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1. 发明授权

US08642596B2 Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arena viruses 失效
标题翻译：磺酰氨基脲，氨基脲和脲，其药物组合物和治疗出血热病毒的方法，包括与竞技场病毒相关的感染
公开(公告)号：US08642596B2
公开(公告)日：2014-02-04
申请号：US11791926
申请日：2005-12-06
申请人： Yijun Deng , Theodore J. Nitz , Thomas R. Bailey , Yuanming Zhang , Sylvie Laquerre
发明人： Yijun Deng , Theodore J. Nitz , Thomas R. Bailey , Yuanming Zhang , Sylvie Laquerre
IPC分类号： A61K31/175 , A61K31/5375 , C07C281/06 , C07D265/30 , C07D241/04
CPC分类号： C07C311/49 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0075 , A61K9/0078 , A61K9/0095 , A61K9/02 , A61K9/06 , A61K9/10 , A61K9/146 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/4866 , A61K31/175 , C07C275/40 , C07D213/74 , C07D231/18 , C07D233/84 , C07D261/10 , C07D265/36 , C07D277/36 , C07D285/06 , C07D295/195 , C07D295/26 , C07D317/48 , C07D319/18 , C12N2760/12211 , Y02A50/387 , Y02A50/397
摘要： Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel semicarbazides, sulfonyl carbazides, ureas and related compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to Arenaviridae (Junin, Machupo, Guanavito, Sabia and Lassa), Filoviridae (ebola and Marburg viruses), Flaviviridae (yellow fever, omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
摘要翻译：公开了通过施用治疗有效量的某些新型氨基脲，磺酰基卡巴肼，脲和相关化合物来治疗病毒感染的化合物，方法和药物组合物。还公开了制备化合物的方法和使用该化合物的方法及其药物组合物。特别地，公开了治疗和预防由出血热病毒引起的病毒感染，即，包括但不限于：活细胞病毒科（Junin，Machupo，Guanavito，Sabia和Lassa），丝状病毒科（埃博拉病毒和马尔堡病毒），黄病毒科（Flaviviridae）黄热病，o疮出血热和Kyasanur森林病毒）和布尼亚病毒科（裂谷热）。

2. 发明申请

US20090203675A1 Sulfonyl Semicarbazides, Semicarbazides and Ureas, Pharmaceutical Compositions Thereof, and Methods for Treating Hemorrhagic Fever Viruses, Including Infections Associated with Arena Viruses 失效
标题翻译：磺酰氨基脲，氨基脲和脲，其药物组合物和治疗出血热病毒的方法，包括与竞技场病毒相关的感染
公开(公告)号：US20090203675A1
公开(公告)日：2009-08-13
申请号：US11791926
申请日：2005-12-06
申请人： Yijun Deng , Theodore J. Nitz , Thomas R. Bailey , Yuanming Zhang , Sylvie Laquerre
发明人： Yijun Deng , Theodore J. Nitz , Thomas R. Bailey , Yuanming Zhang , Sylvie Laquerre
IPC分类号： A61K31/55 , C07C281/06 , A61K31/175 , A61K31/5377 , C07D413/04 , C07D223/04
CPC分类号： C07C311/49 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0075 , A61K9/0078 , A61K9/0095 , A61K9/02 , A61K9/06 , A61K9/10 , A61K9/146 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/4866 , A61K31/175 , C07C275/40 , C07D213/74 , C07D231/18 , C07D233/84 , C07D261/10 , C07D265/36 , C07D277/36 , C07D285/06 , C07D295/195 , C07D295/26 , C07D317/48 , C07D319/18 , C12N2760/12211 , Y02A50/387 , Y02A50/397
摘要： Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel semicarbazides, sulfonyl carbazides, ureas and related compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to Arenaviridae (Junin, Machupo, Guanavito, Sabia and Lassa), Filoviridae (ebola and Marburg viruses), Flaviviridae (yellow fever, omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
摘要翻译：公开了通过施用治疗有效量的某些新型氨基脲，磺酰基卡巴肼，脲和相关化合物来治疗病毒感染的化合物，方法和药物组合物。还公开了制备化合物的方法和使用该化合物的方法及其药物组合物。特别地，公开了治疗和预防由出血热病毒引起的病毒感染，即，包括但不限于：活细胞病毒科（Junin，Machupo，Guanavito，Sabia和Lassa），丝状病毒科（埃博拉病毒和马尔堡病毒），黄病毒科（Flaviviridae）黄热病，o疮出血热和Kyasanur森林病毒）和布尼亚病毒科（裂谷热）。

