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1. 发明授权

US5128135A Percutaneous or trans-mucosal absorption enhancers, preparations containing the enhancers, and a method of preparing thereof 失效
标题翻译：经皮或透皮吸收增强剂，含增强剂的制剂及其制备方法
公开(公告)号：US5128135A
公开(公告)日：1992-07-07
申请号：US468374
申请日：1990-01-22
申请人： Yasunori Morimoto , Kenji Sugibayashi , Seiichi Umeda
发明人： Yasunori Morimoto , Kenji Sugibayashi , Seiichi Umeda
IPC分类号： A61K9/00 , A61K47/08
CPC分类号： A61K9/0014 , A61K47/08
摘要： Percutaneous or trans-mucosal absorption enhancer comprising of a terpeneketone and preparation containing thereof. Preferably, the preparation contains a percutaneous or trans-mucosal absorption enhancer in an amount of 0.01-20 weight % of the preparation. In preparing the preparation, a terpeneketone is dissolved and emulsified in a water soluble organic solvent which is medically allowable.

2. 发明授权

US4769945A Delivery unit of plant tissue 失效
标题翻译：植物组织交付单位
公开(公告)号：US4769945A
公开(公告)日：1988-09-13
申请号：US8737
申请日：1987-01-30
申请人： Shimesu Motoyama , Seiichi Umeda , Hiroaki Ogishima , Sashiro Motegi
发明人： Shimesu Motoyama , Seiichi Umeda , Hiroaki Ogishima , Sashiro Motegi
IPC分类号： A01C1/00 , A01G9/10 , A01H4/00 , C12M3/00 , A01C1/06
CPC分类号： A01G9/1033 , A01H4/001
摘要： A delivery unit of plant tissue of the present invention comprises a vessel in which meristematic tissue having the ability to grow into an entire plant body through differentiation is received. The body of the vessel is made of water-soluble substance and the interior thereof is covered with a water-insoluble substance. Hydrogel is charged in the vessel and the meristematic tissue is held by the hydrogel in a state in which its root or rooting portion is embedded therein or it is placed on the hydrogel. The vessel has a structure of a closed type with a cap or an open type. When the delivery unit of plant tissue is seeded in a medium, the water-soluble substance of the vessel body is dissolved by water contained in the medium and the bud and root grown out of the meristematic tissue breaks the thin film made of a water-insoluble substance which is provided in the interior of the vessel so as to further grow out.
摘要翻译：本发明的植物组织的输送单元包括容器，其中具有通过分化生长成整个植物体的能力的分生组织被接收。容器的主体由水溶性物质制成，其内部被水不溶性物质覆盖。将水凝胶装入容器中，分生组织由其根部或生根部分嵌入其中或将其置于水凝胶上的状态下由水凝胶保持。容器具有封闭形式的具有盖或开放型的结构。当植物组织的输送单元接种在培养基中时，容器体的水溶性物质被包含在培养基中的水溶解，并且从分生组织生长的芽和根分解由水 - 不溶物质，其设置在容器的内部以进一步生长。

3. 发明授权

US4756922A Powder coating method 失效
标题翻译：粉末涂布法
公开(公告)号：US4756922A
公开(公告)日：1988-07-12
申请号：US47779
申请日：1987-05-08
申请人： Shimesu Motoyama , Seiichi Umeda , Hiroaki Ogishima , Sashiro Motegi
发明人： Shimesu Motoyama , Seiichi Umeda , Hiroaki Ogishima , Sashiro Motegi
IPC分类号： A01G1/06 , A01C1/06 , A01G1/00 , A01H4/00 , C12N5/00 , C12N5/04 , B05D7/24
CPC分类号： A01H4/00 , Y10S47/11
摘要： A method in which a plant meristematic tissues which retain aqueous liquid on their surfaces are mixed with fine powder, thereby forming powder-coated bodies to which fine powder is adhered at the periphery thereof, so that meristematic tissues are separated from each other. A quantity of water or a liquid mainly consisting of water large enough to make fine powder adhere to the surfaces of the meristematic tissues which can grow into entire plant bodies directly or after they have passed through differentiation and organogenesis. The meristematic tissues are mixed with the fine powder which does not indicate adhesiveness at least during the mixing process. This mixing process is effected in such a manner that the powder is adhered to the tissues by gently shaking or agitating them without applying excessive shearing stress to the meristematic tissues.
摘要翻译：将其表面保持水性液体的植物分生组织与细粉末混合，从而在其周围形成附着微细粉末的粉末涂覆体，使分生组织彼此分离。一定量的水或液体主要由足够大的水组成的液体，以使细粉末粘附到分生组织的表面，其可以直接生长到整个植物体内，或者在它们通过分化和器官发生后生长。将分生组织与至少在混合过程中不表示粘合性的细粉末混合。这种混合过程以这样的方式进行：粉末通过轻轻地摇动或搅拌而粘附到组织上，而不对分生组织施加过大的剪切应力。

