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1. 发明申请

WO1998022132A1 A METHOD AND COMPOSITION FOR ENABLING PASSAGE THROUGH THE BLOOD-BRAIN BARRIER 审中-公开
标题翻译：通过血脑屏障通气的方法和组合物
公开(公告)号：WO1998022132A1
公开(公告)日：1998-05-28
申请号：PCT/US1997021696
申请日：1997-11-20
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I. , SOREQ, Hermona , FRIEDMAN, Alon , SEIDMAN, Shlomo , KAUFER, Daniela
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I.
IPC分类号： A61K38/46
CPC分类号： C12Y301/01007 , A61K31/137 , A61K31/138 , A61K31/46 , A61K38/465 , A61K2300/00
摘要： A pharmaceutical composition for facilitating passage of compounds through the blood-brain barrier comprising the agent ACHE-I4 readthrough (SEQ ID No:1) splice variant or the I4 peptide (SEQ ID No:2) and analogues of each thereof and a pharmaceutically acceptable carrier is disclosed. Alternatively, the pharmaceutical composition for facilitating passage of compounds through the blood-brain barrier can comprise the agents adrenaline, atropine, dopamine and/or an adrenergic combination and a pharmaceutically acceptable carrier. The composition can comprise at least two of the agents. The composition of the present invention can optionally include the compound to be transported across the blood-brain barrier. Alternatively, the compound can be co-administered (simultaneously) with the composition or can be administered at some point during the biologically effective period of the action of the composition. The present invention provides a method for administering a compound to the CNS of an animal by subjecting the animal to a stress-mimicking agent or treatment. This agent or treatment facilitates disruption of the blood-brain barrier. During the period that the BBB is opened or disrupted a compound can be administered such that the compound is enabled to pass through the disrupted BBB into the CNS.
摘要翻译：一种用于促进化合物通过包含透明试剂ACHE-I4（SEQ ID No：1）剪接变体或I4肽（SEQ ID No：2）及其各自的类似物的药物组合物和药学上可接受的药物组合物载体被披露。或者，用于促进化合物通过血脑屏障的药物组合物可以包含肾上腺素，阿托品，多巴胺和/或肾上腺素能组合剂和药学上可接受的载体。所述组合物可包含至少两种所述试剂。本发明的组合物可以任选地包括待跨越血脑屏障转运的化合物。或者，化合物可以与组合物共同施用（同时），或者可以在组合物的作用的生物学有效期间的某一点施用。本发明提供了通过使动物经受应激模拟剂或治疗而将化合物给予动物的CNS的方法。该药剂或治疗有助于破坏血脑屏障。在BBB开放或破坏的时期期间，化合物可以被施用使得化合物能够通过破坏的BBB进入CNS。

2. 发明申请

WO2004029290A3 PARKINSON'S DISEASE SUSCEPTIBILITY HAPLOTYPE AS A TOOL FOR GENETIC SCREENING 审中-公开
标题翻译：帕金森病的易感性作为遗传筛查的工具
公开(公告)号：WO2004029290A3
公开(公告)日：2004-07-08
申请号：PCT/IL0300764
申请日：2003-09-24
申请人： YISSUM RES DEV CO , UNIV BEN GURION , MOR RESEARCH APPLIC LTD , SOREQ HERMONA , BEN-MOYAL LIAT , BRYK BORIS , FRIEDMAN ALON
发明人： SOREQ HERMONA , BEN-MOYAL LIAT , BRYK BORIS , FRIEDMAN ALON
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： Specific PON1 and ACHE alleles segregate in linkage, forming an haplotype which directly correlates with higher susceptibility to develop Parkinson's Disease (PD). This PD-susceptibility haplotype is herein presented as a tool for predicting the risk of developing Parkinson's Disease and its severity, both for an individual and for the population in general. Thus, the present invention provides the use of said PD-susceptibility haplotype in diagnostic and screening methods.
摘要翻译：特定的PON1和ACHE等位基因以连锁分离，形成与更易发展帕金森病（PD）相关的单体型。这种PD易感性单元型在本文中作为预测帕金森氏病发病风险及其严重程度的工具，既用于个体又用于一般人群。因此，本发明提供了所述PD-易感性单倍型在诊断和筛选方法中的用途。

