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1. 发明申请

US20100121181A1 Method and System for Guidewire Tracking in Fluoroscopic Image Sequences 有权
标题翻译：荧光图像序列中导丝跟踪的方法和系统
公开(公告)号：US20100121181A1
公开(公告)日：2010-05-13
申请号：US12538456
申请日：2009-08-10
申请人： Peng Wang , Ying Zhu , Wei Zhang , Terrence Chen , Peter Durlak , Ulrich Bill , Dorin Comaniciu
发明人： Peng Wang , Ying Zhu , Wei Zhang , Terrence Chen , Peter Durlak , Ulrich Bill , Dorin Comaniciu
IPC分类号： A61B5/05
CPC分类号： A61B6/12 , A61B2034/2065 , A61B2090/376 , G06T7/246 , G06T2207/10016 , G06T2207/10121 , G06T2207/30021
摘要： A method and system for tracking a guidewire in a fluoroscopic image sequence is disclosed. In order to track a guidewire in a fluoroscopic image sequence, guidewire segments are detected in each frame of the fluoroscopic image sequence. The guidewire in each frame of the fluoroscopic image sequence is then detected by rigidly tracking the guidewire from a previous frame of the fluoroscopic image sequence based on the detected guidewire segments in the current frame. The guidewire is then non-rigidly deformed in each frame based on the guidewire position in the previous frame.
摘要翻译：公开了一种用于跟踪透视图像序列中的导丝的方法和系统。为了在透视图像序列中跟踪导丝，在荧光镜图像序列的每个帧中检测导丝段。然后通过基于当前帧中检测到的导丝段从透视图像序列的前一帧刚性跟踪导丝来检测透视图像序列的每个帧中的导丝。然后基于先前框架中的导丝线位置，导丝在每个框架中不会刚性变形。

2. 发明授权

US08423121B2 Method and system for guidewire tracking in fluoroscopic image sequences 有权
标题翻译：荧光图像序列中导丝跟踪的方法和系统
公开(公告)号：US08423121B2
公开(公告)日：2013-04-16
申请号：US12538456
申请日：2009-08-10
申请人： Peng Wang , Ying Zhu , Wei Zhang , Terrence Chen , Peter Durlak , Ulrich Bill , Dorin Comaniciu
发明人： Peng Wang , Ying Zhu , Wei Zhang , Terrence Chen , Peter Durlak , Ulrich Bill , Dorin Comaniciu
IPC分类号： A61B5/05
CPC分类号： A61B6/12 , A61B2034/2065 , A61B2090/376 , G06T7/246 , G06T2207/10016 , G06T2207/10121 , G06T2207/30021
摘要： A method and system for tracking a guidewire in a fluoroscopic image sequence is disclosed. In order to track a guidewire in a fluoroscopic image sequence, guidewire segments are detected in each frame of the fluoroscopic image sequence. The guidewire in each frame of the fluoroscopic image sequence is then detected by rigidly tracking the guidewire from a previous frame of the fluoroscopic image sequence based on the detected guidewire segments in the current frame. The guidewire is then non-rigidly deformed in each frame based on the guidewire position in the previous frame.
摘要翻译：公开了一种用于跟踪透视图像序列中的导丝的方法和系统。为了在透视图像序列中跟踪导丝，在荧光镜图像序列的每个帧中检测导丝段。然后通过基于当前帧中检测到的导丝段从透视图像序列的前一帧刚性跟踪导丝来检测透视图像序列的每个帧中的导丝。然后基于先前框架中的导丝线位置，导丝在每个框架中不会刚性变形。