3. 发明授权

US07265152B2 Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases 失效
标题翻译：苯并呋喃化合物，用于治疗和预防丙型肝炎病毒感染和相关疾病的组合物和方法
公开(公告)号：US07265152B2
公开(公告)日：2007-09-04
申请号：US10699336
申请日：2003-10-31
申请人： Ashis K. Saha , Christopher J Burns , Alfred M. Del Vecchio , Thomas R. Bailey , Jason A. Reinhardt , Bheemashankar A. Kulkarni , Thomas H. Faitg , Hao Feng , Susan R. Rippin , Charles W. Blackledge , David J. Rys , Thomas A. Lessen , John Swestock , Yijun Deng , Theodore J. Nitz
发明人： Ashis K. Saha , Christopher J Burns , Alfred M. Del Vecchio , Thomas R. Bailey , Jason A. Reinhardt , Bheemashankar A. Kulkarni , Thomas H. Faitg , Hao Feng , Susan R. Rippin , Charles W. Blackledge , David J. Rys , Thomas A. Lessen , John Swestock , Yijun Deng , Theodore J. Nitz
IPC分类号： A61K31/343 , C07D307/87
CPC分类号： C07D405/04 , C07D307/84 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to novel benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.
摘要翻译：本发明涉及新的苯并呋喃衍生物和类似物，以及含有该苯并呋喃衍生物和类似物的组合物及其用于治疗或预防与其相关的病毒感染和疾病，特别是由丙型肝炎病毒引起的那些病毒感染和相关疾病的用途。

4. 发明申请

US20090281336A1 BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES 审中-公开
标题翻译：苯佐芬化合物，组合物和方法治疗和预防乙型肝炎病毒感染和相关疾病
公开(公告)号：US20090281336A1
公开(公告)日：2009-11-12
申请号：US12499876
申请日：2009-07-09
申请人： Ashis K. Saha , Christopher J. Burns , Alfred M. Del Vecchio , Thomas R. Bailey , Jason A. Reinhardt , Bheemashankar A. Kulkarni , Thomas H. Faitg , Hao Feng , Susan R. Rippin , Charles W. Blackledge , David J. Rys , Thomas A. Lessen , John Swestock , Yijun Deng , Theodore J. Nitz
发明人： Ashis K. Saha , Christopher J. Burns , Alfred M. Del Vecchio , Thomas R. Bailey , Jason A. Reinhardt , Bheemashankar A. Kulkarni , Thomas H. Faitg , Hao Feng , Susan R. Rippin , Charles W. Blackledge , David J. Rys , Thomas A. Lessen , John Swestock , Yijun Deng , Theodore J. Nitz
IPC分类号： C07D307/82
CPC分类号： C07D405/04 , C07D307/84 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to novel benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.
摘要翻译：本发明涉及新的苯并呋喃衍生物和类似物，以及含有该苯并呋喃衍生物和类似物的组合物及其用于治疗或预防与其相关的病毒感染和疾病，特别是由丙型肝炎病毒引起的那些病毒感染和相关疾病的用途。

5. 发明授权

US07666863B2 Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases 失效
标题翻译：苯并呋喃化合物，用于治疗和预防丙型肝炎病毒感染和相关疾病的组合物和方法
公开(公告)号：US07666863B2
公开(公告)日：2010-02-23
申请号：US11753145
申请日：2007-05-24
申请人： Ashis K. Saha , Christopher J Burns , Alfred M. Del Vecchio , Thomas R. Bailey , Jason A. Reinhardt , Bheemashankar A. Kulkarni , Thomas H. Faitg , Hao Feng , Susan R. Rippin , Charles W. Blackledge , David J. Rys , Thomas A. Lessen , John Swestock , Yijun Deng , Theodore J. Nitz
发明人： Ashis K. Saha , Christopher J Burns , Alfred M. Del Vecchio , Thomas R. Bailey , Jason A. Reinhardt , Bheemashankar A. Kulkarni , Thomas H. Faitg , Hao Feng , Susan R. Rippin , Charles W. Blackledge , David J. Rys , Thomas A. Lessen , John Swestock , Yijun Deng , Theodore J. Nitz
IPC分类号： A61K31/54 , A61K31/53 , C07D307/00 , C07D401/00 , C07D417/00
CPC分类号： C07D405/04 , C07D307/84 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.
摘要翻译：本发明涉及苯并呋喃衍生物和类似物，以及含有它们的组合物及其用于治疗或预防与其相关的病毒感染和疾病的用途，特别是由丙型肝炎病毒引起的那些病毒感染和相关疾病。

