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1. 发明授权

US4820442A Preservative composition 失效
标题翻译：防腐剂组成
公开(公告)号：US4820442A
公开(公告)日：1989-04-11
申请号：US945364
申请日：1986-12-22
申请人： Shimesu Motoyama , Shigeru Ohno , Seiichi Umeda
发明人： Shimesu Motoyama , Shigeru Ohno , Seiichi Umeda
IPC分类号： A01N59/16 , A23B4/023 , A23B4/16 , A23B4/20 , A23B4/24 , A23L3/3526 , A23L3/358 , C08L39/00 , C09K15/18
CPC分类号： C08L39/00 , A01N59/16 , A23B4/023 , A23B4/16 , A23B4/20 , A23B4/24 , A23L3/3526 , A23L3/358
摘要： Disclosed is a preservative composition for foodstuffs and the like, which is comprised of (i) a metal powder or a granulated product thereof, (ii) an oxidation accelerator for the metal, (iii) polyallylamine, and (iv) an optional ethanol vapor-generating member. The polyallylamine is preferably deodorized by loading a solution of polyallylamine or a salt thereof on a carrier, and heating and drying the polyallylamine-loaded carrier.
摘要翻译：公开了一种食品防腐剂组合物，其由（i）金属粉末或其造粒产物，（ii）金属氧化促进剂，（iii）聚烯丙胺和（iv）任选的乙醇蒸气生产成员。聚烯丙基胺优选通过将聚烯丙胺或其盐的溶液加载到载体上，并加热和干燥载有聚烯丙基胺的载体来除臭。

2. 发明授权

US4769945A Delivery unit of plant tissue 失效
标题翻译：植物组织交付单位
公开(公告)号：US4769945A
公开(公告)日：1988-09-13
申请号：US8737
申请日：1987-01-30
申请人： Shimesu Motoyama , Seiichi Umeda , Hiroaki Ogishima , Sashiro Motegi
发明人： Shimesu Motoyama , Seiichi Umeda , Hiroaki Ogishima , Sashiro Motegi
IPC分类号： A01C1/00 , A01G9/10 , A01H4/00 , C12M3/00 , A01C1/06
CPC分类号： A01G9/1033 , A01H4/001
摘要： A delivery unit of plant tissue of the present invention comprises a vessel in which meristematic tissue having the ability to grow into an entire plant body through differentiation is received. The body of the vessel is made of water-soluble substance and the interior thereof is covered with a water-insoluble substance. Hydrogel is charged in the vessel and the meristematic tissue is held by the hydrogel in a state in which its root or rooting portion is embedded therein or it is placed on the hydrogel. The vessel has a structure of a closed type with a cap or an open type. When the delivery unit of plant tissue is seeded in a medium, the water-soluble substance of the vessel body is dissolved by water contained in the medium and the bud and root grown out of the meristematic tissue breaks the thin film made of a water-insoluble substance which is provided in the interior of the vessel so as to further grow out.
摘要翻译：本发明的植物组织的输送单元包括容器，其中具有通过分化生长成整个植物体的能力的分生组织被接收。容器的主体由水溶性物质制成，其内部被水不溶性物质覆盖。将水凝胶装入容器中，分生组织由其根部或生根部分嵌入其中或将其置于水凝胶上的状态下由水凝胶保持。容器具有封闭形式的具有盖或开放型的结构。当植物组织的输送单元接种在培养基中时，容器体的水溶性物质被包含在培养基中的水溶解，并且从分生组织生长的芽和根分解由水 - 不溶物质，其设置在容器的内部以进一步生长。