3. 发明授权

US08355550B2 Methods and apparatus for virtual coronary mapping 有权
标题翻译：虚拟冠状动脉成像的方法和装置
公开(公告)号：US08355550B2
公开(公告)日：2013-01-15
申请号：US12150816
申请日：2008-05-01
申请人： Wei Zhang , Ying Zhu , Adrian Barbu , Richard Socher , Stefan Böhm , Peter Durlak , Dorin Comaniciu
发明人： Wei Zhang , Ying Zhu , Adrian Barbu , Richard Socher , Stefan Böhm , Peter Durlak , Dorin Comaniciu
IPC分类号： G06K9/00
CPC分类号： G06K9/3216 , A61B6/12 , A61B6/481 , A61B6/504 , G06K2009/00932 , G06K2209/05 , G06T7/12 , G06T2207/20044 , G06T2207/30101 , G06T2207/30172
摘要： A virtual map of vessels of interest in medical procedures, such as coronary angioplasty is created so that doses of contrasting agent given to a patient may be reduced. A position of a coronary guidewire is determined and locations of vessel boundaries are found. When the contrast agent has dissipated, virtual maps of the vessels are created as new images. The locations of the determined vessel boundaries are imported to a mapping system and an image obtained without using a contrast agent is modified based on the imported locations of vessel boundaries. This creates a virtual map of the vessels.
摘要翻译：创建医疗程序感兴趣的血管的虚拟地图，例如冠状动脉血管成形术，以便减少给予患者的剂量的造影剂。确定冠状导丝的位置并找到血管边界的位置。当造影剂消散时，血管的虚拟地图被创建为新的图像。确定的容器边界的位置被导入到映射系统，并且基于导入的容器边界的位置来修改不使用造影剂获得的图像。这将创建一个血管的虚拟地图。

4. 发明申请

US20080275335A1 Methods and apparatus for virtual coronary mapping 有权
标题翻译：虚拟冠状动脉成像的方法和装置
公开(公告)号：US20080275335A1
公开(公告)日：2008-11-06
申请号：US12150816
申请日：2008-05-01
申请人： Wei Zhang , Ying Zhu , Adrian Barbu , Richard Socher , Stefan Bohm , Peter Durlak , Dorin Comaniciu
发明人： Wei Zhang , Ying Zhu , Adrian Barbu , Richard Socher , Stefan Bohm , Peter Durlak , Dorin Comaniciu
IPC分类号： A61B5/05 , G06K9/00
CPC分类号： G06K9/3216 , A61B6/12 , A61B6/481 , A61B6/504 , G06K2009/00932 , G06K2209/05 , G06T7/12 , G06T2207/20044 , G06T2207/30101 , G06T2207/30172
摘要： A virtual map of vessels of interest in medical procedures, such as coronary angioplasty is created so that doses of contrasting agent given to a patient may be reduced. A position of a coronary guidewire is determined and locations of vessel boundaries are found. When the contrast agent has dissipated, virtual maps of the vessels are created as new images. The locations of the determined vessel boundaries are imported to a mapping system and an image obtained without using a contrast agent is modified based on the imported locations of vessel boundaries. This creates a virtual map of the vessels.
摘要翻译：创建医疗程序感兴趣的血管的虚拟地图，例如冠状动脉血管成形术，以便减少给予患者的剂量的造影剂。确定冠状导丝的位置并找到血管边界的位置。当造影剂消散时，血管的虚拟地图被创建为新的图像。确定的容器边界的位置被导入到映射系统，并且基于导入的容器边界的位置来修改不使用造影剂获得的图像。这将创建一个血管的虚拟地图。

5. 发明申请

US20110033102A1 System and Method for Coronary Digital Subtraction Angiography 有权
标题翻译：冠状动脉数字减影血管造影术的系统与方法
公开(公告)号：US20110033102A1
公开(公告)日：2011-02-10
申请号：US12774146
申请日：2010-05-05
申请人： Ying Zhu , Simone Prummer , Peng Wang , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
发明人： Ying Zhu , Simone Prummer , Peng Wang , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
IPC分类号： G06K9/00
CPC分类号： G06T7/0016 , G06T2207/10121 , G06T2207/20224 , G06T2207/30101
摘要： A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, a motion estimate is calculated between each of the mask images and a background region of the contrast image and a covariance is calculated for each motion estimate. Multiple background layer predictions are generated by generating a background layer prediction for each mask image based on the calculated motion estimate and covariance. The multiple background layer estimates are combined using statistical fusion to generate a final estimated background layer. The final estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image.
摘要翻译：公开了使用冠状动脉数字减影血管造影（DSA）提取冠脉血管荧光镜图像序列的方法和系统。接收冠状动脉区域的一组掩模图像，并且接收冠状动脉区域的对比度图像序列。对于每个对比度图像，在每个掩模图像和对比度图像的背景区域之间计算运动估计，并且针对每个运动估计计算协方差。通过基于计算的运动估计和协方差为每个掩模图像生成背景层预测来生成多个背景层预测。使用统计融合来组合多个背景层估计以产生最终估计的背景层。从对比度图像中减去最终估计的背景层，以提取对比度图像的冠状血管层。

