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1. 发明申请

US20110033102A1 System and Method for Coronary Digital Subtraction Angiography 有权
标题翻译：冠状动脉数字减影血管造影术的系统与方法
公开(公告)号：US20110033102A1
公开(公告)日：2011-02-10
申请号：US12774146
申请日：2010-05-05
申请人： Ying Zhu , Simone Prummer , Peng Wang , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
发明人： Ying Zhu , Simone Prummer , Peng Wang , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
IPC分类号： G06K9/00
CPC分类号： G06T7/0016 , G06T2207/10121 , G06T2207/20224 , G06T2207/30101
摘要： A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, a motion estimate is calculated between each of the mask images and a background region of the contrast image and a covariance is calculated for each motion estimate. Multiple background layer predictions are generated by generating a background layer prediction for each mask image based on the calculated motion estimate and covariance. The multiple background layer estimates are combined using statistical fusion to generate a final estimated background layer. The final estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image.
摘要翻译：公开了使用冠状动脉数字减影血管造影（DSA）提取冠脉血管荧光镜图像序列的方法和系统。接收冠状动脉区域的一组掩模图像，并且接收冠状动脉区域的对比度图像序列。对于每个对比度图像，在每个掩模图像和对比度图像的背景区域之间计算运动估计，并且针对每个运动估计计算协方差。通过基于计算的运动估计和协方差为每个掩模图像生成背景层预测来生成多个背景层预测。使用统计融合来组合多个背景层估计以产生最终估计的背景层。从对比度图像中减去最终估计的背景层，以提取对比度图像的冠状血管层。

2. 发明授权

US07764808B2 System and method for vehicle detection and tracking 有权
标题翻译：车辆检测和跟踪的系统和方法
公开(公告)号：US07764808B2
公开(公告)日：2010-07-27
申请号：US10805946
申请日：2004-03-22
申请人： Ying Zhu , Dorin Comaniciu , Martin Pellkofer , Thorsten Köhler
发明人： Ying Zhu , Dorin Comaniciu , Martin Pellkofer , Thorsten Köhler
IPC分类号： G06K9/00
CPC分类号： G06K9/3241 , G06T7/20
摘要： A system and method for detecting and tracking an object is disclosed. A camera captures a video sequence comprised of a plurality of image frames. A processor receives the video sequence and analyzes each image frame to determine if an object is detected. The processor applies one or more classifiers to an object in each image frame and computes a confidence score based on the application of the one or more classifiers to the object. A database stores the one or more classifiers and vehicle training samples. A display displays the video sequence.
摘要翻译：公开了一种用于检测和跟踪对象的系统和方法。相机拍摄由多个图像帧组成的视频序列。处理器接收视频序列并分析每个图像帧以确定是否检测到对象。处理器将一个或多个分类器应用于每个图像帧中的对象，并基于对该对象的一个或多个分类器的应用来计算置信度分数。数据库存储一个或多个分类器和车辆训练样本。显示器显示视频序列。

3. 发明申请

US20100121181A1 Method and System for Guidewire Tracking in Fluoroscopic Image Sequences 有权
标题翻译：荧光图像序列中导丝跟踪的方法和系统
公开(公告)号：US20100121181A1
公开(公告)日：2010-05-13
申请号：US12538456
申请日：2009-08-10
申请人： Peng Wang , Ying Zhu , Wei Zhang , Terrence Chen , Peter Durlak , Ulrich Bill , Dorin Comaniciu
发明人： Peng Wang , Ying Zhu , Wei Zhang , Terrence Chen , Peter Durlak , Ulrich Bill , Dorin Comaniciu
IPC分类号： A61B5/05
CPC分类号： A61B6/12 , A61B2034/2065 , A61B2090/376 , G06T7/246 , G06T2207/10016 , G06T2207/10121 , G06T2207/30021
摘要： A method and system for tracking a guidewire in a fluoroscopic image sequence is disclosed. In order to track a guidewire in a fluoroscopic image sequence, guidewire segments are detected in each frame of the fluoroscopic image sequence. The guidewire in each frame of the fluoroscopic image sequence is then detected by rigidly tracking the guidewire from a previous frame of the fluoroscopic image sequence based on the detected guidewire segments in the current frame. The guidewire is then non-rigidly deformed in each frame based on the guidewire position in the previous frame.
摘要翻译：公开了一种用于跟踪透视图像序列中的导丝的方法和系统。为了在透视图像序列中跟踪导丝，在荧光镜图像序列的每个帧中检测导丝段。然后通过基于当前帧中检测到的导丝段从透视图像序列的前一帧刚性跟踪导丝来检测透视图像序列的每个帧中的导丝。然后基于先前框架中的导丝线位置，导丝在每个框架中不会刚性变形。

