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1. 发明申请

US20130231485A1 CRYSTAL OF 6,7-UNSATURATED-7-CARBAMOYL MORPHINAN DERIVATIVE AND METHOD FOR PRODUCING THE SAME 有权
标题翻译： 6,7-不饱和七碳烯醇衍生物的晶体及其生产方法
公开(公告)号：US20130231485A1
公开(公告)日：2013-09-05
申请号：US13884770
申请日：2011-11-11
申请人： Yoshinori Tamura , Kouichi Noguchi , Masanao Inagaki , Kenji Morimoto , Nobuhiro Haga , Shinichi Oda , Sohei Omura
发明人： Yoshinori Tamura , Kouichi Noguchi , Masanao Inagaki , Kenji Morimoto , Nobuhiro Haga , Shinichi Oda , Sohei Omura
IPC分类号： C07D489/08 , C07C303/32 , C07C53/10 , C07C51/41 , C07D271/06 , C07C309/30
CPC分类号： C07D489/08 , A61K9/1629 , C07B2200/13 , C07C51/412 , C07C53/10 , C07C303/32 , C07C309/30 , C07D271/06
摘要： Stable crystalline forms of a compound represented by the formula (IA): an acid addition salt, and/or a solvate thereof are provided by the present invention. Said crystalline forms are extremely useful as materials for preparing medicines. Novel processes for preparing 6,7-unsaturated-7-carbamoyl morphinan derivatives are also provided by the present invention.
摘要翻译：由式（IA）表示的化合物的稳定结晶形式：酸加成盐和/或其溶剂合物由本发明提供。所述结晶形式作为制备药物的材料非常有用。制备6,7-不饱和-7-氨基甲酰吗啡喃衍生物的新方法也由本发明提供。

2. 发明授权

US08349024B2 Hair treatment composition 有权
标题翻译：头发处理组成
公开(公告)号：US08349024B2
公开(公告)日：2013-01-08
申请号：US13387381
申请日：2010-09-28
申请人： Juri Sata , Tomoko Uchiyama , Yoshinori Tamura
发明人： Juri Sata , Tomoko Uchiyama , Yoshinori Tamura
IPC分类号： A61Q5/10
CPC分类号： A61Q5/10 , A61K8/33 , A61Q5/04 , A61Q5/065 , A61Q5/08
摘要： Provided is a hair treatment composition capable of imparting good manageability and excellent hair feel to the hair upon finishing permanent wave or hair dye treatment. The hair treatment composition has the following components (A) and (B): (A) a compound represented by the following formula (1): R1O—(PO)n(EO)m—R2 (1) wherein R1 represents a linear or branched C8-12 alkyl or alkenyl group, PO represents a propyleneoxy group, EO represents an ethyleneoxy group, n represents an average addition mole number and is from 1.5 to 5.0, m represents an average addition mole number and is from 0 to 1.0, and R2 represents a hydrogen atom or a methyl group, and (B) at least one selected from keratin reducing agents, oxidizing agents, alkaline agents, and dyes for hair dye, wherein a content of an R1OH wherein R1 represents a linear or branched C8-12 alkyl or alkenyl group is 300 ppm or less.
摘要翻译：提供一种头发处理组合物，其能够在完成永久烫发或染发剂处理时赋予头发良好的可处理性和优异的头发感觉。毛发处理组合物具有以下成分（A）和（B）：（A）由下式（1）表示的化合物：R1O-（PO）n（EO）m-R2（1）其中R1表示直链或支链C 8-12烷基或烯基，PO表示丙烯氧基，EO表示乙烯氧基，n表示平均加成摩尔数，为1.5〜5.0，m表示平均加成摩尔数，为0〜1.0， R 2表示氢原子或甲基，（B）选自角蛋白还原剂，氧化剂，碱性试剂和染发剂中的至少一种，其中R1OH的含量，其中R1表示直链或支链的C8 -12烷基或链烯基为300ppm以下。

