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1. 发明申请

WO1998024777A1 A PROCESS FOR RECOVERY OF ASCORBIC ACID 审中-公开
标题翻译：抗坏血酸的回收方法
公开(公告)号：WO1998024777A1
公开(公告)日：1998-06-11
申请号：PCT/US1997022395
申请日：1997-11-25
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , A.E. STALEY MANUFACTURING CO. , EYAL, Aharon, Meir
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , A.E. STALEY MANUFACTURING CO.
IPC分类号： C07D307/62
CPC分类号： C07D307/62
摘要： The invention provides a process for the recovery of ascorbic acid from a feed containing at least one precursor of ascorbic acid comprising converting said precursor into at least one product, said at least one product being ascorbic acid in an organic extractant composition, said organic extractant composition comprising at least one secondary or tertiary alkyl amine in which the aggregate number of carbon atoms is at least 20, as a primary extractant, and a polar extraction enhancer compound; wherein said extractant composition comprises at least 2 moles of said polar extraction enhancer compound per one mole of primary extractant; and subjecting said ascorbic acid-containing organic extractant composition to a stripping operation with aqueous solution at a temperature of at least 20 DEG C higher than the temperature at which said conversion is carried out; whereby there is obtained an aqueous solution of ascorbic acid in which the concentration of ascorbic acid is higher than 5 %.
摘要翻译：本发明提供了从含有至少一种抗坏血酸前体的饲料中回收抗坏血酸的方法，包括将所述前体转化成至少一种产物，所述至少一种产物是有机萃取剂组合物中的抗坏血酸，所述有机萃取剂组合物包含至少一种其中总碳原子数为20以上的仲或叔烷基胺作为主要提取剂和极性提取增强剂化合物; 其中所述萃取剂组合物每1摩尔初级萃取剂包含至少2摩尔所述极性提取增强剂化合物; 并在比所述转化进行的温度高至少20℃的温度下用水溶液对所述含有抗坏血酸的有机萃取剂组合物进行汽提操作; 得到抗坏血酸浓度高于5％的抗坏血酸水溶液。

2. 发明申请

WO1997013580A1 A METATHETIC PROCESS UTILIZING A CATION EXCHANGER 审中-公开
标题翻译：一种使用交换器的分解过程
公开(公告)号：WO1997013580A1
公开(公告)日：1997-04-17
申请号：PCT/GB1996002377
申请日：1996-09-26
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , GODWIN, Edgar, James , EYAL, Aharon, Meir
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , GODWIN, Edgar, James
IPC分类号： B01J39/04
CPC分类号： B01J47/00 , B01J39/00 , B01J39/05 , B01J39/07
摘要： The invention provides a metathetic process of the type M'X + M"Y = M'Y + M"X, where M' differs from M" and the reagents and the products are water-soluble salts, comprising the steps of (a) transferring a solution of M"Y through at least one column containing cation exchanger beads loaded with M' cations, obtained in step (b) hereinafter, whereby cation exchange takes place to form a solution of M'Y and cation exchanger beads loaded with M", and (b) transferring a solution of M'X through said column containing cation exchanger beads loaded with M" obtained in step (a) above, whereby cation exchange takes place to form a solution of M"X and cation exchanger beads loaded with M'; characterized in that both M' and M" are selected from the group consisting of sodium, potassium and ammonium; X and Y are different anions; two types of cation exchanger, A and B, are used in the process; cation exchanger A is more acidic than cation exchanger B; in step (a), the solution of M"Y is first transferred through beads of cation exchanger A and then through beads of cation exchanger B, both of which are loaded with M' cations obtained in step (b), whereby cation exchange takes place on both cation exchangers to form a solution of M'Y and to form cation exchanger beads loaded with M"; and in step (b), the solution of M'X is first transferred through beads of cation exchanger B and then through beads of cation exchanger A, both of which are loaded with M" cations obtained in step (a), whereby cation exchange takes place on both cation exchangers to form a solution of M"X and to form cation exchanger beads loaded with M'.
摘要翻译：本发明提供M'X + M“Y = M'Y + M”X型的复分解方法，其中M'不同于M“，试剂和产物是水溶性盐，包括以下步骤：（a ）将M“Y溶液通过至少一个含有阳离子交换剂珠的负载有M'阳离子的柱，在步骤（b）中获得的阳离子交换发生在步骤（b）中，由此进行阳离子交换以形成M'Y和阳离子交换剂珠的溶液， M“，（b）通过上述步骤（a）中得到的载有M”的载有阳离子交换剂珠的M'X的溶液转移，由此进行阳离子交换以形成M“X和阳离子交换剂珠的溶液负载M';其特征在于M'和M“均选自钠，钾和铵; X和Y是不同的阴离子; 在这个过程中使用两种类型的阳离子交换剂A和B; 阳离子交换剂A比阳离子交换剂B更酸性; 在步骤（a）中，首先通过阳离子交换剂A的珠粒转移M“Y的溶液，然后通过阳离子交换剂B的珠子，两者都装载步骤（b）中获得的M'阳离子，由此阳离子交换置于两个阳离子交换剂上以形成M'Y的溶液并形成负载有M“的阳离子交换剂珠; 在步骤（b）中，首先将M'X的溶液通过阳离子交换剂B的珠粒转移，然后通过阳离子交换剂A的珠粒，两者都载有步骤（a）中得到的M“阳离子，由此阳离子交换发生在两个阳离子交换剂上以形成M“X的溶液并形成负载有M'的阳离子交换剂珠粒。

