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1. 发明授权

US08410149B2 Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses 有权
公开(公告)号：US08410149B2
公开(公告)日：2013-04-02
申请号：US12914400
申请日：2010-10-28
申请人： Dongcheng Dai , Tove Bolken , Sean M. Amberg , Dennis E. Hruby , Thomas R. Bailey
发明人： Dongcheng Dai , Tove Bolken , Sean M. Amberg , Dennis E. Hruby , Thomas R. Bailey
IPC分类号： A61K31/175 , A61K31/433 , C07C281/06 , C07D285/04
CPC分类号： C07C311/49 , A61K31/18 , A61K31/357 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/426 , A61K31/433 , A61K31/445 , A61K31/496 , A61K31/5377 , A61K31/538 , A61K31/55 , A61K31/63 , C07D265/36 , C07D285/06 , Y02A50/387 , Y02A50/397
摘要： Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel semicarbazides, sulfonyl carbazides, ureas and related compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to Arenaviridae (Junin, Machupo, Guanavito, Sabia and Lassa), Filoviridae (ebola and Marburg viruses), Flaviviridae (yellow fever, omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).

2. 发明申请

US20110288075A1 Pyridazinone Derivatives 有权
标题翻译：哒嗪酮衍生物
公开(公告)号：US20110288075A1
公开(公告)日：2011-11-24
申请号：US13197243
申请日：2011-08-03
申请人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J.S. Knutsen , Ming Tao , Allison L. Zulli
发明人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J.S. Knutsen , Ming Tao , Allison L. Zulli
IPC分类号： A61K31/55 , A61K31/502 , A61K31/5025 , A61P25/00 , A61K31/50 , A61P25/28 , A61P25/18 , A61K31/501 , A61K31/5377
CPC分类号： C07D498/04 , C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D495/04
摘要： The present invention is directed to novel pyridazinone derivatives that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition/cognitive disorders.
摘要翻译：本发明涉及介导酶活性的新的哒嗪酮衍生物。特别地，这些化合物可有效治疗与组胺H3受体活性相关的疾病或疾病状态，包括例如神经变性疾病，睡眠/觉醒障碍，注意缺陷多动障碍和认知/认知障碍。

3. 发明申请

US20100273779A1 Pyridazinone Derivatives 有权
标题翻译：哒嗪酮衍生物
公开(公告)号：US20100273779A1
公开(公告)日：2010-10-28
申请号：US12815813
申请日：2010-06-15
申请人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J.S. Knutsen , Ming Tao , Allison L. Zulli
发明人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J.S. Knutsen , Ming Tao , Allison L. Zulli
IPC分类号： A61K31/55 , C07D403/12 , A61K31/501 , A61K31/502 , C07D495/04 , A61P3/04 , A61P9/10 , A61P11/00 , A61P25/08 , A61P25/18 , A61P25/24 , A61P25/28 , A61P1/00 , A61P29/00
CPC分类号： C07D498/04 , C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D495/04
摘要： The present invention is directed to novel pyridizinone derivatives that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition.
摘要翻译：本发明涉及介导酶活性的新型吡哒嗪酮衍生物。特别地，这些化合物可有效治疗与组胺H3受体活性相关的疾病或疾病状态，包括例如神经变性疾病，睡眠/觉醒障碍，注意力缺陷多动障碍和认知。

4. 发明申请

US20100227892A1 Compounds, Compositions and Methods for Treatment and Prevention of Orthopoxvirus Infections and Associated Diseases 有权
标题翻译：用于治疗和预防正痘病毒感染和相关疾病的化合物，组合物和方法
公开(公告)号：US20100227892A1
公开(公告)日：2010-09-09
申请号：US12752462
申请日：2010-04-01
申请人： Robert Jordan , Thomas R. Bailey , Susan R. Rippin
发明人： Robert Jordan , Thomas R. Bailey , Susan R. Rippin
IPC分类号： A61K31/4439 , A61K31/343 , C07D307/77 , A61K31/403 , C07D209/56 , C07D401/12 , C07D209/48 , A61K31/4178 , C07D277/593 , A61P31/12
CPC分类号： A61K31/403 , A61K31/407 , A61K31/4439
摘要： Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.
摘要翻译：使用二，三和四环酰肼衍生物和类似物的方法以及含有它们的药物组合物用于治疗或预防病毒感染和与之相关的疾病，特别是由正痘病毒引起的那些病毒感染和相关疾病。

