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1. 发明授权

US5866146A Compositions for fair-skin 失效
标题翻译：公平皮肤的组成
公开(公告)号：US5866146A
公开(公告)日：1999-02-02
申请号：US804821
申请日：1997-02-24
申请人： Yasuharu Itagaki , Morimasa Tanimoto , Seiji Kurosawa , Tetsuro Ohba , Klaas Doesburg , Jan Sikkema , Taisuke Iwasaki
发明人： Yasuharu Itagaki , Morimasa Tanimoto , Seiji Kurosawa , Tetsuro Ohba , Klaas Doesburg , Jan Sikkema , Taisuke Iwasaki
IPC分类号： C12P19/04 , A61K8/00 , A61K8/73 , A61K8/96 , A61K8/99 , A61Q19/02 , C08B37/00 , C12R1/225 , C12R1/48 , A61K7/00 , A61K7/48 , A61K31/715
CPC分类号： A61Q19/02 , A61K8/73 , A61K8/99
摘要： This invention provides compositions for fair-skin containing the phosphorylated polysaccharides produced by lactic acid bacteria as an effective ingredient. The phosphorylated polysaccharides are expressed, for example, by the following formula and contained in the compositions for fair-skin at concentrations of 0.01-20 weight % and are used such as creams, emulsions and toilet lotions.The compositions for fair-skin exhibit fair-skin effect by inhibiting activities to melanoma proliferation and melanin formation. ##STR1## (wherein, Glc, Gal and Rha represent glucose, galactose and rhamnose residues, respectively. Numerals shown by other than subscript represent the respective binding sites and n represents the degree of polymerization of 1,000-5,000).
摘要翻译：本发明提供了含有由乳酸菌生产的磷酸化多糖作为有效成分的合适皮肤的组合物。磷酸化的多糖例如通过下式表达，并且含量在0.01-20重量％浓度的公平皮肤组合物中，并且使用例如乳膏，乳液和洗手液。通过抑制黑色素瘤增殖和黑色素形成的活性，公平皮肤的组合物显示出公平的皮肤效果。（I）（其中，Glc，Gal和Rha分别代表葡萄糖，半乳糖和鼠李糖残基，除下标所示的数字表示各自的结合位点，n表示聚合度为1,000-5,000）。

2. 发明授权

US6143560A Method of synchronizing epithelial cells into G.sub.0 phase 失效
标题翻译：将上皮细胞同步到G0期的方法
公开(公告)号：US6143560A
公开(公告)日：2000-11-07
申请号：US179525
申请日：1998-10-27
申请人： Mio Imamura , Yasuharu Itagaki , Morimasa Tanimoto
发明人： Mio Imamura , Yasuharu Itagaki , Morimasa Tanimoto
IPC分类号： C12N15/09 , C12N5/071 , C12N5/10 , C12N5/00
CPC分类号： C12N5/0631 , C12N2503/00 , C12N2517/10
摘要： The present invention relates to a method of synchronizing epithelial cells into G.sub.0 phase, more specifically, a method of synchronizing epithelial cells into G.sub.0 phase characterized by culturing the cells in a synthetic medium for 5 days or more, wherein said synthetic medium is a medium with the lowered concentration of bovine fetal serum 5% or less and said epithelial cells is bovine mammary gland cells. Further, the present invention relates to a method of culturing cells characterized by using G.sub.0 phase synchronized cells obtained by the present invention, and a method of screening a related to differentiation and/or maturation of said cells by using G.sub.0 phase synchronized cells. The present invention is useful for easily synchronizing epithelial cells into G.sub.0 phase and for screening a factor related to differentiation and/or maturation of epithelial cells.
摘要翻译：本发明涉及将上皮细胞同步至G0期的方法，更具体地说，涉及将上皮细胞同步至G0期的方法，其特征在于在合成培养基中培养细胞5天以上，其中所述合成培养基为牛胎儿血清浓度降低5％以上，所述上皮细胞为牛乳腺细胞。此外，本发明涉及一种培养细胞的方法，其特征在于使用通过本发明获得的G0相同步细胞，以及通过使用G0相同步细胞筛选与所述细胞的分化和/或成熟相关的方法。本发明可用于容易地将上皮细胞同步化为G0期并筛选与上皮细胞的分化和/或成熟有关的因子。