3. 发明申请

WO1997013761A1 A PROCESS FOR THE RECOVERY OF ASCORBIC ACID 审中-公开
标题翻译：抗坏血酸的恢复方法
公开(公告)号：WO1997013761A1
公开(公告)日：1997-04-17
申请号：PCT/GB1996002041
申请日：1996-08-21
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin , EYAL, Aharon, Meir , VITNER, Asher , REUVENY, Tal
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin
IPC分类号： C07D307/62
CPC分类号： C07D307/62
摘要： The invention provides a process for the recovery of ascorbic acid from an aqueous feed solution containing the acid at a concentration of less then 0.7 mol/kg, including adsorbing a major portion of the ascorbic acid with a solid phase adsorbent resin selected from resins carrying a pyridine function and resins of similar or weaker basicity, separating the ascorbic acid-containing resin from residual aqueous solution, and subjecting the ascorbic acid-containing resin to a desorbing operation with a neutral solvent at a temperature of at least 20 DEG C higher than the termperature at which the adsorbtion is carried out, whereby there is obtained a solution of ascorbic acid in solvent in which the concentration of ascorbic acid is at least equal to its concentration in the aqueous feed solution.
摘要翻译：本发明提供了从含有浓度小于0.7mol / kg的酸的含水进料溶液中回收抗坏血酸的方法，包括用固相吸附树脂吸附大部分抗坏血酸，所述固相吸附树脂选自携带吡啶功能和碱性相似或较弱的树脂，将残留水溶液分离出含有抗坏血酸的树脂，并使用含有抗坏血酸的树脂在比中性溶剂至少高20℃以上的温度下进行解吸操作进行吸附的温度，从而得到抗坏血酸在溶剂中的溶液，其中抗坏血酸的浓度至少等于其在进料水溶液中的浓度。

4. 发明申请

WO1996011281A1 PROCESS FOR THE PREPARATION OF LONG-CHAIN ALKYL GLYCOSIDES 审中-公开
标题翻译：制备长链氨基糖苷的方法
公开(公告)号：WO1996011281A1
公开(公告)日：1996-04-18
申请号：PCT/GB1995002373
申请日：1995-10-06
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin , EYAL, Aharon, Meir , KOTLYAR, Sofia , APFELBAUM, Francoise , MAGDASSI, Shlomo , BRAUN, Sergei
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin
IPC分类号： C12P19/44
CPC分类号： C12P19/44
摘要： The invention provides a process for the preparation of long-chain alkyl glycosides, comprising reacting a glucose-containing reactant and a C8-C18 fatty alcohol in the presence of a glucosidase and a reaction promoter effective to promote the formation of the alkyl glycoside when the promoter is present in an amount of less than about 50 wt.% of the total reaction mixture.
摘要翻译：本发明提供了制备长链烷基糖苷的方法，包括在葡萄糖苷酶和反应促进剂存在下使含葡萄糖的反应物与C8-C18脂肪醇反应，所述反应促进剂有效促进烷基糖苷的形成促进剂的存在量小于总反应混合物的约50重量％。