6. 发明授权

US09524550B2 System and method for coronary digital subtraction angiography 有权
标题翻译：冠状动脉数字减影血管造影的系统和方法
公开(公告)号：US09524550B2
公开(公告)日：2016-12-20
申请号：US12774146
申请日：2010-05-05
申请人： Ying Zhu , Simone Prummer , Peng Wang , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
发明人： Ying Zhu , Simone Prummer , Peng Wang , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
IPC分类号： G06T7/00
CPC分类号： G06T7/0016 , G06T2207/10121 , G06T2207/20224 , G06T2207/30101
摘要： A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, a motion estimate is calculated between each of the mask images and a background region of the contrast image and a covariance is calculated for each motion estimate. Multiple background layer predictions are generated by generating a background layer prediction for each mask image based on the calculated motion estimate and covariance. The multiple background layer estimates are combined using statistical fusion to generate a final estimated background layer. The final estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image.
摘要翻译：公开了使用冠状动脉数字减影血管造影（DSA）提取冠脉血管荧光镜图像序列的方法和系统。接收冠状动脉区域的一组掩模图像，并且接收冠状动脉区域的对比度图像序列。对于每个对比度图像，在每个掩模图像和对比度图像的背景区域之间计算运动估计，并且针对每个运动估计计算协方差。通过基于计算的运动估计和协方差为每个掩模图像生成背景层预测来生成多个背景层预测。使用统计融合来组合多个背景层估计以产生最终估计的背景层。从对比度图像中减去最终估计的背景层，以提取对比度图像的冠状血管层。

7. 发明授权

US08345944B2 System and method for coronary digital subtraction angiography 有权
标题翻译：冠状动脉数字减影血管造影的系统和方法
公开(公告)号：US08345944B2
公开(公告)日：2013-01-01
申请号：US12509514
申请日：2009-07-27
申请人： Ying Zhu , Simone Prummer , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
发明人： Ying Zhu , Simone Prummer , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
IPC分类号： G06K9/00
CPC分类号： G06K9/38 , G06K2009/00932 , G06T7/0014 , G06T7/194 , G06T2207/20076 , G06T2207/20081 , G06T2207/30101
摘要： A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, vessel regions are detected in the contrast image using learning-based vessel segment detection and a background region of the contrast image is determined based on the detected vessel regions. Background motion is estimated between one of the mask images and the background region of the contrast image by estimating a motion field between the mask image and the background image and performing covariance-based filtering over the estimated motion field. The mask image is then warped based on the estimated background motion to generate an estimated background layer. The estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image.
摘要翻译：公开了使用冠状动脉数字减影血管造影（DSA）提取冠脉血管荧光镜图像序列的方法和系统。接收冠状动脉区域的一组掩模图像，并且接收冠状动脉区域的对比度图像序列。对于每个对比图像，使用基于学习的血管段检测在对比图像中检测血管区域，并且基于检测到的血管区域确定造影剂图像的背景区域。通过估计掩模图像和背景图像之间的运动场并且在估计的运动场上执行协方差滤波来估计背景运动在掩模图像和对比度图像的背景区域中的一个之间。然后基于估计的背景运动来改变掩模图像以产生估计的背景层。从对比图像中减去估计的背景层，以提取对比度图像的冠状血管层。

8. 发明申请

US20100034446A1 System and Method for Coronary Digital Subtraction Angiography 有权
标题翻译：冠状动脉数字减影血管造影术的系统与方法
公开(公告)号：US20100034446A1
公开(公告)日：2010-02-11
申请号：US12509514
申请日：2009-07-27
申请人： Ying Zhu , Simone Prummer , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
发明人： Ying Zhu , Simone Prummer , Terrence Chen , Martin Ostermeier , Dorin Comaniciu
IPC分类号： G06K9/00
CPC分类号： G06K9/38 , G06K2009/00932 , G06T7/0014 , G06T7/194 , G06T2207/20076 , G06T2207/20081 , G06T2207/30101
摘要： A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, vessel regions are detected in the contrast image using learning-based vessel segment detection and a background region of the contrast image is determined based on the detected vessel regions. Background motion is estimated between one of the mask images and the background region of the contrast image by estimating a motion field between the mask image and the background image and performing covariance-based filtering over the estimated motion field. The mask image is then warped based on the estimated background motion to generate an estimated background layer. The estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image.
摘要翻译：公开了使用冠状动脉数字减影血管造影（DSA）提取冠脉血管荧光镜图像序列的方法和系统。接收冠状动脉区域的一组掩模图像，并且接收冠状动脉区域的对比度图像序列。对于每个对比图像，使用基于学习的血管段检测在对比图像中检测血管区域，并且基于检测到的血管区域确定造影剂图像的背景区域。通过估计掩模图像和背景图像之间的运动场并且在估计的运动场上执行协方差滤波来估计背景运动在掩模图像和对比度图像的背景区域中的一个之间。然后基于估计的背景运动来改变掩模图像以产生估计的背景层。从对比图像中减去估计的背景层，以提取对比度图像的冠状血管层。

