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1. 发明授权

US09834518B2 Compounds for inhibiting cell proliferation in EGFR-driven cancers 有权
公开(公告)号：US09834518B2
公开(公告)日：2017-12-05
申请号：US13464921
申请日：2012-05-04
申请人： David C. Dalgarno , Wei-Sheng Huang , William C. Shakespeare , Yihan Wang , Xiaotian Zhu
发明人： David C. Dalgarno , Wei-Sheng Huang , William C. Shakespeare , Yihan Wang , Xiaotian Zhu
IPC分类号： C07D239/46 , C07D239/50 , C07D401/12 , C07D403/12 , C07D413/12 , A61K31/4025 , A61K31/444 , A61K31/4523 , A61K31/506 , A61K31/505 , A61K31/538 , A61K31/553 , A61P35/00 , C07D239/48 , C07D405/12
CPC分类号： C07D239/48 , A61K31/4025 , A61K31/444 , A61K31/4523 , A61K31/505 , A61K31/506 , A61K31/538 , A61K31/553 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： The invention features compounds, pharmaceutical compositions and methods for treating patients who have an EGFR-driven cancer of formula I: wherein the variables are as defined herein.

2. 发明授权

US08912330B2 Azaindole derivatives as kinase inhibitors 有权
标题翻译： Azaindole衍生物作为激酶抑制剂
公开(公告)号：US08912330B2
公开(公告)日：2014-12-16
申请号：US12998873
申请日：2009-12-11
申请人： Jiwei Qi , Yihan Wang , Feng Li , William C. Shakespeare , Anna Kohlmann , David C. Dalgarno , Xiaotian Zhu
发明人： Jiwei Qi , Yihan Wang , Feng Li , William C. Shakespeare , Anna Kohlmann , David C. Dalgarno , Xiaotian Zhu
IPC分类号： C07D471/04 , C07D401/14 , A61K31/437 , A61K31/44 , A61P35/00
CPC分类号： A61K31/44 , C07D471/04
摘要： This invention relates to compounds of the general formula (I) in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译：本发明涉及其中可变基团如本文所定义的通式（I）的化合物及其制备和用途。

3. 发明申请

US20140024620A1 Methods for Inhibiting Cell Proliferation in EGFR-Driven Cancers 审中-公开
标题翻译：抑制EGFR驱动癌细胞增殖的方法
公开(公告)号：US20140024620A1
公开(公告)日：2014-01-23
申请号：US13878744
申请日：2011-10-14
申请人： David C. Dalgarno , William C. Shakespeare , Xiaotian Zhu , Victor M. Rivera , Juan J. Miret
发明人： David C. Dalgarno , William C. Shakespeare , Xiaotian Zhu , Victor M. Rivera , Juan J. Miret
IPC分类号： C07F9/6558 , C07D401/12 , C07F9/6568 , C07F9/6561
CPC分类号： C07F9/65583 , A61K31/505 , C07D401/12 , C07F9/6561 , C07F9/6568
摘要： The invention features a method for treating patients who have an EGFR-driven cancer, which is, or has become, refractory to a tyrosine kinase inhibitor, such as eriotinib and gefitinib, by administering a compound of formula (I) to the patient. The invention also features treating EGFR-driven cancers having an EGFR mutation identified herein.
摘要翻译：本发明的特征在于通过向患者施用式（I）化合物来治疗患有EGFR驱动的癌症的患者的方法，所述癌症已经或已经成为对酪氨酸激酶抑制剂如埃替替尼和吉非替尼难治的患者。本发明还特征在于治疗具有本文鉴定的EGFR突变的EGFR驱动的癌症。

4. 发明申请

US20120316135A1 Compounds for Inhibiting Cell Proliferation in EGFR-Driven Cancers 有权
标题翻译：用于抑制EGFR驱动的癌细胞增殖的化合物
公开(公告)号：US20120316135A1
公开(公告)日：2012-12-13
申请号：US13464921
申请日：2012-05-04
申请人： David C. Dalgarno , Wei-Sheng Huang , William C. Shakespeare , Yihan Wang , Xiaotian Zhu
发明人： David C. Dalgarno , Wei-Sheng Huang , William C. Shakespeare , Yihan Wang , Xiaotian Zhu
IPC分类号： A61K31/675 , C07F9/6558 , C12N5/09 , C07F9/6561 , A61P35/00 , C12N5/071 , C07F9/6512 , C07F9/6509
CPC分类号： C07D239/48 , A61K31/4025 , A61K31/444 , A61K31/4523 , A61K31/505 , A61K31/506 , A61K31/538 , A61K31/553 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： The invention features compounds, pharmaceutical compositions and methods for treating patients who have an EGFR-driven cancer of formula I: wherein the variables are as defined herein.
摘要翻译：本发明的特征在于用于治疗患有EGFR驱动的式I的癌症的患者的化合物，药物组合物和方法：其中变量如本文所定义。

