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1. 发明申请

US20120202776A1 PHOSPHORUS DERIVATIVES AS KINASE INHIBITORS 有权
标题翻译：磷酸衍生物作为激酶抑制剂
公开(公告)号：US20120202776A1
公开(公告)日：2012-08-09
申请号：US12736910
申请日：2009-05-21
申请人： Yihan Wang , Wei-Sheng Huang , Shuangying Liu , William C. Shakespeare , R. Mathew Thomas , Jiwei Qi , Feng Li , Xiaotian Zhu , Anna Kohlmann , David C. Dalgarno , Jan Antoinette C. Romero , Dong Zou
发明人： Yihan Wang , Wei-Sheng Huang , Shuangying Liu , William C. Shakespeare , R. Mathew Thomas , Jiwei Qi , Feng Li , Xiaotian Zhu , Anna Kohlmann , David C. Dalgarno , Jan Antoinette C. Romero , Dong Zou
IPC分类号： A61K31/675 , C07F9/6512 , C07F9/6561 , A61P35/00 , C07F9/6509 , C07F9/6521 , C07F9/58 , C07F9/6558 , C07F9/6584
CPC分类号： C07F9/6533 , C07D239/48 , C07F9/58 , C07F9/650905 , C07F9/6512 , C07F9/6521 , C07F9/65218 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07F9/65616 , C07F9/65685 , C07F9/657172 , C07F9/65846
摘要： The invention features compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译：本发明的特征在于其中可变基团如本文所定义的通式（I）的化合物及其制备和用途。

2. 发明授权

US09012462B2 Phosphorous derivatives as kinase inhibitors 有权
标题翻译：磷酸衍生物作为激酶抑制剂
公开(公告)号：US09012462B2
公开(公告)日：2015-04-21
申请号：US12736910
申请日：2009-05-21
申请人： Yihan Wang , Wei-Sheng Huang , Shuangying Liu , William C. Shakespeare , R. Mathew Thomas , Jiwei Qi , Feng Li , Xiaotian Zhu , Anna Kohlman , David C. Dalgarno , Jan Antoinette C. Romero , Dong Zou
发明人： Yihan Wang , Wei-Sheng Huang , Shuangying Liu , William C. Shakespeare , R. Mathew Thomas , Jiwei Qi , Feng Li , Xiaotian Zhu , Anna Kohlman , David C. Dalgarno , Jan Antoinette C. Romero , Dong Zou
IPC分类号： A61K31/506 , C07F9/30 , C07D239/48 , C07F9/6509 , C07F9/6512 , C07F9/6521 , C07F9/6558 , C07F9/6561 , C07F9/6568 , C07F9/6571
CPC分类号： C07F9/6533 , C07D239/48 , C07F9/58 , C07F9/650905 , C07F9/6512 , C07F9/6521 , C07F9/65218 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07F9/65616 , C07F9/65685 , C07F9/657172 , C07F9/65846
摘要： The invention features compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译：本发明的特征在于其中可变基团如本文所定义的通式（I）的化合物及其制备和用途。

3. 发明授权

US08912330B2 Azaindole derivatives as kinase inhibitors 有权
标题翻译： Azaindole衍生物作为激酶抑制剂
公开(公告)号：US08912330B2
公开(公告)日：2014-12-16
申请号：US12998873
申请日：2009-12-11
申请人： Jiwei Qi , Yihan Wang , Feng Li , William C. Shakespeare , Anna Kohlmann , David C. Dalgarno , Xiaotian Zhu
发明人： Jiwei Qi , Yihan Wang , Feng Li , William C. Shakespeare , Anna Kohlmann , David C. Dalgarno , Xiaotian Zhu
IPC分类号： C07D471/04 , C07D401/14 , A61K31/437 , A61K31/44 , A61P35/00
CPC分类号： A61K31/44 , C07D471/04
摘要： This invention relates to compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译：本发明涉及其中可变基团如本文所定义的通式（I）的化合物及其制备和用途。

4. 发明申请

US20110294806A1 AZAINDOLE DERIVATIVES AS KINASE INHIBITORS 有权
标题翻译：亚胺衍生物作为激酶抑制剂
公开(公告)号：US20110294806A1
公开(公告)日：2011-12-01
申请号：US12998873
申请日：2009-12-11
申请人： Jiwei Qi , Yihan Wang , Feng Li , William C. Shakespeare , Anna Kohlmann , David C. Dalgarno , Xiaotian Zhu
发明人： Jiwei Qi , Yihan Wang , Feng Li , William C. Shakespeare , Anna Kohlmann , David C. Dalgarno , Xiaotian Zhu
IPC分类号： A61K31/437 , A61P35/00 , A61K31/506 , C07D471/04 , A61K31/5377
CPC分类号： A61K31/44 , C07D471/04
摘要： This invention relates to compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译：本发明涉及其中可变基团如本文所定义的通式（I）的化合物及其制备和用途。