5. 发明授权

US07666863B2 Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases 失效
标题翻译：苯并呋喃化合物，用于治疗和预防丙型肝炎病毒感染和相关疾病的组合物和方法
公开(公告)号：US07666863B2
公开(公告)日：2010-02-23
申请号：US11753145
申请日：2007-05-24
申请人： Ashis K. Saha , Christopher J Burns , Alfred M. Del Vecchio , Thomas R. Bailey , Jason A. Reinhardt , Bheemashankar A. Kulkarni , Thomas H. Faitg , Hao Feng , Susan R. Rippin , Charles W. Blackledge , David J. Rys , Thomas A. Lessen , John Swestock , Yijun Deng , Theodore J. Nitz
发明人： Ashis K. Saha , Christopher J Burns , Alfred M. Del Vecchio , Thomas R. Bailey , Jason A. Reinhardt , Bheemashankar A. Kulkarni , Thomas H. Faitg , Hao Feng , Susan R. Rippin , Charles W. Blackledge , David J. Rys , Thomas A. Lessen , John Swestock , Yijun Deng , Theodore J. Nitz
IPC分类号： A61K31/54 , A61K31/53 , C07D307/00 , C07D401/00 , C07D417/00
CPC分类号： C07D405/04 , C07D307/84 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.
摘要翻译：本发明涉及苯并呋喃衍生物和类似物，以及含有它们的组合物及其用于治疗或预防与其相关的病毒感染和疾病的用途，特别是由丙型肝炎病毒引起的那些病毒感染和相关疾病。

6. 发明授权

US6142230A Wellbore tubular patch system 有权
标题翻译：井筒管状贴片系统
公开(公告)号：US6142230A
公开(公告)日：2000-11-07
申请号：US183943
申请日：1998-10-31
申请人： Michael T. Smalley , Thomas R. Bailey , Ralph D. Wright , David M. Haugen , Frederick T. Tilton
发明人： Michael T. Smalley , Thomas R. Bailey , Ralph D. Wright , David M. Haugen , Frederick T. Tilton
IPC分类号： E21B17/02 , E21B17/08 , E21B29/10 , E21B43/10 , E21B47/09 , F16L55/163 , E21B29/00 , E21B29/08
CPC分类号： E21B43/103 , E21B17/02 , E21B17/08 , E21B29/10 , E21B43/105 , E21B43/106 , E21B47/091
摘要： A wellbore tubular patch for patching a hole in a wellbore has been invented, the tubular patch in certain aspects having an expandable top member having a hollow tubular body and a top end and a bottom end, an expandable bottom member having a hollow tubular body and a top end and a bottom end, an expandable outer sleeve in which is secured a portion of the bottom end of the expandable top member, and a portion of the top end of the expandable bottom member inserted into and held within expandable outer sleeve. A method for making a tubular patch for patching a hole in a tubular in an earth wellbore has been invented, the method in certain aspects including securing a portion of a bottom end of an expandable top member in an expandable outer sleeve, the expandable top member having a hollow tubular body and a top end, and securing a portion of a top end of an expandable bottom member within the expandable outer sleeve, the expandable bottom emmber having a hollow tubular body.
摘要翻译：已经发明了用于在井眼中修补孔的井眼管状补片，在某些方面，管状贴片具有具有中空管状体的可膨胀顶部构件，以及顶端和底端，具有中空管状体的可扩张底部构件，顶端和底端，可扩张的外套筒，其中固定可膨胀顶部构件的底端的一部分，以及可扩张底部构件的顶端的一部分插入并保持在可膨胀的外套筒内。已经发明了一种用于制造用于在地球井筒中的管状孔中修补孔的管状补片的方法，该方法在某些方面包括将可膨胀顶部构件的底端的一部分固定在可膨胀外套筒中，具有中空的管状体和顶端，并且将可扩展底部构件的顶端的一部分固定在可扩张的外套筒内，所述可膨胀底部具有中空的管状体。

