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1. 发明授权

US06391655B1 Oxidized styrenic polymers for DNA binding 失效
标题翻译：用于DNA结合的氧化苯乙烯聚合物
公开(公告)号：US06391655B1
公开(公告)日：2002-05-21
申请号：US09124352
申请日：1998-07-29
申请人： Dana C. Bookbinder , Leroy S. Hersh , Xinying Xie
发明人： Dana C. Bookbinder , Leroy S. Hersh , Xinying Xie
IPC分类号： G01N33545
CPC分类号： C07H21/00 , C12Q1/6834 , G01N33/54393
摘要： A method of immobilizing aminated DNA to a substrate surface is provided for use in DNA hybridization assays. The surface can be widely employed in a variety of molded laboratory products including multiwell plates, cell culture dishes, and biological containers. The method comprises the steps of providing a polystyrene substrate having a surface content of between 0.3 and 4.0% atomic percent oxygen, and attaching amine modified oligonucleotide to the surface of the substrate. A resultant product comprising a polystyrene substrate having a surface oxygen content of between 0.3 and 4.0% atomic percent, and a plurality of amine modified oligonucleotides directly attached to the surface of the substrate, is also disclosed.
摘要翻译：提供将胺化的DNA固定到底物表面的方法用于DNA杂交测定。该表面可广泛用于各种模制实验室产品，包括多孔板，细胞培养皿和生物容器。该方法包括以下步骤：提供具有0.3至4.0％原子百分比氧的表面含量的聚苯乙烯底物，并将胺修饰的寡核苷酸连接到基底的表面。还公开了一种包含表面氧含量为0.3-4.0％原子百分比的聚苯乙烯底物和直接附着在基材表面上的多个胺修饰的寡核苷酸的产物。

2. 发明授权

US5563215A Method of attaching dialdehyde starch to a surface and products produced by that method 失效
标题翻译：将二醛淀粉连接到表面上的方法和通过该方法生产的产物
公开(公告)号：US5563215A
公开(公告)日：1996-10-08
申请号：US184666
申请日：1994-01-21
申请人： Marie D. Bryhan , Leroy S. Hersh , Frances M. Smith
发明人： Marie D. Bryhan , Leroy S. Hersh , Frances M. Smith
IPC分类号： C12M1/00 , B05D7/02 , C03C17/28 , C03C17/34 , C08J7/04 , C09D103/10 , C12N5/06 , C12N11/00
CPC分类号： C08J7/047 , B05D7/02 , C03C17/28 , C03C17/3405 , C09D103/10 , C08J2403/00
摘要： A method of attaching dialdehyde starch to surfaces is disclosed. A substrate to which substances may be coupled, which substrate comprises at least one surface coated with dialdehyde starch, and products produced utilizing the substrate are also provided.
摘要翻译：公开了将二醛淀粉连接到表面上的方法。物质可以被偶联的底物，该底物包含至少一个涂有二醛淀粉的表面，以及利用该底物生产的产品。

3. 发明授权

US5281660A Method of attaching dialdehyde starch to a surface and products produced by that method 失效
标题翻译：将二醛淀粉连接到表面上的方法和通过该方法生产的产物
公开(公告)号：US5281660A
公开(公告)日：1994-01-25
申请号：US972327
申请日：1992-11-05
申请人： Marie D. Bryhan , Leroy S. Hersh , Frances M. Smith
发明人： Marie D. Bryhan , Leroy S. Hersh , Frances M. Smith
IPC分类号： C12M1/00 , B05D7/02 , C03C17/28 , C03C17/34 , C08J7/04 , C09D103/10 , C12N5/06 , C12N11/00 , B05D1/00 , C08B31/18
CPC分类号： C08J7/047 , B05D7/02 , C03C17/28 , C03C17/3405 , C09D103/10 , C08J2403/00
摘要： A method of attaching dialdehyde starch to surfaces is disclosed. A substrate to which substances may be coupled, which substrate comprises at least one surface coated with dialdehyde starch, and products produced utilizing the substrate are also provided.
摘要翻译：公开了将二醛淀粉连接到表面上的方法。物质可以被偶联的底物，该底物包含至少一个涂有二醛淀粉的表面，以及利用该底物生产的产品。

4. 发明授权

US5275766A Method for making semi-permeable polymer membranes 失效
标题翻译：制备半透性聚合物膜的方法
公开(公告)号：US5275766A
公开(公告)日：1994-01-04
申请号：US968661
申请日：1992-10-30
申请人： Kishor P. Gadkaree , Leroy S. Hersh
发明人： Kishor P. Gadkaree , Leroy S. Hersh
IPC分类号： B01D67/00 , B29C59/14 , B29C67/20 , C08J9/26 , B29C71/00
CPC分类号： B01D67/009 , B01D67/003 , B01D71/52 , B29C67/202 , C08J9/26 , B01D2323/02 , B01D2323/12 , B01D2325/38 , B29C2793/0045 , B29C59/14
摘要： A method for making a semi-permeable microporous polymer sheet, useful as a separation membrane or the like, including extruding a melt-blended mixture of a high-temperature thermoplastic polymer and a leachable glass to form sheet and then leaching the glass from the sheet to leave a microporous relict polymer network, wherein the permeability of the sheet is improved by plasma-etching the surface of the sheet before or after leaching. Hydrophilic or hydrophobic porous membranes may be provided.
摘要翻译：制造用作分离膜等的半透性微孔聚合物片的方法，包括挤出高温热塑性聚合物和可浸出玻璃的熔融共混混合物以形成片材，然后从片材中浸出玻璃留下微孔复合聚合物网络，其中通过在浸出之前或之后等离子体蚀刻片材的表面来改善片材的渗透性。可以提供亲水或疏水多孔膜。

5. 发明授权

US3933997A Solid phase radioimmunoassay of digoxin 失效
标题翻译：地高辛的固相放射免疫测定
公开(公告)号：US3933997A
公开(公告)日：1976-01-20
申请号：US447251
申请日：1974-03-01
申请人： Leroy S. Hersh , Sidney Yaverbaum
发明人： Leroy S. Hersh , Sidney Yaverbaum
IPC分类号： G01N33/53 , G01N31/16 , G01N33/543 , G01N33/553 , A61K43/00 , G01T1/16 , G01T1/167 , G21H5/02
CPC分类号： G01N33/54326 , G01N31/16 , Y10S436/804 , Y10S436/815 , Y10S436/817
摘要： Clinically significant concentrations of digoxin can be determined by reacting an unknown amount of digoxin, a known amount of labelled digoxin, and a composite consisting of anti-digoxin antibodies coupled through an intermediate silane to magnetically responsive particles; magnetically separating the immunochemical complexes formed thereby, counting the radioactivity of either the separated products or remaining solution, and relating the count to a standard curve.
摘要翻译：可以通过使未知量的地高辛（已知量的标记的地高辛）和由通过中间体硅烷偶联的抗地高辛抗体与磁性响应性颗粒组成的复合物反应来确定临床显着浓度的地高辛浓度; 磁分离由此形成的免疫化学复合物，计数分离的产物或剩余溶液的放射性，并将计数与标准曲线相关联。

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