4. 发明授权

US07626845B2 Voltage programming switch for one-time-programmable (OTP) memories 有权
标题翻译：用于一次可编程（OTP）存储器的电压编程开关
公开(公告)号：US07626845B2
公开(公告)日：2009-12-01
申请号：US11610284
申请日：2006-12-13
申请人： Clinton H. Holder, Jr. , Kang W. Lee , Joseph E. Simko , Yehuda Smooha , Ying Zhu
发明人： Clinton H. Holder, Jr. , Kang W. Lee , Joseph E. Simko , Yehuda Smooha , Ying Zhu
IPC分类号： G11C17/00
CPC分类号： G11C17/16 , G11C17/18
摘要： In one embodiment, the invention is an integrated circuit (IC) including an OTP memory and conditioning circuitry. The IC receives an externally-generated DC programming voltage signal that the conditioning circuitry transforms into a programming pulse signal for programming the OTP memory. The conditioning circuitry includes: (i) reset protection circuitry for holding the programming pulse signal low if the IC is powering up, (ii) an overvoltage protection circuit for substantially preventing the programming pulse voltage from exceeding predefined boundaries, and (iii) a conversion switch for controlling the programming pulse voltage. The programming pulse voltage is (i) substantially equivalent to the externally-generated DC voltage if an enable signal is on, and (ii) substantially equivalent to a reference voltage if the enable signal is off.
摘要翻译：在一个实施例中，本发明是包括OTP存储器和调节电路的集成电路（IC）。 IC接收外部产生的直流编程电压信号，调理电路变换为用于编程OTP存储器的编程脉冲信号。调节电路包括：（i）复位保护电路，用于在IC上电时保持编程脉冲信号为低电平，（ii）过压保护电路，用于基本上防止编程脉冲电压超出预定义的边界，以及（iii）转换用于控制编程脉冲电压的开关。如果使能信号为开，编程脉冲电压为（i）基本上等于外部产生的直流电压，以及（ii）如果使能信号关闭，则基本上等于参考电压。

5. 发明授权

US07620208B2 System and method for detecting features from images of vehicles 失效
标题翻译：用于从车辆图像检测特征的系统和方法
公开(公告)号：US07620208B2
公开(公告)日：2009-11-17
申请号：US11313599
申请日：2005-12-21
申请人： Ying Zhu , Binglong Xie , Visvanathan Ramesh , Martin Pellkofer , Thorsten Köhler
发明人： Ying Zhu , Binglong Xie , Visvanathan Ramesh , Martin Pellkofer , Thorsten Köhler
IPC分类号： G06K9/00 , H04N7/18
CPC分类号： G06K9/4609 , G06K2209/23
摘要： A method of detecting a feature of a vehicle in an image of a vehicle includes providing a digitized image of a vehicle, providing a first filter mask over a first subdomain of the image, where the filter mask is placed to detect a feature in the image, calculating a function of a gradient of the image inside the first masked subdomain, and detecting the presence or absence of a vehicle feature within the first masked subdomain based on the value of the gradient function.
摘要翻译：一种在车辆图像中检测车辆的特征的方法包括提供车辆的数字化图像，在图像的第一子域上提供第一滤波器掩模，其中放置滤波器掩码以检测图像中的特征计算第一掩蔽子域内的图像的梯度的函数，以及基于梯度函数的值来检测第一掩蔽子域内的车辆特征的存在或不存在。

6. 发明授权

US07480079B2 System and method for sequential kernel density approximation through mode propagation 有权
标题翻译：通过模式传播进行顺序核密度近似的系统和方法
公开(公告)号：US07480079B2
公开(公告)日：2009-01-20
申请号：US10936607
申请日：2004-09-08
申请人： Bohyung Han , Dorin Comaniciu , Ying Zhu , Xiang Sean Zhou
发明人： Bohyung Han , Dorin Comaniciu , Ying Zhu , Xiang Sean Zhou
IPC分类号： G06K15/00 , H04N1/405
CPC分类号： G06K9/6226 , G06F17/18 , G06T7/44
摘要： A system and method for sequential kernel density approximation uses mode propagation to determine mode locations by the mean-shift method and reduce the generated modes. Hessians are calculated corresponding to the mode locations to determine the covariance. Density is approximated to update the density function depending on whether the Hessian is a negative indefinite.
摘要翻译：用于顺序核密度近似的系统和方法使用模式传播来通过平均移位方法确定模式位置并减少生成的模式。对应于模式位置计算Hessians以确定协方差。近似密度来更新密度函数，取决于黑森西是否是负不确定的。

7. 发明申请

US20070140972A1 Targeting compositions and preparation therof 审中-公开
标题翻译：靶向组合物和制备方法
公开(公告)号：US20070140972A1
公开(公告)日：2007-06-21
申请号：US10576086
申请日：2004-10-15
申请人： Ying Zhu , Heli Valtanen , Sami Kaukinen , Oula Penate Medina , IIkka Simpura
发明人： Ying Zhu , Heli Valtanen , Sami Kaukinen , Oula Penate Medina , IIkka Simpura
IPC分类号： A61K49/10 , A61K38/12 , A61K9/127
CPC分类号： C07K7/06 , A61K38/12 , A61K47/60 , A61K47/62 , A61K47/6911 , A61K51/08 , A61K51/088 , C07K7/08 , C07K14/81
摘要： The present invention relates to targeted cancer therapy and tumour imaging, and concerns specifically new derivatives of small matrix metalloproteinase inhibitor peptides. These new derivates are the hydrophilic peptides GRENYHGCTTHWGFTLC and derivates thereof. These peptides have an increased solubility and may be used in the preparation of targeting compositions together with suitable linker molecules such as PEG. Such targeting compositions are useful in therapeutics and imaging liposome compositions for cancer treatment and diagnostics.
摘要翻译：本发明涉及靶向癌症治疗和肿瘤成像，特别涉及小基质金属蛋白酶抑制剂肽的新衍生物。这些新衍生物是亲水肽GRENYHGCTTHWGFTLC及其衍生物。这些肽具有增加的溶解性，并可用于制备靶向组合物以及合适的连接分子如PEG。这样的靶向组合物可用于治疗和成像用于癌症治疗和诊断的脂质体组合物。

