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1. 发明授权

US5777032A Ocular lens and a method for its production 失效
标题翻译：眼镜及其制作方法
公开(公告)号：US5777032A
公开(公告)日：1998-07-07
申请号：US805575
申请日：1997-02-25
申请人： Yasuhiro Yokoyama , Yuriko Watanabe , Sadayasu Tanikawa , Shoji Ichinohe , Toshio Yamazaki
发明人： Yasuhiro Yokoyama , Yuriko Watanabe , Sadayasu Tanikawa , Shoji Ichinohe , Toshio Yamazaki
IPC分类号： C08J7/12 , G02B1/04 , C08F8/30
CPC分类号： C08J7/12 , G02B1/043 , C08J2300/104
摘要： An ocular lens obtained by reacting a hydroxyl group-containing polymer shaped to have an ocular lens shape, with a silicon-containing compound of the formula (I): O.dbd.C.dbd.N--R.sup.1 --Si.sub.n O.sub.n-1 (CH.sub.3).sub.2n+1 (I) wherein R.sup.1 is a C.sub.1-6 linear or branched alkylene group, and n is an integer of from 1 to 15.
摘要翻译：通过使具有眼透镜形状的含羟基的聚合物与式（I）的含硅化合物反应获得的眼晶状体：O = C = N-R1-SinOn-1（CH3）2n + 1 （I）其中R1为C1-6直链或支链亚烷基，n为1〜15的整数。

2. 发明授权

US06495651B1 Process for preparing urethane compound for medical instruments 有权
标题翻译：制备医疗器械用聚氨酯化合物的方法
公开(公告)号：US06495651B1
公开(公告)日：2002-12-17
申请号：US09608004
申请日：2000-06-30
申请人： Tsuyoshi Watanabe , Eri Ito , Sadayasu Tanikawa , Shoji Ichinohe , Toshio Yamazaki
发明人： Tsuyoshi Watanabe , Eri Ito , Sadayasu Tanikawa , Shoji Ichinohe , Toshio Yamazaki
IPC分类号： C08G1822
CPC分类号： C08G18/8175 , C08G18/2063 , C08G18/222 , C08G18/672 , C08G18/61
摘要： A process for preparing an urethane compound for medical instruments, characterized by reacting a hydroxyl compound (A) with an isocyanate compound (B) in the absence of a catalyst or in the presence of a reaction catalyst other than an organic tin compound to give an urethane compound (I). According to the process, the urethane compound showing high safety can be easily prepared, in particular, while molecular weight of the compound is controlled.
摘要翻译：一种用于医疗器械的氨基甲酸酯化合物的制备方法，其特征在于在不存在催化剂的情况下或在除有机锡化合物以外的反应催化剂存在下使羟基化合物（A）与异氰酸酯化合物（B）反应，得到氨基甲酸酯化合物（I）。根据该方法，可以容易地制备显示高安全性的氨基甲酸酯化合物，特别是在控制化合物的分子量时。

3. 发明授权

US06770728B2 Process for preparing ocular lens with urethane compound and process for preparing urethane compound for medical instruments 失效
标题翻译：用氨基甲酸酯化合物制备眼镜片的方法和用于制备医疗器械的聚氨酯化合物的方法
公开(公告)号：US06770728B2
公开(公告)日：2004-08-03
申请号：US10284112
申请日：2002-10-31
申请人： Tsuyoshi Watanabe , Eri Ito , Sadayasu Tanikawa , Shoji Ichinohe , Toshio Yamazaki , Mouad Lamrani
发明人： Tsuyoshi Watanabe , Eri Ito , Sadayasu Tanikawa , Shoji Ichinohe , Toshio Yamazaki , Mouad Lamrani
IPC分类号： C08G1822
CPC分类号： C08G18/2063 , C08G18/222 , C08G18/672 , C08G18/8175 , C08G18/61
摘要： A process for preparing an ocular lens with a urethane compound comprising the steps of a) preparing a urethane compound by reacting at least one hydroxyl compound and at least one isocyanate compound in the presence of an organic iron compound, b) removing the organic iron compound from the urethane compound obtained in the step a) c) mixing the urethane compound obtained in the step b) with at least one compound selected from the group consisting of another copolymerizable compound, a crosslinking agent, a UV absorbent, a dye, a polymerization initiator, a photosensitizer, and an organic solvent to obtain a mixture, and d) curing the mixture obtained in the step c) to prepare a lens.
摘要翻译：一种制备具有氨基甲酸酯化合物的眼用透镜的方法，包括以下步骤：a）在有机铁化合物存在下使至少一种羟基化合物和至少一种异氰酸酯化合物反应制备氨基甲酸酯化合物，b）从有机铁化合物中除去有机铁化合物在步骤a）中获得的氨基甲酸酯化合物c）将步骤b）中获得的氨基甲酸酯化合物与至少一种选自另一种可共聚化合物，交联剂，UV吸收剂，染料，聚合引发剂，光敏剂和有机溶剂以获得混合物，并且d）固化步骤c）中获得的混合物以制备透镜。