5. 发明申请

WO1995025081A1 A PROCESS AND EXTRACTANT COMPOSITION FOR EXTRACTING ACIDS 审中-公开
标题翻译：用于提取酸的方法和提取物组合物
公开(公告)号：WO1995025081A1
公开(公告)日：1995-09-21
申请号：PCT/GB1995000535
申请日：1995-03-13
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin , EYAL, Aharon, Meir
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin
IPC分类号： C07C51/48
CPC分类号： C07C51/48
摘要： The invention provides a process for the recovery of a water-soluble carboxylic or mineral acid having a pKa higher than 2 from an aqueous feed solution containing the acid or a salt thereof, comprising extracting the acid with a water-immiscible extractant composition, the composition comprising: (a) at least one secondary or tertiary alkyl amine, in which the aggregate number of carbon atoms is at least 20, as a primary extractant; and (b) a sterically hindered, polar, organic compound having at least 5 carbon atoms, a basicity weaker than that of the primary extractant, and temperature-sensitive, extraction-modifying properties; separating the acid containing the extractant and subjecting it to a stripping operation at a temperature of at least 20 DEG C higher than the temperature at which the extraction is carried out, wherein the sterically hindered, polar, organic compound both modifies the extracting power of the primary extractant composition and facilitates the temperature-sensitive stripping operation. The invention also provides an extractant composition for use in such a process.
摘要翻译：本发明提供一种从含有酸或其盐的含水进料溶液中回收具有高于2的pKa的水溶性羧酸或无机酸的方法，包括用水不混溶的萃取剂组合物萃取酸，该组合物包括：（a）至少一种其中总碳原子数为20以上的仲或叔烷基胺作为主要提取剂; 和（b）具有至少5个碳原子的空间位阻极性有机化合物，其碱性弱于初级萃取剂，碱度低于温度敏感性，萃取 - 改性性质; 分离含有萃取剂的酸，并在比进行萃取的温度高至少20℃的温度下进行汽提操作，其中空间位阻极性有机化合物改变了萃取剂的萃取力初级萃取剂组合物，并有助于温度敏感的汽提操作。本发明还提供了用于这种方法的萃取剂组合物。

6. 发明申请

WO1998002411A1 A PROCESS FOR THE SEPARATION OF AMINO ACIDS AND THEIR SALTS FROM AN AQUEOUS SOLUTION 审中-公开
标题翻译：一种用于分离氨基酸及其水溶液的方法
公开(公告)号：WO1998002411A1
公开(公告)日：1998-01-22
申请号：PCT/GB1997001874
申请日：1997-07-11
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin , EYAL, Aharon, Meir , COHEN-SYDOV, Nadjda
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , WHALLEY, Kevin
IPC分类号： C07C227/40
CPC分类号： C07C227/40
摘要： The invention provides a process for the separation of amino acids and their salts from impurities contained in an aqueous feed solution containing the same, wherein the solution has a pH value of pH > pl, in the case of acidic amino acids, has a pH value of pH
摘要翻译：本发明提供了一种从含有该氨基酸及其盐的含水原料溶液中的杂质中分离氨基酸及其盐的方法，其中，在酸性氨基酸的情况下，该溶液的pH值> P1的pH值为pH，具有pH值在碱性氨基酸的情况下为pH

