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1. 发明申请

US20080275520A1 Automatic modulation of pacing timing intervals using beat to beat measures 有权
标题翻译：使用节拍措施自动调节起搏定时间隔
公开(公告)号：US20080275520A1
公开(公告)日：2008-11-06
申请号：US11799794
申请日：2007-05-03
申请人： Donald L. Hopper , Yinghong Yu , Allan Charles Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey Stahmann
发明人： Donald L. Hopper , Yinghong Yu , Allan Charles Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey Stahmann
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3684
摘要： Methods and systems to modulate timing intervals for pacing therapy are described. For each cardiac cycle, one or both of an atrioventricular (A-V) timing interval and an atrial (A-A) timing interval are modulated to oppose beat-to-beat ventricular (V-V) timing variability. Pacing therapy is delivered using the modulated timing intervals.
摘要翻译：描述了调节起搏治疗时间间隔的方法和系统。对于每个心动周期，房室（A-V）定时间隔和心房（A-A）定时间隔中的一个或两个被调制以抵抗搏动到心室（V-V）的时间变异性。使用调制的定时间隔来提供起搏治疗。

2. 发明授权

US08103343B2 Automatic modulation of pacing timing intervals using beat to beat measures 有权
标题翻译：使用节拍措施自动调节起搏定时间隔
公开(公告)号：US08103343B2
公开(公告)日：2012-01-24
申请号：US11799794
申请日：2007-05-03
申请人： Donald L. Hopper , Yinghong Yu , Allan Charles Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey Stahmann
发明人： Donald L. Hopper , Yinghong Yu , Allan Charles Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey Stahmann
IPC分类号： A61N1/362
CPC分类号： A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3684
摘要： Methods and systems to modulate timing intervals for pacing therapy are described. For each cardiac cycle, one or both of an atrioventricular (A-V) timing interval and an atrial (A-A) timing interval are modulated to oppose beat-to-beat ventricular (V-V) timing variability. Pacing therapy is delivered using the modulated timing intervals.
摘要翻译：描述了调节起搏治疗时间间隔的方法和系统。对于每个心动周期，房室（A-V）定时间隔和心房（A-A）定时间隔中的一个或两个被调制以抵抗搏动到心室（V-V）的时间变异性。使用调制的定时间隔来提供起搏治疗。

3. 发明申请

US20090082823A1 Variable shortening of AV delay for treatment of cardiac disease 有权
标题翻译： AV延迟可变缩短治疗心脏病
公开(公告)号：US20090082823A1
公开(公告)日：2009-03-26
申请号：US11903758
申请日：2007-09-25
申请人： Allan C. Shuros , Donald L. Hopper , Shantha Arcot-Krishnamurthy
发明人： Allan C. Shuros , Donald L. Hopper , Shantha Arcot-Krishnamurthy
IPC分类号： A61N1/365
CPC分类号： A61N1/3682 , A61N1/3627 , A61N1/36514 , A61N1/36535 , A61N1/36585 , A61N1/3688
摘要： An implantable pacing device for delivering ventricular pacing may be configured to intermittently and variably reduce the AV delay interval used in an atrial triggered pacing mode in a manner that simulates exercise. The device may be programmed to intermittently switch to and from a variably shortened AV delay mode according to defined entry and exit conditions.
摘要翻译：用于递送心室起搏的可植入起搏装置可以被配置为以模拟运动的方式间歇地和可变地减小在心房触发起搏模式中使用的AV延迟间隔。该设备可以被编程为根据定义的进入和退出条件间歇地切换到可变地缩短的AV延迟模式。