3. 发明申请

WO2004029290A2 PARKINSON'S DISEASE SUSCEPTIBILITY HAPLOTYPE AS A TOOL FOR GENETIC SCREENING 审中-公开
标题翻译： PARKINSON'S DISEASE SUSECEPTIBILITY HAPLOTYPE作为一种用于遗传筛选的工具
公开(公告)号：WO2004029290A2
公开(公告)日：2004-04-08
申请号：PCT/IL2003/000764
申请日：2003-09-24
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH & DEVELOPMENT AUTHORITY , MOR RESEARCH APPLICATIONS LTD. , SOREQ, Hermona , BEN-MOYAL, Liat , BRYK, Boris , FRIEDMAN, Alon
发明人： SOREQ, Hermona , BEN-MOYAL, Liat , BRYK, Boris , FRIEDMAN, Alon
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： Specific PON1 and ACHE alleles segregate in linkage, forming an haplotype which directly correlates with higher susceptibility to develop Parkinson's Disease (PD). This PD-susceptibility haplotype is herein presented as a tool for predicting the risk of developing Parkinson's Disease and its severity, both for an individual and for the population in general. Thus, the present invention provides the use of said PD-susceptibility haplotype in diagnostic and screening methods.
摘要翻译：特异性PON1和ACHE等位基因连锁分离，形成与更高易感性发展帕金森病（PD）直接相关的单倍型。这种PD-易感性单倍型在本文中被提供作为用于预测发展中的帕金森病的风险及其严重程度的工具，无论对于个人和一般人群来说。因此，本发明提供了所述PD-敏感性单元型在诊断和筛选方法中的用途。

4. 发明申请

WO9826062A3 SYNTHETIC ANTISENSE OLIGODEOXYNUCLEOTIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：合成抗体寡糖氧化酶和含有它们的药物组合物
公开(公告)号：WO9826062A3
公开(公告)日：1998-11-19
申请号：PCT/US9723598
申请日：1997-12-12
申请人： YISSUM RES DEV CO , KOHN KENNETH I , SOREQ HERMONA , SEIDMAN SHLOMO , ECKSTEIN FRITZ , FRIEDMAN ALON , KAUFER DANIELA
发明人： SOREQ HERMONA , SEIDMAN SHLOMO , ECKSTEIN FRITZ , FRIEDMAN ALON , KAUFER DANIELA
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P25/00 , A61P43/00 , C12N20060101 , C12N15/113 , C12Q1/68 , C12N15/00 , C12N9/00
CPC分类号： C12Y301/01007 , A01K2217/05 , A61K38/00 , C12N15/1137 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/53 , C12N2310/3521
摘要： A synthetic nuclease resistant antisense oligodeoxynucleotide (AS-ODN) capable of selectively modulating human acetylcholinesterase (AChE) production and a pharmaceutical or medical composition comprising at least one AD-ODN as an active ingredient. In an embodiment the AS-ODN can be selected from 5'ACGCTTTCTTGAGGC 3' (SEQ ID NO.1), 5'GGCACCCTGGGCAGC 3' (SEQ ID NO.2); 5'CCACGTCCTCCTGCACCGTC 3' (SEQ ID NO.6); 5'ATGAACTCGATCTCGTAGCC 3' (SEQ ID NO.7); 5'GCCAGAGGAGGAGGAGAAGG 3' (SEQ ID NO.4); 5'TAGCGTCTACCACCCCTGAC 3' (SEQ ID NO.5), 5'TCTGTGTTATAGCCCAGCCC 3' (SEQ ID NO.17); and 5'GGCCTGTAACAGTTTATTT 3' (SEQ ID NO.18). A nuclease resistant antisense targeted against the splice junction in the AChEmRNA post splice message is disclosed. In an embodiment, a nuclease resistant AS-ODN targeted against the E4-E6 junction in the E1-E4-E6 splice variant AChEmRNA is disclosed as being highly specific for the muscle and central nervous system splice variant of AChE. The synthetic nuclease resistant AS-ODNs are capable of selectively modulating human AChE production in the central nervous system or capable of selectively reducing human AChE deposition in the neuromuscular junction. The present invention also provides a method to restore balanced cholinergic signaling in the brain and spinal cord or reduce AChE in the neuromuscular junction in patients in need of such treatment comprising administering to a patient in need of such treatment a therapeutically effective amount of at least one of the synthetic nuclease resistant AS-ODN capable of selectively modulating human AChE production.

