专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5843448A Tumor rejection antigen precursor 失效
标题翻译：肿瘤排斥抗原前体
公开(公告)号：US5843448A
公开(公告)日：1998-12-01
申请号：US560024
申请日：1995-11-17
申请人： Yao-Tseng Chen , Elisabeth Stockert , Yachi Chen , Pilar Garin-Chesa , Wolfgang J. Rettig , Lloyd J. Old
发明人： Yao-Tseng Chen , Elisabeth Stockert , Yachi Chen , Pilar Garin-Chesa , Wolfgang J. Rettig , Lloyd J. Old
IPC分类号： C12N15/02 , A61K38/00 , A61K39/00 , A61K39/395 , A61P35/00 , C07H21/04 , C07K20060101 , C07K7/08 , C07K14/47 , C07K14/705 , C07K16/30 , C12N5/10 , C12N5/20 , C12P21/08 , C12R1/91 , G01N33/574 , A61K38/10 , C07K14/82
CPC分类号： C07K14/4748 , C07K16/30 , A61K38/00 , A61K39/00
摘要： The invention relates to monoclonal antibodies which specifically bind to the tumor rejection antigen precursor molecule MAGE-1, hybridomas which produce these monoclonal antibodies, and their use. Also described is a recombinant form of MAGE-1, peptides which are useful as immunogens, and immunogenic compositions containing the peptides and an adjuvant.
摘要翻译：本发明涉及与肿瘤排斥抗原前体分子MAGE-1特异性结合的单克隆抗体，产生这些单克隆抗体的杂交瘤及其应用。还描述了重组形式的MAGE-1，可用作免疫原的肽和含有肽和佐剂的免疫原性组合物。

2. 发明授权

US5541104A Monoclonal antibodies which bind to tumor rejection antigen precursor mage-1 失效
标题翻译：结合肿瘤排斥抗原前体法师-1的单克隆抗体
公开(公告)号：US5541104A
公开(公告)日：1996-07-30
申请号：US190411
申请日：1994-02-01
申请人： Yao-Tseng Chen , Elisabeth Stockert , Yachi Chen , Pilar Garin-Chesa , Wolfgang J. Rettig , Pierre van der Bruggen , Thierry Boon-Falleur , Lloyd J. Old
发明人： Yao-Tseng Chen , Elisabeth Stockert , Yachi Chen , Pilar Garin-Chesa , Wolfgang J. Rettig , Pierre van der Bruggen , Thierry Boon-Falleur , Lloyd J. Old
IPC分类号： C12N15/02 , A61K38/00 , A61K39/00 , A61K39/395 , A61P35/00 , C07H21/04 , C07K20060101 , C07K7/08 , C07K14/47 , C07K14/705 , C07K16/30 , C12N5/10 , C12N5/20 , C12P21/08 , C12R1/91 , G01N33/574 , C12P21/04 , C07K16/00 , C12N5/00
CPC分类号： C07K14/4748 , C07K16/30 , A61K38/00 , A61K39/00
摘要： The invention relates to monoclonal antibodies which specifically bind to the tumor rejection antigen precursor molecule MAGE-1, hybridomas which produce these monoclonal antibodies, and their use. Also described is a recombinant form of MAGE-1, peptides which are useful as immunogens, and immunogenic compositions containing the peptides and an adjuvant.
摘要翻译：本发明涉及与肿瘤排斥抗原前体分子MAGE-1特异性结合的单克隆抗体，产生这些单克隆抗体的杂交瘤及其应用。还描述了重组形式的MAGE-1，可用作免疫原的肽和含有肽和佐剂的免疫原性组合物。

3. 发明授权

US06440663B1 Renal cancer associated antigens and uses therefor 有权
标题翻译：肾癌相关抗原及其用途
公开(公告)号：US06440663B1
公开(公告)日：2002-08-27
申请号：US09166350
申请日：1998-10-05
申请人： Matthew J. Scanlan , Elisabeth Stockert , Yao-Tseng Chen , Lloyd J. Old , Elke Jager , Alex Knuth
发明人： Matthew J. Scanlan , Elisabeth Stockert , Yao-Tseng Chen , Lloyd J. Old , Elke Jager , Alex Knuth
IPC分类号： C12Q168
CPC分类号： C07K14/47 , A61K35/00 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2035/11 , C12Q1/6886 , C12Q2600/158 , G01N33/57488 , G01N33/57492
摘要： Cancer associated antigens have been identified by autologous antibody screening of libraries of nucleic acids expressed in renal cancer cells using antisera from cancer patients. The invention relates to nucleic acids and encoded polypeptides which are cancer associated antigens expressed in patients afflicted with renal cancer. The invention provides, inter alia, isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more cancer associated antigens.
摘要翻译：已经通过使用来自癌症患者的抗血清的肾癌细胞中表达的核酸文库的自身抗体筛选来鉴定癌症相关抗原。本发明涉及在患有肾癌的患者中表达的癌症相关抗原的核酸和编码多肽。本发明尤其提供了分离的核酸分子，含有这些分子的表达载体和用这些分子转染的宿主细胞。本发明还提供分离的蛋白质和肽，这些蛋白质和肽的抗体以及识别蛋白质和肽的细胞毒性T淋巴细胞。还提供了前述的片段，包括功能片段和变体。另外提供了含有上述分子的试剂盒。本发明提供的分子可用于诊断，监测，研究或治疗以一种或多种癌症相关抗原表达为特征的病症。

