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1. 发明授权

US06770728B2 Process for preparing ocular lens with urethane compound and process for preparing urethane compound for medical instruments 失效
标题翻译：用氨基甲酸酯化合物制备眼镜片的方法和用于制备医疗器械的聚氨酯化合物的方法
公开(公告)号：US06770728B2
公开(公告)日：2004-08-03
申请号：US10284112
申请日：2002-10-31
申请人： Tsuyoshi Watanabe , Eri Ito , Sadayasu Tanikawa , Shoji Ichinohe , Toshio Yamazaki , Mouad Lamrani
发明人： Tsuyoshi Watanabe , Eri Ito , Sadayasu Tanikawa , Shoji Ichinohe , Toshio Yamazaki , Mouad Lamrani
IPC分类号： C08G1822
CPC分类号： C08G18/2063 , C08G18/222 , C08G18/672 , C08G18/8175 , C08G18/61
摘要： A process for preparing an ocular lens with a urethane compound comprising the steps of a) preparing a urethane compound by reacting at least one hydroxyl compound and at least one isocyanate compound in the presence of an organic iron compound, b) removing the organic iron compound from the urethane compound obtained in the step a) c) mixing the urethane compound obtained in the step b) with at least one compound selected from the group consisting of another copolymerizable compound, a crosslinking agent, a UV absorbent, a dye, a polymerization initiator, a photosensitizer, and an organic solvent to obtain a mixture, and d) curing the mixture obtained in the step c) to prepare a lens.
摘要翻译：一种制备具有氨基甲酸酯化合物的眼用透镜的方法，包括以下步骤：a）在有机铁化合物存在下使至少一种羟基化合物和至少一种异氰酸酯化合物反应制备氨基甲酸酯化合物，b）从有机铁化合物中除去有机铁化合物在步骤a）中获得的氨基甲酸酯化合物c）将步骤b）中获得的氨基甲酸酯化合物与至少一种选自另一种可共聚化合物，交联剂，UV吸收剂，染料，聚合引发剂，光敏剂和有机溶剂以获得混合物，并且d）固化步骤c）中获得的混合物以制备透镜。