5. 发明申请

WO2011021175A3 SYSTEM AND METHOD FOR ANALYZING IMAGING DATA 审中-公开
标题翻译：用于分析成像数据的系统和方法
公开(公告)号：WO2011021175A3
公开(公告)日：2011-06-30
申请号：PCT/IL2009000847
申请日：2009-09-01
申请人： UNIV BEN GURION , FRIEDMAN ALON , CHASSIDIM YOASH , PRAGER OFER , SHELEF ILAN
发明人： FRIEDMAN ALON , CHASSIDIM YOASH , PRAGER OFER , SHELEF ILAN
IPC分类号： A61B5/026 , G01R33/563 , G06T7/00
CPC分类号： G06T7/0016 , A61B3/0025 , A61B3/1241 , A61B5/0059 , A61B5/0263 , A61B5/0275 , A61B5/4064 , A61B5/7207 , A61B6/037 , A61B6/501 , A61B6/507 , A61B6/5217 , A61B8/06 , A61B8/5223 , G01R33/5608 , G01R33/563 , G01R33/5635 , G06T2207/10064 , G06T2207/10096 , G06T2207/30016 , G06T2207/30041 , G06T2207/30104
摘要： A method of analyzing a stream of imaging data is disclosed. The method comprises: for each picture-element of the data, associating a vector of features indicative of temporal intensity variation relative to baseline intensity, thereby providing a plurality of vectors. The method further comprises clustering the picture-elements according to the vectors, thereby providing a plurality of clusters, and identifying different compartments in the vasculature based on the clusters.
摘要翻译：公开了一种分析成像数据流的方法。该方法包括：对于数据的每个图像元素，将指示相对于基线强度的时间强度变化的特征向量相关联，从而提供多个向量。该方法还包括根据向量对图像元素进行聚类，从而提供多个聚类，并且基于聚类识别脉管系统中的不同隔室。

6. 发明申请

WO2010065917A1 METHODS OF TREATING NEUROLOGICAL DISORDERS 审中-公开
标题翻译：治疗神经疾病的方法
公开(公告)号：WO2010065917A1
公开(公告)日：2010-06-10
申请号：PCT/US2009/066856
申请日：2009-12-04
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BEN-GURION UNIVERSITY OF THE NEGEV , KAUFER, Daniela , FRIEDMAN, Alon , CACHEAUX, Luisa
发明人： KAUFER, Daniela , FRIEDMAN, Alon , CACHEAUX, Luisa
IPC分类号： A61K31/70
CPC分类号： A61K31/4178 , A61K9/0019 , A61K9/0053 , A61K9/0085 , A61K31/00 , A61K31/4439 , A61K31/70 , A61K45/06 , C07K16/2863 , C07K2317/76 , C12N15/1136
摘要： The present invention provides methods of treating epilepsy and other neurological disorders. The methods generally involve administering to an individual in need thereof an effective amount of an agent that blocks a transforming growth factor-beta pathway
摘要翻译：本发明提供了治疗癫痫和其他神经障碍的方法。所述方法通常涉及向有需要的个体施用有效量的阻断转化生长因子-β途径的药剂