5. 发明申请

US20120135986A1 Bicyclic Heteroaryl Compounds 有权
标题翻译：双环杂芳基化合物
公开(公告)号：US20120135986A1
公开(公告)日：2012-05-31
申请号：US13357745
申请日：2012-01-25
申请人： Dong Zou , Wei-Sheng Huang , R. Mathew Thomas , Jan Antionette C. Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William C. Shakespeare , Rajeswari Sundaramoorthi , Chester A. Metcalf, III , David C. Dalgarno , Tomi K. Sawyer
发明人： Dong Zou , Wei-Sheng Huang , R. Mathew Thomas , Jan Antionette C. Romero , Jiwei Qi , Yihan Wang , Xiaotian Zhu , William C. Shakespeare , Rajeswari Sundaramoorthi , Chester A. Metcalf, III , David C. Dalgarno , Tomi K. Sawyer
IPC分类号： A61K31/5377 , A61K31/4985 , C07D471/04 , A61K31/437 , A61P35/00 , A61K31/5025 , A61K31/53 , A61K31/519 , C07D473/34 , A61K31/52 , C07D487/04 , A61K31/496
CPC分类号： C07D471/04 , C07D473/34 , C07D487/04
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译：本发明涉及以下通式的化合物：其中可变基团如本文所定义，以及其制备和用途。

6. 发明申请

US20100162882A1 Arborist's climbing rope 有权
标题翻译：植树枝爬绳
公开(公告)号：US20100162882A1
公开(公告)日：2010-07-01
申请号：US12660786
申请日：2010-03-04
申请人： William C. Shakespeare
发明人： William C. Shakespeare
IPC分类号： D04C1/00
CPC分类号： A62B1/16 , A63B29/028 , D04C1/12 , D07B1/04 , D07B1/185 , D07B2201/102 , D07B2201/1096 , D07B2201/2056 , D07B2201/2057 , D07B2201/209 , D07B2501/2069 , D07B2801/24
摘要： An arborist's climbing rope in which an eye splice having a splice tuck can be formed at one end includes in one embodiment a core of polypropylene, a first braided tubular sheath of nylon disposed about the core and a second braided tubular sheath of a polyester disposed about the first braided tubular sheath, the core cross-sectional diameter being in the range of 1 to 10% of the total cross-sectional diameter of the arborist's climbing rope. In forming the eye splice a portion of the core is intentionally removed near the eye splice to form a space within the first tubular sheath where the core has been removed and the splice tuck is buried in and substantially completely fills the space within the first tubular sheath where the core has been intentionally removed.
摘要翻译：其中具有接头折页的接头可以在其一端形成的一个手柄的攀爬绳包括在一个实施例中包括聚丙烯芯，设置在芯周围的第一编织尼龙管状护套和布置在其周围的聚酯的第二编织管状护套第一编织管状护套，芯横截面直径在树冠攀爬绳的总截面直径的1至10％的范围内。在形成眼睛接合时，芯部的一部分被有意地在眼睛接头附近移除，以在第一管状护套内形成空间，其中芯已经被移除，并且接合套被埋在第一管状护套中并基本上完全填充第一管状护套内的空间核心被故意删除的地方。

7. 发明授权

US07703372B1 Climbing rope 失效
标题翻译：爬绳
公开(公告)号：US07703372B1
公开(公告)日：2010-04-27
申请号：US11893066
申请日：2007-08-14
申请人： William C. Shakespeare
发明人： William C. Shakespeare
IPC分类号： D04C1/06
CPC分类号： D07B1/04 , A62B1/16 , A63B29/028 , D04C1/12 , D07B1/185 , D07B2201/102 , D07B2201/1096 , D07B2201/2051
摘要： A rope is disclosed that is firm for climbing purposes and in which the end of the rope can be spliced. The rope includes a core of a plurality of strands; a first braided tubular sheath disposed about the core; and a second braided tubular sheath disposed about the first braided tubular sheath. The plurality of strands fill at least a length of a center void formed in the first braided tubular sheath. The plurality of core strands are formed in an un-braided manner in at least one of twisted and non-twisted strands. At the splice the splice tucks fill the center void while the core strands fill only center void outside of the splice.
摘要翻译：公开了一种用于攀爬目的的绳索，绳索的末端可以被拼接。绳子包括多根股线的芯部; 设置在芯周围的第一编织管状护套; 以及围绕第一编织管状护套设置的第二编织管状护套。多个股线填充形成在第一编织管状护套中的中心空隙的至少一段长度。多个芯股线以非编织方式形成在绞合线和非绞合线中的至少一个中。在接合处，接头折叠填充中心空隙，而芯线仅填充接头外部的中心空隙。

