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1. 发明授权

US08048842B2 Thickening/foam-promoting agent 有权
标题翻译：增稠/促泡剂
公开(公告)号：US08048842B2
公开(公告)日：2011-11-01
申请号：US12090970
申请日：2006-10-31
申请人： Yasuhiro Doi , Masaki Inoue , Kaoru Omae , Yoshinori Tamura
发明人： Yasuhiro Doi , Masaki Inoue , Kaoru Omae , Yoshinori Tamura
IPC分类号： C11D1/722 , A61K8/39 , A61Q5/02 , C07C43/11
CPC分类号： C11D1/722 , A61K8/046 , A61K8/39 , A61Q5/02 , A61Q19/10 , C07C41/03 , C07C43/11 , C11D1/721 , C11D3/0094
摘要： The present invention provides a thickening/foam-promoting agent having thickening/foam-promoting properties and a low odor, and a detergent composition containing the agent. The thickening/foam-promoting agent is composed of the following component (A):(A) a compound represented by the following formula (1): R1O—(PO)n/(EO)m—R2 (1), wherein R1 is a linear alkyl or an alkenyl group having 8 to 10 carbon atoms, PO is a propyleneoxy group, EO is an ethyleneoxy group, an average added molar number n is a number of 1.5 to 3.0, an average added molar number m is a number of 0 to 1.0, and R2 is a hydrogen atom or a methyl group, wherein the content of an alcohol of the formula (1), when n=0, m=0 and R2 is a hydrogen atom, is not more than 3000 ppm, and the detergent composition contains the component (A) and a surfactant (B).
摘要翻译：本发明提供具有增稠/促泡性和低气味的增稠/促泡剂和含有该试剂的洗涤剂组合物。增稠/增泡剂由以下组分（A）组成：（A）由下式（1）表示的化合物：R 1 O-（PO）n /（EO）m -R 2（1），其中R 1 是具有8〜10个碳原子的直链烷基或烯基，PO是亚丙氧基，EO是乙烯氧基，平均加成摩尔数n是1.5〜3.0的数，平均加成摩尔数m是数为0〜1.0，R2为氢原子或甲基，其中，当n = 0，m = 0，R2为氢原子时，式（1）的醇的含量为3000ppm以下，洗涤剂组合物含有成分（A）和表面活性剂（B）。

2. 发明申请

US20090124523A1 THICKENING/FOAM-PROMOTING AGENT 有权
标题翻译：增稠/泡沫促进剂
公开(公告)号：US20090124523A1
公开(公告)日：2009-05-14
申请号：US12090970
申请日：2006-10-31
申请人： Yasuhiro Dol , Masaki Inoue , Kaoru Omae , Yoshinori Tamura
发明人： Yasuhiro Dol , Masaki Inoue , Kaoru Omae , Yoshinori Tamura
IPC分类号： A61K8/33 , A61Q19/10 , A61Q5/02 , B01F17/00
CPC分类号： C11D1/722 , A61K8/046 , A61K8/39 , A61Q5/02 , A61Q19/10 , C07C41/03 , C07C43/11 , C11D1/721 , C11D3/0094
摘要： The present invention provides a thickening/foam-promoting agent having thickening/foam-promoting properties and a low odor, as well as a detergent composition containing the same therein.The thickening/foam-promoting agent is composed of the following component (A): (A) a compound represented by the following general formula (1): R1O—(PO)n/(EO)m—R2 (1) (wherein, R1 represents a linear alkyl or an alkenyl group having 8 to 10 carbon atoms, PO represents a propyleneoxy group, EO represents an ethyleneoxy group, an average added molar number n represents a number of 1.5 to 3.0, an average added molar number m represents a number of 0 to 1.0, and R2 represents a hydrogen atom or a methyl group), wherein, the content of an alcohol of the formula (1), wherein n=0, m=0 and R2 is a hydrogen atom, is not more than 3000 ppm, and the detergent composition contains the component (A) and a surfactant (B).
摘要翻译：本发明提供具有增稠/促泡性和低气味的增稠/增泡剂，以及含有其的洗涤剂组合物。增稠/促泡剂由以下组分（A）组成：（A）由以下通式（1）表示的化合物：<？in-line-formula description =“In-line Formulas”end =“ 引线“→R1O-（PO）n /（EO）m-R2（1）<？in-line-formula description =”In-line Formulas“end =”tail“？>（其中，R1表示直链烷基或具有8〜10个碳原子的烯基，PO表示丙烯氧基，EO表示乙烯氧基，平均加成摩尔数n表示1.5〜3.0的数，平均加成摩尔数m表示0〜1.0的数，R2表示氢原子或甲基），式中，n = 0，m = 0，R2为氢原子的式（1）所示的醇的含量为3000ppm以下，洗涤剂组合物含有组分（A）和表面活性剂（B）。