7. 发明授权

US5846986A Therapeutic phenoxyalkylazoles and phenoxyalkylazines 失效
公开(公告)号：US5846986A
公开(公告)日：1998-12-08
申请号：US978233
申请日：1997-11-25
申请人： David J. Aldous , Thomas R. Bailey , Guy Dominic Diana , Theodore J. Nitz , Gee-Hong Kuo
发明人： David J. Aldous , Thomas R. Bailey , Guy Dominic Diana , Theodore J. Nitz , Gee-Hong Kuo
IPC分类号： C07D257/04 , C07D271/06 , C07D277/24 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D521/00 , A61K31/41
CPC分类号： C07D257/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D271/06 , C07D277/24 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： Compounds of the formula ##STR1## wherein Azo is alkyltetrazolyl or is chosen from the group consisting of oxadiazolyl, imidazolyl, pyrazolyl, triazolyl, oxazolyl, triazinyl, thiazolyl, isothiazolyl or any of these substituted with a member of the group consisting of alkyl, alkylthio, alkoxy, hydroxy, halo, cyano, nitro, hydroxyalkyl, alkoxyalkyl, alkoxycarbonyl, alkanoyl, fluoroalkyl or the N-oxide of any of the preceding; Y is an alkylene bridge of 3-9 carbon atoms; R.sub.1 and R.sub.2 are each individually chosen from hydrogen, halo, alkyl, alkenyl, amino, alkylthio, hydroxy, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, alkoxy, nitro, carboxy, alkoxycarbonyl, dialkylaminoalkyl, alkylaminoalkyl, aminoalkyl, difluoromethyl, trifluoromethyl or cyano; R.sub.3 is alkoxycarbonyl, alkyltetrazolyl, phenyl or a heterocycle chosen from benzoxazolyl, benzathiazolyl, thiadiazolyl, imidazolyl, dihydroimidazolyl, oxazolyl, thiazolyl, oxadiazolyl, pyrazolyl, isoxazolyl, isothiazolyl, furyl, triazolyl, tetrazolyl, thiophenyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl or substituted phenylor substituted heterocyclyl wherein the substitution is with alkyl, alkoxyalkyl, cycloalkyl, haloalkyl, hydroxyalkyl, alkoxy, hydroxy, furyl, thienyl or fluoroalkyl; the N-oxide thereof; or a pharmaceutically acceptable acid addition salt thereof is an effective antipicornaviral agents.

8. 发明授权

US5830905A Compounds, compositions and methods for treatment of hepatitis C 失效
公开(公告)号：US5830905A
公开(公告)日：1998-11-03
申请号：US625718
申请日：1996-03-29
申请人： Guy D. Diana , Thomas R. Bailey , Theodore J. Nitz
发明人： Guy D. Diana , Thomas R. Bailey , Theodore J. Nitz
IPC分类号： C07D211/58 , C07D211/62 , C07D401/14 , A61K31/445 , C07D401/06
CPC分类号： C07D401/14 , C07D211/58 , C07D211/62
摘要： Derivatives of piperidine are useful in prophylaxis and treatment of hepatitis C virus infections.

9. 发明授权

US5721261A Therapeutic phenoxyalkylazoles and phenoxyalkylazines 失效
标题翻译：治疗性苯氧基烷基唑和苯氧基烷基嗪
公开(公告)号：US5721261A
公开(公告)日：1998-02-24
申请号：US693530
申请日：1996-08-02
申请人： David J. Aldous , Thomas R. Bailey , Guy Dominic Diana , Theodore J. Nitz , Gee-Hong Kuo
发明人： David J. Aldous , Thomas R. Bailey , Guy Dominic Diana , Theodore J. Nitz , Gee-Hong Kuo
IPC分类号： C07D257/04 , C07D271/06 , C07D277/24 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D521/00 , A61K31/41
CPC分类号： C07D257/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D271/06 , C07D277/24 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： Compounds of the formula ##STR1## wherein Azo is alkyltetrazolyl or is chosen from the group consisting of oxadiazolyl, imidazolyl, pyrazolyl, triazolyl, oxazolyl, triazinyl, thiazolyl, isothiazolyl or any of these substituted with a member of the group consisting of alkyl, alkylthio, alkoxy, hydroxy, halo, cyano, nitro, hydroxyalkyl, alkoxyalkyl, alkoxycarbonyl, alkanoyl, fluoroalkyl or the N-oxide of any of the preceding; Y is an alkylene bridge of 3-9 carbon atoms; R.sub.1 and R.sub.2 are each individually chosen from hydrogen, halo, alkyl, alkenyl, amino, alkylthio, hydroxy, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, alkoxy, nitro, carboxy, alkoxycarbonyl, dialkylaminoalkyl, alkylaminoalkyl, aminoalkyl, difluoromethyl, trifluoromethyl or cyano; R.sub.3 is alkoxycarbonyl, alkyltetrazolyl, phenyl or a heterocycle chosen from benzoxazolyl, benzathiazolyl, thiadiazolyl, imidazolyl, dihydroimidazolyl, oxazolyl, thiazolyl, oxadiazolyl, pyrazolyl, isoxazolyl, isothiazolyl, furyl, triazolyl, tetrazolyl, thiophenyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl or substituted phenylor substituted heterocyclyl wherein the substitution is with alkyl, alkoxyalkyl, cycloalkyl, haloalkyl, hydroxyalkyl, alkoxy, hydroxy, furyl, thienyl or fluoroalkyl; the N-oxide thereof; or a pharmaceutically acceptable acid addition salt thereof is an effective antipicornaviral agents.
摘要翻译：式I的化合物，其中偶氮是烷基四唑基或选自恶二唑基，咪唑基，吡唑基，三唑基，恶唑基，三嗪基，噻唑基，异噻唑基或其中任何一个被烷基取代的基团，烷硫基，烷氧基，羟基，卤素，氰基，硝基，羟基烷基，烷氧基烷基，烷氧基羰基，烷酰基，氟代烷基或任何前述的N-氧化物; Y是3-9个碳原子的亚烷基桥; R 1和R 2各自独立地选自氢，卤素，烷基，烯基，氨基，烷硫基，羟基，羟基烷基，烷氧基烷基，烷硫基烷基，烷基亚磺酰基烷基，烷基磺酰基烷基，烷氧基，硝基，羧基，烷氧基羰基，二烷基氨基烷基，烷基氨基烷基，氨基烷基，二氟甲基，三氟甲基或氰基; R3是烷氧基羰基，烷基四唑基，苯基或选自苯并恶唑基，苯并噻唑基，噻二唑基，咪唑基，二氢咪唑基，恶唑基，噻唑基，恶二唑基，吡唑基，异恶唑基，异噻唑基，呋喃基，三唑基，四唑基，噻吩基，吡啶基，嘧啶基，吡嗪基，哒嗪基或取代的苯基或取代的杂环基，其中取代为烷基，烷氧基烷基，环烷基，卤代烷基，羟基烷基，烷氧基，羟基，呋喃基，噻吩基或氟代烷基; 其N-氧化物; 或其药学上可接受的酸加成盐是有效的抗虫病毒药剂。