8. 发明申请

US20090176781A1 Acetylenic Heteroaryl Compounds 有权
标题翻译：乙酰杂芳基化合物
公开(公告)号：US20090176781A1
公开(公告)日：2009-07-09
申请号：US12227002
申请日：2007-05-08
申请人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zhu , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
发明人： Yihan Wang , Xiaotian Zhu , Rajeswari Sundaramoorthi , Wei-Sheng Huang , Dong Zhu , R. Mathew Thomas , Jiwei Qi , Jan Antoinette C. Romero , David C. Dalgarno , William C. Shakespeare , Tomi K. Sawyer , Chester A. Metcalf, III
IPC分类号： A61K31/5377 , C07D401/14 , A61K31/4439 , A61K31/506 , C07D403/12 , C07D413/12 , A61P35/00
CPC分类号： C07D213/56 , C07D213/73 , C07D213/75 , C07D213/78 , C07D217/14 , C07D217/22 , C07D237/20 , C07D237/28 , C07D239/26 , C07D241/12 , C07D241/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D413/12 , C07D417/12 , C07D471/04
摘要： This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use.
摘要翻译：本发明涉及以下通式的化合物：其中可变基团如本文所定义，及其制备和用途。

9. 发明授权

US07238679B2 Heterocycles and uses thereof 有权
标题翻译：杂环及其用途
公开(公告)号：US07238679B2
公开(公告)日：2007-07-03
申请号：US10744601
申请日：2003-12-23
申请人： Terence P. Keenan , William C. Shakespeare
发明人： Terence P. Keenan , William C. Shakespeare
IPC分类号： A61K31/517 , A61K31/675 , C07F9/02 , A01N57/00 , C07D211/32 , C07D233/00 , C07D249/04 , C07D257/10 , C07D263/30 , C07D277/20 , C07D403/00 , C07D413/00
CPC分类号： C07F9/65586 , C07F9/65128 , C07F9/65583
摘要： Compounds of the following formula are disclosed: wherein RB is a substituted or unsubstituted aryl or heteroaryl moiety; at least one of RU and RL is a phosphorus-containing moiety, J, and the other of RU and RL is independently chosen from H; halogen; —CN; —NO2; -J; —SO2R; —SO2NRR′; or —ZRJ, wherein each occurrence of Z is independently —O—, —S— or —NR— and each occurrence of RJ is independently —R, —COR, —COOR or —CONRR′.
摘要翻译：公开了下式的化合物：其中R B是取代或未取代的芳基或杂芳基部分; R“和”L“中的至少一个是含磷部分J，另一个R U和R” L 独立地选自H; 卤素; -CN; -NO 2; -J; -SO 2 R; -SO 2 NRR'; 或-ZR 9，其中每次出现的Z独立地是-O - ， - S-或-NR-，并且每次出现的R i独立地是-R，-COR ，-COOR或-CONRR'。

10. 发明授权

US07132427B2 Quinazolines and uses thereof 有权
标题翻译：喹唑啉及其用途
公开(公告)号：US07132427B2
公开(公告)日：2006-11-07
申请号：US10177595
申请日：2002-06-21
申请人： Yihan Wang , Chester A. Metcalf, III , William C. Shakespeare , Tomi K. Sawyer , Regine Bohacek , Rajeswari Sundaramoorthi
发明人： Yihan Wang , Chester A. Metcalf, III , William C. Shakespeare , Tomi K. Sawyer , Regine Bohacek , Rajeswari Sundaramoorthi
IPC分类号： A61K31/70 , A61K31/517 , C07F9/02 , C07D401/00 , C07D403/00 , C07D413/00 , C07D417/00 , C07D419/00 , A01N43/04 , A61P19/10 , C08B3/00 , C07H11/04
CPC分类号： C07D239/94 , C07F9/65128 , C07F9/65583
摘要： This invention relates to compounds of the general formula: in which RA, RB, RC and RD are as defined herein, and to their preparation and use.
摘要翻译：本发明涉及以下通式的化合物：其中R A，R B，R C和R D D均为 >如本文所定义，以及其制备和使用。

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