3. 发明授权

US06830754B2 Amphipatic lipid dispersion 有权
标题翻译：两亲性脂质分散体
公开(公告)号：US06830754B2
公开(公告)日：2004-12-14
申请号：US09468777
申请日：1999-12-21
申请人： Keiko Hasebe , Juri Sata , Yasuhiro Doi , Yoshinori Tamura , Masaki Inoue , Hiroshi Sonohara
发明人： Keiko Hasebe , Juri Sata , Yasuhiro Doi , Yoshinori Tamura , Masaki Inoue , Hiroshi Sonohara
IPC分类号： A61K600
CPC分类号： A61K8/39 , A61K8/442 , A61K8/4993 , A61K8/604 , A61K8/68 , A61Q5/02 , A61Q15/00 , A61Q19/10 , Y10S514/88
摘要： Described in the present invention are a dispersion which comprises, as a dispersoid, (a) 5 to 40 wt. % of an amphipatic lipid containing, in the molecule thereof, at least one hydroxy and amide group, and (b) 2 to 55 wt. % of a surfactant in an aqueous medium; a washing-away type cosmetic composition comprising the dispersion; and a washing-away type cosmetic composition comprising (A) 0.01 to 10 wt. % of an amphipatic lipid which contains, in the molecule thereof, at least one hydroxy and amide group and having a melting point not less than 30° C. and (B) 5 to 95 wt. % of a surfactant. The dispersion according to the present invention is useful as a component of a washing-away type cosmetic composition having both an emulsion-like or pearl-lustrous appearance and low skin irritation. The washing-away type cosmetic composition according to the present invention has an emulsion-like or pearl-lustrous appearance and is mild to the skin owing to reduced adsorption, to the skin, of the surfactant contained in the composition.
摘要翻译：在本发明中描述的是一种分散体，其包含作为分散质的（a）5至40重量％在其分子中含有至少一个羟基和酰胺基团的两性脂质的百分比，和（b）2-55重量％％表面活性剂在水性介质中; 一种洗涤型化妆品组合物，其包含该分散体; 和洗涤型化妆品组合物，其包含（A）0.01〜10重量％在其分子中含有至少一个羟基和酰胺基并且具有不低于30℃的熔点和（B）5-95重量％的两性脂质的百分比。％的表面活性剂。根据本发明的分散体可用作洗涤型化妆品组合物的组分，其具有乳状液或珍珠岩外观和低皮肤刺激性。根据本发明的洗衣型化妆品组合物具有乳状或珍珠色的外观，并且由于组合物中包含的表面活性剂对皮肤的吸附减少，对皮肤温和。

4. 发明授权

US5858936A Detergent composition 失效
标题翻译：洗涤剂组成
公开(公告)号：US5858936A
公开(公告)日：1999-01-12
申请号：US821302
申请日：1997-03-20
申请人： Yoshinori Tamura , Yasuhiro Doi , Keiko Hasebe , Masafumi Shonaka , Tadashi Moriyama , Yuichi Hioki , Hiroshi Sonohara
发明人： Yoshinori Tamura , Yasuhiro Doi , Keiko Hasebe , Masafumi Shonaka , Tadashi Moriyama , Yuichi Hioki , Hiroshi Sonohara
IPC分类号： A61K8/00 , A61K8/33 , A61K8/36 , A61K8/362 , A61K8/365 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/43 , A61K8/44 , A61K8/46 , A61Q5/00 , A61Q5/02 , A61Q17/00 , C11D1/86
CPC分类号： A61K8/44 , A61K8/40 , A61K8/416 , A61K8/43 , A61K8/463 , A61Q17/005 , A61K2800/51 , A61Q19/10 , A61Q5/006 , A61Q5/02
摘要： Described is a detergent composition comprising (A) a sulfate ester surfactant, (B) at least one surfactant selected from amphoteric surfactants, amine oxide surfactants, alkanol amide surfactants and amide amino-acid surfactants, (C) a cationic bactericide and (D) a metal chelating agent, the weight ratio of said (A) to (B) being 1-50 and the content of said (C) being 0.2 wt. % to 5 wt. %.The detergent composition according to the present invention has excellent detergency, foamability and foam durability and at the same time, has high bactericidal effects because it can be mixed stably with a cationic bactericide.
摘要翻译：描述了一种洗涤剂组合物，其包含（A）硫酸酯表面活性剂，（B）选自两性表面活性剂，氧化胺表面活性剂，链烷醇酰胺表面活性剂和酰胺氨基酸表面活性剂中的至少一种表面活性剂，（C）阳离子杀菌剂和（D）金属螯合剂，所述（A）与（B）的重量比为1-50，所述（C）的含量为0.2重量％。％至5wt。％。根据本发明的洗涤剂组合物具有优异的洗涤性，发泡性和泡沫耐久性，同时具有高的杀菌效果，因为它可以与阳离子杀菌剂稳定地混合。