6. 发明授权

US5514692A Substituted quinoline derivatives useful as antipiconaviral agents 失效
标题翻译：可用作抗病毒药物的取代喹啉衍生物
公开(公告)号：US5514692A
公开(公告)日：1996-05-07
申请号：US449463
申请日：1995-05-24
申请人： David J. Aldous , Thomas R. Bailey , Guy D. Diana , Gee-Hong Kuo , Theodore J. Nitz , Michael Reuman
发明人： David J. Aldous , Thomas R. Bailey , Guy D. Diana , Gee-Hong Kuo , Theodore J. Nitz , Michael Reuman
IPC分类号： C07D413/06 , C07D413/14 , A61K31/47 , C07D401/04
CPC分类号： C07D413/06 , C07D413/14
摘要： The invention discloses compounds of the formula ##STR1## wherein, Het.sub.1 is chosen from the group consisting of substituted or unsubstituted furyl, oxazolyl, isoxazolyl, oxadiazolyl, tetrazolyl, thiadiazolylY is an alkylene bridge of 3 to 9 carbon atoms.Het.sub.2 is quinolyl quinolyl substituted by R.sub.1 and R.sub.2 ;R.sub.1 and R.sub.2 are each individually chosen from hydrogen, halo, alkyl, alkenyl, amino, alkylthio, hydroxy, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkylsulfinyl alkyl, alkylsulfonylalkyl, alkoxy, nitro, carboxy, alkoxycarbonyl, dialkylaminoalkyl, alkylaminoalkyl, aminoalkyl, difluoromethyl, trifluoromethyl or cyano;R.sub.3 is alkyltetrazolyl, or substituted or unsubstituted heterocyclyl chosen from benzoxazolyl, benzathiazolyl, thiadiazolyl, imidazolyl, dihydroimidazolyl, oxazolyl, thiazolyl, oxadiazolyl, pyrazolyl, isoxazolyl, isothiazolyl, furyl, triazolyl, tetrazolyl, thiophenyl the N-oxide thereof or a pharmaceutically acceptable acid addition salt thereof are effective antipicornaviral agents.
摘要翻译：本发明公开了下式化合物：其中Het1选自取代或未取代的呋喃基，恶唑基，异恶唑基，恶二唑基，四唑基，噻二唑基，Y为3至9个碳原子的亚烷基桥。 Het2是被R1和R2取代的喹啉基喹啉基; R 1和R 2各自独立地选自氢，卤素，烷基，烯基，氨基，烷硫基，羟基，羟基烷基，烷氧基烷基，烷硫基烷基，烷基亚磺酰基烷基，烷基磺酰基烷基，烷氧基，硝基，羧基，烷氧基羰基，二烷基氨基烷基，烷基氨基烷基，氨基烷基，二氟甲基，或氰基; R3是烷基四唑基，或者是取代或未取代的选自苯并恶唑基，苯并噻唑基，噻二唑基，咪唑基，二氢咪唑基，恶唑基，噻唑基，恶二唑基，吡唑基，噻唑基，恶唑基，呋喃基，三唑基，四唑基，噻吩基，其N-氧化物或其药学上可接受的酸其加成盐是有效的抗虫病毒药剂。