3. 发明授权

US06287771B1 Method for determining mastitis using keratin and casein which are amplified by primers 失效
标题翻译：使用通过引物扩增的角蛋白和酪蛋白来确定乳腺炎的方法
公开(公告)号：US06287771B1
公开(公告)日：2001-09-11
申请号：US09297960
申请日：1999-05-27
申请人： Mio Imamura , Yasuharu Itagaki , Morimasa Tanimoto
发明人： Mio Imamura , Yasuharu Itagaki , Morimasa Tanimoto
IPC分类号： C12Q168
CPC分类号： C07K14/4732 , C07K14/4741 , C12Q1/6883 , C12Q2600/158
摘要： A novel primer is provided which is useful in the reverse transcription polymerase chain reaction to amplify &agr;S1-casein gene and keratin gene contained in milk. A method is also provided for using the expression ratio of their genes to examine the pathological conditions of mammalian mastitis or determine the milk protein synthesis level in mammary gland cells. The method is quick and accurate and avoids the need for excising mammary gland tissue.
摘要翻译：提供了一种新的引物，其可用于逆转录聚合酶链反应以扩增牛奶中所含的αS1-酪蛋白基因和角蛋白基因。还提供了使用其基因的表达比率来检查哺乳动物乳腺炎的病理状况或确定乳腺细胞中的乳蛋白质合成水平的方法。该方法快速准确，避免了切除乳腺组织的需要。

4. 发明授权

US5260280A Bacterial toxin neutralizer 失效
标题翻译：细菌毒素中和剂
公开(公告)号：US5260280A
公开(公告)日：1993-11-09
申请号：US913491
申请日：1992-07-14
申请人： Hiroko Isoda , Yoshihiro Kawasaki , Morimasa Tanimoto , Shunichi Dosako , Tadashi Idota
发明人： Hiroko Isoda , Yoshihiro Kawasaki , Morimasa Tanimoto , Shunichi Dosako , Tadashi Idota
IPC分类号： A61K31/70 , A61K38/17 , A61K38/40 , A61K31/715
CPC分类号： A61K38/40 , A61K31/70 , A61K38/1709
摘要： Sialic acid binding proteins, sialic acid-binding peptides and sialic acid containing oligo-saccharides are active ingredients of a novel bacterial enterotoxin neutralizer and interfere with the binding of enterotoxins, including cholera toxin, to receptors so as to exert an effect of neutralizing the toxicity, thus being utilized as an effective neutralizer and are safe and available cheaply and abundantly from by-products produced during the processing of cow's milk which renders the enterotoxin neutralizer economically advantageous for commercial use.
摘要翻译：唾液酸结合蛋白，唾液酸结合肽和含唾液酸的寡糖是新型细菌肠毒素中和剂的活性成分，并干扰肠毒素（包括霍乱毒素）与受体的结合，从而发挥中和毒性作用，因此被用作有效的中和剂，并且从牛奶加工过程中产生的副产物廉价和大量地安全和可用，这使得肠毒素中和剂在经济上有利于商业用途。

5. 发明授权

US5614328A Reflow-plated member and a manufacturing method therefor 失效
标题翻译：回流构件及其制造方法
公开(公告)号：US5614328A
公开(公告)日：1997-03-25
申请号：US534330
申请日：1995-09-27
申请人： Satoshi Suzuki , Kazuya Takahashi , Teruo Kawada , Yuuji Suzuki , Morimasa Tanimoto
发明人： Satoshi Suzuki , Kazuya Takahashi , Teruo Kawada , Yuuji Suzuki , Morimasa Tanimoto
IPC分类号： C25D5/50 , B32B15/20
CPC分类号： C25D5/505 , Y10S379/912 , Y10S428/935 , Y10S428/939 , Y10T428/12715
摘要： Provided is a method for manufacturing a reflow-plated member, which comprises a process for forming a plated layer of Sn or Sn alloy on the surface of a base material, at least the surface of which is formed of Cu or Cu alloy, by electroplating, and a process for running the base material at a traveling speed equivalent to 80% to 90% of the lowest traveling speed that said plated layer does not melt when the base material is continuously run for reflowing in a heating furnace at a predetermined temperature. The obtained reflow-plated member is excellent in any of properties including solderability, heat resistance, bendability, wear resistance, and corrosion resistance.
摘要翻译：提供了一种制造回流部件的方法，其包括在基材表面上形成Sn或Sn合金的镀层的工艺，至少其表面由Cu或Cu合金形成，通过电镀以及当在预定温度下在加热炉中连续运行用于回流的所述镀层不熔化的最低行进速度的80％至90％的行进速度下运行所述基材的工艺。获得的回流镀层构件在包括可焊性，耐热性，弯曲性，耐磨性和耐腐蚀性的任何特性方面都是优异的。

