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1. 发明授权

US4405597A Medicament capsules for rectal application 失效
标题翻译：用于直肠应用的药物胶囊
公开(公告)号：US4405597A
公开(公告)日：1983-09-20
申请号：US292040
申请日：1981-08-11
申请人： Yasushi Takagishi , Yoshio Doi , Kiichiro Ohsuga , Noboru Hoshi , Shionogi & Co., Ltd.
发明人： Yasushi Takagishi , Yoshio Doi , Kiichiro Ohsuga , Noboru Hoshi , Shionogi & Co., Ltd.
IPC分类号： A61K9/02 , A61K9/36 , A61K9/48
CPC分类号： A61K9/4816 , A61K9/025
摘要： The invention provides a novel means for the administration of a therapeutically effective ingredient in the form of a rectally applicable medicament capsule, in which the otherwise unavoidable extreme variation in the absorbability of the effective ingredient among the individuals rectally treated with the capsules is minimized. It has been unexpectedly found that, when the effective ingredient is contained in the capsule in the form of a liquid medicine, the osmotic pressure of the liquid content plays a very essential role in the absorption of the effective ingredient through the rectum and the variation in the absorbability of the effective ingredient among the individuals can be minimized when the osmotic pressure of the liquid content is substantially higher than the osmotic pressure of the rectal fluid with which the capsules are contacted.
摘要翻译：本发明提供了一种用于施用直肠可用药物胶囊形式的治疗有效成分的新方法，其中用胶囊直肠治疗的个体之间有效成分的吸收性的其他不可避免的极端变化最小化。已经意外地发现，当液体药物形式的胶囊中含有有效成分时，液体含量的渗透压在通过直肠的有效成分的吸收中发挥非常重要的作用，当液体含量的渗透压显着高于胶囊与其接触的直肠液的渗透压时，个体之间有效成分的吸收能力可被最小化。

2. 发明授权

US4402692A Medicament capsules for rectal application 失效
标题翻译：用于直肠应用的药物胶囊
公开(公告)号：US4402692A
公开(公告)日：1983-09-06
申请号：US269706
申请日：1981-06-02
申请人： Yasushi Takagishi , Yoshio Doi , Kanji Aita , Noboru Hoshi
发明人： Yasushi Takagishi , Yoshio Doi , Kanji Aita , Noboru Hoshi
IPC分类号： A61K31/48 , A61K9/02 , A61K9/48 , A61M7/00
CPC分类号： A61K9/025 , A61K9/4816 , Y10S514/962
摘要： The invention provides a novel and efficient means for the administration of a therapeutically effective ingredient by rectal application in the form of a medicament capsule encapsulating the effective ingredient. The medicament capsule according to the invention is formed of a hard capsule shell made of a mixed ester of a cellulose ether, e.g. alkyl-, hydroxyalkyl- and hydroxyalkyl alkylcelluloses, esterified with aliphatic monacyl groups and acidic succinyl groups. When the capsule is inserted into the rectum, the capsule shell is disintegrated and the rectally absorbable effective ingredient is readily and smoothly released into the rectum and absorbed to exhibit therapeutical effects as efficiently as with conventional suppositories.
摘要翻译：本发明提供了一种用于通过直肠施用以包封有效成分的药物胶囊的形式施用治疗有效成分的新型和有效的方法。根据本发明的药物胶囊由纤维素醚混合酯制成的硬胶囊壳形成。烷基，羟基烷基和羟烷基烷基纤维素，用脂族单酰基和酸性琥珀酰基酯化。当胶囊插入直肠时，胶囊壳崩解，直肠可吸收的有效成分容易平稳地释放到直肠中并被吸收以显示与常规栓剂一样有效的治疗效果。

3. 发明授权

US4397835A Enterosoluble hard-capsulated medicaments 失效
公开(公告)号：US4397835A
公开(公告)日：1983-08-09
申请号：US372791
申请日：1982-04-28
申请人： Yasushi Takagishi , Yoshio Doi , Noboru Hoshi
发明人： Yasushi Takagishi , Yoshio Doi , Noboru Hoshi
IPC分类号： A61K9/48
CPC分类号： A61K9/4858 , A61K9/4816 , A61K9/485
摘要： The invention provides a novel means for overcoming the problem of undue and irregular delay in the exhibition of the effect of medicine when a patient is administrated with an enterosoluble hard-capsulated medicament. The unexpected discovery that the key parameter ruling the smooth transfer of an enterosoluble capsule from the stomach to the intestinal canals is the overall specific gravity of the capsule has led to the establishment of the invention which proposes an enterosoluble hard-capsulated medicament having an overall specific gravity of at least 1.05 or, preferably, at least 1.10.