4. 发明授权

US06770727B2 Process for preparing urethane compound for medical instruments 有权
标题翻译：制备医疗器械用聚氨酯化合物的方法
公开(公告)号：US06770727B2
公开(公告)日：2004-08-03
申请号：US10284104
申请日：2002-10-31
申请人： Tsuyoshi Watanabe , Eri Ito , Sadayasu Tanikawa , Shoji Ichinohe , Toshio Yamazaki
发明人： Tsuyoshi Watanabe , Eri Ito , Sadayasu Tanikawa , Shoji Ichinohe , Toshio Yamazaki
IPC分类号： C08G1822
CPC分类号： C08G18/8175 , C08G18/2063 , C08G18/222 , C08G18/672 , C08G18/61
摘要： A process for preparing an urethane compound for medical instruments, characterized by reacting a hydroxyl compound (A) with an isocyanate compound (B) in the absence of a catalyst or in the presence of a reaction catalyst other than an organic tin compound to give an urethane compound (I). According to the process, the urethane compound showing high safety can be easily prepared, in particular, while molecular weight of the compound is controlled.
摘要翻译：一种用于医疗器械的氨基甲酸酯化合物的制备方法，其特征在于在不存在催化剂的情况下或在除有机锡化合物以外的反应催化剂存在下使羟基化合物（A）与异氰酸酯化合物（B）反应，得到氨基甲酸酯化合物（I）。根据该方法，可以容易地制备显示高安全性的氨基甲酸酯化合物，特别是在控制化合物的分子量时。

5. 发明授权

US06544953B2 Ophthalmic composition 失效
标题翻译：眼科成分
公开(公告)号：US06544953B2
公开(公告)日：2003-04-08
申请号：US09833621
申请日：2001-04-13
申请人： Akira Tsuzuki , Sadayasu Tanikawa
发明人： Akira Tsuzuki , Sadayasu Tanikawa
IPC分类号： A61K3170
CPC分类号： A61L12/14 , Y10S514/912
摘要： An ophthalmic composition which contains a component A consisting of at least one member selected from the group consisting of polyoxyalkylene block copolymers and their derivatives, and a component B consisting of at least one member selected from the group consisting of glycyrrhizic acid and its salts.
摘要翻译：含有由选自聚氧化烯嵌段共聚物及其衍生物中的至少一种的组分A和由选自甘草酸及其盐中的至少一种构成的组分B的组合物A的眼用组合物。

6. 发明申请

US20060052340A1 Ophthalmic solution 审中-公开
标题翻译：眼科溶液
公开(公告)号：US20060052340A1
公开(公告)日：2006-03-09
申请号：US11265130
申请日：2005-11-02
申请人： Akira Tsuzuki , Sayuri Iwamuro , Sadayasu Tanikawa
发明人： Akira Tsuzuki , Sayuri Iwamuro , Sadayasu Tanikawa
IPC分类号： A61K31/716
CPC分类号： A61K47/38 , A61K9/0048
摘要： It is an object of the present invention to provide an ophthalmic solution, which provides an enhanced comfort by suitably exhibiting an moisturizing effect to an eye and advantageously preventing an occurrence of unpleasant feelings caused by fluctuation of visual acuity. The ophthalmic solution of the present invention is provided by dissolving, in an aqueous medium, a hydroxypropylmethylcellulose, which has a molecular weight below a critical molecular weight for entanglements of an aqueous solution, which contains 3 w/w % of the hydroxypropylmethylcellulose, wherein kinematic viscosity of the ophthalmic solution at 20° C. is not higher than 2 mm2/s.
摘要翻译：本发明的目的是提供一种眼用溶液，其通过适当地对眼睛具有保湿作用而提供增强的舒适性，并且有利地防止由视力波动引起的令人不快的感觉的发生。本发明的眼用溶液是通过在水性介质中溶解羟丙基甲基纤维素而得到的羟丙基甲基纤维素，该羟丙基甲基纤维素的分子量低于临界分子量，用于含有3w / w％的羟丙基甲基纤维素的水溶液的缠结，其中运动学眼用溶液在20℃下的粘度不高于2mmHg。