4. 发明授权

US06403373B1 Isolated nucleic acid molecules associated with colon, renal, and stomach cancer and methods of using these 失效
标题翻译：与结肠，肾和胃癌相关的分离的核酸分子及其使用方法
公开(公告)号：US06403373B1
公开(公告)日：2002-06-11
申请号：US09102322
申请日：1998-06-22
申请人： Matthew J. Scanlan , Yao-Tseng Chen , Elisabeth Stockert , Lloyd J. Old
发明人： Matthew J. Scanlan , Yao-Tseng Chen , Elisabeth Stockert , Lloyd J. Old
IPC分类号： C12N510
CPC分类号： G01N33/56977 , A61K38/00 , C07K14/4748 , C12Q1/6886 , C12Q2600/158 , G01N33/5748
摘要： Various molecules associated with cancer are disclosed. The invention also discloses diagnostic and therapeutic methods based upon these molecules.
摘要翻译：公开了与癌症相关的各种分子。本发明还公开了基于这些分子的诊断和治疗方法。

5. 发明授权

US07314721B2 Small cell lung cancer associated antigens and uses therefor 有权
标题翻译：小细胞肺癌相关抗原及其用途
公开(公告)号：US07314721B2
公开(公告)日：2008-01-01
申请号：US10761169
申请日：2004-01-20
申请人： Ali O. Gure , Elisabeth Stockert , Matthew J. Scanlan , Dirk Jager , Lloyd J. Old , Yao-Tseng Chen
发明人： Ali O. Gure , Elisabeth Stockert , Matthew J. Scanlan , Dirk Jager , Lloyd J. Old , Yao-Tseng Chen
IPC分类号： G01N33/53 , C07K1/00 , C07K16/00
CPC分类号： G01N33/574 , A61K38/00 , A61K39/00 , C07K14/4748 , G01N33/57423
摘要： Cancer associated antigens have been identified by autologous antibody screening of libraries of nucleic acids expressed in small cell lung cancer cells using antisera from cancer patients. The invention relates to nucleic acids and encoded polypeptides which are cancer associated antigens expressed in patients afflicted with small cell lung cancer. The invention provides, among other things, isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more cancer associated antigens.
摘要翻译：已经通过使用来自癌症患者的抗血清的小细胞肺癌细胞中表达的核酸文库的自身抗体筛选来鉴定癌症相关抗原。本发明涉及在患有小细胞肺癌的患者中表达的癌症相关抗原的核酸和编码多肽。本发明尤其提供了分离的核酸分子，含有这些分子的表达载体和用这些分子转染的宿主细胞。本发明还提供分离的蛋白质和肽，这些蛋白质和肽的抗体以及识别蛋白质和肽的细胞毒性T淋巴细胞。还提供了前述的片段，包括功能片段和变体。另外提供了含有上述分子的试剂盒。本发明提供的分子可用于诊断，监测，研究或治疗以一种或多种癌症相关抗原表达为特征的病症。

6. 发明授权

US06982316B1 Isolated nucleic acid molecules associated with colon cancer and methods for diagnosing and treating colon cancer 失效
标题翻译：与结肠癌相关的分离的核酸分子以及诊断和治疗结肠癌的方法
公开(公告)号：US06982316B1
公开(公告)日：2006-01-03
申请号：US09502945
申请日：2000-02-11
申请人： Matthew J. Scanlan , Yao-Tseng Chen , Elisabeth Stockert , Lloyd J. Old
发明人： Matthew J. Scanlan , Yao-Tseng Chen , Elisabeth Stockert , Lloyd J. Old
IPC分类号： C07K14/47 , C07K7/00
CPC分类号： C07K14/4748 , A61K38/00 , C12Q1/6886 , G01N33/56977 , G01N33/5748
摘要： Various molecules associated with disorders such as cancer are disclosed. The invention also discloses diagnostic aid therapeutic methods based upon these molecules, as well as compositions for stimulating an immune response and methods for identifying cancer-associated nucleic acid and polypeptide molecules.
摘要翻译：公开了与疾病如癌症相关的各种分子。本发明还公开了基于这些分子的诊断辅助治疗方法，以及用于刺激免疫应答的组合物和用于鉴定癌症相关核酸和多肽分子的方法。