7. 发明申请

WO2011021175A2 SYSTEM AND METHOD FOR ANALYZING IMAGING DATA 审中-公开
标题翻译：用于分析成像数据的系统和方法
公开(公告)号：WO2011021175A2
公开(公告)日：2011-02-24
申请号：PCT/IL2009/000847
申请日：2009-09-01
申请人： BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY , FRIEDMAN, Alon , CHASSIDIM, Yoash , PRAGER, Ofer , SHELEF, Ilan
发明人： FRIEDMAN, Alon , CHASSIDIM, Yoash , PRAGER, Ofer , SHELEF, Ilan
IPC分类号： G06T7/00
CPC分类号： G06T7/0016 , A61B3/0025 , A61B3/1241 , A61B5/0059 , A61B5/0263 , A61B5/0275 , A61B5/4064 , A61B5/7207 , A61B6/037 , A61B6/501 , A61B6/507 , A61B6/5217 , A61B8/06 , A61B8/5223 , G01R33/5608 , G01R33/563 , G01R33/5635 , G06T2207/10064 , G06T2207/10096 , G06T2207/30016 , G06T2207/30041 , G06T2207/30104
摘要： A method of analyzing a stream of imaging data is disclosed. The method comprises: for each picture-element of the data, associating a vector of features indicative of temporal intensity variation relative to baseline intensity, thereby providing a plurality of vectors. The method further comprises clustering the picture-elements according to the vectors, thereby providing a plurality of clusters, and identifying different compartments in the vasculature based on the clusters.
摘要翻译：公开了一种分析成像数据流的方法。该方法包括：对于数据的每个图像元素，将指示相对于基线强度的时间强度变化的特征矢量相关联，由此提供多个矢量。该方法还包括根据矢量对图像元素进行聚类，从而提供多个聚类，并且基于聚类识别脉管系统中的不同隔室。

8. 发明申请

WO0073343A3 DIAGNOSTIC USES OF ANTIBODIES AGAINST ACETYLCHOLINESTERASE OR C-TERMINAL PEPTIDES THEREOF 审中-公开
标题翻译：对乙酰胆碱酯酶或其C-末端肽的抗体的诊断用途
公开(公告)号：WO0073343A3
公开(公告)日：2001-01-18
申请号：PCT/IL0000312
申请日：2000-05-31
申请人： YISSUM RES DEV CO , SOREQ HERMONA , KAUFER DANIELA , FRIEDMAN ALON , SEIDMAN SHLOMO
发明人： SOREQ HERMONA , KAUFER DANIELA , FRIEDMAN ALON , SEIDMAN SHLOMO
IPC分类号： C07K16/40 , G01N33/573
CPC分类号： C07K16/40 , G01N2800/2821
摘要： The invention relates to antibodies recognizing acetylcholinesterase or a C-terminal peptide derived from acetylcholinesterase, useful in diagnosing central nervous system (CNS) stress, elevated glucocorticoid level, disruption of the blood-brain barrier or Alzheimer's disease. The invention also relates to methods for the diagnosis of central nervous system (CNS) stress, elevated glucocorticoid level or disruption of the blood-brain barrier in a mammal, by use of the antibodies of the invention.
摘要翻译：本发明涉及可用于诊断中枢神经系统（CNS）应激，升高的糖皮质激素水平，血脑屏障或阿尔茨海默病破坏的乙酰胆碱酯酶或源自乙酰胆碱酯酶的C-末端肽的抗体。本发明还涉及通过使用本发明的抗体诊断中枢神经系统（CNS）应激，升高的糖皮质激素水平或哺乳动物血脑屏障破坏的方法。