7. 发明申请

US20060035842A1 Ophthalmic composition 审中-公开
标题翻译：眼科成分
公开(公告)号：US20060035842A1
公开(公告)日：2006-02-16
申请号：US11229290
申请日：2005-09-16
申请人： Akira Tsuzuki , Sadayasu Tanikawa
发明人： Akira Tsuzuki , Sadayasu Tanikawa
IPC分类号： A61K31/70 , A61K31/16
CPC分类号： A61K9/0024 , A61K9/0048 , A61K9/0085 , A61K31/155 , A61K31/16 , A61K31/785 , A61K47/26 , A61K47/34
摘要： It is an object of the present invention to provide an ophthalmic composition, wherein: the ophthalmic composition assures a sufficiently high degree of safety to eyes of the lens wearer; the ophthalmic composition reduces symptoms such as an unpleasant feeling or dryness of the eyes; the ophthalmic composition does not adversely affect a contact lens, such as a change of the size of the contact lens; and the ophthalmic composition advantageously improves a water wettability of surfaces of the contact lens, and the ophthalmic composition for the contact lens is prepared by adding at least one specific amino-sugar derivative to an aqueous medium.
摘要翻译：本发明的目的是提供一种眼用组合物，其中：所述眼用组合物确保对眼镜佩戴者的眼睛具有足够高的安全性; 眼用组合物可减轻眼睛不适感或干燥症状。眼用组合物不会对隐形眼镜产生不利影响，例如隐形眼镜尺寸的变化; 并且眼用组合物有利地改善了隐形眼镜表面的水润湿性，并且通过向水性介质中加入至少一种特定的氨基糖衍生物来制备隐形眼镜用眼用组合物。

8. 发明授权

US5919742A Contact lens cleaning material formed of a polymer 失效
标题翻译：由聚合物形成的隐形眼镜清洁材料
公开(公告)号：US5919742A
公开(公告)日：1999-07-06
申请号：US901773
申请日：1997-07-28
申请人： Akira Tsuzuki , Sadayasu Tanikawa
发明人： Akira Tsuzuki , Sadayasu Tanikawa
IPC分类号： G02C13/00 , A61L2/18 , C11D1/68 , C11D3/00 , C11D3/37 , C11D3/48 , C11D17/00
CPC分类号： C11D3/0078 , C11D3/3757
摘要： A cleaning material for a contact lens formed of a polymer which is obtained by polymerizing a polymeric composition including at least a nonionic surface active agent having a polymerizable unsaturated double bond, and a cross-linking agent having a plurality of polymerizable unsaturated double bonds.
摘要翻译：一种由聚合物形成的隐形眼镜用清洁材料，该聚合物是通过聚合至少包含具有可聚合不饱和双键的非离子表面活性剂的聚合物组合物和具有多个可聚合不饱和双键的交联剂而获得的。

9. 发明授权

US07261844B2 Photochromic contact lens having excellent discoloring characteristic 失效
标题翻译：具有优异褪色特性的光致变色隐形眼镜
公开(公告)号：US07261844B2
公开(公告)日：2007-08-28
申请号：US11175888
申请日：2005-07-06
申请人： Sadayasu Tanikawa , Naotaka Kamiya , Shigeyasu Nagai
发明人： Sadayasu Tanikawa , Naotaka Kamiya , Shigeyasu Nagai
IPC分类号： G02B5/23 , G02B1/04 , G02C7/04 , C07D265/12
CPC分类号： G02B1/043 , G02C7/04 , G02C7/102 , G02C7/105 , C08L25/18 , C08L43/04
摘要： A photochromic contact lens having a period of time for discoloring the contact lens from a colored state to the uncolored state shortened, wherein the photochromic contact lens is made of an oxygen-permeable polymer material having a second-order transition point of not higher than 110° C., and formed to have an oxygen permeation coefficient of not less than 50, and wherein the contact lens contains a dye capable of exhibiting photochromism.
摘要翻译：具有将隐形眼镜从着色状态变色至未着色状态的一段时间的光致变色隐形眼镜缩短，其中光致变色隐形眼镜由二级转变点不高于110°的透氧性聚合物材料制成并且形成为具有不小于50的氧气渗透系数，并且其中隐形眼镜含有能够显示光致变色的染料。

10. 发明申请

US20050243273A1 Photochromic contact lens having excellent discoloring characteristic 失效
标题翻译：具有优异褪色特性的光致变色隐形眼镜
公开(公告)号：US20050243273A1
公开(公告)日：2005-11-03
申请号：US11175888
申请日：2005-07-06
申请人： Sadayasu Tanikawa , Naotaka Kamiya , Shigeyasu Nagai
发明人： Sadayasu Tanikawa , Naotaka Kamiya , Shigeyasu Nagai
IPC分类号： G02B1/04 , G02C7/04 , G02C7/10
CPC分类号： G02B1/043 , G02C7/04 , G02C7/102 , G02C7/105 , C08L25/18 , C08L43/04
摘要： A photochromic contact lens having a period of time for discoloring the contact lens from a colored state to the uncolored state shortened, wherein the photochromic contact lens is made of an oxygen-permeable polymer material having a second-order transition point of not higher than 110° C., and formed to have an oxygen permeation coefficient of not less than 50, and wherein the contact lens contains a dye capable of exhibiting photochromism.
摘要翻译：具有将隐形眼镜从着色状态变色至未着色状态的一段时间的光致变色隐形眼镜缩短，其中光致变色隐形眼镜由二级转变点不高于110°的透氧性聚合物材料制成并且形成为具有不小于50的氧气渗透系数，并且其中隐形眼镜含有能够显示光致变色的染料。

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