5. 发明申请

US20120135978A1 6,7-UNSATURATED-7-CARBAMOYL SUBSTITUTED MORPHINAN DERIVATIVE 有权
标题翻译： 6,7-不饱和的7-羧基取代的摩尔衍生物
公开(公告)号：US20120135978A1
公开(公告)日：2012-05-31
申请号：US13308483
申请日：2011-11-30
申请人： Masanao INAGAKI , Shin-ichiro Hara , Nobuhiro Haga , Yoshinori Tamura , Yoshihisa Goto , Tsuyoshi Hasegawa
发明人： Masanao INAGAKI , Shin-ichiro Hara , Nobuhiro Haga , Yoshinori Tamura , Yoshihisa Goto , Tsuyoshi Hasegawa
IPC分类号： A61K31/485 , A61K31/5377 , A61K31/506 , A61P25/04 , A61K31/519 , C07D491/18 , A61P1/08 , A61P1/00 , C07D489/08 , C07D491/22
CPC分类号： C07D489/08
摘要： A novel compound which is useful as an agent for treating and/or preventing emesis, vomiting and/or constipation.A compound represented by the formula (I): wherein R1 and R2 are each independently hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted cycloalkyl, optionally substituted aryl etc., R3 is hydrogen, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted lower alkoxy etc., R4 is hydrogen or lower alkyl, R5 is hydrogen, lower alkyl, cycloalkyl lower alkyl or lower alkenyl, or a pharmaceutically acceptably salt, or a solvate thereof is provided.
摘要翻译：可用作治疗和/或预防呕吐，呕吐和/或便秘的药剂的新型化合物。由式（I）表示的化合物：其中R 1和R 2各自独立地为氢，任选取代的低级烷基，任选取代的低级烯基，任选取代的环烷基，任选取代的芳基等，R 3为氢，羟基，任选取代的低级烷基，提供任选取代的低级烯基，任选取代的低级炔基，任选取代的低级烷氧基等，R4是氢或低级烷基，R5是氢，低级烷基，环烷基低级烷基或低级烯基，或其药学上可接受的盐或其溶剂化物。