4. 发明授权

US08972007B2 Variable shortening of AV delay for treatment of cardiac disease 有权
公开(公告)号：US08972007B2
公开(公告)日：2015-03-03
申请号：US11903758
申请日：2007-09-25
申请人： Allan C. Shuros , Donald L. Hopper , Shantha Arcot-Krishnamurthy
发明人： Allan C. Shuros , Donald L. Hopper , Shantha Arcot-Krishnamurthy
IPC分类号： A61N1/365 , A61N1/362 , A61N1/368
CPC分类号： A61N1/3682 , A61N1/3627 , A61N1/36514 , A61N1/36535 , A61N1/36585 , A61N1/3688
摘要： An implantable pacing device for delivering ventricular pacing may be configured to intermittently and variably reduce the AV delay interval used in an atrial triggered pacing mode in a manner that simulates exercise. The device may be programmed to intermittently switch to and from a variably shortened AV delay mode according to defined entry and exit conditions.

5. 发明申请

US20080221636A1 METHOD AND APPARATUS FOR CLOSED-LOOP INTERMITTENT CARDIAC STRESS AUGMENTATION PACING 失效
标题翻译：闭环循环心脏紧张应激的方法和装置
公开(公告)号：US20080221636A1
公开(公告)日：2008-09-11
申请号：US11682448
申请日：2007-03-06
申请人： Joseph M. Pastore , Tamara Colette Baynham , Donald L. Hopper , Allan C. Shuros , Shantha Arcot-Krishnamurthy
发明人： Joseph M. Pastore , Tamara Colette Baynham , Donald L. Hopper , Allan C. Shuros , Shantha Arcot-Krishnamurthy
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36585
摘要： A cardiac pacing system controls the progression of a cardiac disorder such as heart failure by delivering cardiac pacing to create or augment regional stress in the heart. The cardiac pacing is delivered intermittently, such as on a periodic basis, according to a cardiac stress augmentation pacing sequence that includes alternating pacing and non-pacing periods. One or more physiological signals are monitored for closed-loop control of the cardiac pacing using baseline characteristics of the cardiac disorder, acute cardiac stress created by the cardiac pacing, and/or risk associated with the cardiac pacing.
摘要翻译：心脏起搏系统通过递送心脏起搏来创建或增加心脏中的区域应力来控制心脏病症如心力衰竭的进展。根据包括交替起搏和非起搏期的心脏应激增加起搏序列，间歇地递送心脏起搏，例如周期性地起搏。使用心脏病症的基线特征，由心脏起搏产生的急性心脏应激和/或与心脏起搏相关的风险来监测一个或多个生理信号用于心脏起搏的闭环控制。

6. 发明授权

US08615296B2 Method and apparatus for closed-loop intermittent cardiac stress augmentation pacing 失效
标题翻译：用于闭环间歇性心脏应激增强起搏的方法和装置
公开(公告)号：US08615296B2
公开(公告)日：2013-12-24
申请号：US11682448
申请日：2007-03-06
申请人： Joseph M. Pastore , Tamara Colette Baynham , Donald L. Hopper , Allan C. Shuros , Shantha Arcot-Krishnamurthy
发明人： Joseph M. Pastore , Tamara Colette Baynham , Donald L. Hopper , Allan C. Shuros , Shantha Arcot-Krishnamurthy
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36585
摘要： A cardiac pacing system controls the progression of a cardiac disorder such as heart failure by delivering cardiac pacing to create or augment regional stress in the heart. The cardiac pacing is delivered intermittently, such as on a periodic basis, according to a cardiac stress augmentation pacing sequence that includes alternating pacing and non-pacing periods. One or more physiological signals are monitored for closed-loop control of the cardiac pacing using baseline characteristics of the cardiac disorder, acute cardiac stress created by the cardiac pacing, and/or risk associated with the cardiac pacing.
摘要翻译：心脏起搏系统通过递送心脏起搏来创建或增加心脏中的区域应力来控制心脏病症如心力衰竭的进展。根据包括交替起搏和非起搏期的心脏应激增加起搏序列，间歇地递送心脏起搏，例如周期性地起搏。使用心脏病症的基线特征，由心脏起搏产生的急性心脏应激和/或与心脏起搏相关的风险来监测一个或多个生理信号用于心脏起搏的闭环控制。

