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1. 发明授权

US06440663B1 Renal cancer associated antigens and uses therefor 有权
标题翻译：肾癌相关抗原及其用途
公开(公告)号：US06440663B1
公开(公告)日：2002-08-27
申请号：US09166350
申请日：1998-10-05
申请人： Matthew J. Scanlan , Elisabeth Stockert , Yao-Tseng Chen , Lloyd J. Old , Elke Jager , Alex Knuth
发明人： Matthew J. Scanlan , Elisabeth Stockert , Yao-Tseng Chen , Lloyd J. Old , Elke Jager , Alex Knuth
IPC分类号： C12Q168
CPC分类号： C07K14/47 , A61K35/00 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2035/11 , C12Q1/6886 , C12Q2600/158 , G01N33/57488 , G01N33/57492
摘要： Cancer associated antigens have been identified by autologous antibody screening of libraries of nucleic acids expressed in renal cancer cells using antisera from cancer patients. The invention relates to nucleic acids and encoded polypeptides which are cancer associated antigens expressed in patients afflicted with renal cancer. The invention provides, inter alia, isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more cancer associated antigens.
摘要翻译：已经通过使用来自癌症患者的抗血清的肾癌细胞中表达的核酸文库的自身抗体筛选来鉴定癌症相关抗原。本发明涉及在患有肾癌的患者中表达的癌症相关抗原的核酸和编码多肽。本发明尤其提供了分离的核酸分子，含有这些分子的表达载体和用这些分子转染的宿主细胞。本发明还提供分离的蛋白质和肽，这些蛋白质和肽的抗体以及识别蛋白质和肽的细胞毒性T淋巴细胞。还提供了前述的片段，包括功能片段和变体。另外提供了含有上述分子的试剂盒。本发明提供的分子可用于诊断，监测，研究或治疗以一种或多种癌症相关抗原表达为特征的病症。

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