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1. 发明申请

US20080114410A1 CLOSED LOOP IMPEDANCE-BASED CARDIAC RESYNCHRONIZATION THERAPY SYSTEMS, DEVICES, AND METHODS 有权
标题翻译：基于闭环阻塞的心脏再生治疗系统，装置和方法
公开(公告)号：US20080114410A1
公开(公告)日：2008-05-15
申请号：US12016830
申请日：2008-01-18
申请人： Jiang Ding , Julio Spinelli , Yinghong Yu , Jeffrey Stahmann
发明人： Jiang Ding , Julio Spinelli , Yinghong Yu , Jeffrey Stahmann
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/053 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.
摘要翻译：本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。第三个例子测量心室容积的峰 - 峰体积或最大变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

2. 发明申请

US20060259086A1 Apparatus and method for optimizing atrioventricular delay 有权
标题翻译：用于优化房室延迟的装置和方法
公开(公告)号：US20060259086A1
公开(公告)日：2006-11-16
申请号：US11126490
申请日：2005-05-11
申请人： Yinghong Yu , Jiang Ding , Jeffrey Stahmann
发明人： Yinghong Yu , Jiang Ding , Jeffrey Stahmann
IPC分类号： A61N1/362
CPC分类号： A61N1/3682 , A61N1/3627 , A61N1/3706
摘要： Systems and methods to optimize atrioventricular delay during sensing or pacing of the atrium and for a plurality of sensed rates or pacing rates. In one example, a paced atrioventricular delay is calculated using a sensed atrioventricular interval and a paced atrioventricular interval. In another example, a plurality of paced atrioventricular delays for different pacing rates can be calculated. In another example embodiment, a plurality of sensed atrioventricular delays for different sensing rates can be calculated. Combinations of the various systems and methods are also possible.
摘要翻译：在心房的感测或起搏期间以及多个感测速率或起搏速率下优化房室延迟的系统和方法。在一个示例中，使用感测的房室间隔和起搏房室间隔来计算起搏房室延迟。在另一个示例中，可以计算用于不同起搏速率的多个起搏房室延迟。在另一示例性实施例中，可以计算用于不同感测速率的多个感测的房室延迟。各种系统和方法的组合也是可能的。

3. 发明申请

US20060271119A1 Closed loop impedance-based cardiac resynchronization therapy systems, devices, and methods 有权
标题翻译：基于闭环阻抗的心脏再同步治疗系统，装置和方法
公开(公告)号：US20060271119A1
公开(公告)日：2006-11-30
申请号：US11264941
申请日：2005-11-02
申请人： Quan Ni , Jiang Ding , Yinghong Yu , Douglas Daum , Julio Spinelli , Jeffrey Stahmann
发明人： Quan Ni , Jiang Ding , Yinghong Yu , Douglas Daum , Julio Spinelli , Jeffrey Stahmann
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61B5/053 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.
摘要翻译：本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。第三个例子测量心室容积的峰 - 峰体积或最大变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

4. 发明申请

US20060241512A1 Thoracic or intracardiac impedance detection with automatic vector selection 有权
公开(公告)号：US20060241512A1
公开(公告)日：2006-10-26
申请号：US11110418
申请日：2005-04-20
申请人： Jonathan Kwok , Kent Lee , Jesse Hartley , Jeffrey Stahmann , Yinghong Yu , Jiang Ding
发明人： Jonathan Kwok , Kent Lee , Jesse Hartley , Jeffrey Stahmann , Yinghong Yu , Jiang Ding
IPC分类号： A61B5/05
CPC分类号： A61B5/0205 , A61B5/053 , A61B5/0538 , A61N1/36185 , A61N1/36521 , A61N1/3686
摘要： This document discusses, among other things, a cardiac function management device or other implantable medical device that includes a test mode and a diagnostic mode. During a test mode, the device cycles through various electrode configurations for collecting thoracic impedance data. At least one figure of merit is calculated from the impedance data for each such electrode configuration. In one example, only non-arrhythmic beats are used for computing the figure of merit. A particular electrode configuration is automatically selected using the figure of merit. During a diagnostic mode, the device collects impedance data using the selected electrode configuration. In one example, the figure of merit includes a ratio of a cardiac stroke amplitude and a respiration amplitude. Other examples of the figure of merit are also described.