7. 发明申请

WO1998026062A2 SYNTHETIC ANTISENSE OLIGODEOXYNUCLEOTIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：合成抗体寡糖氧化酶和含有它们的药物组合物
公开(公告)号：WO1998026062A2
公开(公告)日：1998-06-18
申请号：PCT/US1997023598
申请日：1997-12-12
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I. , SOREQ, Hermona , SEIDMAN, Shlomo , ECKSTEIN, Fritz , FRIEDMAN, Alon , KAUFER, Daniela
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I.
IPC分类号： C12N15/00
CPC分类号： C12Y301/01007 , A01K2217/05 , A61K38/00 , C12N15/1137 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/53 , C12N2310/3521
摘要： A synthetic nuclease resistant antisense oligodeoxynucleotide (AS-ODN) capable of selectively modulating human acetylcholinesterase (AChE) production and a pharmaceutical or medical composition comprising at least one AD-ODN as an active ingredient. In an embodiment the AS-ODN can be selected from 5'ACGCTTTCTTGAGGC 3' (SEQ ID NO.1), 5'GGCACCCTGGGCAGC 3' (SEQ ID NO.2); 5'CCACGTCCTCCTGCACCGTC 3' (SEQ ID NO.6); 5'ATGAACTCGATCTCGTAGCC 3' (SEQ ID NO.7); 5'GCCAGAGGAGGAGGAGAAGG 3' (SEQ ID NO.4); 5'TAGCGTCTACCACCCCTGAC 3' (SEQ ID NO.5), 5'TCTGTGTTATAGCCCAGCCC 3' (SEQ ID NO.17); and 5'GGCCTGTAACAGTTTATTT 3' (SEQ ID NO.18). A nuclease resistant antisense targeted against the splice junction in the AChEmRNA post splice message is disclosed. In an embodiment, a nuclease resistant AS-ODN targeted against the E4-E6 junction in the E1-E4-E6 splice variant AChEmRNA is disclosed as being highly specific for the muscle and central nervous system splice variant of AChE. The synthetic nuclease resistant AS-ODNs are capable of selectively modulating human AChE production in the central nervous system or capable of selectively reducing human AChE deposition in the neuromuscular junction. The present invention also provides a method to restore balanced cholinergic signaling in the brain and spinal cord or reduce AChE in the neuromuscular junction in patients in need of such treatment comprising administering to a patient in need of such treatment a therapeutically effective amount of at least one of the synthetic nuclease resistant AS-ODN capable of selectively modulating human AChE production.
摘要翻译：能够选择性调节人乙酰胆碱酯酶（AChE）生产的合成核酸酶抗性反义寡脱氧核苷酸（AS-ODN）和包含至少一种AD-ODN作为活性成分的药物或医药组合物。在一个实施方案中，AS-ODN可以选自5'ACGCTTTCTTGAGGC 3'（SEQ ID NO.1），5'GGCACCCTGGGCAGC 3'（SEQ ID NO.2）; 5'CCACGTCCTCCTGCACCGTC 3'（SEQ ID NO.6）; 5'ATGAACTCGATCTCGTAGCC 3'（SEQ ID NO.7）; 5'GCCAGAGGAGGAGGAGAAGG 3'（SEQ ID NO.4）; 5'TAGCGTCTACCACCCCTGAC 3'（SEQ ID NO.5），5'TCTGTGTTATAGCCCAGCCC 3'（SEQ ID NO.17）; 和5'GGCCTGTAACAGTTTATTT 3'（SEQ ID NO.18）。公开了针对针对AChEmRNA后剪接消息中的剪接连接的核酸酶抗性反义。在一个实施方案中，公开了针对E1-E4-E6剪接变体AChEmRNA中的E4-E6连接的核酸酶抗性AS-ODN作为AChE的肌肉和中枢神经系统剪接变体的高度特异性。合成的核酸酶抗性AS-ODNs能够选择性调节中枢神经系统中的人AChE产生或能够选择性地降低神经肌肉接头中的人类AChE沉积。本发明还提供一种在需要这种治疗的患者中恢复脑和脊髓中的平衡胆碱能信号传导或减少神经肌肉接头中的AChE的方法，包括向需要这种治疗的患者施用治疗有效量的至少一种的能够选择性调节人AChE生产的合成核酸酶抗性AS-ODN。

