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1. 发明授权

US4638009A Derivatives of 3-pyrrolidinopropiophenone and a process for preparation thereof 失效
标题翻译： 3-吡咯烷基苯丙酮的衍生物及其制备方法
公开(公告)号：US4638009A
公开(公告)日：1987-01-20
申请号：US573862
申请日：1984-01-25
申请人： Yasuo Itho , Hideo Kato , Nobuo Ogawa , Kagari Yamagishi , Eiichi Koshinaka , Hiroyuki Nishino
发明人： Yasuo Itho , Hideo Kato , Nobuo Ogawa , Kagari Yamagishi , Eiichi Koshinaka , Hiroyuki Nishino
IPC分类号： C07D295/108 , A61K31/41 , C07D207/06
CPC分类号： C07D295/108
摘要： Certain 4'-alkyl-2-methyl-3-pyrrolidinopropiophenones, acid addition salts thereof, their method of preparation, pharmaceutical compositions embodying the same, and a method of muscle relaxation therewith, are disclosed.
摘要翻译：公开了某些4'-烷基-2-甲基-3-吡咯烷基苯丙酮，其酸加成盐，其制备方法，含有其的药物组合物及其与肌肉松弛的方法。

2. 发明授权

US5153207A Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same 失效
标题翻译：哌啶衍生物，其制备方法和包含其的药物组合物
公开(公告)号：US5153207A
公开(公告)日：1992-10-06
申请号：US520064
申请日：1990-05-03
申请人： Yasuo Ito , Hideo Kato , Eiichi Koshinaka , Nobuo Ogawa , Hiroyuki Nishino , Jun Sakaguchi
发明人： Yasuo Ito , Hideo Kato , Eiichi Koshinaka , Nobuo Ogawa , Hiroyuki Nishino , Jun Sakaguchi
IPC分类号： C07D211/46 , C07D211/54
CPC分类号： C07D211/54 , C07D211/46
摘要： A piperidine derivative represented by the following general formula (I): ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each independently represents a hydrogen atom, a halogen atom, a lower alkyl group, or a lower alkoxy group; R.sub.3 represents a hydrogen atom or a lower alkyl group; X represents an oxygen atom or a sulfur atom; Y represents an alkylene group having 1 to 7 carbon atoms which may be optionally substituted with a lower alkyl group, or Y represents an --A--O--B-- group wherein A and B are the same or different and each independently represents an alkylene group having 1 to 3 carbon atoms which may be optionally substituted with a lower alkyl group is disclosed. Also disclosed are a pharmacologically acceptable salt of a compound of formula (I), an antihistaminic and antiallergic agent comprising a compound of formula (I), a pharmaceutical composition comprising a compound of formula (I), and a method for the treatment of an allergic disease by administering a compound of formula (I).

3. 发明授权

US4983633A Amide compounds, process for preparing the same, and composition for activating gastric motor function containing the same 失效
标题翻译：酰胺化合物，其制备方法和用于激活含有其的运动功能的组合物
公开(公告)号：US4983633A
公开(公告)日：1991-01-08
申请号：US241028
申请日：1988-09-02
申请人： Yasuo Itoh , Hideo Kato , Eiichi Koshinaka , Nobuo Ogawa , Hiroyuki Nishino , Jun Sakaguchi
发明人： Yasuo Itoh , Hideo Kato , Eiichi Koshinaka , Nobuo Ogawa , Hiroyuki Nishino , Jun Sakaguchi
IPC分类号： A61K31/165 , C07C233/12 , C07C233/73 , C07C235/48 , C07C311/15 , C07D295/08 , C07D295/092 , C07D317/68
CPC分类号： C07D295/088 , C07C255/00 , C07D317/68
摘要： Amide-compounds represented by the formula (I): ##STR1## wherein R.sub.1 represents hydrogen, lower alkoxy, hydroxy, lower alkyl, halogen, amino which can be substituted by lower alkyl, nitro, cyano, sulfamoyl which can be substituted by lower alkyl, R.sub.2 represents hydrogen, lower alkoxy, hydroxy, lower alkyl, halogen, amino, nitro, wherein R.sub.1 and R.sub.2 can be combined to form methylenedioxy, R.sub.3 means hydrogen, lower alkyl, halogen, or amino, R.sub.4 and R.sub.5 may be the same or different and each represents lower alkyl or wherein R.sub.4 and R.sub.5 may be combined together with nitrogen to form 1-pyrrolidinyl or piperidino, and pharmacologically-acceptable acid-addition salts thereof, which exhibit excellent effects in the activation of gastric motor function, a process for preparation pharmaceutical compositons thereof, as well as a method for the treatment of a subject suffering from an ailment associated with inadequate gastric motor function by administrating such a compound to the said subject, are all disclosed.