5. 发明申请

US20060253162A1 Closed loop cardiac resynchronization therapy using cardiac activation sequence information 有权
标题翻译：闭环心脏再同步治疗使用心脏激活序列信息
公开(公告)号：US20060253162A1
公开(公告)日：2006-11-09
申请号：US11125068
申请日：2005-05-09
申请人： Yi Zhang , Yinghong Yu , Aaron McCabe , Jiang Ding , Jeffrey Stahmann , Carlos Ricci , Scott Meyer
发明人： Yi Zhang , Yinghong Yu , Aaron McCabe , Jiang Ding , Jeffrey Stahmann , Carlos Ricci , Scott Meyer
IPC分类号： A61N1/365
CPC分类号： A61N1/3712 , A61N1/3627 , A61N1/365 , G06F19/00
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend closed-loop cardiac resynchronization therapy using cardiac activation sequence information. Devices and methods involve sensing a plurality of composite cardiac signals using a plurality of electrodes, the electrodes configured for implantation in a patient. A source separation is performed using the sensed plurality of composite cardiac signals, producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences. A cardiac resynchronization therapy is adjusted using one or both of the one or more cardiac signal vectors and the signals associated with the one or more cardiac signal vectors. In further embodiments, the cardiac resynchronization therapy may be initiated, terminated, or one or more parameters of the resynchronization therapy may be altered.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。心脏信号分离用于使用心脏激活序列信息来检测，监测，跟踪和/或趋势闭环心脏再同步治疗。设备和方法包括使用多个电极感测多个复合心脏信号，所述电极被配置用于植入患者体内。使用所感测的多个复合心脏信号进行源分离，产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号载体。使用一个或多个心脏信号向量和与一个或多个心脏信号载体相关联的信号中的一个或两个来调整心脏再同步治疗。在另外的实施方案中，心脏再同步治疗可以被启动，终止，或者可以改变再同步治疗的一个或多个参数。

6. 发明申请

US20060271121A1 Closed loop impedance-based cardiac resynchronization therapy systems, devices, and methods 审中-公开
公开(公告)号：US20060271121A1
公开(公告)日：2006-11-30
申请号：US11136894
申请日：2005-05-25
申请人： Jiang Ding , Julio Spinelli , Yinghong Yu , Jeffrey Stahmann
发明人： Jiang Ding , Julio Spinelli , Yinghong Yu , Jeffrey Stahmann
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61B5/053 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.

7. 发明申请

US20080275520A1 Automatic modulation of pacing timing intervals using beat to beat measures 有权
标题翻译：使用节拍措施自动调节起搏定时间隔
公开(公告)号：US20080275520A1
公开(公告)日：2008-11-06
申请号：US11799794
申请日：2007-05-03
申请人： Donald L. Hopper , Yinghong Yu , Allan Charles Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey Stahmann
发明人： Donald L. Hopper , Yinghong Yu , Allan Charles Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey Stahmann
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3684
摘要： Methods and systems to modulate timing intervals for pacing therapy are described. For each cardiac cycle, one or both of an atrioventricular (A-V) timing interval and an atrial (A-A) timing interval are modulated to oppose beat-to-beat ventricular (V-V) timing variability. Pacing therapy is delivered using the modulated timing intervals.
摘要翻译：描述了调节起搏治疗时间间隔的方法和系统。对于每个心动周期，房室（A-V）定时间隔和心房（A-A）定时间隔中的一个或两个被调制以抵抗搏动到心室（V-V）的时间变异性。使用调制的定时间隔来提供起搏治疗。

8. 发明申请

US20060069322A1 Cardiac activation sequence monitoring and tracking 有权
公开(公告)号：US20060069322A1
公开(公告)日：2006-03-30
申请号：US10955397
申请日：2004-09-30
申请人： Yi Zhang , Scott Meyer , Aaron McCabe , Jeffrey Stahmann , Yinghong Yu , Carlos Ricci
发明人： Yi Zhang , Scott Meyer , Aaron McCabe , Jeffrey Stahmann , Yinghong Yu , Carlos Ricci
IPC分类号： A61B5/0402
CPC分类号： A61B5/04011 , A61B5/7203
摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, diagnosis, and defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, performs a source separation, and produces one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences based on the source separation. A method of signal separation involves detecting a change in a characteristic of the cardiac signal vector relative to a baseline. One or more vectors and/or activation sequences may be selected, and information associated with the vectors and/or activation sequences may be stored and tracked.