5. 发明申请

US20160024024A1 Novel Choline Kinase Inhibitors 有权
标题翻译：新型胆碱激酶抑制剂
公开(公告)号：US20160024024A1
公开(公告)日：2016-01-28
申请号：US14774359
申请日：2014-03-13
申请人： Stephan G. ZECH , Anna KOHLMANN , Feng LI , Yihan WANG , Tianjun ZHOU , David C. DALGARNO , William C. SHAKESPEARE , Xiaotian ZHU , ARIAD PHARMACEUTICALS, INC.
发明人： Stephan G. Zech , Anna Kohlmann , Feng Li , Yihan Wang , Tianjun Zhou , David C. Dalgarno , William C. Shakespeare , Xiaotian Zhu
IPC分类号： C07D243/08 , C07D401/10 , C07D413/10 , C07D401/14 , C07D403/14 , C07D417/10 , C07D403/10 , C07F9/645 , C07D413/14
CPC分类号： C07D243/08 , A61K31/551 , C07D245/02 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07F9/645
摘要： This invention relates to compounds of the general formula (I): in which the variable groups are as identified herein, and to preparation and use of the compounds.
摘要翻译：本发明涉及通式（I）的化合物：其中可变基团如本文所鉴定，以及化合物的制备和使用。

6. 发明申请

US20140171649A1 Methods and Compositions for the Synthesis of Multimerizing Agents 有权
标题翻译：用于合成多聚化试剂的方法和组合物
公开(公告)号：US20140171649A1
公开(公告)日：2014-06-19
申请号：US13981051
申请日：2012-01-26
申请人： Feng Li , Yihan Wang
发明人： Feng Li , Yihan Wang
IPC分类号： C07D211/60 , C07D205/04 , C07C231/02 , C07C51/06 , C07C209/08 , C07D319/06 , C07C235/34
CPC分类号： C07D401/12 , C07B53/00 , C07B2200/07 , C07C51/06 , C07C209/08 , C07C209/62 , C07C209/74 , C07C231/02 , C07C231/18 , C07C235/34 , C07D205/04 , C07D211/60 , C07D319/04 , C07D319/06 , C07C211/15 , C07C211/13 , C07C235/20 , C07C59/64
摘要： The invention features methods and compositions for the synthesis of multimerizing agents. An exemplary method for producing AP20187 may comprise: (a) coupling 2-N,Ndimethylaminomethyl-1,3-diaminopropane with AP20792 to produce the dimeric alcohol, AP20793; and (b) coupling the AP20793 so produced with API7362 to yield AP20187. In particular embodiments, the method further includes the step of producing API7362 by coupling API7360 with methyl-L-pipecolic acid, or a salt thereof.
摘要翻译：本发明的特征在于用于合成多聚化剂的方法和组合物。制备AP20187的示例性方法可以包括：（a）将2-N，N-二甲基氨基甲基-1,3-二氨基丙烷与AP20792偶联以产生二聚醇AP20793; 和（b）将如此生产的AP20793与API7362耦合以产生AP20187。在具体实施方案中，该方法还包括通过将API7360与甲基-L-哌啶酸或其盐偶联制备API7362的步骤。

7. 发明授权

US09024028B2 Methods and compositions for the synthesis of multimerizing agents 有权
标题翻译：用于合成多聚化剂的方法和组合物
公开(公告)号：US09024028B2
公开(公告)日：2015-05-05
申请号：US13981051
申请日：2012-01-26
申请人： Feng Li , Yihan Wang
发明人： Feng Li , Yihan Wang
IPC分类号： C07D211/60 , C07C51/06 , C07C209/08 , C07C231/02 , C07C235/34 , C07D205/04 , C07D319/06 , C07D319/04 , C07B53/00 , C07C209/62 , C07C209/74 , C07C231/18
CPC分类号： C07D401/12 , C07B53/00 , C07B2200/07 , C07C51/06 , C07C209/08 , C07C209/62 , C07C209/74 , C07C231/02 , C07C231/18 , C07C235/34 , C07D205/04 , C07D211/60 , C07D319/04 , C07D319/06 , C07C211/15 , C07C211/13 , C07C235/20 , C07C59/64
摘要： The invention features methods and compositions for the synthesis of multimerizing agents. An exemplary method for producing AP20187 may comprise: (a) coupling 2-N,Ndimethylaminomethyl-1,3-diaminopropane with AP20792 to produce the dimeric alcohol, AP20793; and (b) coupling the AP20793 so produced with API7362 to yield AP20187. In particular embodiments, the method further includes the step of producing API7362 by coupling API7360 with methyl-L-pipecolic acid, or a salt thereof.
摘要翻译：本发明的特征在于用于合成多聚化剂的方法和组合物。制备AP20187的示例性方法可以包括：（a）将2-N，N-二甲基氨基甲基-1,3-二氨基丙烷与AP20792偶联以产生二聚醇AP20793; 和（b）将如此生产的AP20793与API7362耦合以产生AP20187。在具体实施方案中，该方法还包括通过将API7360与甲基-L-哌啶酸或其盐偶联制备API7362的步骤。