6. 发明授权

US07435710B2 Detergent composition comprising a sub-stoichiometric alkoxylated phosphate ester 有权
标题翻译：包含亚化学计量的烷氧基化磷酸酯的洗涤剂组合物
公开(公告)号：US07435710B2
公开(公告)日：2008-10-14
申请号：US11622742
申请日：2007-01-12
申请人： Yoshinori Tamura , Ryosuke Fujii , Tomoko Uchiyama
发明人： Yoshinori Tamura , Ryosuke Fujii , Tomoko Uchiyama
IPC分类号： C11D1/72 , C11D7/36
CPC分类号： C11D1/345
摘要： Provided is a detergent composition having components (A) and (B1): (A) a phosphate monoester (1), and (B1) a phosphate monoester (2), wherein n=1; components (A), (B1) and (B2): (A) a phosphate monoester (1), (B1) a phosphate monoester (2), wherein n=1, and (B2) a phosphate monoester (2), wherein n=2; components (A), (B1) and (B2): (A) a phosphate monoester (1), (B1) a phosphate monoester (2) wherein n=1, and (B2) a phosphate monoester (2), wherein n=2; components (A) and (C): (A) a phosphate monoester (1), and (C) a phosphate monoester (3); or a phosphate-based surfactant produced by reacting a compound obtained by adding to an alcohol an alkylene oxide of 2 to 4 carbon atoms, with phosphoric acid, a polyphosphoric acid or P2O5: The detergent composition is mild to the skin, is high in versatility, and has a good foaming property in weak acidic water or in hard water.
摘要翻译：本发明提供一种具有成分（A）和（B 1）的洗涤剂组合物：（A）磷酸酯单酯（1）和（B 1/3）磷酸酯单酯（2 ），其中n = 1; 组分（A），（B 1/2）和（B 2）：（A）磷酸酯单酯（1），（B 1 H 2）磷酸酯单酯（2），其中n = 1，和（B 2 H 2）磷酸酯单酯（2），其中n = 2; 组分（A），（B 1/2）和（B 2）：（A）磷酸酯单酯（1），（B 1 H 2）其中n = 1的磷酸酯单酯（2）和磷酸酯单酯（2）的（B 2）2，其中n = 2; 组分（A）和（C）：（A）磷酸酯单酯（1）和（C）磷酸酯单酯（3）; 或通过将通过向醇中加入2至4个碳原子的烯化氧获得的化合物与磷酸，多磷酸或P 2 O 5 O 5反应而制备的磷酸盐基表面活性剂，洗涤剂组合物对皮肤温和，通用性高，在弱酸性水或硬水中具有良好的起泡性。

7. 发明申请

US20080119513A1 Sulfonamide Derivative Selectively Inhibiting Mmp-13 审中-公开
标题翻译：磺酰胺衍生物选择性抑制Mmp-13
公开(公告)号：US20080119513A1
公开(公告)日：2008-05-22
申请号：US11574801
申请日：2004-09-06
申请人： Fumihiko Watanabe , Yoshinori Tamura , Naoki Yoshikawa
发明人： Fumihiko Watanabe , Yoshinori Tamura , Naoki Yoshikawa
IPC分类号： A61K31/195 , C07C317/14 , C07D209/08 , A61K31/47 , A61P35/00 , A61P31/12 , A61P19/02 , A61K31/404 , C07D215/06
CPC分类号： C07D333/34 , C07C311/19 , C07C311/29 , C07C311/42 , C07C311/46 , C07C323/58 , C07C2601/08 , C07C2601/14 , C07D209/18 , C07D215/12 , C07D307/84 , C07D309/08 , C07D333/62
摘要： It is considered that MMP-13 inhibitors contribute to the treatment or prevention against the diseases caused by or related to activity of MMP-13, especially osteoarthritis (OA). Therefore, the development of MMP-13 inhibitors has been desired.A compound represented by the general formula (I): wherein Z is 1,4-phenylene and the like; R1 is hydroxy and the like; R2 is hydrogen atom, optionally substituted lower alkyl, and the like; R12 is hydrogen atom; or R2 and R12 taken together with the adjacent carbon atom may form a ring; R3 is hydrogen atom, optionally substituted lower alkyl, and the like; R4 is halogen, lower alkyl, and the like; m is 0, 1, or 2; X is a bond, —C≡C—, and the like; Y is optionally substituted phenyl, optionally substituted naphthyl, and the like, its optically active substance, their pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译：认为MMP-13抑制剂有助于治疗或预防由MMP-13，特别是骨关节炎（OA）的活动引起的或与其相关的疾病。因此，期望MMP-13抑制剂的发展。由通式（I）表示的化合物：其中Z是1,4-亚苯基等; R 1是羟基等; R 2是氢原子，任选取代的低级烷基等; R 12是氢原子; 或R 2和R 12与相邻碳原子一起可以形成环; R 3是氢原子，任选取代的低级烷基等; R 4是卤素，低级烷基等; m为0,1或2; X是键，-C≡C-等; Y是任选取代的苯基，任选取代的萘基等，其光学活性物质，其药学上可接受的盐或其溶剂化物。