9. 发明授权

US08103343B2 Automatic modulation of pacing timing intervals using beat to beat measures 有权
标题翻译：使用节拍措施自动调节起搏定时间隔
公开(公告)号：US08103343B2
公开(公告)日：2012-01-24
申请号：US11799794
申请日：2007-05-03
申请人： Donald L. Hopper , Yinghong Yu , Allan Charles Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey Stahmann
发明人： Donald L. Hopper , Yinghong Yu , Allan Charles Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey Stahmann
IPC分类号： A61N1/362
CPC分类号： A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3684
摘要： Methods and systems to modulate timing intervals for pacing therapy are described. For each cardiac cycle, one or both of an atrioventricular (A-V) timing interval and an atrial (A-A) timing interval are modulated to oppose beat-to-beat ventricular (V-V) timing variability. Pacing therapy is delivered using the modulated timing intervals.
摘要翻译：描述了调节起搏治疗时间间隔的方法和系统。对于每个心动周期，房室（A-V）定时间隔和心房（A-A）定时间隔中的一个或两个被调制以抵抗搏动到心室（V-V）的时间变异性。使用调制的定时间隔来提供起搏治疗。

10. 发明申请

US20060253044A1 Arrhythmia discrimination using electrocardiograms sensed from multiple implanted electrodes 有权
标题翻译：使用从多个植入电极感测的心电图的心律失常辨别
公开(公告)号：US20060253044A1
公开(公告)日：2006-11-09
申请号：US11125020
申请日：2005-05-09
申请人： Yi Zhang , Carlos Ricci , Jeffrey Stahmann , Aaron McCabe , Scott Meyer , Yinghong Yu
发明人： Yi Zhang , Carlos Ricci , Jeffrey Stahmann , Aaron McCabe , Scott Meyer , Yinghong Yu
IPC分类号： A61B5/04
CPC分类号： A61B5/04011 , A61B5/7203
摘要： Cardiac monitoring and/or stimulation methods and systems provide for monitoring, diagnosing, defibrillation and pacing therapies, or a combination of these capabilities, including cardiac systems incorporating or cooperating with neuro-stimulating devices, drug pumps, or other therapies. Embodiments of the present invention relate generally to implantable medical devices employing automated cardiac activation sequence monitoring and/or tracking for arrhythmia discrimination. Embodiments of the invention are directed to devices and methods involving sensing a plurality of composite cardiac signals using a plurality of implantable electrodes. A source separation is performed using the sensed plurality of composite cardiac signals and the separation produces one or more cardiac signal vectors associated with one or more cardiac activation sequences that is indicative of ischemia. A change of the one or more cardiac signal vectors is detected using the one or more cardiac signal vectors. Cardiac arrhythmias are discriminated using the one or more cardiac signal vectors.
摘要翻译：心脏监测和/或刺激方法和系统提供监测，诊断，除颤和起搏治疗，或这些功能的组合，包括结合或与神经刺激装置，药物泵或其他疗法组合的心脏系统。本发明的实施方案一般涉及使用自动心脏激活序列监测和/或跟踪用于心律失常鉴别的可植入医疗装置。本发明的实施例涉及使用多个可植入电极感测多个复合心脏信号的装置和方法。使用感测的多个复合心脏信号进行源分离，并且分离产生与指示缺血的一个或多个心脏激活序列相关联的一个或多个心脏信号载体。使用一个或多个心脏信号矢量检测一个或多个心脏信号矢量的改变。使用一个或多个心脏信号载体来区分心律失常。

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