7. 发明授权

US06794501B2 Colon cancer antigen panel 失效
标题翻译：结肠癌抗原组
公开(公告)号：US06794501B2
公开(公告)日：2004-09-21
申请号：US09849602
申请日：2001-05-04
申请人： Yao-Tseng Chen , Lloyd J. Old , Matthew J. Scanlan , Elisabeth Stockert
发明人： Yao-Tseng Chen , Lloyd J. Old , Matthew J. Scanlan , Elisabeth Stockert
IPC分类号： C07H2104
CPC分类号： G01N33/57419 , A61K38/00 , C07K14/4748 , C07K16/3046 , C12Q1/6886 , C12Q2600/156
摘要： The invention provides methods for diagnosing cancer including colon cancer, based on the identification of certain colon cancer-associated polypeptides as antigens that elicit immune responses in colon cancer. The identified antigens can be utilized as markers for diagnosing colon cancer, and for following the course of treatment of colon cancer.
摘要翻译：本发明基于鉴定某些结肠癌相关多肽作为在结肠癌中引起免疫应答的抗原，提供诊断包括结肠癌的癌症的方法。所鉴定的抗原可用作诊断结肠癌的标志物，以及用于治疗结肠癌的过程。

8. 发明授权

US06517837B1 Isolated nucleic acid molecules associated with colon cancer and methods for diagnosing and treating colon cancer 有权
标题翻译：与结肠癌相关的分离的核酸分子以及诊断和治疗结肠癌的方法
公开(公告)号：US06517837B1
公开(公告)日：2003-02-11
申请号：US09510543
申请日：2000-02-22
申请人： Matthew J. Scanlan , Yao-Tseng Chen , Elisabeth Stockert , Lloyd J. Old
发明人： Matthew J. Scanlan , Yao-Tseng Chen , Elisabeth Stockert , Lloyd J. Old
IPC分类号： A61K3900
CPC分类号： G01N33/56977 , A61K38/00 , C07K14/4748 , C12Q1/6886 , C12Q2600/158 , G01N33/5748
摘要： Various molecules associated with disorders such as cancer are disclosed. The invention also discloses diagnostic and therapeutic methods based upon these molecules, as well as compositions for stimulating an immune response and methods for identifying cancer-associated nucleic acid and polypeptide molecules.
摘要翻译：公开了与疾病如癌症相关的各种分子。本发明还公开了基于这些分子的诊断和治疗方法，以及用于刺激免疫应答的组合物和用于鉴定癌症相关核酸和多肽分子的方法。

9. 发明授权

US06297364B1 Isolated nucleic acid molecule encoding cancer associated antigen, the antigen itself, and uses thereof 失效
标题翻译：编码癌相关抗原的分离的核酸分子，抗原本身及其用途
公开(公告)号：US06297364B1
公开(公告)日：2001-10-02
申请号：US09061709
申请日：1998-04-17
申请人： Yao-Tseng Chen , Ali Gure , Solam Tsang , Elisabeth Stockert , Elke Jäger , Knuth Alexander , Lloyd J. Old
发明人： Yao-Tseng Chen , Ali Gure , Solam Tsang , Elisabeth Stockert , Elke Jäger , Knuth Alexander , Lloyd J. Old
IPC分类号： C07H2102
CPC分类号： C07K14/4748 , A61K2039/505
摘要： The invention relates to the isolation of a nucleic acid molecule which encodes a cancer associated antigen. Also a part of the invention is the antigen itself, and the uses of the nucleic acid molecule and the antigen, and peptides derived from it.
摘要翻译：本发明涉及分离编码癌相关抗原的核酸分子。本发明的一部分也是抗原本身，以及核酸分子和抗原的用途以及从其衍生的肽。

10. 发明授权

US07335467B2 Breast cancer antigens 有权
标题翻译：乳腺癌抗原
公开(公告)号：US07335467B2
公开(公告)日：2008-02-26
申请号：US10146473
申请日：2002-05-15
申请人： Matthew J. Scanlan , Ivan Gout , Elisabeth Stockert , Lloyd J. Old , Ali Gure , Yao-Tseng Chen
发明人： Matthew J. Scanlan , Ivan Gout , Elisabeth Stockert , Lloyd J. Old , Ali Gure , Yao-Tseng Chen
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/567 , G01N33/574 , G01N1/00 , G01N33/48 , C12P19/34
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/158 , Y10T436/25
摘要： The invention provides methods for diagnosing cancer including breast cancer, based on the identification of certain breast cancer-associated polypeptides as antigens that elicit immune responses in breast cancer. The identified antigens can be utilized as markers for diagnosing breast cancer, and for following the course of treatment of breast cancer.
摘要翻译：本发明提供了鉴定某些乳腺癌相关多肽作为在乳腺癌中引起免疫反应的抗原来诊断包括乳腺癌在内的癌症的方法。鉴定的抗原可用作诊断乳腺癌的标志物，并用于跟踪乳腺癌的治疗过程。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式