7. 发明授权

US5514679A Therapeutic phenoxyalklpyridazines and intermediates therefor 失效
标题翻译：治疗性苯氧亚胺idaz嗪及其中间体
公开(公告)号：US5514679A
公开(公告)日：1996-05-07
申请号：US242528
申请日：1994-05-13
申请人： David J. Aldous , Thomas R. Bailey , Guy D. Diana , Theodore J. Nitz
发明人： David J. Aldous , Thomas R. Bailey , Guy D. Diana , Theodore J. Nitz
IPC分类号： C07D237/08 , C07D307/42 , C07D403/12 , C07D405/04 , C07D405/12 , C07D407/04 , C07D413/12 , C07D413/14 , A61K31/50 , C07D237/12
CPC分类号： C07D307/42 , C07D237/08 , C07D403/12 , C07D405/04 , C07D405/12 , C07D407/04 , C07D413/12 , C07D413/14
摘要： Compounds of the formula ##STR1## wherein: R.sub.1 and R.sub.2 are independently hydrogen, halo, alkyl, alkenyl, alkoxy, hydroxy, hydroxyalkyl, hydroxyhaloalkyl, alkoxyalkyl, alkylthioalkynyl, hydroxyalkoxy, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, amino, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxycarbonyl, carboxy or cyanomethyl, nitro, difluoromethyl, trifluoromethyl or cyano;Y is alkylene of 3 to 9 carbon atoms;R.sub.3 and R.sub.4 are independently hydrogen, alkyl, alkoxy, hydroxy, cycloalkyl, hydroxyalkyl, hydroxyhaloalkyl, alkoxyalkyl, hydroxyalkoxy, alkylthioalkyl, alkanoyl, alkanoyloxy, alkylsulfinylalkyl, alkylsulfonylalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxycarbonyl, carboxy, cyanomethyl, fluoroalkyl, cyano, phenyl, alkynyl, alkene, or halo;R.sub.5 is alkoxycarbonyl, alkyltetrazolyl, phenyl or a heterocycle;or a pharmaceutically acceptable acid addition salts thereof; N-oxides thereof, are useful as antipirconaviral agents.
摘要翻译：其中：R1和R2独立地是氢，卤素，烷基，烯基，烷氧基，羟基，羟基烷基，羟基卤代烷基，烷氧基烷基，烷基硫代炔基，羟基烷氧基，烷基硫代烷基，烷基亚磺酰基烷基，烷基磺酰基烷基，氨基，氨基烷基，烷基氨基烷基，二烷基氨基烷基，烷氧基羰基，羧基或氰基甲基，硝基，二氟甲基，三氟甲基或氰基; Y为3至9个碳原子的亚烷基; R3和R4独立地是氢，烷基，烷氧基，羟基，环烷基，羟基烷基，羟基卤代烷基，烷氧基烷基，羟基烷氧基，烷硫基烷基，烷酰基，烷酰氧基，烷基亚磺酰基烷基，烷基磺酰基烷基，氨基烷基，烷基氨基烷基，二烷基氨基烷基，烷氧基羰基，羧基，氰基甲基，氟代烷基，，炔基，烯烃或卤素; R5是烷氧基羰基，烷基四唑基，苯基或杂环; 或其药学上可接受的酸加成盐; 其N-氧化物可用作抗血管病毒药物。

8. 发明授权

US6127384A Compounds, compositions and methods for treatment of hepatitis C 失效
标题翻译：用于治疗丙型肝炎的化合物，组合物和方法
公开(公告)号：US6127384A
公开(公告)日：2000-10-03
申请号：US84538
申请日：1998-05-26
申请人： Guy D. Diana , Thomas R. Bailey , Theodore J. Nitz
发明人： Guy D. Diana , Thomas R. Bailey , Theodore J. Nitz
IPC分类号： C07D211/58 , C07D211/62 , C07D401/14 , A01N43/40
CPC分类号： C07D401/14 , C07D211/58 , C07D211/62
摘要： Derivatives of piperidine are useful in prophylaxis and treatment of hepatitis C virus infections.
摘要翻译：哌啶的衍生物可用于预防和治疗丙型肝炎病毒感染。

9. 发明授权

US5935957A Compounds, compositions and methods for treating influenza 失效
标题翻译：用于治疗流感的化合物，组合物和方法
公开(公告)号：US5935957A
公开(公告)日：1999-08-10
申请号：US82656
申请日：1998-05-21
申请人： Guy D. Diana , Thomas R. Bailey , Theodore J. Nitz , Dorothy C. Young , William P. Gorczyca
发明人： Guy D. Diana , Thomas R. Bailey , Theodore J. Nitz , Dorothy C. Young , William P. Gorczyca
IPC分类号： C07D237/02 , A61K31/50 , A61K31/501 , A61P31/16 , C07D237/14 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/10 , C07D407/10 , C07D409/10 , C07D413/10 , C07D417/10 , A61K43/60
CPC分类号： C07D403/10 , C07D237/14 , C07D407/10
摘要： Compounds of the formula: ##STR1## wherein R1 represents a lower alkyl (C1-C6) substituent which may be straight or branched; R2 represents an aryl substituent of the formula: ##STR2## and Q, V, W, X, Y and Z are as set forth in the accompanying specification, are useful in prophylaxis of influenza virus infection.
摘要翻译：下式的化合物：其中R 1表示可以是直链或支链的低级烷基（C1-C6）取代基; R2表示下式的芳基取代基：Q，V，W，X，Y和Z如所附说明书所述，可用于预防流感病毒感染。