7. 发明授权

US08738133B2 Rate adaptive cardiac pacing systems and methods 有权
标题翻译：评估自适应心脏起搏系统和方法
公开(公告)号：US08738133B2
公开(公告)日：2014-05-27
申请号：US13730362
申请日：2012-12-28
申请人： Allan Charles Shuros , Donald L. Hopper , Michael J. Kane
发明人： Allan Charles Shuros , Donald L. Hopper , Michael J. Kane
IPC分类号： A61N1/00
CPC分类号： A61N1/36585 , G06F19/00 , G06F19/3418 , G06F19/3481
摘要： The invention relates to cardiac rhythm management systems, and more particularly, to rate adaptive cardiac pacing systems and methods. In an embodiment, the invention includes a cardiac rhythm management device. The device can include a pulse generator for generating electrical pulses to be delivered to a heart at a pacing rate, a processor in communication with the pulse generator, and one or more sensors for sensing pulmonary function and cardiac function. The processor can be configured to increase the pacing rate if the pulmonary function is increasing with time and the cardiac function is not decreasing with time, maintain the pacing rate if the pulmonary function is increasing with time and the cardiac function is decreasing with time, and decrease the pacing rate if the respiratory function is decreasing with time.
摘要翻译：本发明涉及心律管理系统，更具体地说，涉及适应性心脏起搏系统和方法的速率。在一个实施例中，本发明包括心律管理装置。该装置可以包括脉冲发生器，用于产生要以起搏速率递送到心脏的电脉冲，与脉冲发生器通信的处理器以及用于感测肺功能和心脏功能的一个或多个传感器。如果肺功能随时间增加，心脏功能不随时间减少，则可以配置处理器以增加起搏速率，如果肺功能随时间增加而保持起搏速率，并且心脏功能随时间减少，以及如果呼吸功能随时间的推移，降低起搏率。

8. 发明授权

US08065010B2 Method and apparatus for monitoring heart failure patients with cardiopulmonary comorbidities 有权
标题翻译：监测心肺合并症心力衰竭患者的方法和装置
公开(公告)号：US08065010B2
公开(公告)日：2011-11-22
申请号：US12319642
申请日：2009-01-08
申请人： Marina V. Brockway , Donald L. Hopper , Gerrard M. Carlson , Veerichetty Kadhiresan , Kenneth C. Beck
发明人： Marina V. Brockway , Donald L. Hopper , Gerrard M. Carlson , Veerichetty Kadhiresan , Kenneth C. Beck
IPC分类号： A61N1/36
CPC分类号： A61B5/087 , A61B5/02405 , A61B5/053 , A61B5/4878 , A61N1/3627 , A61N1/36521
摘要： A system receives signals indicative of cardiopulmonary conditions sensed by a plurality of sensors and provides for monitoring and automated differential diagnosis of the cardiopulmonary conditions based on the signals. Cardiogenic pulmonary edema is detected based on one or more signals sensed by implantable sensors. If the cardiogenic pulmonary edema is not detected, obstructive pulmonary disease and restrictive pulmonary disease are each detected based on a forced vital capacity (FVC) parameter and a forced expiratory volume (FEV) parameter measured from a respiratory signal sensed by an implantable or non-implantable sensor. In one embodiment, an implantable medical device senses signals indicative of the cardiopulmonary conditions, and an external system detects the cardiopulmonary conditions based on these signals by executing an automatic detection algorithm.
摘要翻译：系统接收指示由多个传感器感测到的心肺疾病的信号，并且基于该信号提供对心肺病状态的监测和自动鉴别诊断。基于由可植入传感器感测到的一个或多个信号来检测心源性肺水肿。如果未检测到心源性肺水肿，则基于由可植入或非可行的肺动脉血流检测的呼吸信号测量的强制肺活量（FVC）参数和强制呼气量（FEV）参数，每个都检测到阻塞性肺疾病和限制性肺部疾病，植入式传感器。在一个实施例中，可植入医疗装置感测指示心肺病的信号，外部系统通过执行自动检测算法基于这些信号来检测心肺病。

