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    • 2. 发明授权
    • N-substituted flavone-8-carboxamides
    • N-取代的黄酮-8-甲酰胺
    • US4525356A
    • 1985-06-25
    • US546481
    • 1983-10-28
    • Yasuo IthoHideo KatoNobuo OgawaKagari YamagishiEiichi KoshinakaKazuya Mitani
    • Yasuo IthoHideo KatoNobuo OgawaKagari YamagishiEiichi KoshinakaKazuya Mitani
    • C07D311/30C07D405/12A61K31/35C07D405/10
    • C07D405/12C07D311/30
    • Derivatives of N-substituted flavone-8-carboxamides represented by general formula (I) ##STR1## wherein R.sub.1 represents a hydrogen atom, a methyl group or an ethyl group, R.sub.2 represents a hydrogen atom, a lower alkyl group, a lower alkoxyl group, a halogen atom or a nitro group, R.sub.3 represents a hydrogen atom or a lower alkyl group, k represents 0, 1, 2, or 3, m represents 0 or 1; X and Y, which must be different, represent a hydrogen atom or methyl group. A represents an amino group having the formula ##STR2## wherein, R.sub.4 and R.sub.5, which may be the same or different, represent a lower alkyl group or a cyclic amino group together with the nitrogen atom and with or without an oxygen atom, R.sub.6 represents a lower alkyl group and n represents 2 or 3, are disclosed, as well as pharmaceutical compositions thereof and method of treating therewith.The N-substituted flavone-8-carboxamides derivatives are useful as agents for treatment of dysurea.
    • 由通式(I)表示的N-取代的黄酮-8-甲酰胺的衍生物其中R1表示氢原子,甲基或乙基,R2表示氢原子,低级烷基,低级烷氧基 卤素原子或硝基,R3表示氢原子或低级烷基,k表示0,1,2或3,m表示0或1; X和Y必须不同,表示氢原子或甲基。 A表示具有式“IMAGE”的氨基,其中可以相同或不同的R 4和R 5与氮原子一起表示低级烷基或环状氨基,并且具有或不具有氧原子,R6表示 低级烷基和n代表2或3,以及其药物组合物和其处理方法。 N-取代的黄酮-8-甲酰胺衍生物可用作治疗尿素的药剂。