3. 发明申请

US20110014145A1 HAIR CONDITIONING COMPOSITION 有权
标题翻译：头发调理组合物
公开(公告)号：US20110014145A1
公开(公告)日：2011-01-20
申请号：US12933626
申请日：2009-04-03
申请人： Juri Sata , Yoshinori Tamura , Hiromoto Mizushima
发明人： Juri Sata , Yoshinori Tamura , Hiromoto Mizushima
IPC分类号： A61K8/81 , A61Q5/12
CPC分类号： A61K8/39 , A61Q5/12
摘要： Provided is a low odor hair conditioning composition which is free of oily and greasy feel upon finish, and can impart good manageability and moisturized feel. Specifically provided is a hair conditioning composition including a component (A): a compound represented by a general formula (1) R1O—(PO)n/(EO)m—R2 (1), where R1 represents a straight or branched, alkyl or alkenyl group having 8 to 12 carbon atoms, PO represents a propyleneoxy group, EO represents an ethyleneoxy group, an average addition mole number “n” represents a number of 1.5 to 3.0, an average addition mole number “m” represents a number of 0 to 1.0, and R2 represents a hydrogen atom or a methyl group; and a component (B): a surfactant other than the component (A), wherein a content of R1OH, where R1 represents a straight or branched, alkyl or alkenyl group having 8 to 12 carbon atoms, is 80 ppm or less.
摘要翻译：提供了一种低气味的头发调理组合物，其在完成后不含油性和油腻感，并且可以赋予良好的可管理性和保湿感。具体提供的是包含组分（A）：由通式（1）R1O-（PO）n /（EO）m -R2（1）表示的化合物的头发调理组合物，其中R 1表示直链或支链烷基或碳原子数为8〜12的烯基，PO表示丙烯氧基，EO表示乙烯氧基，平均加成摩尔数“n”表示1.5〜3.0的数，平均加成摩尔数“m”表示 0〜1.0，R2表示氢原子或甲基; 和组分（B）：除组分（A）以外的表面活性剂，其中R1表示碳原子数为8〜12的直链或支链烷基或烯基的R1OH的含量为80ppm以下。

4. 发明申请

US20070111922A1 DETERGENT COMPOSITIONS 有权
标题翻译：洗涤剂组合物
公开(公告)号：US20070111922A1
公开(公告)日：2007-05-17
申请号：US11622742
申请日：2007-01-12
申请人： Yoshinori TAMURA , Ryosuke Fujii , Tomoko Uchiyama
发明人： Yoshinori TAMURA , Ryosuke Fujii , Tomoko Uchiyama
IPC分类号： C11D1/34
CPC分类号： C11D1/345
摘要： Provided is a detergent composition having components (A) and (B1): (A) a phosphate monoester (1), and (B1) a phosphate monoester (2), wherein n=1; components (A), (B1) and (B2): (A) a phosphate monoester (1), (B1) a phosphate monoester (2), wherein n=1, and (B2) a phosphate monoester (2), wherein n=2; components (A), (B1) and (B2): (A) a phosphate monoester (1), (B1) a phosphate monoester (2) wherein n=1, and (B2) a phosphate monoester (2), wherein n=2; components (A) and (C): (A) a phosphate monoester (1), and (C) a phosphate monoester (3); or a phosphate-based surfactant produced by reacting a compound obtained by adding to an alcohol an alkylene oxide of 2 to 4 carbon atoms, with phosphoric acid, a polyphosphoric acid or P2O5: The detergent composition is mild to the skin, is high in versatility, and has a good foaming property in weak acidic water or in hard water.
摘要翻译：本发明提供一种具有成分（A）和（B 1）的洗涤剂组合物：（A）磷酸酯单酯（1）和（B 1/3）磷酸酯单酯（2 ），其中n = 1; 组分（A），（B 1/2）和（B 2）：（A）磷酸酯单酯（1），（B 1 H 2）磷酸酯单酯（2），其中n = 1，和（B 2 H 2）磷酸酯单酯（2），其中n = 2; 组分（A），（B 1）和（B 2）：（A）磷酸酯单酯（1），（B 1 2 N）其中n = 1的磷酸酯单酯（2）和磷酸酯单酯（2）的（B 2）2，其中n = 2; 组分（A）和（C）：（A）磷酸酯单酯（1）和（C）磷酸酯单酯（3）; 或通过将通过向醇中加入2至4个碳原子的烯化氧获得的化合物与磷酸，多磷酸或P 2 O 5 O 5反应而制备的磷酸盐基表面活性剂，洗涤剂组合物对皮肤温和，通用性高，在弱酸性水或硬水中具有良好的起泡性。