9. 发明授权

US07833164B2 System and method for monitoring autonomic balance and physical activity 有权
标题翻译：监测自主性平衡和身体活动的系统和方法
公开(公告)号：US07833164B2
公开(公告)日：2010-11-16
申请号：US12538553
申请日：2009-08-10
申请人： Avram Scheiner , Donald L. Hopper , Gerrard M. Carlson
发明人： Avram Scheiner , Donald L. Hopper , Gerrard M. Carlson
IPC分类号： A61B5/00
CPC分类号： A61B5/4035 , A61B5/029 , A61B5/0472 , A61N1/36585 , G06F19/00
摘要： An implantable device monitors the balance between sympathetic tone and parasympathetic tone as a function of an activity level. Cardio-neurological healthy users exhibit a generally sympathetic tone in conjunction with heavy activity level and a generally parasympathetic tone in conjunction with periods of low activity level. Deviations from expected results are associated with a health problem. Measured conditions are stored and available for subsequent reporting to a remote programmer. Therapy delivered by an implantable device is determined as a function of the relationship between autonomic balance and activity level.
摘要翻译：可植入装置监测交感神经张力和副交感神经紧张度之间的平衡，作为活动水平的函数。心脏神经系统健康用户表现出与大量活动水平和大体上副交感神经紧张以及低活动水平结合的共同心情。与预期结果的偏差与健康问题有关。测量条件存储并可用于后续报告给远程程序员。由植入式装置提供的治疗作为自主平衡与活动水平之间关系的函数确定。

10. 发明申请

US20100298729A1 Cardiac Activation Sequence Monitoring for Ischemia Detection 失效
标题翻译：缺血检测心脏激活序列监测
公开(公告)号：US20100298729A1
公开(公告)日：2010-11-25
申请号：US12847657
申请日：2010-07-30
申请人： Yi Zhang , Scott A. Meyer , Jeffrey E. Stahmann , Carlos Alberto Ricci , Marina Brockway , Aaron R. McCabe , Yinghong Yu , Donald L. Hopper
发明人： Yi Zhang , Scott A. Meyer , Jeffrey E. Stahmann , Carlos Alberto Ricci , Marina Brockway , Aaron R. McCabe , Yinghong Yu , Donald L. Hopper
IPC分类号： A61B5/0452
CPC分类号： A61N1/3702 , A61B5/0452 , A61B5/7203
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track and/or trend ischemia using cardiac activation sequence information. Ischemia detection may involve sensing composite cardiac signals using implantable electrodes, and performing a signal separation that produces one or more cardiac activation signal vectors associated with one or more cardiac activation sequences. A change in the signal vector may be detected using subsequent separations. The change may be an elevation or depression of the ST segment of a cardiac cycle or other change indicative of myocardial ischemia, myocardial infarction, or other pathological change. The change may be used to predict, quantify, and/or qualify an event such as an arrhythmia, a myocardial infarction, or other pathologic change. Information associated with the vectors may be stored and used to track the vectors.
摘要翻译：提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。使用心脏信号分离来使用心脏激活序列信息来检测，监测，跟踪和/或趋势性缺血。缺血检测可以涉及使用可植入电极感测复合心脏信号，并且执行产生与一个或多个心脏激活序列相关联的一个或多个心脏激活信号载体的信号分离。可以使用后续分离来检测信号矢量的变化。该变化可以是心脏周期的ST段的升高或抑制或指示心肌缺血，心肌梗死或其他病理变化的其它变化。该变化可用于预测，量化和/或限定诸如心律失常，心肌梗死或其它病理变化的事件。与矢量相关联的信息可以被存储并用于跟踪矢量。

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