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1. 发明授权

US4419349A Interferon inducer, a process for producing the same and pharmaceutical composition containing the same 失效
标题翻译：干扰素诱导剂，其制备方法和含有其的药物组合物
公开(公告)号：US4419349A
公开(公告)日：1983-12-06
申请号：US266038
申请日：1981-05-22
申请人： Yasuhiko Kojima , Seishi Konno , Sadao Tamamura , Yoshimoto Sano , Nobuyuki Shibukawa , Takashi Hashimoto
发明人： Yasuhiko Kojima , Seishi Konno , Sadao Tamamura , Yoshimoto Sano , Nobuyuki Shibukawa , Takashi Hashimoto
IPC分类号： A61K36/535 , C07C7/00 , C07G99/00 , A61K35/78
CPC分类号： A61K36/535
摘要： An interferon inducer isolated from the plant tissue, having an elemental analysis of H: 8.5-8.7 %, C: 48.8-49 %, N: 6.3-6.5 % and P: 1.0-1.1 % and a molecular weight of from about 100,000 to about 3,000,000 (mainly about 200,000 to about 1,000,000) and containing as main constituents amino acids, sugars and phosphoric acid. This substance is believed to be a homogeneous polymer of protein and sugars, containing phosphoric acid. This substance has an excellent interferon inducing activity and low toxicity and is significantly active against various viruses. The interferon inducer may be produced by extracting a substance having interferon inducing activity from the tissue of a plant of the genus Perilla of the family Labiatae or a variant thereof containing said active substance and recovering the active substance from the extract thereby obtained. Preferably, the extraction may be effected with water and the recovery may be effected by ultrafiltration. Pharmaceutical composition of this invention comprises as active ingredient the interferon inducer of this invention in association with a pharmaceutical carrier or excipient.
摘要翻译：从植物组织分离的干扰素诱导物，其H分析为8.5-8.7％，C：48.8-49％，N：6.3-6.5％，P：1.0-1.1％，分子量为约100,000至约300万（主要为约20万至约100万），主要成分为氨基酸，糖和磷酸。该物质被认为是含有磷酸的蛋白质和糖的均匀聚合物。该物质具有优异的干扰素诱导活性和低毒性，对各种病毒具有显着的活性。干扰素诱导剂可以通过从Labiatae家族的紫苏属植物的组织或其含有所述活性物质的变体的组织提取具有干扰素诱导活性的物质，并从由此获得的提取物中回收活性物质来制备。优选地，提取可以用水进行，并且可以通过超滤实现回收。本发明的药物组合物与药物载体或赋形剂一起包含本发明的干扰素诱导剂作为活性成分。

2. 发明授权

US4442087A Interferon inducer, a process for producing the same and pharmaceutical composition containing the same 失效
标题翻译：干扰素诱导剂，其制备方法和含有其的药物组合物
公开(公告)号：US4442087A
公开(公告)日：1984-04-10
申请号：US282468
申请日：1981-07-13
申请人： Yasuhiko Kojima , Seishi Konno , Sadao Tamamura , Takashi Hashimoto , Nobuyuki Shibukawa
发明人： Yasuhiko Kojima , Seishi Konno , Sadao Tamamura , Takashi Hashimoto , Nobuyuki Shibukawa
IPC分类号： C07G99/00 , A61K36/28 , A61K36/282 , A61P43/00 , C07K14/415 , A61K31/69 , A61K39/00 , A61K45/02
CPC分类号： C07K14/415 , Y10S514/889
摘要： An interferon inducer isolated from the plant tissue, having an elemental analysis of H:7.4.+-.0.4%, C: 45.6.+-.0.4%, N: 13.5.+-.0.4%, P: 2.8.+-.0.3% and a molecular weight of from about 100,000 to about 3,000,000 (mainly about 200,000 to about 1,000,000) and containing as main chemical constituents amino acids and phosporic acid. This substance is believed to be a homogeneous polymer of protein and phosphoric acid.This substance has an excellent interferon inducing activity and low toxicity and is significantly active upon various viruses. This interferon inducer may be produced by extracting a substance having interferon inducing activity from the tissue of a plant of the genus Artemisia of the family Compositae or a variant thereof containing the said active substance with water and recovering the active substance from the extracted solution. The recovery may preferably be effected by ultrafiltration. Pharmaceutical composition of this invention comprises as active ingredient the said active substance in association with a pharmaceutical carrier or excipient.
摘要翻译：从植物组织分离的干扰素诱导物，具有H：7.4 +/- 0.4％，C：45.6 +/- 0.4％，N：13.5 +/- 0.4％，P：2.8 +/- 0.3％的元素分析和分子量为约100,000至约3,000,000（主要为约200,000至约1,000,000），并含有主要化学成分的氨基酸和磷酸。该物质被认为是蛋白质和磷酸的均匀聚合物。该物质具有优异的干扰素诱导活性和低毒性，对各种病毒具有显着的活性。这种干扰素诱导剂可以通过从菊科的蒿属植物的组织或其含有所述活性物质的变体的组织中提取具有干扰素诱导活性的物质，并从提取的溶液中回收活性物质来制备。回收率优选通过超滤来实现。本发明的药物组合物与药物载体或赋形剂一起包含作为活性成分的所述活性物质。

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