5. 发明授权

US06878739B2 Composition for treating or preventing glomerulopathy 失效
标题翻译：用于治疗或预防肾小球病的组合物
公开(公告)号：US06878739B2
公开(公告)日：2005-04-12
申请号：US10162865
申请日：2002-06-06
申请人： Hidetake Kurihara , Fumihiko Watanabe , Yoshinori Tamura , Toshihiro Sinosaki
发明人： Hidetake Kurihara , Fumihiko Watanabe , Yoshinori Tamura , Toshihiro Sinosaki
IPC分类号： A61K31/18 , A61K20060101 , A61K31/38 , A61K31/381 , A61K31/404 , A61K31/405 , A61K31/41 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/4245 , A61P13/12 , A61P43/00 , C07C311/19 , C07C311/37 , C07C311/39 , C07D209/04 , C07D209/20 , C07D257/04 , C07D263/32 , C07D271/06 , C07D333/12 , C07D333/18 , C07D333/34 , C07D403/12 , C07D409/04 , C07D411/04 , C07D413/04
CPC分类号： C07C311/29 , A61K31/18 , A61K31/381 , A61K31/404 , A61K31/41 , A61K31/421 , A61K31/4245 , C07C311/19 , C07C311/44 , C07C311/46 , C07C323/62 , C07D209/16 , C07D257/04 , C07D271/06 , C07D333/18 , C07D403/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04
摘要： A composition for treating or preventing glomerulopathy which contains a compound of the formula (I): wherein, for example, R1 and R2 are each independently hydrogen atom, optionally substituted lower alkyl, optionally substituted aralkyl, etc.; R3 is 1,4-phenylene and 2,5-thiophendiyl; R4 is the substituents represented by the formula, etc.: wherein R5 is hydrogen atom, optionally substituted amino, etc.; and Y is NHOH or OH, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.
摘要翻译：一种用于治疗或预防肾小球病的组合物，其含有式（I）化合物：其中，例如R 1和R 2各自独立地为氢原子，任选取代的低级烷基，任选取代的芳烷基等; R 3是1,4-亚苯基和2,5-噻吩二基; R 4是由式等表示的取代基：其中R 5是氢原子，任选取代的氨基等; 和Y是NHOH或OH，其光学活性物质，其药学上可接受的盐或水合物。

6. 发明授权

US6008177A Germicidal composition 失效
标题翻译：杀菌组成
公开(公告)号：US6008177A
公开(公告)日：1999-12-28
申请号：US77875
申请日：1998-06-08
申请人： Juri Sata , Yoshinori Tamura , Keiko Hasebe , Tadashi Moriyama
发明人： Juri Sata , Yoshinori Tamura , Keiko Hasebe , Tadashi Moriyama
IPC分类号： A61K8/30 , A01N25/02 , A01N33/12 , A01N57/12 , A61K8/00 , A61K8/34 , A61K8/41 , A61K8/42 , A61K8/60 , A61K8/73 , A61Q5/02 , A61Q5/12 , A61Q17/00 , A61Q19/10 , C11D3/48 , C11D7/32 , C11D1/62 , C11D7/36
CPC分类号： A61Q17/005 , A01N33/12 , A01N57/12 , A61K8/416 , A61Q19/10 , A61Q5/02 , A61K2800/59
摘要： A germicidal composition comprising: i) a compound of formula (1): ##STR1## wherein at least one of R.sup.1, R.sup.2 and R.sup.3 represents a linear or branched C.sub.8-30 alkyl or alkenyl group and the remaining groups are the same or different and individually represent a methyl, ethyl or benzyl group; R.sup.4 represents a methyl or ethyl group; R.sup.5 represents a linear or branched C.sub.1-30 alkyl or alkenyl group, or a polyoxyalkylene alkyl ether or polyoxyalkylene alkenyl ether having a linear or branched C.sub.1-30 alkyl or alkenyl group; and M represents a hydrogen atom or an alkali metal atom; andii) a compound of formula (2): ##STR2## wherein R.sup.1 to R.sup.4 have the same meanings as defined above and R.sup.6 and R.sup.7 are the same or different and individually have the same meanings as R.sup.5, wherein the weight ratio of compound (1) to compound (2) is from 99:1 to 80:20.
摘要翻译： PCT No.PCT / JP96 / 03451。 371日期：1998年6月5日 102（e）1998年6月8日PCT PCT 1996年11月26日PCT公布。公开号WO97 / 21348 日期：1997年6月19日一种杀菌组合物，其包含：i）式（1）化合物：其中R 1，R 2和R 3中的至少一个表示直链或支链C 8-30烷基或烯基，其余基团相同或不同且单独表示甲基，乙基或苄基; R4表示甲基或乙基; R5表示直链或支链C1-30烷基或烯基，或具有直链或支链C1-30烷基或烯基的聚氧化烯烷基醚或聚氧化烯链烯基醚; M表示氢原子或碱金属原子; 和ii）式（2）的化合物：其中R 1至R 4具有与上述相同的含义，R 6和R 7相同或不同，并且各自具有与R 5相同的含义，其中化合物（1）与化合物（2）为99:1至80:20。