4. 发明授权

US5095022A Piperidine derivatives and pharmaceutical compositions comprising the same 失效
标题翻译：哌啶衍生物和包含其的药物组合物
公开(公告)号：US5095022A
公开(公告)日：1992-03-10
申请号：US538085
申请日：1990-06-13
申请人： Yasuo Ito , Hideo Kato , Eiichi Koshinaka , Nobuo Ogawa , Hiroyuki Nishino , Jun Sakaguchi
发明人： Yasuo Ito , Hideo Kato , Eiichi Koshinaka , Nobuo Ogawa , Hiroyuki Nishino , Jun Sakaguchi
IPC分类号： C07D211/70 , C07D405/04
CPC分类号： C07D405/04 , C07D211/70
摘要： A piperidine derivative represented by the following general formula (I): ##STR1## wherein R represents a hydrogen atom or a lower alkyl group; X represents --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, or --CH.sub.2 O--; Y represents an alkylene group having 1 to 5 carbon atoms which may be optionally substituted with a lower alkyl group, or Y represents an --A--O--B-- group wherein A and B are the same or different and each independently represented an alkylene group having 1 to 3 carbon atoms which may be optionally substituted with a lower alkyl group is disclosed. Also disclosed are a pharmacologically acceptable salt of a compound of formula (I), a method for preparation of a compound of formula (I), an antihistaminic and antiallergic agent comprising a compound of formula (I), a pharmaceutical composition comprising a compound of formula (I), and a method for the treatment of an allergic disease by administering a compound of formula (I).

5. 发明授权

US4612329A Pharmaceutical alpha-aminoalkyl-alpha-alkylphenylacetonitriles 失效
标题翻译：药物α-氨基烷基-α-烷基苯基乙腈
公开(公告)号：US4612329A
公开(公告)日：1986-09-16
申请号：US786742
申请日：1985-10-11
申请人： Yasuo Itoh , Hideo Kato , Eiichi Koshinaka , Nobuo Ogawa , Sakae Kurata , Hiroyuki Nishino , Toshihiko Yoshida
发明人： Yasuo Itoh , Hideo Kato , Eiichi Koshinaka , Nobuo Ogawa , Sakae Kurata , Hiroyuki Nishino , Toshihiko Yoshida
IPC分类号： A61K31/275 , A61K31/445 , C07C20060101 , C07C255/58 , C07D20060101 , C07D211/08 , C07D295/08 , C07C121/78
CPC分类号： C07C255/00
摘要： Novel alpha-aminoalkyl-alpha-alkylphenylacetonitrile derivatives useful for treatment of cartino vaso diseases, a peripheral circulatory insufficiency and cerebral circulation failure are disclosed.
摘要翻译：公开了用于治疗纸浆血管疾病，外周循环功能不全和脑循环衰竭的新型α-氨基烷基-α-烷基苯基乙腈衍生物。

6. 发明授权

US5334594A Amphoteric tricyclic compound 失效
标题翻译：两性三环化合物
公开(公告)号：US5334594A
公开(公告)日：1994-08-02
申请号：US15812
申请日：1993-02-10
申请人： Yasuo Ito , Hideo Kato , Shingo Yasuda , Noriyuki Kado , Nobuhiko Iwasaki , Hiroyuki Nishino , Makoto Takeshita
发明人： Yasuo Ito , Hideo Kato , Shingo Yasuda , Noriyuki Kado , Nobuhiko Iwasaki , Hiroyuki Nishino , Makoto Takeshita
IPC分类号： A61K31/445 , A61K31/00 , A61K31/4465 , A61K31/4523 , A61K31/4545 , A61K31/55 , A61P11/00 , A61P17/00 , A61P27/16 , A61P37/00 , A61P37/08 , A61P43/00 , C07D491/04 , C07D491/044 , C07D491/052
CPC分类号： C07D491/04
摘要： Novel amphoteric tricyclic compound represented by the following formula: ##STR1## wherein R.sup.1 represents a hydrogen atom or a halogen atom; X represents --O--, --CH.sub.2 O--, or --OCH.sub.2 --; and Y represents a C.sub.2 -C.sub.5 alkylene group which may optionally be substituted with a lower alkyl group, and a pharmacologically acceptable salt thereof are disclosed. Also disclosed are a pharmaceutical composition comprising the same and a method for treatment of an allergic disease or bronchial asthma.
摘要翻译：由下式表示的新型两性三环化合物：其中R 1表示氢原子或卤素原子; X表示-O-，-CH 2 O-或-OCH 2 - ; 并且Y表示可以任选被低级烷基取代的C 2 -C 5亚烷基，并且其公开的药理学上可接受的盐。还公开了包含其的药物组合物和治疗过敏性疾病或支气管哮喘的方法。

