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    • 2. 发明授权
    • Process for production of 5-ene-3-one or 3,6-dione derivatives of sterols, processes for production of lipid metabolism improvers, foods, drinks, and animal feeds, and analytical method
    • 甾醇的5-烯-3-酮或3,6-二酮衍生物的制备方法,脂质代谢改进剂的生产方法,食品,饮料和动物饲料,以及分析方法
    • US08008040B2
    • 2011-08-30
    • US11632072
    • 2005-07-12
    • Kunio SuzukiTadashi NagashimaShinya Nagahashi
    • Kunio SuzukiTadashi NagashimaShinya Nagahashi
    • C12P33/00
    • C12P33/00
    • An object of the present invention is to provide a process according to which 5-ene-3-one or 3,6-dione derivatives of sterols can be synthesized with a better yield, as well as a process for production of lipid metabolism improvers, foods, drinks, and animal feeds containing the 5-ene-3-one or 3,6-dione derivatives of sterols.The process for production of 5-ene-3-one or 3,6-dione derivatives of sterols of the present invention involves preparing a culturing solution containing an Arthrobacter bacterium, which is a microorganism exhibiting a cholesterol oxidase activity, and then, adding to the culturing solution an equivalent amount of hexane so as to prepare a bilayer solution consisting of an aqueous layer and a hydrocarbon-based solvent layer. Thereafter, sterol, or a derivative thereof, is made as a substrate contained therein, a reaction performed with cholesterol oxidase at 30° C. for 2 days, and, ethanol then added to separate a hydrocarbon-based solvent layer. Thereafter, the layer is dried to a state of dryness by means of a vacuum dryer so as to obtain 5-ene-3-one or 3,6-dione derivatives.
    • 本发明的目的是提供可以以更好的产率合成甾醇的5-烯-3-酮或3,6-二酮衍生物的方法,以及脂质代谢改进剂的生产方法, 含有甾醇的5-烯-3-酮或3,6-二酮衍生物的食品,饮料和动物饲料。 制备本发明的甾醇的5-烯-3-酮或3,6-二酮衍生物的方法包括制备含有作为显示胆固醇氧化酶活性的微生物的节杆菌细菌的培养液,然后加入 培养液中加入等量的己烷,以制备由水层和烃基溶剂层组成的双层溶液。 此后,将固醇或其衍生物作为其中含有的底物,在30℃下用胆固醇氧化酶进行反应2天,然后加入乙醇以分离烃基溶剂层。 此后,通过真空干燥器将该层干燥至干燥状态,以获得5-烯-3-酮或3,6-二酮衍生物。
    • 3. 发明申请
    • Process for Production of 5-Ene-3-One or 3,6-Dione Derivatives of Sterols, Processes for Production of Lipid Metabolism Improvers, Foods, Drinks, and Animal Feeds, and Analytical Method
    • 甾醇的5-烯-3-酮或3,6-二酮衍生物的制备方法,脂质代谢改良剂,食品,饮料和动物饲料的生产方法和分析方法
    • US20080248520A1
    • 2008-10-09
    • US11632072
    • 2005-07-12
    • Kunio SuzukiTadashi NagashimaShinya Nagahashi
    • Kunio SuzukiTadashi NagashimaShinya Nagahashi
    • C12P33/00G01N30/02
    • C12P33/00
    • An object of the present invention is to provide a process according to which 5-ene-3-one or 3,6-dione derivatives of sterols can be synthesized with a better yield, as well as a process for production of lipid metabolism improvers, foods, drinks, and animal feeds containing the 5-ene-3-one or 3,6-dione derivatives of sterols.The process for production of 5-ene-3-one or 3,6-dione derivatives of sterols of the present invention involves preparing a culturing solution containing an Arthrobacter bacterium, which is a microorganism exhibiting a cholesterol oxidase activity, and then, adding to the culturing solution an equivalent amount of hexane so as to prepare a bilayer solution consisting of an aqueous layer and a hydrocarbon-based solvent layer. Thereafter, sterol, or a derivative thereof, is made as a substrate contained therein, a reaction performed with cholesterol oxidase at 30° C. for 2 days, and, ethanol then added to separate a hydrocarbon-based solvent layer. Thereafter, the layer is dried to a state of dryness by means of a vacuum dryer so as to obtain 5-ene-3-one or 3,6-dione derivatives.