7. 发明申请

US20120135978A1 6,7-UNSATURATED-7-CARBAMOYL SUBSTITUTED MORPHINAN DERIVATIVE 有权
标题翻译： 6,7-不饱和的7-羧基取代的摩尔衍生物
公开(公告)号：US20120135978A1
公开(公告)日：2012-05-31
申请号：US13308483
申请日：2011-11-30
申请人： Masanao INAGAKI , Shin-ichiro Hara , Nobuhiro Haga , Yoshinori Tamura , Yoshihisa Goto , Tsuyoshi Hasegawa
发明人： Masanao INAGAKI , Shin-ichiro Hara , Nobuhiro Haga , Yoshinori Tamura , Yoshihisa Goto , Tsuyoshi Hasegawa
IPC分类号： A61K31/485 , A61K31/5377 , A61K31/506 , A61P25/04 , A61K31/519 , C07D491/18 , A61P1/08 , A61P1/00 , C07D489/08 , C07D491/22
CPC分类号： C07D489/08
摘要： A novel compound which is useful as an agent for treating and/or preventing emesis, vomiting and/or constipation.A compound represented by the formula (I): wherein R1 and R2 are each independently hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted cycloalkyl, optionally substituted aryl etc., R3 is hydrogen, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted lower alkoxy etc., R4 is hydrogen or lower alkyl, R5 is hydrogen, lower alkyl, cycloalkyl lower alkyl or lower alkenyl, or a pharmaceutically acceptably salt, or a solvate thereof is provided.
摘要翻译：可用作治疗和/或预防呕吐，呕吐和/或便秘的药剂的新型化合物。由式（I）表示的化合物：其中R 1和R 2各自独立地为氢，任选取代的低级烷基，任选取代的低级烯基，任选取代的环烷基，任选取代的芳基等，R 3为氢，羟基，任选取代的低级烷基，提供任选取代的低级烯基，任选取代的低级炔基，任选取代的低级烷氧基等，R4是氢或低级烷基，R5是氢，低级烷基，环烷基低级烷基或低级烯基，或其药学上可接受的盐或其溶剂化物。

8. 发明授权

US07435710B2 Detergent composition comprising a sub-stoichiometric alkoxylated phosphate ester 有权
标题翻译：包含亚化学计量的烷氧基化磷酸酯的洗涤剂组合物
公开(公告)号：US07435710B2
公开(公告)日：2008-10-14
申请号：US11622742
申请日：2007-01-12
申请人： Yoshinori Tamura , Ryosuke Fujii , Tomoko Uchiyama
发明人： Yoshinori Tamura , Ryosuke Fujii , Tomoko Uchiyama
IPC分类号： C11D1/72 , C11D7/36
CPC分类号： C11D1/345
摘要： Provided is a detergent composition having components (A) and (B1): (A) a phosphate monoester (1), and (B1) a phosphate monoester (2), wherein n=1; components (A), (B1) and (B2): (A) a phosphate monoester (1), (B1) a phosphate monoester (2), wherein n=1, and (B2) a phosphate monoester (2), wherein n=2; components (A), (B1) and (B2): (A) a phosphate monoester (1), (B1) a phosphate monoester (2) wherein n=1, and (B2) a phosphate monoester (2), wherein n=2; components (A) and (C): (A) a phosphate monoester (1), and (C) a phosphate monoester (3); or a phosphate-based surfactant produced by reacting a compound obtained by adding to an alcohol an alkylene oxide of 2 to 4 carbon atoms, with phosphoric acid, a polyphosphoric acid or P2O5: The detergent composition is mild to the skin, is high in versatility, and has a good foaming property in weak acidic water or in hard water.
摘要翻译：本发明提供一种具有成分（A）和（B 1）的洗涤剂组合物：（A）磷酸酯单酯（1）和（B 1/3）磷酸酯单酯（2 ），其中n = 1; 组分（A），（B 1/2）和（B 2）：（A）磷酸酯单酯（1），（B 1 H 2）磷酸酯单酯（2），其中n = 1，和（B 2 H 2）磷酸酯单酯（2），其中n = 2; 组分（A），（B 1/2）和（B 2）：（A）磷酸酯单酯（1），（B 1 H 2）其中n = 1的磷酸酯单酯（2）和磷酸酯单酯（2）的（B 2）2，其中n = 2; 组分（A）和（C）：（A）磷酸酯单酯（1）和（C）磷酸酯单酯（3）; 或通过将通过向醇中加入2至4个碳原子的烯化氧获得的化合物与磷酸，多磷酸或P 2 O 5 O 5反应而制备的磷酸盐基表面活性剂，洗涤剂组合物对皮肤温和，通用性高，在弱酸性水或硬水中具有良好的起泡性。