6. 发明授权

US4997914A Method for separating and purifying lactoferrin from milk by use of sulfuric ester 失效
标题翻译：通过使用硫酸酯从乳中分离和纯化乳铁蛋白的方法
公开(公告)号：US4997914A
公开(公告)日：1991-03-05
申请号：US273337
申请日：1988-11-09
申请人： Hiroshi Kawakami , Morimasa Tanimoto , Shunichi Dousako
发明人： Hiroshi Kawakami , Morimasa Tanimoto , Shunichi Dousako
IPC分类号： C07K1/22 , C07K14/435 , C07K14/79
CPC分类号： C07K14/79 , Y10S530/832
摘要： A method for separating and purifying lactoferrin from milk is disclosed, which method comprises the steps of bringing raw milk containing lactoferrin into contact with a sulfuric ester of a crosslinked polysaccharide so that lactoferrin may be adsorbed by the sulfuric ester, and then eluting the adsorbed lactoferrin. The elution of the adsorbed lactoferrin is preferably conducted by the use of a buffer solution containing a 0.4-1.5 M aqueous sodium chloride solution.

7. 再颁专利

USRE38588E1 Lead material for electronic part, lead and semiconductor device using the same 有权
标题翻译：电子元件引线材料，铅和半导体器件使用该材料
公开(公告)号：USRE38588E1
公开(公告)日：2004-09-14
申请号：US10218559
申请日：2002-08-14
申请人： Morimasa Tanimoto , Satoshi Suzuki , Akira Matsuda , Kinya Sugie
发明人： Morimasa Tanimoto , Satoshi Suzuki , Akira Matsuda , Kinya Sugie
IPC分类号： H01L2348
CPC分类号： H01L23/49582 , B32B15/01 , C22C13/00 , C22C13/02 , H01L24/45 , H01L24/48 , H01L2224/45015 , H01L2224/45124 , H01L2224/45147 , H01L2224/48091 , H01L2224/48247 , H01L2924/01039 , H01L2924/01047 , H01L2924/01078 , H01L2924/01322 , H01L2924/181 , H01L2924/19041 , Y10T428/12708 , Y10T428/12715 , H01L2924/00014 , H01L2924/00 , H01L2924/2076 , H01L2924/00015 , H01L2924/00012
摘要： A lead material for an electronic part having no adverse effect on the environment, having excellent solderability, desirable welding strength during welding and a low degree of nonuniform thickness of the plated layer during reflow processing. The lead material has a first plated layer and a second plated layer, both of which do not contain Pb, laminated on the surface of a conductive substrate in such order. The melting point of the second plated layer is lower than that of the first plated layer. The first and second plated layers are made of a Sn substance and a Sn alloy, respectively or vice versa.