3. 发明授权

US4756922A Powder coating method 失效
标题翻译：粉末涂布法
公开(公告)号：US4756922A
公开(公告)日：1988-07-12
申请号：US47779
申请日：1987-05-08
申请人： Shimesu Motoyama , Seiichi Umeda , Hiroaki Ogishima , Sashiro Motegi
发明人： Shimesu Motoyama , Seiichi Umeda , Hiroaki Ogishima , Sashiro Motegi
IPC分类号： A01G1/06 , A01C1/06 , A01G1/00 , A01H4/00 , C12N5/00 , C12N5/04 , B05D7/24
CPC分类号： A01H4/00 , Y10S47/11
摘要： A method in which a plant meristematic tissues which retain aqueous liquid on their surfaces are mixed with fine powder, thereby forming powder-coated bodies to which fine powder is adhered at the periphery thereof, so that meristematic tissues are separated from each other. A quantity of water or a liquid mainly consisting of water large enough to make fine powder adhere to the surfaces of the meristematic tissues which can grow into entire plant bodies directly or after they have passed through differentiation and organogenesis. The meristematic tissues are mixed with the fine powder which does not indicate adhesiveness at least during the mixing process. This mixing process is effected in such a manner that the powder is adhered to the tissues by gently shaking or agitating them without applying excessive shearing stress to the meristematic tissues.
摘要翻译：将其表面保持水性液体的植物分生组织与细粉末混合，从而在其周围形成附着微细粉末的粉末涂覆体，使分生组织彼此分离。一定量的水或液体主要由足够大的水组成的液体，以使细粉末粘附到分生组织的表面，其可以直接生长到整个植物体内，或者在它们通过分化和器官发生后生长。将分生组织与至少在混合过程中不表示粘合性的细粉末混合。这种混合过程以这样的方式进行：粉末通过轻轻地摇动或搅拌而粘附到组织上，而不对分生组织施加过大的剪切应力。

4. 发明授权

US4540602A Process for the preparation of activated pharmaceutical compositions 失效
标题翻译：活性药物组合物的制备方法
公开(公告)号：US4540602A
公开(公告)日：1985-09-10
申请号：US420384
申请日：1982-09-20
申请人： Shimesu Motoyama , Satashi Sato , Seiichi Umeda , Hirotsune Yasumi , Emiko Suto , Yuko Takasaka , Takuichi Tsujino
发明人： Shimesu Motoyama , Satashi Sato , Seiichi Umeda , Hirotsune Yasumi , Emiko Suto , Yuko Takasaka , Takuichi Tsujino
IPC分类号： A61K9/14 , A61K9/50 , B01J13/02
CPC分类号： A61K9/5047 , A61K9/14 , A61K9/5031 , A61K9/5036
摘要： Disclosed is a process for the preparation of an activated pharmaceutical composition containing a solid drug that is scarcely soluble in water, the pharmaceutical composition being characterized in that, when it is administered orally, the drug is readily absorbed to attain its high blood concentration quickly. This process is carried out by providing a solid drug that is scarcely soluble in water, dispersing the drug in water in the presence of a water-soluble high-molecular substance to form a disperse system containing the drug in the form of finely divided particles substantially not greater than 10.mu. in diameter, and then removing the water from the disperse system.
摘要翻译：公开了一种制备含有几乎不溶于水的固体药物的活性药物组合物的方法，该药物组合物的特征在于，口服给药时，药物容易被吸收以迅速达到高血药浓度。该方法通过提供几乎不溶于水的固体药物，在水溶性高分子物质的存在下将药物分散在水中，形成含有基本上细碎颗粒形式的药物的分散体系直径不大于10微米，然后从分散体系中除去水分。

5. 发明授权

US4751241A Pharmaceutical composition of cyclandelate having a high degree of bioavailability 失效
标题翻译：具有高生物利用度的环丙磺酸盐的药物组合物
公开(公告)号：US4751241A
公开(公告)日：1988-06-14
申请号：US724502
申请日：1985-04-19
申请人： Shimesu Motoyama , Satoshi Sato , Seiichi Umeda , Hirotsune Yasumi , Emiko Sudo , Takuichi Tsujino , Akira Akazawa
发明人： Shimesu Motoyama , Satoshi Sato , Seiichi Umeda , Hirotsune Yasumi , Emiko Sudo , Takuichi Tsujino , Akira Akazawa
IPC分类号： A61K31/22 , A61K47/14 , A61K31/235
CPC分类号： A61K47/14 , Y10S514/937
摘要： An oral pharmaceutical composition which comprises a polyglycerol ester of an unsaturated fatty acid and a drug which is very slightly soluble in water.
摘要翻译：一种口服药物组合物，其包含不饱和脂肪酸的聚甘油酯和非常微溶于水的药物。