4. 发明授权

US4339463A Enterosoluble hard-capsulated medicaments 失效
标题翻译：肠溶性硬封闭药物
公开(公告)号：US4339463A
公开(公告)日：1982-07-13
申请号：US169395
申请日：1980-07-16
申请人： Yasushi Takagishi , Yoshio Doi , Noboru Hoshi
发明人： Yasushi Takagishi , Yoshio Doi , Noboru Hoshi
IPC分类号： A61K9/48 , A61K47/00
CPC分类号： A61K9/4858 , A61K9/4816 , A61K9/485
摘要： The invention provides a novel means for overcoming the problem of undue and irregular delay in the exhibition of the effect of medicine when a patient is administrated with an enterosoluble hard-capsulated medicament. The unexpected discovery that the key parameter ruling the smooth transfer of an enterosoluble capsule from the stomach to the intestinal canals is the overall specific gravity of the capsule has led to the establishment of the invention which proposes an enterosoluble hard-capsulated medicament having an overall specific gravity of at least 1.05 or, preferably, at least 1.10.
摘要翻译：本发明提供了一种新颖的手段，克服了当患者服用肠溶性硬封闭药物时，展示药物效果的不当和不规律延误的问题。意外的发现是，将肠溶胶囊从胃平滑转移到肠道的关键参数是胶囊的总比重导致本发明的建立，其提出了具有总体特异性的肠溶性硬封闭药物重力至少为1.05，优选为至少1.10。

5. 发明授权

US4915940A Film-formation-type antifungal preparation 失效
标题翻译：成膜型抗真菌剂
公开(公告)号：US4915940A
公开(公告)日：1990-04-10
申请号：US271304
申请日：1988-11-15
申请人： Izumi Saitoh , Kaori Ikeda , Yoshio Doi , Shohei Egawa
发明人： Izumi Saitoh , Kaori Ikeda , Yoshio Doi , Shohei Egawa
IPC分类号： A61K9/70 , A61K31/27 , A61P31/04 , A61P31/10
CPC分类号： A61K31/27 , A61K9/7015
摘要： Film-formation-type antifungal preparations for external application, consisting essentially of about 0.1% to about 1.5% of tolnaphtate, about 10% to about 20% of a dimethylaminoethyl methacrylate-methacrylic acid ester copolymer and 0.5% to about 10% of a medium chain fatty acid ester in an alcoholic solvent but containing practically no water.

6. 发明授权

US4648918A Abrasion resistant aluminum alloy 失效
标题翻译：耐磨铝合金
公开(公告)号：US4648918A
公开(公告)日：1987-03-10
申请号：US647397
申请日：1984-09-05
申请人： Kazuhiko Asano , Osamu Takezoe , Yoshinori Yasuda , Kenji Hayashi , Masanobu Aoki , Yoshio Doi , Makoto Shimata
发明人： Kazuhiko Asano , Osamu Takezoe , Yoshinori Yasuda , Kenji Hayashi , Masanobu Aoki , Yoshio Doi , Makoto Shimata
IPC分类号： C22C21/02
CPC分类号： C22C21/02
摘要： An abrasion resistant aluminum alloy characterized in that the aluminum alloy has a chemical composition basically containing 7.5-15 wt % of Si, 3.0-6.0 wt % of Cu, 0.3-1.0 wt % of Mg, 0.25-1.0 wt % of Fe, 0.25-1.0 wt % of Mn, and the balance of Al and impurities, and an alloy structure with a primary Si crystal size smaller than 80 microns, a Si-Mn-Fe compound grain size smaller than 120 microns, and an alpha-Al phase size smaller than 100 microns.
摘要翻译：一种耐磨铝合金，其特征在于，铝合金的化学成分基本上含有Si：3.5〜15重量％，Cu：3.0〜6.0重量％，Mg：0.3〜1.0重量％，Fe：0.25〜1.0重量％ -1.0重量％的Mn和余量的Al和杂质，以及初级Si晶体尺寸小于80微米的合金结构，小于120微米的Si-Mn-Fe化合物晶粒尺寸和α-Al相尺寸小于100微米。