4. 发明授权

US5128131A Process for preparing a watersoluble composition containing ginkgo leaf extracts 失效
标题翻译：制备含有银杏叶提取物的水溶性组合物的方法
公开(公告)号：US5128131A
公开(公告)日：1992-07-07
申请号：US431022
申请日：1989-11-02
申请人： Shimesu Motoyama, deceased , Seiichi Umeda , Yukihiro Saito
发明人： Shimesu Motoyama, deceased , Seiichi Umeda , Yukihiro Saito
IPC分类号： A23L2/38 , A23L1/30 , A61K36/00 , A61K36/16 , A61K36/18 , A61K36/346 , A61K36/81 , A61K47/14 , A61K47/36 , A61K47/46
CPC分类号： A61K47/36 , A61K36/16 , A61K36/346 , A61K36/81 , A61K47/14
摘要： A composition containing an extract obtained by a water-containing organic solvent, comprising: (a) an extract containing active ingredients including flavone glycoside or biflavone almost insoluble in water, said extract being obtained for ginkgo plant tissues by extraction with a water-containing organic solvent, and at least one of (b) a water-soluble high-molecular substance and (c) a fatty acid ester of polyglycerol. This composition can be formulated into preparations not containing ethanol, i.e. solid preparations including tablets, granules, and powder preparations, or non-alcoholic liquid preparations such as drinkable preparations and syrups, in such a way that the extract contained is well absorbed through the digestive tract.

5. 发明授权

US4751241A Pharmaceutical composition of cyclandelate having a high degree of bioavailability 失效
标题翻译：具有高生物利用度的环丙磺酸盐的药物组合物
公开(公告)号：US4751241A
公开(公告)日：1988-06-14
申请号：US724502
申请日：1985-04-19
申请人： Shimesu Motoyama , Satoshi Sato , Seiichi Umeda , Hirotsune Yasumi , Emiko Sudo , Takuichi Tsujino , Akira Akazawa
发明人： Shimesu Motoyama , Satoshi Sato , Seiichi Umeda , Hirotsune Yasumi , Emiko Sudo , Takuichi Tsujino , Akira Akazawa
IPC分类号： A61K31/22 , A61K47/14 , A61K31/235
CPC分类号： A61K47/14 , Y10S514/937
摘要： An oral pharmaceutical composition which comprises a polyglycerol ester of an unsaturated fatty acid and a drug which is very slightly soluble in water.
摘要翻译：一种口服药物组合物，其包含不饱和脂肪酸的聚甘油酯和非常微溶于水的药物。

6. 发明授权

US5158770A Aqueous solution containing ginkgo leaf extract 失效
标题翻译：含有银杏叶提取物的水溶液
公开(公告)号：US5158770A
公开(公告)日：1992-10-27
申请号：US634393
申请日：1990-12-27
申请人： Yukihiro Saito , Naomi Yoshida , Seiichi Umeda
发明人： Yukihiro Saito , Naomi Yoshida , Seiichi Umeda
IPC分类号： A61K36/16 , C08B37/00 , C13K13/00
CPC分类号： A61K36/16
摘要： An aqueous solution containing a high concentration of ginkgo leaf extract having good preservability is prepared. The aqueous solution containing ginkgo leaf extract comprises at least 1 weight % of a hydrous organic solvent extract obtained from ginkgo leaf, and further disaccharide alcohols and/or trisaccharide alcohols, and/or organic compounds having a basic nitrogen atom in the molecule and a solubility in water at normal temperature of at least 10 g/100 ml.