8. 发明授权

US10337700B2 Bolt locking structure for waterproof LED lamp 有权
公开(公告)号：US10337700B2
公开(公告)日：2019-07-02
申请号：US15310791
申请日：2015-09-17
申请人： Feng Li
发明人： Feng Li
IPC分类号： F21V15/01 , F21V31/00 , F21V17/10 , F21Y115/10
摘要： A bolt locking structure for a waterproof LED lamp contains: a first casing and a second casing. The first casing includes multiple first protrusions and multiple first recesses which are arranged on each of four peripheral walls thereof respectively. The second casing includes multiple second protrusions and multiple second recesses which are arranged on each of four peripheral walls thereof respectively. The multiple first protrusions retain with the multiple second recesses, and the multiple first recesses retain with the multiple second protrusions. Multiple through holes are coaxial and form on each peripheral wall of each of the first casing and the second casing respectively, wherein each of the multiple through holes passes through each of the multiple first protrusions and the multiple second protrusions, such that each of multiple connection bolts inserts into the multiple through holes, thus locking the first casing and the second casing together.

9. 发明授权

US10077892B2 Packaging structure for LED lamp having insert rod 有权
公开(公告)号：US10077892B2
公开(公告)日：2018-09-18
申请号：US15310767
申请日：2015-05-18
申请人： Feng Li
发明人： Feng Li
IPC分类号： F21V17/10 , F21V15/01 , F21V21/08 , F21V19/00 , F21S2/00
CPC分类号： F21V21/0808 , F21S2/00 , F21V15/01 , F21V17/10 , F21V17/104 , F21V19/001 , F21V19/002 , F21V19/0035 , F21W2131/103 , F21Y2115/10
摘要： A packaging structure for an LED lamp contains: a casing, a substrate, a printed circuit board (PCB), and at least one locking element. The casing, the PCB, and the substrate are stacked and adhered together. The at least one locking element respectively inserts into and retains with two connection gaps between the casing and the substrate so as to fix the casing and the substrate together. The substrate includes a stepped groove defined on a central portion thereof and facing the casing, and the stepped groove of the substrate has a first accommodation part and a second accommodation part. A size, a profile, and a depth of the first accommodation part correspond to a size, a profile, and a thickness of the casing. A size, a profile, and a depth of the second accommodation part correspond to a size, a profile, and a thickness of the PCB.

10. 发明授权

US09435349B2 Axial flow impeller 有权
标题翻译：轴流叶轮
公开(公告)号：US09435349B2
公开(公告)日：2016-09-06
申请号：US13823447
申请日：2011-09-13
申请人： Bin Qian , Qisong Jiang , Denghao Wu , Feng Li , Dong Wang
发明人： Bin Qian , Qisong Jiang , Denghao Wu , Feng Li , Dong Wang
IPC分类号： F04D29/18 , F04D29/32 , F04D29/38
CPC分类号： F04D29/181 , F04D29/324 , F04D29/38
摘要： An axial flow impeller includes a hub, at least three base blades, and a cover blade detachably mounted to each base blade. When the impeller is applied in a medium environment having a high density and viscosity, the impeller will meet the requirement only by virtue of the base blade with the cover blade being removed. When the impeller is applied in a medium environment having low density and viscosity, the cover blade can be mounted in the front and/or rear of the base blade in order to improve the efficiency of the impeller. In this case, the consumption of electrical power can be reduced significantly while producing an equivalent propulsive force, thereby being advantageous for energy conservation. Therefore, the impeller can be adaptable to different medium environments and efficiency requirements, and thus can have good adaptability, need minimal investment cost and can be convenient to use.
摘要翻译：轴向流动叶轮包括轮毂，至少三个基本叶片和可拆卸地安装到每个基础叶片上的盖板。当叶轮被施加在具有高密度和粘度的介质环境中时，叶轮将仅通过除去盖板的基础叶片才能满足要求。当叶轮被施加在具有低密度和粘度的介质环境中时，盖叶片可以安装在基础叶片的前部和/或后部，以便提高叶轮的效率。在这种情况下，能够在产生等效推进力的同时显着降低电力消耗，有利于节能。因此，叶轮可以适应不同的介质环境和效率要求，因此具有良好的适应性，投资成本最低，使用方便。

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