7. 发明申请

US20130002037A1 CONTACTLESS POWER-FEED EQUIPMENT 有权
标题翻译：无连接供电设备
公开(公告)号：US20130002037A1
公开(公告)日：2013-01-03
申请号：US13533097
申请日：2012-06-26
申请人： Yoshio Doi
发明人： Yoshio Doi
IPC分类号： H01F38/14
CPC分类号： H02J50/12 , H02J5/005
摘要： Contactless power-feed equipment includes: a power-supply device that outputs an AC constant current having a predetermined oscillation frequency to a main induction line; a primary coil provided on the main induction line connected to the power-supply device; a secondary coil that forms an insulating transformer with the primary coil and is connected in parallel with the sub induction line, a resonance capacitor that is connected in parallel with the secondary coil and constitutes a parallel resonant circuit with the sub induction line, and a switch provided between the secondary coil and the parallel resonant circuit. In the parallel resonant circuit, the sub induction line and the resonance capacitor have constants such that the parallel resonant circuit has a resonance frequency equal to the oscillation frequency of the power-supply device.
摘要翻译：非接触供电设备包括：向主感应线输出具有预定振荡频率的交流恒定电流的电源装置; 设置在与所述电源装置连接的所述主感应线上的初级线圈; 与初级线圈形成绝缘变压器并与副感应线并联连接的次级线圈，与次级线圈并联连接并与副感应线构成并联谐振电路的谐振电容器，以及开关设置在次级线圈和并联谐振电路之间。在并联谐振电路中，副感应线和谐振电容器具有使得并联谐振电路的谐振频率等于电源装置的振荡频率的常数。

8. 发明授权

US4513366A Menu programmed machine tool numerical controller with an interference checking function 失效
标题翻译：菜单编程机床数字控制器具有干扰检查功能
公开(公告)号：US4513366A
公开(公告)日：1985-04-23
申请号：US475509
申请日：1983-03-15
申请人： Kenichi Munekata , Yoshio Doi , Isao Suzuki , Shigeru Doi
发明人： Kenichi Munekata , Yoshio Doi , Isao Suzuki , Shigeru Doi
IPC分类号： G05B19/19 , G05B19/4061 , G05B19/4068 , G05B19/4093 , G05B23/02 , G05B9/02
CPC分类号： G05B19/4061 , G05B2219/35287 , G05B2219/49157 , Y10T82/2502
摘要： A numerical controller for a machining center comprising a microprocessor connected to a data input device, a CRT display device and a data storage device. The microprocessor prepares an NC program for a workpiece to be machined, based upon machining information manually input by the use of the data input device and stored in the data storage device. The debugging of the prepared NC program is then executed, wherein the microprocessor obtains by calculation a workpiece interference space defined outwardly from the outer periphery of the workpiece, based upon workpiece blank shape and dimension data and workpiece mounting position data stored in the data storage device. The microprocessor further calculates, based upon the NC program, a tool path along which a tool spindle of the machining center would be moved relative to a work table in accordance with the NC program. The microprocessor ascertains based upon the tool path, a tool interference space, defined outwardly from the outer periphery of each tool, and the workpiece interference space, whether or not the tool interference space would enter the workpiece interference space in any rapid feed movement if relative movement between the tool spindle and the work table were effected in accordance with the NC program. When detecting the entry of the tool interference space into the workpiece interference space, the microprocessor displays on the CRT screen a message informing an operator of the occurrence of an interference.
摘要翻译：一种用于加工中心的数字控制器，包括连接到数据输入装置的微处理器，CRT显示装置和数据存储装置。基于通过使用数据输入装置手动输入并存储在数据存储装置中的加工信息，微处理器为要加工的工件准备NC程序。然后执行所准备的NC程序的调试，其中微处理器基于工件坯件形状和尺寸数据以及存储在数据存储装置中的工件安装位置数据通过计算获得从工件的外周向外限定的工件干涉空间。微处理器还根据NC程序进一步计算一个刀具路径，根据NC程序，加工中心的刀具主轴将相对于工作台移动到该刀具路径上。微处理器基于刀具路径，从每个刀具的外周边向外定义的刀具干涉空间和工件干涉空间，无论刀具干涉空间是否进入任何快速进给运动中的工件干涉空间，如果相对根据NC程序进行刀具主轴和工作台之间的移动。当检测到工件干涉空间进入工件干涉空间时，微处理器在CRT屏幕上显示通知操作者出现干扰的消息。