6. 发明授权

US4623098A Granulating and coating machine 失效
标题翻译：造粒机及涂布机
公开(公告)号：US4623098A
公开(公告)日：1986-11-18
申请号：US542471
申请日：1983-10-17
申请人： Shimesu Motoyama , Kaoru Kurita , Shizuka Sakashita , Narimichi Takei , Shigeru Ohno
发明人： Shimesu Motoyama , Kaoru Kurita , Shizuka Sakashita , Narimichi Takei , Shigeru Ohno
IPC分类号： B01J2/16 , B05B7/14 , B02C23/26
CPC分类号： B05B7/144 , B01J2/10 , B01J2/16 , B05B15/003
摘要： A machine for use in granulation, coating, mixing, drying etc. of powdery or granular raw materials such as medicine or foods etc. The machine is comprised of a casing for containing raw materials, a rotator for tumbling and giving centrifugal force to the material in the casing rotatable horizontally in the casing and at least one disintegrator provided above the rotator for subdividing undesirously large particles. At least one agitator is provided above the rotator for agitating and kneading materials to be granulated or coated. The rotator is movable or fixed in vertical position, and an annular slit is formed between an annular slit forming ring or inner wall of the casing and outer periphery of the rotator. The slit forming ring is movable or fixed in vertical position. At least one ventilating portion is formed on at least one portion of the rotator, and a gas flow rate adjusting mechanism is provided for controlling flow rate of gas passed through the ventilating portion.
摘要翻译：一种用于粉末或颗粒状原料如药物或食品等的造粒，涂布，混合，干燥等的机器。该机器包括用于包含原料的壳体，用于翻转并向材料提供离心力的旋转器在壳体中可水平旋转的壳体和设置在转子上方的至少一个分解器，用于细分不期望的大颗粒。在旋转体上方设置至少一个搅拌器，用于搅拌和捏合待造粒或涂覆的材料。旋转体可移动或固定在垂直位置，并且在环形狭缝形成环或壳体的内壁和旋转体的外周之间形成环形狭缝。狭缝形成环可在垂直位置上移动或固定。在旋转体的至少一部分上形成有至少一个通气部，并且设置有用于控制通过通气部的气体的流量的气体流量调节机构。

7. 发明授权

US4556175A Granulating and coating machine 失效
标题翻译：造粒机及涂布机
公开(公告)号：US4556175A
公开(公告)日：1985-12-03
申请号：US535387
申请日：1983-09-23
申请人： Shimesu Motoyama , Kaora Kurita , Shizuka Sakashita , Narimichi Takei , Shigeru Ohno
发明人： Shimesu Motoyama , Kaora Kurita , Shizuka Sakashita , Narimichi Takei , Shigeru Ohno
IPC分类号： B01J2/14 , B01J2/16 , B05B7/14 , F26B11/14 , B02C23/26
CPC分类号： B05B7/144 , B01J2/16 , B05B15/003 , F26B11/14
摘要： A granulating and coating machine for use in granulation, coating, mixing, drying etc. of powdery or granular materials. The machine includes a casing for holding the powdery or granular raw materials, a rotator for performing granulation or coating arranged at the bottom of the casing and formed with at least one ventilating porition, an annular slit formed between the periphery of the rotator and the inner wall of the casing. A gas flow adjusting mechanism including two separated ducts for gas flow is provided in order to control independently the rate of gas fed through the ventilating portion and the slit gas fed through the slit. An agitator for agitating the powdery or granular materials and a disintegrator for breaking undesirously large particles of the powdery or granular materials may be provided above the rotator. The slit may be formed by an annular slit forming ring mounted on the inner wall of the casing. The slit forming ring may be moved vertically by a slit adjusting mechanism to change the width of the slit so as to adjust the rate of flow of the slit gas fed through the slit.
摘要翻译：用于粉状或粒状物料的造粒，涂布，混合，干燥等的造粒和涂布机。该机器包括用于保持粉末或颗粒状原料的壳体，用于进行造粒或涂布的旋转器，布置在壳体的底部并形成有至少一个通风口，形成在旋转器的周边和内部外壳的墙壁。提供了包括用于气流的两个分开的管道的气流调节机构，以便独立地控制通过通风部分供给的气体和通过狭缝进料的狭缝气体的速率。用于搅拌粉状或粒状材料的搅拌器和用于破碎粉状或颗粒状材料的不希望的大颗粒的粉碎机可以设置在旋转器的上方。狭缝可以由安装在壳体的内壁上的环形狭缝形成环形成。狭缝形成环可以通过狭缝调节机构垂直移动以改变狭缝的宽度，以调节通过狭缝供给的狭缝气体的流动速率。