8. 发明授权

US6140583A Lead member with multiple conductive layers and specific grain size 失效
标题翻译：导电元件具有多个导电层和特定的晶粒尺寸
公开(公告)号：US6140583A
公开(公告)日：2000-10-31
申请号：US864339
申请日：1997-05-28
申请人： Satoshi Suzuki , Morimasa Tanimoto
发明人： Satoshi Suzuki , Morimasa Tanimoto
IPC分类号： C23C28/02 , H01L21/60 , H01L23/48 , H01L23/49 , H01L23/50 , H05K1/00
CPC分类号： H01L24/45 , H01L24/43 , H01L2224/43825 , H01L2224/43848 , H01L2224/45139 , H01L2224/45147 , H01L2224/4516 , H01L2224/45565 , H01L2224/45572 , H01L2224/45573 , H01L2224/45611 , H01L2224/45639 , H01L2224/45644 , H01L2224/45647 , H01L2224/45655 , H01L2224/45657 , H01L2224/45663 , H01L2224/45664 , H01L2224/45669 , H01L2224/45673 , H01L2224/45676 , H01L2224/45678 , H01L2224/4851 , H01L2924/00011 , H01L2924/00014 , H01L2924/01004 , H01L2924/01005 , H01L2924/01007 , H01L2924/01011 , H01L2924/01014 , H01L2924/01015 , H01L2924/01027 , H01L2924/01028 , H01L2924/01029 , H01L2924/0103 , H01L2924/01033 , H01L2924/01044 , H01L2924/01045 , H01L2924/01047 , H01L2924/0105 , H01L2924/01075 , H01L2924/01076 , H01L2924/01077 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/01084 , H01L2924/01322 , H01L2924/014 , H01L2924/10253 , H01L2924/19041 , H01L2924/19043
摘要： A lead member for electronic parts which has excellent heat resistance, oxidation resistance and corrosion resistance and is especially excellent in solderability and a process of producing such a lead member at low cost by plating are provided. The lead member comprises a base, at least a surface region of which is made of Cu or a Cu alloy, a primary coat of Ni, Co, a Ni alloy or a Co alloy and a surface layer of Pd, Ru, a Pd alloy or a Ru alloy formed sequentially on the base in the order mentioned. The primary coat consists of grains having a grain size of 20 .mu.m or more.
摘要翻译：提供了具有优异的耐热性，抗氧化性和耐腐蚀性并且特别优异的可焊性的电子部件的引线部件和通过电镀以低成本制造这种引线部件的工艺。引线构件包括基底，至少其表面区域由Cu或Cu合金制成，Ni，Co，Ni合金或Co合金的初级涂层以及Pd，Ru，Pd合金的表面层或Ru合金按照所述顺序依次形成在基材上。初级涂层由粒径20μm以上的晶粒构成。

9. 发明授权

US5075424A Process for producing .kappa.-casein glycomacropeptides 失效
标题翻译：生产（KAPPA）-Casein GLYCOMACROPEPTITIDES的方法
公开(公告)号：US5075424A
公开(公告)日：1991-12-24
申请号：US476196
申请日：1990-02-07
申请人： Morimasa Tanimoto , Yoshihiro Kawasaki , Hiroshi Shinmoto , Shunichi Dosako , Akira Tomizawa
发明人： Morimasa Tanimoto , Yoshihiro Kawasaki , Hiroshi Shinmoto , Shunichi Dosako , Akira Tomizawa
IPC分类号： A23L1/305 , A23J1/20 , A23J3/08 , A23J3/34 , A61K38/17 , A61P1/02 , A61P3/04 , A61P31/04 , A61P31/12 , A61P31/16 , C07K1/34 , C07K14/47
CPC分类号： A23J1/202 , C07K14/4732
摘要： A process for producing .kappa.-casein glycomacropeptides which comprises adjusting the pH of a solution of milk starting materials containing the .kappa.-casein glycomacropeptides to below 4, treating the solution by ultrafiltration with a membrane having a fraction molecular weight of 10,000-50,000, and concentrating the obtained filtrate with a membrane having a fraction molecular weight of 50,000 or less.

10. 发明授权

US5087369A Fluidized bed separation and recovery of proteins from fluids in a rotary column 失效
标题翻译：流化床分离和回收来自旋转柱中的流体的蛋白质的流化床分离
公开(公告)号：US5087369A
公开(公告)日：1992-02-11
申请号：US643988
申请日：1991-01-22
申请人： Morimasa Tanimoto , Kaoru Sato , Shinichi Dosako , Yoshihiko Honda
发明人： Morimasa Tanimoto , Kaoru Sato , Shinichi Dosako , Yoshihiko Honda
IPC分类号： G01N33/53 , B01D15/02 , C07K1/14 , C07K1/16 , C07K1/22 , C07K14/00 , C07K14/235 , C07K14/52 , C07K14/555 , C07K14/79 , C07K16/00 , C12P21/00
CPC分类号： C07K1/16 , C07K1/22 , C07K14/235 , C07K14/79
摘要： Disclosed is a method for separating and recovering very small amounts of biologically active proteins (such as enzymes, antigens and antibodies) present in a various fluids, with a high recovery and on a large scale, in which a fluid containing a desired protein is introduced into a rotary column through orifices therein and brought into contact with a gel carrier capable of selectively adsorbing the desired protein, while the carrier is being gentle fluidized in a liquid by the rotary motion successively by wash water and eluting fluid, so that the column, after which the fluid is displaced, the carrier having the desired protein adsorbed thereon is washed and the desired protein is recovered therefrom by elution while the carrier fluidized.

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