8. 发明授权

US06897237B2 MMP-12 inhibitors 失效
标题翻译： MMP-12抑制剂
公开(公告)号：US06897237B2
公开(公告)日：2005-05-24
申请号：US10257478
申请日：2001-04-23
申请人： Yozo Hori , Fumihiko Watanabe , Hiroshige Tsuzuki , Shingo Furue , Yoshinori Tamura
发明人： Yozo Hori , Fumihiko Watanabe , Hiroshige Tsuzuki , Shingo Furue , Yoshinori Tamura
IPC分类号： A61P11/00 , A61P43/00 , C07C311/19 , C07C311/29 , C07C311/46 , C07C323/58 , C07D209/20 , C07D257/04 , C07D271/06 , C07D271/10 , C07D271/107 , C07D333/34 , A61K31/192 , A61K31/215 , C07C69/612
CPC分类号： C07D257/04 , C07C311/19 , C07C311/29 , C07C311/46 , C07C323/58 , C07D209/20 , C07D271/06 , C07D271/107 , C07D333/34
摘要： A compound of the formula (I): wherein R1 is hydroxy and the like; R2 is optionally substituted lower alkyl and the like; R3 is hydrogen atom and the like; R4 is optionally substituted arylene and the like; R5 is —C≡C— and the like; R6 is optionally substituted naphtyl and the like its optically active substance, its prodrug, their pharmaceutically acceptable salt, or solvate thereof.
摘要翻译：式（I）的化合物：其中R 1是羟基等; R 2是任选取代的低级烷基等; R 3是氢原子等; R 4是任选取代的亚芳基等; R 5是-C≡C-等; R 6是任选取代的萘基等，其光学活性物质，其前药，其药学上可接受的盐或溶剂化物。

9. 发明授权

US06495578B1 Sulfonamide derivatives having oxadiazole rings 失效
标题翻译：具有恶二唑环的磺酰胺衍生物
公开(公告)号：US06495578B1
公开(公告)日：2002-12-17
申请号：US09959008
申请日：2001-10-17
申请人： Fumihiko Watanabe , Yoshinori Tamura , Yasuhiko Fujii
发明人： Fumihiko Watanabe , Yoshinori Tamura , Yasuhiko Fujii
IPC分类号： A61K314196
CPC分类号： C07D413/04
摘要： Sulfonamide derivatives having a matrix metalloprotease inhibiting effect, which are compounds represented by general formula (I), optical isomers of the same, pharmaceutically acceptable salts of both, or solvates of them: wherein R1 and R2 are each independently hydrogen atom, optionally substituted lower alkyl or the like; R3 is optionally substituted aryl, optionally substituted heteroaryl or the like; X is —CH═CH—, —O—, or —S—; Y is NHOH, hydroxy, or lower alkyloxy.
摘要翻译：具有基质金属蛋白酶抑制作用的磺酰胺衍生物，其为通式（I）表示的化合物，其光学异构体，它们的药学上可接受的盐或它们的溶剂合物：其中R1和R2各自独立地为氢原子，任选取代的低级烷基等; R3是任选取代的芳基，任选取代的杂芳基等; X是-CH = CH-，-O-或-S-; Y是NHOH，羟基或低级烷氧基。

10. 发明授权

US09108975B2 Crystal of 6,7-unsaturated-7-carbamoyl morphinan derivative and method for producing the same 有权
标题翻译： 6,7-不饱和-7-氨基甲酰吗啡喃衍生物的结晶及其制备方法
公开(公告)号：US09108975B2
公开(公告)日：2015-08-18
申请号：US13884770
申请日：2011-11-11
申请人： Yoshinori Tamura , Kouichi Noguchi , Masanao Inagaki , Kenji Morimoto , Nobuhiro Haga , Shinichi Oda , Sohei Omura
发明人： Yoshinori Tamura , Kouichi Noguchi , Masanao Inagaki , Kenji Morimoto , Nobuhiro Haga , Shinichi Oda , Sohei Omura
IPC分类号： C07D471/00 , A61K31/44 , C07D489/08 , C07C51/41 , C07C53/10 , C07C303/32 , C07C309/30 , C07D271/06 , A61K9/16
CPC分类号： C07D489/08 , A61K9/1629 , C07B2200/13 , C07C51/412 , C07C53/10 , C07C303/32 , C07C309/30 , C07D271/06
摘要： Stable crystalline forms of a compound represented by the formula (IA): an acid addition salt, and/or a solvate thereof are provided by the present invention. Said crystalline forms are extremely useful as materials for preparing medicines. Novel processes for preparing 6,7-unsaturated-7-carbamoyl morphinan derivatives are also provided by the present invention.
摘要翻译：由式（IA）表示的化合物的稳定结晶形式：酸加成盐和/或其溶剂合物由本发明提供。所述结晶形式作为制备药物的材料非常有用。制备6,7-不饱和-7-氨基甲酰吗啡喃衍生物的新方法也由本发明提供。

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