2. 发明申请

US20120164208A1 CHITOSAN HYDROGEL DERIVATIVES AS A COATING AGENT WITH BROAD SPECTRUM OF ANTIMICROBIAL ACTIVITIES 有权
标题翻译： CHOSOSAN氢化衍生物作为具有广谱抗体活性的涂层剂
公开(公告)号：US20120164208A1
公开(公告)日：2012-06-28
申请号：US13383684
申请日：2009-07-13
申请人： Chan Bee Eng Mary , Poon Yin Fun , Mouad Lamrani , Shinichi Hamaguchi
发明人： Chan Bee Eng Mary , Poon Yin Fun , Mouad Lamrani , Shinichi Hamaguchi
IPC分类号： A61K9/00 , A61K31/722 , A61K8/60 , C08B37/08
CPC分类号： A61L27/34 , A61K8/042 , A61K8/736 , A61L27/20 , A61L27/52 , A61L27/54 , A61L29/043 , A61L29/085 , A61L29/145 , A61L31/042 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/232 , A61L2300/404 , A61Q19/00 , C08B37/003 , C08F290/10 , C08G81/00 , C08J3/075 , C08J3/24 , C08J3/28 , C08J2305/08 , G02B1/043 , C08L1/00 , C08F220/28 , C08L5/08
摘要： The present invention relates to water soluble quaternized chitosan derivatives which form hydrogel matrix with broad antimicrobial properties for the protection and coating of medical device. Hydrogel is attractive as an antimicrobial coating since its hydrophilicity intrinsically prevents the reversible nonspecific attachment of microbes.In order to achieve hydrogel formation, quaternized chitosan can be grafted with polymerizable groups, especially photocrosslinkable groups, such as methacrylates, PEG derivatives and be converted into hydrogels through a thermal or UV polymerization process. Hydrogels are hydrated cross-linked polymeric systems that contain water in an equilibrium state forming cushion water shield. The present invention is widely used in many medical devices for example biomedical devices such as contact lenses, bio-implants such as urinary catheters, pacemaker, heart valves, artificial heart, mammary prosthesis, intraocular lenses, wound dressings, artificial organs and delivery carriers for the bioactive reagents, total joint replacement due to their high degree of biocompatibility, antimicrobial property and good wetting characteristics. This invention describes the formation of novel hydrogels based on quaternized ammonium chitosan derivatives which has been grafted with photocrosslinkable groups, hence providing hydrogels as antimicrobial water shield coating agent.
摘要翻译：本发明涉及水溶性季铵化壳聚糖衍生物，其形成具有广泛抗微生物性质的水凝胶基质用于保护和涂覆医疗装置。水凝胶作为抗微生物涂层是有吸引力的，因为它的亲水性本质上防止微生物的可逆非特异性附着。为了实现水凝胶形成，季铵化壳聚糖可以用可聚合基团，特别是可光致交联的基团如甲基丙烯酸酯，PEG衍生物接枝，并通过热或UV聚合方法转化成水凝胶。水凝胶是水合交联聚合物体系，其在平衡状态下形成缓冲水屏蔽层。本发明广泛用于诸如隐形眼镜，诸如导尿管，心脏起搏器，心脏瓣膜，人造心脏，乳房假体，人工晶状体，伤口敷料，人造器官和输送载体等生物医学装置的生物医学装置生物活性试剂，由于其高生物相容性，抗菌性和良好的润湿特性而导致的总关节置换。本发明描述了基于已经用光可交联基团接枝的季铵化壳聚糖衍生物的新型水凝胶的形成，因此提供水凝胶作为抗微生物水屏蔽涂层剂。

3. 发明申请

US20140193476A1 CHITOSAN HYDROGEL DERIVATIVES AS A COATING AGENT WITH BROAD SPECTRUM OF ANTIMICROBIAL ACTIVITIES 有权
标题翻译： CHOSOSAN氢化衍生物作为具有广谱抗体活性的涂层剂
公开(公告)号：US20140193476A1
公开(公告)日：2014-07-10
申请号：US14209602
申请日：2014-03-13
申请人： Chan Bee Eng Mary , Poon Yin Fun , Mouad Lamrani , Shinichi Hamaguchi
发明人： Chan Bee Eng Mary , Poon Yin Fun , Mouad Lamrani , Shinichi Hamaguchi
IPC分类号： A61L27/34 , A61L27/20 , A61K8/73 , A61L27/54
CPC分类号： A61L27/34 , A61K8/042 , A61K8/736 , A61L27/20 , A61L27/52 , A61L27/54 , A61L29/043 , A61L29/085 , A61L29/145 , A61L31/042 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/232 , A61L2300/404 , A61Q19/00 , C08B37/003 , C08F290/10 , C08G81/00 , C08J3/075 , C08J3/24 , C08J3/28 , C08J2305/08 , G02B1/043 , C08L1/00 , C08F220/28 , C08L5/08
摘要： The present invention relates to water soluble quaternized chitosan derivatives which form hydrogel matrix with broad antimicrobial properties for the protection and coating of medical device. Hydrogel is attractive as an antimicrobial coating since its hydrophilicity intrinsically prevents the reversible nonspecific attachment of microbes.In order to achieve hydrogel formation, quaternized chitosan can be grafted with polymerizable groups, especially photocrosslinkable groups, such as methacrylates, PEG derivatives and be converted into hydrogels through a thermal or UV polymerization process. Hydrogels are hydrated cross-linked polymeric systems that contain water in an equilibrium state forming cushion water shield. The present invention is widely used in many medical devices. This invention describes the formation of novel hydrogels based on quaternized ammonium chitosan derivatives which has been grafted with photocrosslinkable groups, hence providing hydrogels as antimicrobial water shield coating agent.
摘要翻译：本发明涉及水溶性季铵化壳聚糖衍生物，其形成具有广泛抗微生物性质的水凝胶基质用于保护和涂覆医疗装置。水凝胶作为抗微生物涂层是有吸引力的，因为它的亲水性本质上防止微生物的可逆非特异性附着。为了实现水凝胶形成，季铵化壳聚糖可以用可聚合基团，特别是可光致交联的基团如甲基丙烯酸酯，PEG衍生物接枝，并通过热或UV聚合方法转化成水凝胶。水凝胶是水合交联聚合物体系，其在平衡状态下形成缓冲水屏蔽层。本发明广泛应用于许多医疗装置。本发明描述了基于已经用光可交联基团接枝的季铵化壳聚糖衍生物的新型水凝胶的形成，因此提供水凝胶作为抗微生物水屏蔽涂层剂。

