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1. 发明授权

US07364849B2 Treatment of substrates for immobilizing biomolecules 失效
标题翻译：用于固定生物分子的底物的处理
公开(公告)号：US07364849B2
公开(公告)日：2008-04-29
申请号：US10729619
申请日：2003-12-05
申请人： Yijia Bao , Guangshan Li , Nalini Raghavachari , Mingqian He , Xinying Xie , Yuming Xie
发明人： Yijia Bao , Guangshan Li , Nalini Raghavachari , Mingqian He , Xinying Xie , Yuming Xie
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： G01N33/54393
摘要： A method of treating a substrate for immobilizing a biomolecule and substrates produced by the method are disclosed. The method includes contacting at least a portion of a substrate with a reducing agent such as a hydride. Treatment with an appropriate reducing agent substantially eliminates autofluorescence on substrates.
摘要翻译：公开了一种处理基板以固定生物分子的方法和通过该方法制备的基板。该方法包括使至少一部分底物与还原剂如氢化物接触。用合适的还原剂进行处理基本上消除了底物上的自发荧光。

2. 发明授权

US07141374B2 Treatment of substrates for immobilizing biomolecules 失效
公开(公告)号：US07141374B2
公开(公告)日：2006-11-28
申请号：US10729618
申请日：2003-12-05
申请人： Yijia Bao , Guangshan Li , Nalini Raghavachari , Mingqian He , Xinying Xie , Yuming Xie
发明人： Yijia Bao , Guangshan Li , Nalini Raghavachari , Mingqian He , Xinying Xie , Yuming Xie
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/54393
摘要： A method of treating a substrate for immobilizing a biomolecule and substrates produced by the method are disclosed. The method includes contacting at least a portion of a substrate with a reducing agent such as a hydride. Treatment with an appropriate reducing agent substantially eliminates autofluorescence on substrates.

3. 发明授权

US06787312B2 Treatment of substrates for immobilizing biomolecules 失效
标题翻译：用于固定生物分子的底物的处理
公开(公告)号：US06787312B2
公开(公告)日：2004-09-07
申请号：US09925808
申请日：2001-08-09
申请人： Yijia Bao , Guangshan Li , Nalini Raghavachari , Mingqian He , Xinying Xie , Yuming Xie
发明人： Yijia Bao , Guangshan Li , Nalini Raghavachari , Mingqian He , Xinying Xie , Yuming Xie
IPC分类号： C12Q168
CPC分类号： G01N33/54393
摘要： A method of treating a substrate for immobilizing a biomolecule and substrates produced by the method are disclosed. The method includes contacting at least a portion of a substrate with a reducing agent such as a hydride. Treatment with an appropriate reducing agent substantially eliminates autofluorescence on substrates.
摘要翻译：公开了一种处理基板以固定生物分子的方法和通过该方法制备的基板。该方法包括使至少一部分底物与还原剂如氢化物接触。用合适的还原剂进行处理基本上消除了底物上的自发荧光。

4. 发明申请

US20050136413A1 Reagent systems for biological assays 审中-公开
标题翻译：用于生物测定的试剂系统
公开(公告)号：US20050136413A1
公开(公告)日：2005-06-23
申请号：US10745835
申请日：2003-12-22
申请人： Michael Briggs , Thomas Bunch , Andrew Ferrie , Xinying Xie
发明人： Michael Briggs , Thomas Bunch , Andrew Ferrie , Xinying Xie
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837
摘要： A reagent system for printing, assaying, and processing nucleic acid microarrays is provided. The system comprises: a printing kit, which includes a nucleic acid spotting solution; and a hybridization kit, which includes a nucleic acid pre-hybridization solution, a nucleic acid hybridization solution, and first, second, and third wash reagents, wherein the respective constituent components of the printing and hybridization kits are stable and retain functional performance, when stored together at a temperature between about 10° C. to about 50° C. A background reducing agent or solution is also included. The present reagent solutions are optimized for use with glass substrates having preferably an amine-coating, such as GAPS.
摘要翻译：提供了用于印刷，测定和处理核酸微阵列的试剂系统。该系统包括：印刷套件，其包括核酸点样溶液; 和杂交试剂盒，其包括核酸预杂交溶液，核酸杂交溶液和第一，第二和第三洗涤试剂，其中印刷和杂交试剂盒的各组成成分是稳定的并保持功能性能，当在约10℃至约50℃的温度下一起储存。还包括背景还原剂或溶液。本发明的试剂溶液被优化用于优选具有胺涂层（例如GAPS）的玻璃基底。

5. 发明授权

US06391655B1 Oxidized styrenic polymers for DNA binding 失效
标题翻译：用于DNA结合的氧化苯乙烯聚合物
公开(公告)号：US06391655B1
公开(公告)日：2002-05-21
申请号：US09124352
申请日：1998-07-29
申请人： Dana C. Bookbinder , Leroy S. Hersh , Xinying Xie
发明人： Dana C. Bookbinder , Leroy S. Hersh , Xinying Xie
IPC分类号： G01N33545
CPC分类号： C07H21/00 , C12Q1/6834 , G01N33/54393
摘要： A method of immobilizing aminated DNA to a substrate surface is provided for use in DNA hybridization assays. The surface can be widely employed in a variety of molded laboratory products including multiwell plates, cell culture dishes, and biological containers. The method comprises the steps of providing a polystyrene substrate having a surface content of between 0.3 and 4.0% atomic percent oxygen, and attaching amine modified oligonucleotide to the surface of the substrate. A resultant product comprising a polystyrene substrate having a surface oxygen content of between 0.3 and 4.0% atomic percent, and a plurality of amine modified oligonucleotides directly attached to the surface of the substrate, is also disclosed.
摘要翻译：提供将胺化的DNA固定到底物表面的方法用于DNA杂交测定。该表面可广泛用于各种模制实验室产品，包括多孔板，细胞培养皿和生物容器。该方法包括以下步骤：提供具有0.3至4.0％原子百分比氧的表面含量的聚苯乙烯底物，并将胺修饰的寡核苷酸连接到基底的表面。还公开了一种包含表面氧含量为0.3-4.0％原子百分比的聚苯乙烯底物和直接附着在基材表面上的多个胺修饰的寡核苷酸的产物。

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