10. 发明授权

US5665763A Therapeutic phenoxyalkylpyridazines and intermediates therefor 失效
标题翻译：治疗性苯氧基烷基哒嗪及其中间体
公开(公告)号：US5665763A
公开(公告)日：1997-09-09
申请号：US706109
申请日：1996-08-30
申请人： David J. Aldous , Thomas R. Bailey , Guy Dominic Diana , Theodore J. Nitz
发明人： David J. Aldous , Thomas R. Bailey , Guy Dominic Diana , Theodore J. Nitz
IPC分类号： C07D237/08 , C07D307/42 , C07D403/12 , C07D405/04 , C07D405/12 , C07D407/04 , C07D413/12 , C07D413/14 , A61K31/34 , A61K31/38 , C07D409/12
CPC分类号： C07D307/42 , C07D237/08 , C07D403/12 , C07D405/04 , C07D405/12 , C07D407/04 , C07D413/12 , C07D413/14
摘要： Compounds of the formula ##STR1## wherein: R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined in the specification,Y is alkylene of 3 to 9 carbon atoms,R.sub.5 is alkoxycarbonyl, alkyltetrazolyl, phenyl or a heterocycle chosen from benzoxazolyl, benzathiazolyl, thiadiazolyl, imidazolyl, dihydroimidazolyl, oxazolyl, thiazolyl, oxadiazolyl, pyrazolyl, oxazolinyl, isoxazolyl, isothiazolyl, furyl, triazolyl, thiophenyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl or any of the above substituted with alkyl, alkoxyalkyl, cycloalkyl, halo alkyl, hydroxyalkyl, alkoxy, hydroxy, halo, furyl, thienyl, fluoroalkyl;or a pharmaceutically acceptable acid addition salts thereof; N-oxides thereof, are useful as antipirconaviral agents.
摘要翻译：其中：R1，R2，R3和R4如说明书中所定义，Y是3至9个碳原子的亚烷基，R 5是烷氧基羰基，烷基四唑基，苯基或选自苯并恶唑基的杂环，苯并噻唑基，噻二唑基，咪唑基，二氢咪唑基，恶唑基，噻唑基，恶二唑基，吡唑基，恶唑啉基，异恶唑基，异噻唑基，呋喃基，三唑基，噻吩基，吡啶基，嘧啶基，吡嗪基，哒嗪基或任何上述被烷基，烷氧基烷基，环烷基，，羟基烷基，烷氧基，羟基，卤素，呋喃基，噻吩基，氟代烷基; 或其药学上可接受的酸加成盐; 其N-氧化物可用作抗血管病毒药物。

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