10. 发明授权

US5763461A Therapeutic phenoxyalkylheterocycles 失效
标题翻译：治疗苯氧基烷基杂环
公开(公告)号：US5763461A
公开(公告)日：1998-06-09
申请号：US822995
申请日：1997-03-21
申请人： David J. Aldous , Thomas R. Bailey , Guy Dominic Diana , Gee-Hong Kuo , Theodore J. Nitz
发明人： David J. Aldous , Thomas R. Bailey , Guy Dominic Diana , Gee-Hong Kuo , Theodore J. Nitz
IPC分类号： C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04 , A61K31/44 , A61K31/415 , A61K31/47 , A61K31/505 , C07D213/16 , C07D239/26 , C07D401/10 , C07D403/10
CPC分类号： C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04
摘要： Compounds of the formula ##STR1## wherein Pyr is chosen from the group consisting of pyridyl, pyrazyl, pyrimidyl, quinolyl, indolyl and 7-azaindolyl or any of these substituted with one or two substitutents chosen from alkyl, alkoxy, hydroxy, halo, cyano, nitro, hydroxyalkyl, alkoxyalkyl, alkanoyl, fluoroalkyl or the N-oxide of any of these; Y is an alkylene bridge of 3-9 carbon atoms; R.sub.1 and R.sub.2 are each independently chosen from hydrogen, halo, alkyl, alkenyl, amino, alkylthio, hydroxy, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkylsulfinylaikyl, alkylsulfonylalkyl, alkoxy, nitro, carboxy, alkoxycarbonyl, dialkylaminoalkyl, alkylaminoalkyl, aminoalkyl, difluoromethyl, trifluoromethyl or cyano; R.sub.3 is alkoxycarbonyl, alkyltetrazolyl, phenyl or heterocyclyl chosen from benzoxazolyl, benzathiazolyl, thiadiazolyl, imidazolyl, dihydroimidazolyl, oxazolyl, thiazolyl, oxadiazolyl, pyrazolyl, isoxazolyl, isothiazolyl, furyl, triazolyl, thiophenyl, pyridyl, pyrimidinyl, pyrazlnyl, pyridazinyl or a substituted phenyl or substituted heterocyclyl wherein the substitution is with alkyl, alkoxyalkyl, cycloalkyl, halo alkyl, hydroxyalkyl, alkoxy, hydroxy, furyl, or thienyl or fluoroalkyl, the N-oxide thereof, or a pharmaceutically acceptable acid addition salt thereof is an effective antipicornaviral agents.
摘要翻译：下式的化合物其中Pyr选自吡啶基，吡唑基，嘧啶基，喹啉基，吲哚基和7-氮杂吲哚基，或者被一个或两个选自烷基，烷氧基，羟基，卤代的取代基取代的那些氰基，硝基，羟基烷基，烷氧基烷基，烷酰基，氟代烷基或其中任何一种的N-氧化物; Y是3-9个碳原子的亚烷基桥; R 1和R 2各自独立地选自氢，卤素，烷基，烯基，氨基，烷硫基，羟基，羟基烷基，烷氧基烷基，烷硫基烷基，烷基亚磺酰基烷基，烷基磺酰基烷基，烷氧基，硝基，羧基，烷氧基羰基，二烷基氨基烷基，烷基氨基烷基，氨基烷基，二氟甲基，三氟甲基或氰基; R3是烷氧基羰基，烷基四唑基，苯基或选自苯并恶唑基，苯并噻唑基，噻二唑基，咪唑基，二氢咪唑基，恶唑基，噻唑基，恶二唑基，吡唑基，异唑基，异噻唑基，呋喃基，三唑基，噻吩基，吡啶基，嘧啶基，吡嗪基，哒嗪基或取代苯基或取代的杂环基，其中取代为烷基，烷氧基烷基，环烷基，卤代烷基，羟基烷基，烷氧基，羟基，呋喃基或噻吩基或氟代烷基，其N-氧化物或其药学上可接受的酸加成盐是有效的抗虫病毒药剂。

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