9. 发明授权

US4538341A Machine tool with tool change function 失效
标题翻译：具有换刀功能的机床
公开(公告)号：US4538341A
公开(公告)日：1985-09-03
申请号：US477990
申请日：1983-03-22
申请人： Yoshio Doi , Tetsuro Yamakage , Kunimichi Nakashima , Akihiro Matsuura
发明人： Yoshio Doi , Tetsuro Yamakage , Kunimichi Nakashima , Akihiro Matsuura
IPC分类号： B23B31/117 , B23B31/26 , B23P23/00 , B23Q3/12 , B23Q3/157
CPC分类号： B23B31/263 , B23Q3/15706 , B23Q3/1574 , B23Q3/15773 , B23Q3/1578 , Y10T409/30448 , Y10T409/308456 , Y10T409/309296 , Y10T483/1757 , Y10T483/1786
摘要： A machine tool having an automatic tool changer for transferring tools between a tool magazine and a horizontal tool spindle rotatably mounted in a spindle head and which includes a vertical head which rotatably carries a vertical tool spindle and a horizontal drive shaft connected thereto is removably mounted on a vertical head support. In advance of a machining operation on a top surface of a workpiece, relative movement between the vertical head support and the spindle head is effected in a vertical direction and first and second horizontal directions, so that the vertical head is mounted on the spindle head, with the drive shaft being drivingly connected with the horizontal tool spindle. A tool support station mounted on the vertical head support is provided with two tool grippers each for vertically holding a tool. The tool support station is brought under the vertical head being mounted on the spindle head and selectively presents the two tool grippers in vertical axial alignment with the vertical tool spindle. In this state, the spindle head is moved in the vertical direction and the axial direction of the horizontal tool spindle and enables the vertical tool spindle to return a used tool therefrom to one of the tool grippers and then, to receive therein a new tool from the other tool gripper. A tool transfer device, which cooperates with the tool changer to receive a new tool therefrom and hand over a used tool thereto, is provided between the tool changer and the tool support station and transfers tools therebetween.
摘要翻译：一种具有自动换刀装置的机床，用于在工具仓和可旋转地安装在主轴头中的卧式工具主轴之间传送工具，该工具包括可旋转地承载垂直工具主轴的垂直头部和与其连接的水平驱动轴可拆卸地安装在垂直头部支撑。在工件的上表面上的加工操作之前，垂直头部支撑件和主轴头之间的相对运动在垂直方向和第一和第二水平方向上进行，使得垂直头部安装在主轴头上，驱动轴与水平工具主轴驱动连接。安装在垂直头部支撑件上的工具支撑台设置有两个工具夹持件，每个用于垂直地保持工具。工具支撑台被放置在安装在主轴头上的垂直头下方，并且选择性地将两个工具夹具垂直地与垂直工具主轴对齐。在这种状态下，主轴头在水平刀具主轴的垂直方向和轴向方向上移动，并且使得垂直刀具主轴能够将所使用的刀具从其中的一个工具夹紧器返回到其中，从而从其中接收新的刀具另一个工具夹具。工具传送装置与工具更换器配合以从其接收新工具并将其使用的工具移交到工具更换器和工具支撑台之间，并在其间传送工具。

10. 发明授权

US09331496B2 Contactless power-feed equipment 有权
标题翻译：非接触式供电设备
公开(公告)号：US09331496B2
公开(公告)日：2016-05-03
申请号：US13533097
申请日：2012-06-26
申请人： Yoshio Doi
发明人： Yoshio Doi
IPC分类号： H01F38/14 , H02J5/00
CPC分类号： H02J50/12 , H02J5/005
摘要： Contactless power-feed equipment includes: a power-supply device that outputs an AC constant current having a predetermined oscillation frequency to a main induction line; a primary coil provided on the main induction line connected to the power-supply device; a secondary coil that forms an insulating transformer with the primary coil and is connected in parallel with the sub induction line, a resonance capacitor that is connected in parallel with the secondary coil and constitutes a parallel resonant circuit with the sub induction line, and a switch provided between the secondary coil and the parallel resonant circuit. In the parallel resonant circuit, the sub induction line and the resonance capacitor have constants such that the parallel resonant circuit has a resonance frequency equal to the oscillation frequency of the power-supply device.
摘要翻译：非接触供电设备包括：向主感应线输出具有预定振荡频率的交流恒定电流的电源装置; 设置在与所述电源装置连接的所述主感应线上的初级线圈; 与初级线圈形成绝缘变压器并与副感应线并联连接的次级线圈，与次级线圈并联连接并与副感应线构成并联谐振电路的谐振电容器，以及开关设置在次级线圈和并联谐振电路之间。在并联谐振电路中，副感应线和谐振电容器具有使得并联谐振电路的谐振频率等于电源装置的振荡频率的常数。

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