8. 发明申请

WO1998024300A1 CAROTENOID-ASSOCIATED PROTEINS USEFUL FOR HIGH CAROTENOID ACCUMULATION AND PRODUCTION IN PLANTS AND OTHER ORGANISMS 审中-公开
标题翻译：与植物和其他有机体相关的高碳毛虫积累和生产有关的CAROTENOID相关蛋白
公开(公告)号：WO1998024300A1
公开(公告)日：1998-06-11
申请号：PCT/IL1997000399
申请日：1997-12-04
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , VAINSTEIN, Alexander , VISHNEVETSKY, Michael , OVADIS, Marianna , ITZHAKI, Hanan
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
IPC分类号： A01H01/00
CPC分类号： C12N15/8237 , C07K14/415 , C12N15/823 , C12N15/8238 , C12N15/825
摘要： A method for production of high amounts of carotenoids in plants, bacteria or cells. Carotenoid-associated proteins CHRC and CHRD isolated from corollas of Cucumis sativus, chrc gene, CHRC deduced sequence, the molecular cloning, cDNA and RNA. A new CHRC promoter able to direct expression for foreign genes. The cloned promoter comprising approximately 3.5 kb of the CHRC upstream region.
摘要翻译：用于在植物，细菌或细胞中产生大量类胡萝卜素的方法。从Cucumis sativus，chrc基因，CHRC推导序列，分子克隆，cDNA和RNA的花冠分离的类胡萝卜素相关蛋白CHRC和CHRD。一个能够引导外源基因表达的新型CHRC启动子。克隆的启动子包含大约3.5kb的CHRC上游区。

9. 发明申请

WO1997049423A2 LIPOSOMAL INFLUENZA VACCINE COMPOSITION AND METHOD 审中-公开
标题翻译：脂肪流感疫苗组合物和方法
公开(公告)号：WO1997049423A2
公开(公告)日：1997-12-31
申请号：PCT/IL1997000210
申请日：1997-06-24
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KEDAR, Eliezer , BABAI, Ilan , BARENHOLZ, Yechezkel
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
IPC分类号： A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/55505 , A61K2039/55522 , A61K2039/55533 , A61K2039/55555 , C12N2760/16134 , Y10S436/829 , A61K38/2013 , A61K38/193 , A61K2300/00
摘要： Subunit influenza vaccines containing an influenza H/N antigen and a cytokine immunopotentiator, where at least one and preferably both are encapsulated in liposomes, are described. The vaccines stimulate a strong humoral and CTL response. Also described are methods of immunization using such vaccines.
摘要翻译：描述了含有流感H / N抗原的亚单位流感疫苗和细胞因子免疫增强剂，其中至少一个并且优选二者被包封在脂质体中。疫苗刺激强烈的体液和CTL反应。还描述了使用这种疫苗免疫的方法。

10. 发明申请

WO1997037008A1 MEANS AND PROCESS FOR NITRATE REMOVAL 审中-公开
标题翻译：硝酸盐去除的手段和方法
公开(公告)号：WO1997037008A1
公开(公告)日：1997-10-09
申请号：PCT/IL1997000116
申请日：1997-04-01
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , VAN RIJN , Jaap , NUSSINOVITCH, Amos , TAL, Joseph
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
IPC分类号： C12N11/10
CPC分类号： C02F3/108 , C02F3/2806 , C02F3/30 , C02F3/302 , C02F3/34 , C12N11/04 , Y02W10/15 , Y10S435/821
摘要： A system for nitrate removal from aquariums, both fresh water and marine aquariums, by means of permeable polymeric beads which contain a combination of fermentative and denitrifying bacteria and a carbon source. Preferred beads are beads made from sodium alginate or chitosan. The bacteria, in the presence of the carbon source, are able to reduce nitrate to nitrogen gas. Bacteria which are not harmful to fish are used. The porous beads used in the process are novel and part of the invention.
摘要翻译：通过含有发酵和反硝化细菌和碳源的组合的可渗透聚合物珠子，从水族馆，淡水和海洋水族箱中去除硝酸盐的系统。优选的珠粒是由藻酸钠或壳聚糖制成的珠粒。在碳源的存在下，细菌能够将硝酸盐还原成氮气。使用对鱼无害的细菌。在该方法中使用的多孔珠是新颖的和本发明的一部分。

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