9. 发明申请

US20080119513A1 Sulfonamide Derivative Selectively Inhibiting Mmp-13 审中-公开
标题翻译：磺酰胺衍生物选择性抑制Mmp-13
公开(公告)号：US20080119513A1
公开(公告)日：2008-05-22
申请号：US11574801
申请日：2004-09-06
申请人： Fumihiko Watanabe , Yoshinori Tamura , Naoki Yoshikawa
发明人： Fumihiko Watanabe , Yoshinori Tamura , Naoki Yoshikawa
IPC分类号： A61K31/195 , C07C317/14 , C07D209/08 , A61K31/47 , A61P35/00 , A61P31/12 , A61P19/02 , A61K31/404 , C07D215/06
CPC分类号： C07D333/34 , C07C311/19 , C07C311/29 , C07C311/42 , C07C311/46 , C07C323/58 , C07C2601/08 , C07C2601/14 , C07D209/18 , C07D215/12 , C07D307/84 , C07D309/08 , C07D333/62
摘要： It is considered that MMP-13 inhibitors contribute to the treatment or prevention against the diseases caused by or related to activity of MMP-13, especially osteoarthritis (OA). Therefore, the development of MMP-13 inhibitors has been desired.A compound represented by the general formula (I): wherein Z is 1,4-phenylene and the like; R1 is hydroxy and the like; R2 is hydrogen atom, optionally substituted lower alkyl, and the like; R12 is hydrogen atom; or R2 and R12 taken together with the adjacent carbon atom may form a ring; R3 is hydrogen atom, optionally substituted lower alkyl, and the like; R4 is halogen, lower alkyl, and the like; m is 0, 1, or 2; X is a bond, —C≡C—, and the like; Y is optionally substituted phenyl, optionally substituted naphthyl, and the like, its optically active substance, their pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译：认为MMP-13抑制剂有助于治疗或预防由MMP-13，特别是骨关节炎（OA）的活动引起的或与其相关的疾病。因此，期望MMP-13抑制剂的发展。由通式（I）表示的化合物：其中Z是1,4-亚苯基等; R 1是羟基等; R 2是氢原子，任选取代的低级烷基等; R 12是氢原子; 或R 2和R 12与相邻碳原子一起可以形成环; R 3是氢原子，任选取代的低级烷基等; R 4是卤素，低级烷基等; m为0,1或2; X是键，-C≡C-等; Y是任选取代的苯基，任选取代的萘基等，其光学活性物质，其药学上可接受的盐或其溶剂化物。

10. 发明授权

US06897237B2 MMP-12 inhibitors 失效
标题翻译： MMP-12抑制剂
公开(公告)号：US06897237B2
公开(公告)日：2005-05-24
申请号：US10257478
申请日：2001-04-23
申请人： Yozo Hori , Fumihiko Watanabe , Hiroshige Tsuzuki , Shingo Furue , Yoshinori Tamura
发明人： Yozo Hori , Fumihiko Watanabe , Hiroshige Tsuzuki , Shingo Furue , Yoshinori Tamura
IPC分类号： A61P11/00 , A61P43/00 , C07C311/19 , C07C311/29 , C07C311/46 , C07C323/58 , C07D209/20 , C07D257/04 , C07D271/06 , C07D271/10 , C07D271/107 , C07D333/34 , A61K31/192 , A61K31/215 , C07C69/612
CPC分类号： C07D257/04 , C07C311/19 , C07C311/29 , C07C311/46 , C07C323/58 , C07D209/20 , C07D271/06 , C07D271/107 , C07D333/34
摘要： A compound of the formula (I): wherein R1 is hydroxy and the like; R2 is optionally substituted lower alkyl and the like; R3 is hydrogen atom and the like; R4 is optionally substituted arylene and the like; R5 is —C≡C— and the like; R6 is optionally substituted naphtyl and the like its optically active substance, its prodrug, their pharmaceutically acceptable salt, or solvate thereof.
摘要翻译：式（I）的化合物：其中R 1是羟基等; R 2是任选取代的低级烷基等; R 3是氢原子等; R 4是任选取代的亚芳基等; R 5是-C≡C-等; R 6是任选取代的萘基等，其光学活性物质，其前药，其药学上可接受的盐或溶剂化物。

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