7. 发明授权

US4540602A Process for the preparation of activated pharmaceutical compositions 失效
标题翻译：活性药物组合物的制备方法
公开(公告)号：US4540602A
公开(公告)日：1985-09-10
申请号：US420384
申请日：1982-09-20
申请人： Shimesu Motoyama , Satashi Sato , Seiichi Umeda , Hirotsune Yasumi , Emiko Suto , Yuko Takasaka , Takuichi Tsujino
发明人： Shimesu Motoyama , Satashi Sato , Seiichi Umeda , Hirotsune Yasumi , Emiko Suto , Yuko Takasaka , Takuichi Tsujino
IPC分类号： A61K9/14 , A61K9/50 , B01J13/02
CPC分类号： A61K9/5047 , A61K9/14 , A61K9/5031 , A61K9/5036
摘要： Disclosed is a process for the preparation of an activated pharmaceutical composition containing a solid drug that is scarcely soluble in water, the pharmaceutical composition being characterized in that, when it is administered orally, the drug is readily absorbed to attain its high blood concentration quickly. This process is carried out by providing a solid drug that is scarcely soluble in water, dispersing the drug in water in the presence of a water-soluble high-molecular substance to form a disperse system containing the drug in the form of finely divided particles substantially not greater than 10.mu. in diameter, and then removing the water from the disperse system.
摘要翻译：公开了一种制备含有几乎不溶于水的固体药物的活性药物组合物的方法，该药物组合物的特征在于，口服给药时，药物容易被吸收以迅速达到高血药浓度。该方法通过提供几乎不溶于水的固体药物，在水溶性高分子物质的存在下将药物分散在水中，形成含有基本上细碎颗粒形式的药物的分散体系直径不大于10微米，然后从分散体系中除去水分。

8. 发明授权

US5010685A Artificial seed comprising a sustained-release sugar granule 失效
标题翻译：包含缓释糖颗粒的人造种子
公开(公告)号：US5010685A
公开(公告)日：1991-04-30
申请号：US345897
申请日：1989-05-01
申请人： Yuji Sakamoto , Seiichi Umeda , Hiroaki Ogishima
发明人： Yuji Sakamoto , Seiichi Umeda , Hiroaki Ogishima
IPC分类号： C07H3/02 , A01C1/00 , A01H4/00 , A61K9/14 , A61K47/00 , A61K47/34 , C05F11/00 , C12N5/04
CPC分类号： C12N5/04 , A01H4/006
摘要： A sustained-release granule of sugar comprising a core comprising primarily one or more of a monosaccharide, a disaccharide and a trisaccharide and an outer film comprising 10-90% by weight of an ethylene-vinyl acetate copolymer and 90-10% by weight of a wax. This sustained-release granule of sugar may be prepared by coating a core comprising primarily one or more of a monosaccharide, a disaccharide and a trisaccharide with a coating material comprising 10-90% by weight of an ethylene-vinyl acetate copolymer and 90-10% by weight of a wax by spraying a solution of the coating material onto the core while tumbling or fluidizing the core. The sustained-release granule of sugar can be applied in an artificial seed comprising an active plant tissue and the sustained-release granule of sugar which are encapsulated in a gel matrix.
摘要翻译：糖的持续释放颗粒，其包含主要包含单糖，二糖和三糖中的一种或多种的核心，以及包含10-90重量％的乙烯 - 乙酸乙烯酯共聚物和90-10重量％蜡。这种持续释放的糖颗粒可以通过包含主要包含一种或多种单糖，二糖和三糖的核与包含10-90重量％的乙烯 - 乙酸乙烯酯共聚物和90-10重量％的涂料来制备通过在将芯体翻转或流化的同时将涂覆材料的溶液喷涂到芯上，重量％的蜡。糖的缓释颗粒可以应用于包含活性植物组织和包封在凝胶基质中的糖的缓释颗粒的人造种子中。

9. 发明授权

US4820442A Preservative composition 失效
标题翻译：防腐剂组成
公开(公告)号：US4820442A
公开(公告)日：1989-04-11
申请号：US945364
申请日：1986-12-22
申请人： Shimesu Motoyama , Shigeru Ohno , Seiichi Umeda
发明人： Shimesu Motoyama , Shigeru Ohno , Seiichi Umeda
IPC分类号： A01N59/16 , A23B4/023 , A23B4/16 , A23B4/20 , A23B4/24 , A23L3/3526 , A23L3/358 , C08L39/00 , C09K15/18
CPC分类号： C08L39/00 , A01N59/16 , A23B4/023 , A23B4/16 , A23B4/20 , A23B4/24 , A23L3/3526 , A23L3/358
摘要： Disclosed is a preservative composition for foodstuffs and the like, which is comprised of (i) a metal powder or a granulated product thereof, (ii) an oxidation accelerator for the metal, (iii) polyallylamine, and (iv) an optional ethanol vapor-generating member. The polyallylamine is preferably deodorized by loading a solution of polyallylamine or a salt thereof on a carrier, and heating and drying the polyallylamine-loaded carrier.
摘要翻译：公开了一种食品防腐剂组合物，其由（i）金属粉末或其造粒产物，（ii）金属氧化促进剂，（iii）聚烯丙胺和（iv）任选的乙醇蒸气生产成员。聚烯丙基胺优选通过将聚烯丙胺或其盐的溶液加载到载体上，并加热和干燥载有聚烯丙基胺的载体来除臭。

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