8. 发明申请

US20050286738A1 Graphical object models for detection and tracking 有权
标题翻译：用于检测和跟踪的图形对象模型
公开(公告)号：US20050286738A1
公开(公告)日：2005-12-29
申请号：US11135210
申请日：2005-05-23
申请人： Leonid Sigal , Ying Zhu , Dorin Comaniciu
发明人： Leonid Sigal , Ying Zhu , Dorin Comaniciu
IPC分类号： G06K9/00 , G06T7/20
CPC分类号： G06K9/00805 , G06K9/32 , G06T7/277
摘要： A computer implemented method for object detection includes providing a spatio-temporal model for an object to be detected, providing a video including a plurality of images including the object, and measuring the object as a collection of components in each image. The method further includes determining a probability that the object is in each image, and detecting the object in any image upon comparing the probabilities for each image to a threshold for detecting the object.
摘要翻译：一种用于对象检测的计算机实现方法包括：提供用于待检测对象的时空模型，提供包括包括对象在内的多个图像的视频，以及将对象作为每个图像中的组件的集合进行测量。该方法还包括确定对象在每个图像中的概率，并且在将每个图像的概率与用于检测对象的阈值进行比较时，检测任何图像中的对象。

9. 发明授权

US08989461B2 Method of deformable motion correction and image registration in X-ray stent imaging 有权
标题翻译： X射线支架成像中可变形运动校正和图像配准的方法
公开(公告)号：US08989461B2
公开(公告)日：2015-03-24
申请号：US13469311
申请日：2012-05-11
申请人： Ying Zhu , Liping Zhou
发明人： Ying Zhu , Liping Zhou
IPC分类号： G06K9/00 , G06K9/62 , G06T3/00 , G06T5/50 , G06T7/00
CPC分类号： G06T3/0068 , G06K9/6207 , G06T5/50 , G06T7/33 , G06T2207/10016 , G06T2207/10121 , G06T2207/30021 , G06T2207/30048 , G06T2207/30101 , G06T2207/30204
摘要： A method (100) that provides image processing of X-ray images that is particularly effective for the alignment of stent images and that, ultimately, provides stent image quality enhancement.
摘要翻译：提供对支架图像的对准特别有效的X射线图像的图像处理的方法（100），并且最终提供支架图像质量增强。

10. 发明授权

US08831308B2 Shape based conditional random fields for segmenting intracranial aneurysms 有权
标题翻译：基于形状的条件随机场分割颅内动脉瘤
公开(公告)号：US08831308B2
公开(公告)日：2014-09-09
申请号：US13456542
申请日：2012-05-30
申请人： Sajjad Hussain Baloch , Erkang Cheng , Tong Fang , Ying Zhu
发明人： Sajjad Hussain Baloch , Erkang Cheng , Tong Fang , Ying Zhu
IPC分类号： G06K9/00 , G06T7/00 , G06K9/46
CPC分类号： G06T7/0083 , G06K9/4638 , G06K9/468 , G06K2209/05 , G06T7/12 , G06T7/143 , G06T7/149 , G06T2207/10072 , G06T2207/20076 , G06T2207/20124 , G06T2207/30101
摘要： A method for segmenting intracranial aneurysms in digital medical images includes extracting a mesh representing a vessel surface from a volumetric digital image, the mesh comprising a set of points {pi} and edges {eij} respective points, and finding a set of binary labelings that minimizes an energy functional of the labelings and of shape descriptors of each point in the mesh, where the binary labelings segments an aneurysm from the surface by associating one of two labels with each point pi, where a label indicates whether an associated point is on a vessel or on an aneurysm, where the energy functional includes a unary potential term summed over all points that represent a posterior distribution of the labels over the points, and a pairwise potential term summed over all edges that represents neighborhood labeling relationships.
摘要翻译：用于在数字医学图像中分割颅内动脉瘤的方法包括从体积数字图像中提取表示血管表面的网格，所述网格包括一组点{pi}和边缘{eij}各个点，并且找到一组二进制标记，最小化网格中每个点的标签和形状描述符的能量功能，其中二进制标签通过将两个标签中的一个与每个点pi相关联来从表面分割动脉瘤，其中标签指示关联点是否在血管或动脉瘤，其中能量功能包括表示标记在点上的后验分布的所有点上的一元潜在项，以及表示邻域标记关系的所有边缘上的成对潜在项。

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