7. 发明授权

US6075035A Crystal of hydrate and process for preparation thereof 失效
标题翻译：水合物晶体及其制备方法
公开(公告)号：US6075035A
公开(公告)日：2000-06-13
申请号：US11752
申请日：1998-02-23
申请人： Yasuo Ito , Hideo Kato , Shingo Yasuda , Noriyuki Kado , Nobuhiko Iwasaki , Hiroyuki Nishino , Makoto Takeshita
发明人： Yasuo Ito , Hideo Kato , Shingo Yasuda , Noriyuki Kado , Nobuhiko Iwasaki , Hiroyuki Nishino , Makoto Takeshita
IPC分类号： C07D491/04 , C07D491/044 , A01N43/42
CPC分类号： C07D491/04
摘要： Dihydrate crystal of 3-[4-(8-fluoro-5,11-dihydrobenz[b]oxepino[4,3-b]pyridin-11-ylidene)piperidino]propionic acid providing high-intensity diffraction peaks at diffraction angles (2.theta.) of about 4.2.degree., 17.0.degree., and 21.3.degree. in a powder X-ray diffraction profile; a medicament comprising the dihydrate crystal; and a process for preparing the dihydrate crystal which comprises the steps of treating a crystalline substance containing an anhydride crystal of the above compound with hydrous acetone, and subjecting the product to drying treatment and moistening treatment.
摘要翻译： PCT No.PCT / JP96 / 02352 Sec。 371日期1998年2月23日 102（e）1998年2月23日PCT PCT 1996年8月23日PCT公布。出版物WO97 / 09330 日期1997年3月13日提供高强度衍射峰的3- [4-（8-氟-5,11-二氢苯并[b]氧杂环庚烯并[4,3-b]吡啶-11-亚基）哌啶子基]丙酸的二水合晶体在衍射角（2θ）为约4.2°，17.0°和21.3°的粉末X射线衍射图中; 包含二水合物晶体的药物; 以及制备二水合物晶体的方法，包括以下步骤：用含水丙酮处理含有上述化合物的无水物结晶的结晶物质，并对产物进行干燥处理和润湿处理。

8. 发明授权

US5500422A Benzamide derivative 失效
标题翻译：苯甲酰胺衍生物
公开(公告)号：US5500422A
公开(公告)日：1996-03-19
申请号：US348808
申请日：1994-11-28
申请人： Yasuo Ito , Hideo Kato , Shingo Yasuda , Nobuhiko Iwasaki , Hiroyuki Nishino , Makoto Takeshita
发明人： Yasuo Ito , Hideo Kato , Shingo Yasuda , Nobuhiko Iwasaki , Hiroyuki Nishino , Makoto Takeshita
IPC分类号： C07D211/58 , C07D451/04 , C07D451/14 , C07D211/36 , A61K31/445
CPC分类号： C07D451/04 , C07D211/58 , C07D451/14
摘要： A benzamide derivative represented by the following formula: ##STR1## wherein R.sup.1 represents a hydrogen atom or a lower alkanoyl group; R.sup.2 represents a hydrogen atom or a halogen atom; R.sup.3 represents a lower alkoxy group; R.sup.4 represents a hydrogen atom or a lower alkyl group; R.sup.5 represents a hydrogen atom, a lower alkyl group, or a lower alkoxy group; A represents C.sub.1 -C.sub.7 alkylene group which may optionally be substituted with a lower alkyl group; X represents a methylene group, an oxygen atom, or a sulfur atom; m represents an integer of from 0 to 3; n represents an integer of from 0 to 3; and p represents an integer of from 0 to 2 and a pharmacologically acceptable salt thereof is provided. These compounds are useful since they have gastrointestinal stimulating activity, and a pharmaceutical composition comprising said compound is useful for the treatment of gastrointestinal diseases.
摘要翻译：由下式表示的苯甲酰胺衍生物：其中R 1表示氢原子或低级烷酰基; R2表示氢原子或卤素原子; R3表示低级烷氧基; R4代表氢原子或低级烷基; R5表示氢原子，低级烷基或低级烷氧基; A表示可以被低级烷基取代的C1-C7亚烷基; X表示亚甲基，氧原子或硫原子; m表示0〜3的整数， n表示0〜3的整数， p表示0〜2的整数，并且其药理学上可接受的盐。这些化合物是有用的，因为它们具有胃肠道刺激活性，并且包含所述化合物的药物组合物可用于治疗胃肠道疾病。