9. 发明申请

WO1998026062A2 SYNTHETIC ANTISENSE OLIGODEOXYNUCLEOTIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：合成抗体寡糖氧化酶和含有它们的药物组合物
公开(公告)号：WO1998026062A2
公开(公告)日：1998-06-18
申请号：PCT/US1997023598
申请日：1997-12-12
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I. , SOREQ, Hermona , SEIDMAN, Shlomo , ECKSTEIN, Fritz , FRIEDMAN, Alon , KAUFER, Daniela
发明人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , KOHN, Kenneth, I.
IPC分类号： C12N15/00
CPC分类号： C12Y301/01007 , A01K2217/05 , A61K38/00 , C12N15/1137 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/53 , C12N2310/3521
摘要： A synthetic nuclease resistant antisense oligodeoxynucleotide (AS-ODN) capable of selectively modulating human acetylcholinesterase (AChE) production and a pharmaceutical or medical composition comprising at least one AD-ODN as an active ingredient. In an embodiment the AS-ODN can be selected from 5'ACGCTTTCTTGAGGC 3' (SEQ ID NO.1), 5'GGCACCCTGGGCAGC 3' (SEQ ID NO.2); 5'CCACGTCCTCCTGCACCGTC 3' (SEQ ID NO.6); 5'ATGAACTCGATCTCGTAGCC 3' (SEQ ID NO.7); 5'GCCAGAGGAGGAGGAGAAGG 3' (SEQ ID NO.4); 5'TAGCGTCTACCACCCCTGAC 3' (SEQ ID NO.5), 5'TCTGTGTTATAGCCCAGCCC 3' (SEQ ID NO.17); and 5'GGCCTGTAACAGTTTATTT 3' (SEQ ID NO.18). A nuclease resistant antisense targeted against the splice junction in the AChEmRNA post splice message is disclosed. In an embodiment, a nuclease resistant AS-ODN targeted against the E4-E6 junction in the E1-E4-E6 splice variant AChEmRNA is disclosed as being highly specific for the muscle and central nervous system splice variant of AChE. The synthetic nuclease resistant AS-ODNs are capable of selectively modulating human AChE production in the central nervous system or capable of selectively reducing human AChE deposition in the neuromuscular junction. The present invention also provides a method to restore balanced cholinergic signaling in the brain and spinal cord or reduce AChE in the neuromuscular junction in patients in need of such treatment comprising administering to a patient in need of such treatment a therapeutically effective amount of at least one of the synthetic nuclease resistant AS-ODN capable of selectively modulating human AChE production.
摘要翻译：能够选择性调节人乙酰胆碱酯酶（AChE）生产的合成核酸酶抗性反义寡脱氧核苷酸（AS-ODN）和包含至少一种AD-ODN作为活性成分的药物或医药组合物。在一个实施方案中，AS-ODN可以选自5'ACGCTTTCTTGAGGC 3'（SEQ ID NO.1），5'GGCACCCTGGGCAGC 3'（SEQ ID NO.2）; 5'CCACGTCCTCCTGCACCGTC 3'（SEQ ID NO.6）; 5'ATGAACTCGATCTCGTAGCC 3'（SEQ ID NO.7）; 5'GCCAGAGGAGGAGGAGAAGG 3'（SEQ ID NO.4）; 5'TAGCGTCTACCACCCCTGAC 3'（SEQ ID NO.5），5'TCTGTGTTATAGCCCAGCCC 3'（SEQ ID NO.17）; 和5'GGCCTGTAACAGTTTATTT 3'（SEQ ID NO.18）。公开了针对针对AChEmRNA后剪接消息中的剪接连接的核酸酶抗性反义。在一个实施方案中，公开了针对E1-E4-E6剪接变体AChEmRNA中的E4-E6连接的核酸酶抗性AS-ODN作为AChE的肌肉和中枢神经系统剪接变体的高度特异性。合成的核酸酶抗性AS-ODNs能够选择性调节中枢神经系统中的人AChE产生或能够选择性地降低神经肌肉接头中的人类AChE沉积。本发明还提供一种在需要这种治疗的患者中恢复脑和脊髓中的平衡胆碱能信号传导或减少神经肌肉接头中的AChE的方法，包括向需要这种治疗的患者施用治疗有效量的至少一种的能够选择性调节人AChE生产的合成核酸酶抗性AS-ODN。

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