    • 本发明的目的是提供可以以更好的产率合成甾醇的5-烯-3-酮或3,6-二酮衍生物的方法,以及脂质代谢改进剂的生产方法, 含有甾醇的5-烯-3-酮或3,6-二酮衍生物的食品,饮料和动物饲料。 制备本发明的甾醇的5-烯-3-酮或3,6-二酮衍生物的方法包括制备含有节杆菌属细菌的培养液,其为显示胆固醇氧化酶活性的微生物,然后加入 培养液中加入等量的己烷,以制备由水层和烃基溶剂层组成的双层溶液。 此后,将固醇或其衍生物作为其中含有的底物,在30℃下用胆固醇氧化酶进行反应2天,然后加入乙醇以分离烃基溶剂层。 此后,通过真空干燥器将该层干燥至干燥状态,以获得5-烯-3-酮或3,6-二酮衍生物。
    • 4. 发明授权
    • Paper feeding apparatus in web threading apparatus
    • 卷筒纸穿线装置中的送纸装置
    • US5921453A
    • 1999-07-13
    • US021003
    • 1998-02-09
    • Kunio Suzuki
    • Kunio Suzuki
    • B41F13/06B41F13/03B41F33/06B65H19/10B65H20/02G03B1/56B65H20/24
    • G03B1/56B41F13/03B65H20/02B65H2301/522B65H2403/42B65H2801/21
    • A paper feeding apparatus is provided for use in a web threading apparatus of a rotary press for threading a web along a web threading path by drawing a leading end of the web using a web threading member movably provided on an outside portion of the web threading path and along the web threading path. The paper feeding apparatus includes a pair of an upstream roller and a downstream roller extending substantially parallel to a width direction of the web in the web threading path, and a driving mechanism for driving the upstream and downstream rollers in a feeding direction of the web and for ensuring that a peripheral speed of the downstream roller is at least equal to a moving speed of the web threading member. The upstream and downstream rollers are offset on an upstream side and a downstream side in a direction of the web threading path so that the web is not nipped by both the upstream roller and the downstream roller. A peripheral surface of one of the upstream and downstream rollers contacts a first side surface of the web and a peripheral surface of the other of the upstream and downstream rollers contacts a second side surface of the web, in a manner such that slipping between the rollers and the web is increased in response to a lowering of a tension on the web and such that slipping between the rollers and the web is decreased in response to an increase of the tension on the web. In addition, the upstream roller is displaceable in accordance with a variation of the tension on the web so as to constantly apply a force against the tension.
    • 一种供纸装置,用于旋转印刷机的卷筒纸穿线装置中,用于通过使用可移动地设置在卷筒纸穿线路径的外侧部分上的卷筒纸穿纱件拉伸卷筒纸的前端,沿着卷筒纸穿线路径来卷绕纸卷 并沿着网络线程路径。 供纸装置包括一对上游辊和下游辊,该辊沿着幅材穿过路径中的幅材的宽度方向基本上平行延伸;以及驱动机构,用于沿纸幅的进给方向驱动上游辊和下游辊;以及 用于确保下游辊的圆周速度至少等于卷筒纸穿线构件的移动速度。 上游辊和下游辊在幅材穿线路径的方向上的上游侧和下游侧偏移,使得幅材不被上游辊和下游辊夹持。 上游辊和下游辊中的一个的周边表面接触幅材的第一侧表面,并且另一个上游辊和下游辊的外周表面以这样的方式接触纸幅的第二侧表面,使得在辊之间滑动 并且纤维网响应于纸幅上的张力的降低而增加,并且响应于幅材上的张力的增加,辊和纸幅之间的滑动减小。 此外,上游辊可以根据幅材上的张力的变化而移位,以便不断地施加抵抗张力的力。