9. 发明授权

US5395832A Benzamide derivatives 失效
标题翻译：苯甲酰胺衍生物
公开(公告)号：US5395832A
公开(公告)日：1995-03-07
申请号：US104095
申请日：1993-08-11
申请人： Yasuo Ito , Hideo Kato , Shingo Yasuda , Nobuhiko Iwasaki , Hiroyuki Nishino , Makoto Takeshita
发明人： Yasuo Ito , Hideo Kato , Shingo Yasuda , Nobuhiko Iwasaki , Hiroyuki Nishino , Makoto Takeshita
IPC分类号： C07D211/58 , C07D451/04 , C07D451/14 , A61K31/46 , A61K31/44
CPC分类号： C07D451/04 , C07D211/58 , C07D451/14
摘要： A benzamide derivative represented by the following formula: ##STR1## wherein R.sup.1 represents a hydrogen atom or a lower alkanoyl group; R.sup.2 represents a hydrogen atom or a halogen atom; R.sup.3 represents a lower alkoxy group; R.sup.4 represents a hydrogen atom or a lower alkyl group; R.sup.5 represents a hydrogen atom, a lower alkyl group, or a lower alkoxy group; A represents C.sub.1 -C.sub.7 alkylene group which may optionally be substituted with a lower alkyl group; X represents a methylene group, an oxygen atom, or a sulfur atom; m represents an integer of from 0 to 3; n represents an integer of from 0 to 3; and p represents an integer of from 0 to 2 and a pharmacologically acceptable salt thereof is provided. These compounds are useful since they have gastrointestinal stimulating activity, and a pharmaceutical composition comprising said compound is useful for the treatment of gastrointestinal diseases.
摘要翻译： PCT No.PCT / JP92 / 00134 Sec。 371日期：1993年8月11日 102（e）日期1993年8月11日PCT提交1992年2月12日PCT公布。公开号WO92 / 14705 日本9月3日，1992。一种苯甲酰胺衍生物，由下式表示：其中R1表示氢原子或低级烷酰基; R2表示氢原子或卤素原子; R3表示低级烷氧基; R4代表氢原子或低级烷基; R5表示氢原子，低级烷基或低级烷氧基; A表示可以被低级烷基取代的C1-C7亚烷基; X表示亚甲基，氧原子或硫原子; m表示0〜3的整数， n表示0〜3的整数， p表示0〜2的整数，并且其药理学上可接受的盐。这些化合物是有用的，因为它们具有胃肠道刺激活性，并且包含所述化合物的药物组合物可用于治疗胃肠道疾病。

10. 发明授权

US09451679B2 Illuminating light communication device 有权
标题翻译：照明灯通讯装置
公开(公告)号：US09451679B2
公开(公告)日：2016-09-20
申请号：US13215165
申请日：2011-08-22
申请人： Hiroyuki Nishino , Eiji Shiohama , Shigeaki Yamasaki
发明人： Hiroyuki Nishino , Eiji Shiohama , Shigeaki Yamasaki
IPC分类号： H05B37/02 , H04B10/114 , H04B10/116
CPC分类号： H05B37/0272 , H04B10/1149 , H04B10/116
摘要： An illuminating light communication device comprises a constant current source, a smoothing capacitor connected to an output of the constant current source, a load circuit comprising a light emitting diode and connected to the output of the constant current source, a load change element added to the load circuit and thereby partially changing load characteristic of the load circuit, and a switch element configured to determine whether or not the load change element is added to the load circuit in accordance with a binary optical communication signal.
摘要翻译：一种照明光通信装置，包括恒流源，连接到恒流源的输出的平滑电容器，包括发光二极管并连接到恒流源的输出的负载电路，加载到所述恒流源的负载变换元件负载电路，从而部分地改变负载电路的负载特性;以及开关元件，其被配置为根据二进制光通信信号确定负载变换元件是否被加到负载电路。

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