4. 发明授权

US08709470B2 Chitosan hydrogel derivatives as a coating agent with broad spectrum of antimicrobial activities 有权
标题翻译：壳聚糖水凝胶衍生物作为具有广谱抗菌活性的涂层剂
公开(公告)号：US08709470B2
公开(公告)日：2014-04-29
申请号：US13383684
申请日：2009-07-13
申请人： Chan Bee Eng Mary , Poon Yin Fun , Mouad Lamrani , Shinichi Hamaguchi
发明人： Chan Bee Eng Mary , Poon Yin Fun , Mouad Lamrani , Shinichi Hamaguchi
IPC分类号： A61K9/00 , A61K31/722 , A61K8/60 , C08B37/08
CPC分类号： A61L27/34 , A61K8/042 , A61K8/736 , A61L27/20 , A61L27/52 , A61L27/54 , A61L29/043 , A61L29/085 , A61L29/145 , A61L31/042 , A61L31/10 , A61L31/145 , A61L31/16 , A61L2300/232 , A61L2300/404 , A61Q19/00 , C08B37/003 , C08F290/10 , C08G81/00 , C08J3/075 , C08J3/24 , C08J3/28 , C08J2305/08 , G02B1/043 , C08L1/00 , C08F220/28 , C08L5/08
摘要： The present invention relates to water soluble quaternized chitosan derivatives which form hydrogel matrix with broad antimicrobial properties for the protection and coating of medical device. Hydrogel is attractive as an antimicrobial coating since its hydrophilicity intrinsically prevents the reversible nonspecific attachment of microbes.In order to achieve hydrogel formation, quaternized chitosan can be grafted with polymerizable groups, especially photocrosslinkable groups, such as methacrylates, PEG derivatives and be converted into hydrogels through a thermal or UV polymerization process. Hydrogels are hydrated cross-linked polymeric systems that contain water in an equilibrium state forming cushion water shield. The present invention is widely used in many medical devices. This invention describes the formation of novel hydrogels based on quaternized ammonium chitosan derivatives which has been grafted with photocrosslinkable groups, hence providing hydrogels as antimicrobial water shield coating agent.
摘要翻译：本发明涉及水溶性季铵化壳聚糖衍生物，其形成具有广泛抗微生物性质的水凝胶基质用于保护和涂覆医疗装置。水凝胶作为抗微生物涂层是有吸引力的，因为它的亲水性本质上防止微生物的可逆非特异性附着。为了实现水凝胶形成，季铵化壳聚糖可以用可聚合基团，特别是可光致交联的基团如甲基丙烯酸酯，PEG衍生物接枝，并通过热或UV聚合方法转化成水凝胶。水凝胶是水合交联聚合物体系，其在平衡状态下形成缓冲水屏蔽层。本发明广泛应用于许多医疗装置。本发明描述了基于已经用光可交联基团接枝的季铵化壳聚糖衍生物的新型水凝胶的形成，因此提供水凝胶作为抗微生物水屏蔽涂层剂。

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