8. 发明授权

US4472960A Method of and apparatus for testing properties 失效
标题翻译：性能测试方法和设备
公开(公告)号：US4472960A
公开(公告)日：1984-09-25
申请号：US287687
申请日：1981-07-28
申请人： Shimesu Motoyama , Kaoru Kurita , Akira Iwasaki
发明人： Shimesu Motoyama , Kaoru Kurita , Akira Iwasaki
IPC分类号： G01N33/00 , G01N33/15 , G01N35/00 , G01N3/56 , G01N3/40
CPC分类号： G01N33/15 , G01N35/00 , G01N2033/0077
摘要： Method of and apparatus for testing required properties of the specimen solids such as tablets, pills, granules, capsules, etc. automatically and continuously. After nondestructive tests are performed, then destructive tests are performed automatically and continuously. The data obtained by the tests can be processed to record and display the processed data. The nondestructive tests comprise at least one of the tests of the weight, diameter, thickness, color difference, and surface area, etc. which are performed in order or simultaneously. The destructive tests comprise at least one of the tests of the hardness, disintegration, dissolution, abrasion and chemical analysis. The apparatus consists of supply a mechanism for supplying the solids, nondestructive test mechanisms, destructive test mechanisms and a system for transferring solids from one test position to the next test position.
摘要翻译：自动连续地测试样品固体如片剂，丸剂，颗粒剂，胶囊等所需性质的方法和装置。进行非破坏性试验后，自动连续进行破坏性试验。可以处理通过测试获得的数据来记录和显示处理的数据。非破坏性试验包括按顺序或同时进行的重量，直径，厚度，色差和表面积等的试验中的至少一种。破坏性测试包括硬度，分解，溶解，磨损和化学分析的至少一个测试。该设备包括提供用于供应固体的机构，非破坏性测试机构，破坏性测试机构和用于将固体从一个测试位置传递到下一个测试位置的系统。

9. 发明授权

US4027624A Fluid granulating/coating apparatus utilizing suction air current 失效
标题翻译：利用吸入气流的流体造粒/涂布装置
公开(公告)号：US4027624A
公开(公告)日：1977-06-07
申请号：US615123
申请日：1975-09-19
申请人： Shimesu Motoyama
发明人： Shimesu Motoyama
IPC分类号： A61J3/06 , B01J2/16 , B05B17/00
CPC分类号： B01J2/16
摘要： In the fluid granulating/coating apparatus to be worked by utilizing suction air current, a granulating/coating apparatus wherein a receptacle for accommodating bag filters as disposed in the upper part of the apparatus is in the shape of a cylinder with smooth interior, the suction air current is supposed to be discharged by way of one side wall of said cylindrical receptacle, a fan for generating the suction air current and a damper for stopping air suction are installed on the outside of said cylindrical receptacle, and a large-sized safety lid is installed on the upper part of the cylindrical receptacle.
摘要翻译：在通过利用吸入气流加工的流体造粒/涂布装置中，制粒/涂布装置，其中设置在装置的上部的用于容纳袋式过滤器的容器是具有平滑内部的气缸的形状，假设气流通过所述圆筒形容器的一个侧壁排出，用于产生吸入气流的风扇和用于停止吸气的阻尼器安装在所述圆筒形容器的外侧，并且安装有大型安全盖安装在圆柱形容器的上部。

10. 发明授权

US4640218A Tablet coating apparatus 失效
标题翻译：片剂涂布装置
公开(公告)号：US4640218A
公开(公告)日：1987-02-03
申请号：US537739
申请日：1983-09-30
申请人： Shimesu Motoyama , Masakazu Gotou , Hiromu Shirakawa , Takamoto Makino
发明人： Shimesu Motoyama , Masakazu Gotou , Hiromu Shirakawa , Takamoto Makino
IPC分类号： A23P1/00 , A23G3/26 , A61J3/00 , A61J3/06 , B01J2/00 , B01J2/12 , B01J2/14 , B05C5/00 , B05C19/00
CPC分类号： A61J3/005 , A23G3/26
摘要： An apparatus for coating pharmaceutical tablets or the like with other material such as sugar or the like. The apparatus includes a cylindrical rotary drum in which the tablets are charged and tumbled, and at least one perforated area for ventilating hot gas or the like so as to dry the sugar coated on the tablets. The perforated area of the drum is covered by a baffle plate. The leading edge of the baffle plate is in contact with the inner surface of the drum, and the trailing edge of the baffle plate forms a ventilating opening through which the hot gas flows. The side edges of the baffle plate is provided with side plates. The ventilating opening is provided with a ventilating plate.
摘要翻译：用其他材料如糖等涂覆药片等的装置。该装置包括一个圆柱形的旋转鼓，其中片剂被装载和翻滚，以及至少一个用于通风热气等的穿孔区域，以便干燥涂在片剂上的糖。滚筒的穿孔区域被挡板覆盖。挡板的前缘与滚筒的内表面接触，挡板的后缘形成热气流过的通风口。挡板的侧边缘设有侧板。通风口设有通风板。

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