9. 发明授权

US08094903B2 System and method for coronary digital subtraction angiography 有权
标题翻译：冠状动脉数字减影血管造影的系统和方法
公开(公告)号：US08094903B2
公开(公告)日：2012-01-10
申请号：US12157837
申请日：2008-06-13
申请人： Ying Zhu , Wei Zhang , Adrian Barbu , Simone Prummer , Martin Ostermeier , Dorin Comaniciu
发明人： Ying Zhu , Wei Zhang , Adrian Barbu , Simone Prummer , Martin Ostermeier , Dorin Comaniciu
IPC分类号： G06K9/03
CPC分类号： A61B6/504 , A61B6/481 , G06T5/50 , G06T7/215 , G06T7/30 , G06T2207/10016 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, vessel regions are detected in the contrast image using learning-based vessel segment detection and a background region of the contrast image is determined based on the detected vessel regions. Background motion is estimated between one of the mask images and the background region of the contrast image, and the mask image is warped based on the estimated background motion to generate an estimated background layer. The estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image.
摘要翻译：公开了使用冠状动脉数字减影血管造影（DSA）提取冠脉血管荧光镜图像序列的方法和系统。接收冠状动脉区域的一组掩模图像，并且接收冠状动脉区域的对比度图像序列。对于每个对比图像，使用基于学习的血管段检测在对比图像中检测血管区域，并且基于检测到的血管区域确定造影剂图像的背景区域。在掩模图像之一和对比度图像的背景区域之间估计背景运动，并且基于所估计的背景运动来对掩模图像进行翘曲以生成估计的背景层。从对比图像中减去估计的背景层，以提取对比度图像的冠状血管层。

10. 发明申请

US20090010512A1 System and method for coronary digital subtraction angiography 有权
标题翻译：冠状动脉数字减影血管造影的系统和方法
公开(公告)号：US20090010512A1
公开(公告)日：2009-01-08
申请号：US12157837
申请日：2008-06-13
申请人： Ying Zhu , Wei Zhang , Adrian Barbu , Simone Prummer , Martin Ostermeier , Dorin Comaniciu
发明人： Ying Zhu , Wei Zhang , Adrian Barbu , Simone Prummer , Martin Ostermeier , Dorin Comaniciu
IPC分类号： H05G1/64 , G06K9/00
CPC分类号： A61B6/504 , A61B6/481 , G06T5/50 , G06T7/215 , G06T7/30 , G06T2207/10016 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： A method and system for extracting coronary vessels fluoroscopic image sequences using coronary digital subtraction angiography (DSA) are disclosed. A set of mask images of a coronary region is received, and a sequence of contrast images for the coronary region is received. For each contrast image, vessel regions are detected in the contrast image using learning-based vessel segment detection and a background region of the contrast image is determined based on the detected vessel regions. Background motion is estimated between one of the mask images and the background region of the contrast image, and the mask image is warped based on the estimated background motion to generate an estimated background layer. The estimated background layer is subtracted from the contrast image to extract a coronary vessel layer for the contrast image.
摘要翻译：公开了使用冠状动脉数字减影血管造影（DSA）提取冠脉血管荧光镜图像序列的方法和系统。接收冠状动脉区域的一组掩模图像，并且接收冠状动脉区域的对比度图像序列。对于每个对比图像，使用基于学习的血管段检测在对比图像中检测血管区域，并且基于检测到的血管区域确定造影剂图像的背景区域。在掩模图像之一和对比度图像的背景区域之间估计背景运动，并且基于所估计的背景运动来对掩模图像进行翘曲以生成估计的背景层。从对比图像中减去估计的背景层，以提取对比度图像的冠状血管层。

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