的电压检测电平数据为期望的电压检测电平和滞后特性容易实现。

9. 发明授权

US08315820B2 Potentiometric titration method and potentiometric titration apparatus 有权
标题翻译：电位滴定法和电位滴定仪
公开(公告)号：US08315820B2
公开(公告)日：2012-11-20
申请号：US12705214
申请日：2010-02-12
申请人： Masahiro Sasaki , Toshiyuki Kamo , Yoko Ohashi
发明人： Masahiro Sasaki , Toshiyuki Kamo , Yoko Ohashi
IPC分类号： G01N31/00
CPC分类号： G01N31/164
摘要： A potentiometric titration method including calculating a titration curve and a differential curve from measured values; computing a straight line (D) connecting the two measured values on the titration curve which are present adjacent to a tentative terminal point (P); computing a first estimation line (B1) and a second estimation line (B2) by a least squares method based on a set of the measured values (d1), (d2) and (d3) and a set of the measured values (d4), (d5) and (d6), respectively, on the titration curve, which are respectively spaced by a predetermined level apart from the tentative terminal point (P) by using the number of decision points (n) as an index where the number of decision points (n) represents the number of measured values on the previously set titration curve; computing an intermediate line (C) between the first estimation line (B1) and the second estimation line (B2); and computing an intersection point (A) of the intermediate line (C) and the straight line (D) to read out a value of the intersection point on an abscissa axis as a terminal point (a) of the titration.
摘要翻译：电位滴定法，包括从测量值计算滴定曲线和微分曲线; 计算连接临时终点（P）附近的滴定曲线上的两个测量值的直线（D）; 基于一组测量值（d1），（d2）和（d3）和一组测量值（d4），通过最小二乘法计算第一估计线（B1）和第二估计线（B2），（d5）和（d6）分别通过使用决定点（n）的数量作为指标的数量，分别与临时终点（P）间隔预定水平的滴定曲线决策点（n）表示先前设定的滴定曲线上的测量值的数量; 计算第一估计线（B1）和第二估计线（B2）之间的中间线（C）; 并计算中间线（C）和直线（D）的交点（A），以读出横坐标轴上的交点的值作为滴定的终点（a）。

10. 发明授权

US07784445B2 Control unit for internal combustion engine 有权
标题翻译：内燃机控制单元
公开(公告)号：US07784445B2
公开(公告)日：2010-08-31
申请号：US12257074
申请日：2008-10-23
申请人： Nobuyuki Takahashi , Masahiro Sasaki , Takuya Mayuzumi , Mitsuhiko Watanabe , Ryoichi Oura
发明人： Nobuyuki Takahashi , Masahiro Sasaki , Takuya Mayuzumi , Mitsuhiko Watanabe , Ryoichi Oura
IPC分类号： F02M51/00
CPC分类号： F02D41/20 , F02D41/221 , F02D2041/2013 , F02D2041/2044 , F02D2041/2058 , F02D2041/2093 , F02D2041/227 , Y02T10/40
摘要： There is proposed a control unit for an internal combustion engine, which comprises a boost circuit, a switching element, a current detecting resistor and a controller and is designed to be actuated such that the boost circuit is used to boost a power source voltage to create a boosted voltage and the controller is used to control the switching element so as to enable the boosted voltage to flow to the injector solenoid coil. This control unit is designed such that, when the boost circuit goes out of order, the injector solenoid coil is excited by making use of the power source voltage without using the boosted voltage and without creating a peak current to thereby generate a first holding current required for opening the injector and a second holding current required for retaining the opened state of the injector, the second holding current being lower in intensity than the first holding current.
摘要翻译：提出了一种用于内燃机的控制单元，其包括升压电路，开关元件，电流检测电阻器和控制器，并被设计为被致动，使得升压电路用于提高电源电压以产生升压电压，并且控制器用于控制开关元件，以便使升压的电压能够流到喷射器螺线管线圈。该控制单元被设计成使得当升压电路不顺序时，通过利用电源电压而不使用升压电压而激励喷射器螺线管线圈，并且不产生峰值电流，从而产生所需的第一保持电流用于打开喷射器和保持喷射器的打开状态所需的第二保持电流，第二保持电流的强度低于第一保持电流。

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