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    • 3. 发明授权
    • Systems and methods for analyzing microarrays
    • 用于分析微阵列的系统和方法
    • US08340915B2
    • 2012-12-25
    • US11866964
    • 2007-10-03
    • Lei M. LiChao ChengHuanying Ge
    • Lei M. LiChao ChengHuanying Ge
    • G01N33/50G01N33/48
    • G06F19/20
    • The present invention discloses methods and systems for analyzing microarray data. The method includes the general steps of providing microarray data, normalizing the data using a least trimmed squares regression, and then analyzing the normalized microarray data to obtain a desired result such as an expression profile. There is also disclosed a method of subdividing an array into subarrays before normalization. This approach provides a method for improving measurement accuracy and salvaging array data from arrays containing minor defects. Also disclosed is a Probe-Treatment-Reference (PTR) model for streamlining normalization and summarization of microarray data by allowing multiple references. Other aspects of the present invention include computer systems and computer readable media encoding methods of the present invention.
    • 本发明公开了用于分析微阵列数据的方法和系统。 该方法包括提供微阵列数据的一般步骤,使用最小修正平方回归归一化数据,然后分析归一化微阵列数据以获得期望的结果,例如表达谱。 还公开了在归一化之前将阵列细分为子阵列的方法。 这种方法提供了一种提高测量精度并从包含轻微缺陷的阵列中挽救阵列数据的方法。 还公开了一种用于通过允许多个参考来精简归一化和汇总微阵列数据的探针治疗 - 参考(PTR)模型。 本发明的其它方面包括本发明的计算机系统和计算机可读介质编码方法。
    • 4. 发明申请
    • SYSTEMS AND METHODS FOR ANALYZING MICROARRAYS
    • 用于分析微阵列的系统和方法
    • US20080319679A1
    • 2008-12-25
    • US11866964
    • 2007-10-03
    • Lei M. LiChao ChengHuanying Ge
    • Lei M. LiChao ChengHuanying Ge
    • G06F17/18G01N33/48
    • G06F19/20
    • The present invention discloses methods and systems for analyzing microarray data. The method includes the general steps of providing microarray data, normalizing the data using a least trimmed squares regression, and then analyzing the normalized microarray data to obtain a desired result such as an expression profile. There is also disclosed a method of subdividing an array into subarrays before normalization. This approach provides a method for improving measurement accuracy and salvaging array data from arrays containing minor defects. Also disclosed is a Probe-Treatment-Reference (PTR) model for streamlining normalization and summarization of microarray data by allowing multiple references. Other aspects of the present invention include computer systems and computer readable media encoding methods of the present invention.
    • 本发明公开了用于分析微阵列数据的方法和系统。 该方法包括提供微阵列数据的一般步骤,使用最小修正平方回归归一化数据,然后分析归一化微阵列数据以获得期望的结果,例如表达谱。 还公开了在归一化之前将阵列细分为子阵列的方法。 这种方法提供了一种提高测量精度并从包含轻微缺陷的阵列中挽救阵列数据的方法。 还公开了一种用于通过允许多个参考来精简归一化和汇总微阵列数据的探针治疗 - 参考(PTR)模型。 本发明的其它方面包括本发明的计算机系统和计算机可读介质编码方法。